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Vitamin D and SARS-CoV-2 Infection: SERVE Study (SARS-CoV-2 Exposure and the Role of Vitamin D among Hospital Employees)
Liu et al., The Journal of Nutrition, doi:10.1016/j.tjnut.2023.03.001
Liu et al., Vitamin D and SARS-CoV-2 Infection: SERVE Study (SARS-CoV-2 Exposure and the Role of Vitamin D among Hospital.., The Journal of Nutrition, doi:10.1016/j.tjnut.2023.03.001
Mar 2023   Source   PDF  
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Prospective study of 250 healthcare workers in the USA. The results are unclear - Figure 3 shows ~40% lower incidence with vitamin D supplementation, while the text indicates OR 1.18.
Authors collected symptom information, stating that "55% were symptomatic; the most common symptoms were cough, sore throat, and loss of taste or smell. Nine participants (16%) sought medical care...", but provide no information on symptoms per group for vitamin D supplementation. It is unclear what the definition of infection is - based on the antibody tests only, or also including self-reported cases? The meaning of increased antibodies is also not clear - vitamin D may improve antibody production.
Authors state "Despite a lack of evidence, a recent study found that nearly 70% of health care workers reported recommending vitamin D supplements...", however there is extensive evidence. There are currently 107 studies showing 37% [31‑42%] lower risk, including 26 RCTs showing 31% [17‑42%] lower risk.
Authors perform multivariable analysis for serum levels, but do not provide the results other than indicating they did not reach statistical significance. Similarly, they note no significant association between levels and symptoms, without providing any details. Authors do not provide multivariable analysis for supplement use. Authors make no comment on symptom prevalence for supplement use. Discussion is biased, for example referencing only 4 of the 25 RCTs at the time, strongly biased towards those reporting lower efficacy. No baseline information per group is provided.
38% of patients were lost to followup. We could not find any prospective registration or protocol. Funding was disclosed from Novartis and Radius Pharmaceuticals (whose lead product abaloparatide is an osteoporosis treatment).
Liu et al., 5 Mar 2023, prospective, USA, peer-reviewed, survey, mean age 40.0, 15 authors, dosage 2,250IU daily, average dose.
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Abstract: Journal Pre-proof Vitamin D and SARS-CoV-2 Infection: SERVE Study (SARS-CoV-2 Exposure and the Role of Vitamin D among Hospital Employees) Yi Liu, Shannon Clare, Gia D’Erasmo, Alison Heilbronner, Alexander Dash, Alexandra Krez, Caroline Zaworski, Katherine Haseltine, Alana Serota, Andy Miller, Keila Veiga, Marvin Sandoval Theresa T. Lu, Donald J McMahon, Jeri W. Nieves, Emily Margaret Stein PII: S0022-3166(23)35280-5 DOI: Reference: TJNUT 157 To appear in: The Journal of Nutrition Received Date: 28 November 2022 Revised Date: 27 February 2023 Accepted Date: 1 March 2023 Please cite this article as: Y. Liu, S. Clare, G. D’Erasmo, A. Heilbronner, A. Dash, A. Krez, C. Zaworski, K. Haseltine, A. Serota, A. Miller, K. Veiga, M.S. Theresa T. Lu, D.J McMahon, J.W. Nieves, E.M. Stein, Vitamin D and SARS-CoV-2 Infection: SERVE Study (SARS-CoV-2 Exposure and the Role of Vitamin D among Hospital Employees) The Journal of Nutrition, This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. © 2023 American Society for Nutrition. Published by Elsevier Inc. All rights reserved. Vitamin D and SARS-CoV-2 Infection: SERVE Study (SARS-CoV-2 Exposure and the Role of Vitamin D among Hospital Employees) 4 5 6 7 Yi Liu1,2, Shannon Clare1,2, Gia D’Erasmo1,2, Alison Heilbronner1,2, Alexander Dash1,2, Alexandra Krez1,2, Caroline Zaworski1,2, Katherine Haseltine1,2, Alana Serota2, Andy Miller3, Keila Veiga4, Marvin Sandoval Theresa T. Lu4, Donald J McMahon1,2, Jeri W. Nieves2, Emily Margaret Stein1,2,4 8 1 Division of Endocrinology, Hospital for Special Surgery, New York, NY, USA, 10021 9 2 Metabolic Bone Service, Hospital for Special Surgery, New York, NY, USA, 10021 10 3 Division of Infectious Diseases, Hospital for Special Surgery, New York, NY, USA, 10021 11 4 Research Institute, Hospital for Special Surgery, New York, NY, USA, 10021 12 Abbreviated Title: Vitamin D and SARS-CoV-2 Infection 14 Word Count: 3429 15 Key Words: Vitamin D, SARS-CoV-2 infection, COVID-19 -p ro 13 of 1 2 3 re 16 Corresponding Author 18 19 20 21 22 23 24 25 26 27 28 29 30 Emily M. Stein MD, MS Director of Research Metabolic Bone Service Hospital for Special Surgery Associate Professor of Medicine Weill Cornell Medical College 535 East 70th Street New York, NY 10021 Phone (646) 714-6558 ORCID iD: 0000-0002-1463-5774 Please address reprint requests to Dr. Stein 31 32 33 34 35 36 37 38 Funding Sources: This work was funded by a COVID-19 research grant from the Hospital for Special Surgery. Jo ur na lP 17 Disclosures: YL, SC, GD, AH, AD, AK, CZ, KH, AS, AM, KV, MS, TTL, DJM have nothing to disclose. JWN reports research support from Radius Pharmaceuticals. EMS reports research support from Novartis and Radius Pharmaceuticals. 1 Abbreviations: 40 25OHD: serum 25-hydroxyvitamin D 41 ACE2: angiotensin-converting enzyme..
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