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The Role of Vitamin D in the Age of COVID-19: A Systematic Review and Meta-Analysis

Ghasemian et al., The International Journal of Clinical Practice, doi:10.1111/ijcp.14675
Jul 2021  
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Systematic review and meta analysis of 23 studies, finding significantly higher risk of COVID-19 cases and severity with vitamin D deficiency. Mortality risk was higher with deficiency, but not reaching statistical significance, OR 1.6 [0.5-4.4].
9 meta analyses show significant improvements with vitamin D treatment for mortality Argano, D’Ecclesiis, Hariyanto, Hosseini, Nikniaz, Shah, Xie, mechanical ventilation Hariyanto, Shah, Xie, ICU admission Hariyanto, Hosseini, Shah, Tentolouris, Xie, hospitalization Argano, severity D’Ecclesiis, Nikniaz, Varikasuvu, Xie, and cases Varikasuvu.
Currently there are 115 vitamin D treatment for COVID-19 studies, showing 36% lower mortality [27‑43%], 16% lower ventilation [-8‑35%], 47% lower ICU admission [29‑61%], 20% lower hospitalization [8‑29%], and 16% fewer cases [7‑23%].
Ghasemian et al., 29 Jul 2021, peer-reviewed, 25 authors.
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The role of vitamin D in the age of COVID‐19: A systematic review and meta‐analysis
Roya Ghasemian, Amir Danial Shamshirian, Keyvan Heydari, Mohammad Malekan, Reza Alizadeh‐navaei, Mohammad Ali Ebrahimzadeh, Majid Ebrahimi Warkiani, Hamed Jafarpour, Sajad Razavi Bazaz, Arash Rezaei Shahmirzadi, Mehrdad Khodabandeh, Benyamin Seyfari, Alireza Motamedzadeh, Ehsan Dadgostar, Marzieh Aalinezhad, Meghdad Sedaghat, Nazanin Razzaghi, Bahman Zarandi, Anahita Asadi, Vahid Yaghoubi Naei, Reza Beheshti, Amirhossein Hessami, Soheil Azizi, Ali Reza Mohseni, Danial Shamshirian
International Journal of Clinical Practice, doi:10.1111/ijcp.14675
This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record.
Ethics approval and consent to participate Not applicable. Consent for publication Not applicable. Competing interests The authors declare that they have no competing interests. Funding None.
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