Abstract: Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. Endocrine Practice 27 (2021) 271e278 Contents lists available at ScienceDirect Endocrine Practice journal homepage: www.endocrinepractice.org Original Article Association of Vitamin D Status With Hospital Morbidity and Mortality in Adult Hospitalized Patients With COVID-19 Nipith Charoenngam, MD 1, 2, Arash Shirvani, MD, PhD 1, Niyoti Reddy, MBBS 1, Danica M. Vodopivec, MD 1, Caroline M. Apovian, MD 3, Michael F. Holick, PhD, MD 1, * 1 Section Endocrinology, Diabetes, Nutrition and Weight Management, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Thailand 3 Section of Endocrinology, Diabetes and Hypertension, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 2 a r t i c l e i n f o a b s t r a c t Article history: Available online 9 March 2021 Objective: To determine the association between vitamin D status and morbidity and mortality in adult hospitalized coronavirus disease 2019 (COVID-19) patients Methods: We performed a retrospective chart review study in COVID-19 patients aged
18 year hospitalized at Boston University Medical Center between March 1 and August 4, 2020. All studied patients tested positive for COVID-19 and had serum levels of 25-hydroxyvitamin D (25[OH]D) results measured within 1 year prior to the date of positive tests. Medical information was retrieved from the electronic medical record and was analyzed to determine the association between vitamin D status and hospital morbidity and mortality. Results: Among the 287 patients, 100 (36%) were vitamin D sufficient (25[OH]D >30 ng/mL) and 41 (14%) died during hospitalization. Multivariate analysis in patients aged
65 years revealed that vitamin D sufficiency (25[OH]D
30 ng/mL) was statistically significantly associated with decreased odds of death (adjusted OR 0.33, 95% CI, 0.12-0.94), acute respiratory distress syndrome (adjusted OR 0.22, 95% CI, 0.050.96), and severe sepsis/septic shock (adjusted OR 0.26, 95% CI, 0.08-0.88), after adjustment for potential confounders. Among patients with body mass index <30 kg/m2, vitamin D sufficiency was statistically significantly associated with a decreased odds of death (adjusted OR 0.18, 95% CI, 0.04-0.84). No significant association was found in the subgroups of patients aged <65 years or with body mass index
30 kg/m2. Conclusion: We revealed an independent association between vitamin D sufficiency defined by serum 25(OH)D
30 ng/mL and decreased risk of mortality from COVID-19 in elderly patients and patients without obesity. © 2021 AACE. Published by Elsevier Inc. All rights reserved. Key words: vitamin..