Efficacy and Safety of Vitamin D Supplementation to Prevent COVID-19 in Frontline Healthcare Workers. A Randomized Clinical Trial
Villasis-Keever et al.,
Efficacy and Safety of Vitamin D Supplementation to Prevent COVID-19 in Frontline Healthcare Workers. A..,
Archives of Medical Research, doi:10.1016/j.arcmed.2022.04.003
RCT 321 healthcare workers in Mexico, showing significantly lower SARS-CoV-2 infection with vitamin D prophylaxis. 4,000IU daily for 30 days.
In comparison to
[Jolliffe], this study used a higher dose, the participants had much higher exposure to SARS-CoV-2 patients, and the study was prior to vaccination. In
[Jolliffe], 89% of participants had received a vaccine dose by the end of the study period, and the period overlapped with increasing solar UVB.
For more discussion see
[]
risk of hospitalization, 66.5% lower, RR 0.33, p = 1.00, treatment 0 of 150 (0.0%), control 1 of 152 (0.7%), NNT 152, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), ITT.
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risk of case, 78.0% lower, RR 0.22, p = 0.001, treatment 7 of 150 (4.7%), control 26 of 152 (17.1%), NNT 8.0, adjusted per study, multivariable, Table 3.
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Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
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Villasis-Keever et al., 18 Apr 2022, Double Blind Randomized Controlled Trial, placebo-controlled, Mexico, peer-reviewed, 16 authors, study period 15 July, 2020 - 30 December, 2020, dosage 4,000IU daily.
Abstract: Journal Pre-proof
Efficacy and Safety of Vitamin D Supplementation to Prevent
COVID-19 in Frontline Healthcare Workers. A Randomized Clinical
Trial
Miguel A Villasis-Keever , Mardia G López-Alarcón ,
Guadalupe Miranda-Novales , Jessie N Zurita-Cruz ,
Aly S Barrada-Vázquez , Joaquı́n González-Ibarra ,
Monserrat Martı́nez-Reyes , Concepción Grajales-Muñiz ,
Clara E Santacruz-Tinoco , Bernardo Martı́nez-Miguel ,
Jorge Maldonado-Hernández , Yazmı́n Cifuentes-González ,
Miguel Klünder-Klünder , Juan Garduño-Espinosa ,
Briseida López-Martı́nez , Israel Parra-Ortega
PII:
DOI:
Reference:
S0188-4409(22)00045-5
https://doi.org/10.1016/j.arcmed.2022.04.003
ARCMED 2733
To appear in:
Archives of Medical Research
Received date:
Revised date:
Accepted date:
February 28, 2022
March 25, 2022
April 11, 2022
Please
cite
this
article
as:
Miguel A Villasis-Keever ,
Mardia G López-Alarcón ,
Guadalupe Miranda-Novales ,
Jessie N Zurita-Cruz ,
Aly S Barrada-Vázquez ,
Joaquı́n González-Ibarra ,
Monserrat Martı́nez-Reyes ,
Concepción Grajales-Muñiz ,
Clara E Santacruz-Tinoco ,
Bernardo Martı́nez-Miguel ,
Jorge Maldonado-Hernández ,
Yazmı́n Cifuentes-González ,
Miguel Klünder-Klünder ,
Juan Garduño-Espinosa ,
Briseida López-Martı́nez , Israel Parra-Ortega , Efficacy and Safety of Vitamin D Supplementation to Prevent COVID-19 in Frontline Healthcare Workers. A Randomized Clinical Trial, Archives of
Medical Research (2022), doi: https://doi.org/10.1016/j.arcmed.2022.04.003
This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition
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© 2022 Published by Elsevier Inc. on behalf of Instituto Mexicano del Seguro Social (IMSS).
Arch Med Res
22-00242
Highlights
Due to its immunomodulatory properties, vitamin D is expected to have a role in viral
infections including SARS-CoV-2
Supplementation with vitamin D in highly exposed individuals such as frontline health care
workers, decreases the susceptibility for SARS-CoV-2 infection
The preventive effect of vitamin D supplementation is independent of vitamin D status
Medium doses of vitamin D (4000 IU per day) seems safe for short periods of
supplementation
1
Arch Med Res
22-00242
ORIGINAL ARTICLE
Vitamin D effectiveness to Prevent COVID-19
Efficacy and Safety of Vitamin D Supplementation to Prevent COVID-19 in Frontline Healthcare
Workers. A Randomized Clinical Trial
Miguel A Villasis-Keevera, Mardia G López-Alarcónb, Guadalupe Miranda-Novalesa, Jessie N
Zurita-Cruzc, Aly S Barrada-Vázquezb, Joaquín González-Ibarrad, Monserrat Martínez-Reyesb,
Concepción Grajales-Muñize, Clara E Santacruz-Tinocoe, Bernardo Martínez-Miguele, Jorge
Maldonado-Hernándezb, Yazmín Cifuentes-Gonzálezb, Miguel Klünder-Klünderf, Juan GarduñoEspinosaf, Briseida López-Martínezf, Israel Parra-Ortegaf
a
Unidad de Investigación en Análisis y Síntesis de la Evidencia, Centro Médico Nacional Siglo XXI,
Instituto Mexicano del Seguro Social, Ciudad de México, México
b
Unidad de Investigación Médica..
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