Association of vitamin D status with hospital morbidity and mortality in adult hospitalized COVID-19 patients
Charoenngam et al.
, Association of vitamin D status with hospital morbidity and mortality in adult hospitalized COVID-19 patients
, Endocrine Practice, doi:10.1016/j.eprac.2021.02.013
Retrospective 287 hospitalized patients in the USA showing significantly lower mortality with vitamin D sufficiency in elderly patients and patients without obesity; and lower mortality for all patients but not reaching statistical signifance.
risk of death, 34.1% lower, RR 0.66, p = 0.26, high D levels 12 of 100 (12.0%), low D levels 29 of 187 (15.5%), adjusted per study, odds ratio converted to relative risk, >=30ng/mL.
risk of mechanical ventilation, 37.2% lower, RR 0.63, p = 0.17, high D levels 14 of 100 (14.0%), low D levels 34 of 187 (18.2%), adjusted per study, odds ratio converted to relative risk, >=30ng/mL.
risk of ICU admission, 23.1% lower, RR 0.77, p = 0.28, high D levels 25 of 100 (25.0%), low D levels 56 of 187 (29.9%), NNT 20, adjusted per study, odds ratio converted to relative risk, >=30ng/mL.
risk of death, 58.1% lower, RR 0.42, p = 0.05, high D levels 7 of 57 (12.3%), low D levels 25 of 79 (31.6%), NNT 5.2, adjusted per study, odds ratio converted to relative risk, >65 years old, >=30ng/mL.
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Charoenngam et al., 8 Mar 2021, retrospective, USA, peer-reviewed, 6 authors.
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Endocrine Practice 27 (2021) 271e278
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journal homepage: www.endocrinepractice.org
Association of Vitamin D Status With Hospital Morbidity and Mortality
in Adult Hospitalized Patients With COVID-19
Nipith Charoenngam, MD 1, 2, Arash Shirvani, MD, PhD 1, Niyoti Reddy, MBBS 1,
Danica M. Vodopivec, MD 1, Caroline M. Apovian, MD 3, Michael F. Holick, PhD, MD 1, *
Section Endocrinology, Diabetes, Nutrition and Weight Management, Department of Medicine, Boston University School of Medicine, Boston,
Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Thailand
Section of Endocrinology, Diabetes and Hypertension, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts
a r t i c l e i n f o
a b s t r a c t
Available online 9 March 2021
Objective: To determine the association between vitamin D status and morbidity and mortality in adult
hospitalized coronavirus disease 2019 (COVID-19) patients
Methods: We performed a retrospective chart review study in COVID-19 patients aged 18 year hospitalized at Boston University Medical Center between March 1 and August 4, 2020. All studied patients
tested positive for COVID-19 and had serum levels of 25-hydroxyvitamin D (25[OH]D) results measured
within 1 year prior to the date of positive tests. Medical information was retrieved from the electronic
medical record and was analyzed to determine the association between vitamin D status and hospital
morbidity and mortality.
Results: Among the 287 patients, 100 (36%) were vitamin D sufﬁcient (25[OH]D >30 ng/mL) and 41 (14%)
died during hospitalization. Multivariate analysis in patients aged 65 years revealed that vitamin D
sufﬁciency (25[OH]D 30 ng/mL) was statistically signiﬁcantly associated with decreased odds of death
(adjusted OR 0.33, 95% CI, 0.12-0.94), acute respiratory distress syndrome (adjusted OR 0.22, 95% CI, 0.050.96), and severe sepsis/septic shock (adjusted OR 0.26, 95% CI, 0.08-0.88), after adjustment for potential
confounders. Among patients with body mass index <30 kg/m2, vitamin D sufﬁciency was statistically
signiﬁcantly associated with a decreased odds of death (adjusted OR 0.18, 95% CI, 0.04-0.84). No signiﬁcant association was found in the subgroups of patients aged <65 years or with body mass index 30
Conclusion: We revealed an independent association between vitamin D sufﬁciency deﬁned by serum
25(OH)D 30 ng/mL and decreased risk of mortality from COVID-19 in elderly patients and patients
© 2021 AACE. Published by Elsevier Inc. All rights reserved.
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