Association of Vitamin D Status With Hospital Morbidity and Mortality in Adult Hospitalized Patients With COVID-19
MD Nipith Charoenngam, MD, PhD Arash Shirvani, MBBS Niyoti Reddy, MD Danica M Vodopivec, MD Caroline M Apovian, PhD, MD Michael F Holick
Endocrine Practice, doi:10.1016/j.eprac.2021.02.013
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Disclosure M.F.H. is a consultant for Quest Diagnostics, Inc, Biogena, Inc, and Ontometrics, Inc, and on the speaker's bureau for Abbott, Inc. C.M.A. reports receiving personal fees from Nutrisystem, Zafgen, Sanofi-Aventis, Orexigen, EnteroMedics, GI Dynamics, Scientific Intake, Gelesis, Novo Nordisk, SetPoint Health, Xeno Biosciences, Rhythm Pharmaceuticals, Eisai, and Takeda outside of the funded work, reports receiving grant funding from Aspire Bariatrics, GI Dynamics, Orexigen, Takeda, the Vela Foundation, Gelesis, Energesis, Coherence Lab, and Novo Nordisk outside of the funded work, and reports past equity interest in ScienceSmart, LLC. The remaining authors have no conflicts of interest.
References
Amrein, Schnedl, Holl, Effect of high-dose vitamin D3 on hospital length of stay in critically ill patients with vitamin D deficiency: the VITdAL-ICU randomized clinical trial, JAMA
Aygun, Vitamin D can prevent COVID-19 infection-induced multiple organ damage, Naunyn Schmiedebergs Arch Pharmacol
Bikle, Schwartz, Vitamin D binding protein, total and free vitamin D levels in different physiological and pathophysiological conditions, Front Endocrinol
Boonstra, Barrat, Crain, Heath, Savelkoul et al., 1alpha,25-Dihydroxyvitamin D3 has a direct effect on naive CD4(þ) T cells to enhance the development of Th2 cells, J Immunol
Castillo, Costa, Barrios, Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: a pilot randomized clinical study, J Steroid Biochem Mol Biol
Charoenngam, Holick, Immunologic effects of vitamin D on human health and disease, Nutrients
Charoenngam, Shirvani, Holick, Vitamin D for skeletal and non-skeletal health: what we should know, J Clin Orthop Trauma
Charoenngam, Shirvani, Reddy, None, Endocrine Practice
De Haan, Groeneveld, De Geus, Egal, Struijs, Vitamin D deficiency as a risk factor for infection, sepsis and mortality in the critically ill: systematic review and meta-analysis, Crit Care
Gibson, Davis, Zhu, Dietary vitamin D and its metabolites nongenomically stabilize the endothelium, PLoS One
Hars, Mendes, Serratrice, Sex-specific association between vitamin D deficiency and COVID-19 mortality in older patients, Osteoporos Int
Hern Andez, Nan, Fernandez-Ayala, Vitamin D status in hospitalized patients with SARS-CoV-2 infection, J Clin Endocrinol Metab
Holick, Binkley, Bischoff-Ferrari, Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline, J Clin Endocrinol Metab
Holick, Vitamin D deficiency, N Engl J Med
Hussain, Mahawar, Xia, Yang, El-Hasani, Obesity and mortality of COVID-19. Meta-analysis, Obes Res Clin Pract
Jain, Gautam, Naseem, Acute-phase proteins: as diagnostic tool, J Pharm Bioallied Sci
Kaufman, Niles, Kroll, Bi, Holick, SARS-CoV-2 positivity rates associated with circulating 25-hydroxyvitamin D levels, PLOS ONE
Khunti, Singh, Pareek, Hanif, Is ethnicity linked to incidence or outcomes of covid-19?, BMJ
Kim, Meza, Clarke, Kim, Hickner, Vitamin D and endothelial function, Nutrients
Kroll, Bi, Garber, Temporal relationship between vitamin D status and parathyroid hormone in the United States, PLOS ONE
Lemire, Archer, Beck, Spiegelberg, Immunosuppressive actions of 1,25-dihydroxyvitamin D3: preferential inhibition of Th1 functions, J Nutr
Liu, Stenger, Li, Toll-like receptor triggering of a vitamin Dmediated human antimicrobial response
Maghbooli, Sahraian, Ebrahimi, Vitamin D sufficiency, a serum 25-hydroxyvitamin D at least 30 ng/mL reduced risk for adverse clinical outcomes in patients with COVID-19 infection, PLOS ONE
Martineau, Jolliffe, Hooper, Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data, BMJ
Meltzer, Best, Zhang, Vokes, Arora et al., Association of vitamin D status and other clinical characteristics with COVID-19 test results, JAMA Network Open
Migliaccio, Nisio, Mele, Obesity and hypovitaminosis D: causality or casualty?, Int J Obes Suppl
Ortega, Serrano, Pujol, Rangel, Role of changes in SARS-CoV-2 spike protein in the interaction with the human ACE2 receptor: an in silico analysis, EXCLI J
Radujkovic, Hippchen, Tiwari-Heckler, Dreher, Boxberger, Vitamin D deficiency and outcome of COVID-19 patients, Nutrients
Romero Starke, Petereit-Haack, Schubert, The age-related risk of severe outcomes due to COVID-19 infection: a rapid review, meta-analysis, and meta-regression, Int J Environ Res Public Health
Rudnicka, Napierała, Podfigurna, Me ˛czekalski, Smolarczyk et al., The World Health Organization (WHO) approach to healthy ageing, Maturitas
Shahmiri, Enciso, Adda, Smith, Perugini et al., Membrane core-specific antimicrobial action of cathelicidin LL-37 peptide switches between pore and nanofibre formation, Sci Rep
Snowden, Graaf, COVID-19, social determinants past, present, and future, and African Americans' health, J Racial Ethn Health Disparities
Tang, Zhou, Luger, Calcitriol suppresses antiretinal autoimmunity through inhibitory effects on the Th17 effector response, J Immunol
Vanlint, Vitamin D and obesity, Nutrients
Wacker, Holick, Sunlight and vitamin D: a global perspective for health, Dermatoendocrinol
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'inhibition of Th1 functions',
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'author': 'Hernández',
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'author': 'Bikle',
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