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The Role of Vitamin D in the Age of COVID-19: A Systematic Review and Meta-Analysis
Ghasemian et al., The International Journal of Clinical Practice, doi:10.1111/ijcp.14675 (meta analysis)
Ghasemian et al., The Role of Vitamin D in the Age of COVID-19: A Systematic Review and Meta-Analysis, The International Journal of Clinical Practice, doi:10.1111/ijcp.14675 (meta analysis)
Jul 2021   Source   PDF  
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Systematic review and meta analysis of 23 studies, finding significantly higher risk of COVID-19 cases and severity with vitamin D deficiency. Mortality risk was higher with deficiency, but not reaching statistical significance, OR 1.6 [0.5-4.4].
Currently there are 107 vitamin D studies and meta analysis shows:
OutcomeImprovement
Mortality36% lower [28‑44%]
Ventilation26% lower [-2‑46%]
ICU admission50% lower [33‑62%]
Hospitalization20% lower [8‑31%]
Cases15% fewer [6‑23%]
Ghasemian et al., 29 Jul 2021, peer-reviewed, 25 authors.
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Abstract: Accepted Article The Role of Vitamin D in the Age of COVID-19: A Systematic Review and Meta-Analysis Roya Ghasemian1, Amir Shamshirian2,3*, Keyvan Heydari3,4, Mohammad Malekan4, Reza AlizadehNavaei3, Mohammad Ali Ebrahimzadeh5, Majid Ebrahimi Warkiani6,7, Hamed Jafarpour4, Sajad Razavi Bazaz6, Arash Rezaei Shahmirzadi8, Mehrdad Khodabandeh9, Benyamin Seyfari10, Alireza Motamedzadeh11, Ehsan Dadgostar12, Marzieh Aalinezhad13, Meghdad Sedaghat14, Nazanin Razzaghi8, Bahman Zarandi15, Anahita Asadi5, Vahid Yaghoubi Naei16, Reza Beheshti5, Amirhossein Hessami2, Soheil Azizi17, Ali Reza Mohseni17,18, Danial Shamshirian19* 1. Antimicrobial Resistance Research Center, Department of Infectious Diseases, Mazandaran University of Medical Sciences, Sari, Iran. 2. Department of Medical Laboratory Sciences, Student Research Committee, School of Allied Medical Science, Mazandaran University of Medical Sciences, Sari, Iran. 3. Gastrointestinal Cancer Research Center, Mazandaran University of Medical Sciences, Sari, Iran. 4. Student Research Committee, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. 5. Pharmaceutical Sciences Research Center, Department of Medicinal Chemistry, School of Pharmacy, Mazandaran University of Medical Science, Sari, Iran. 6. School of Biomedical Engineering, University of Technology Sydney, Sydney, Ultimo, NSW, 2007, Australia. 7. Institute of Molecular Medicine, Sechenov First Moscow State University, Moscow, 119991, Russia. 8. Student Research Committee, Golestan University of Medical Sciences, Gorgan, Iran. 9. Neuromusculoskeletal Research Center, Department of Physical Medicine and Rehabilitation, Iran University of Medical Sciences, Tehran, Iran. 10. Department of Surgery, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran. 11. Department of Internal Medicine, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran. 12. Halal Research Center of IRI, FDA, Tehran, Iran. 13. Department of Radiology, Isfahan University of Medical Sciences, Isfahan, I.R. Iran. 14. Department of Internal Medicine, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 15. Student Research Committee, Iran University of Medical Sciences, Tehran, Iran. 16. Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. 17. Department of Medical Laboratory Sciences, School of Allied Medical Science, Mazandaran University of Medical Sciences, Sari, Iran. This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/ijcp.14675 This article is protected by copyright. All rights reserved Accepted Article 18. Thalassemia Research Center, Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran. 19. Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran. Corresponding authors: 1. Danial Shamshirian, Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran. E-Mail: shamshirian@sbmu.ac.ir Tel: +98 912 640 6146 2. Amir Shamshirian;..
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