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0 0.5 1 1.5 2+ Mortality 43% Improvement Relative Risk Severe case 43% Case 22% c19early.org/d Oristrell et al. Vitamin D for COVID-19 Prophylaxis Favors vitamin D Favors control
Association of Calcitriol Supplementation with Reduced COVID-19 Mortality in Patients with Chronic Kidney Disease: A Population-based Study
Oristrell et al., Biomedicines, doi:10.3390/biomedicines9050509 (date from earlier preprint)
6 Apr 2021    Source   PDF   Share   Tweet
Retrospective study of calcitriol supplementation with chronic kidney disease patients in Catalonia showing lower cases, severe cases, and mortality with supplementation. A dose-response relationship was found for severe cases and mortality.
risk of death, 43.0% lower, HR 0.57, p = 0.001, treatment 2,296, control 3,407, multivariate, patients with CKD stages 4-5.
risk of severe case, 43.0% lower, HR 0.57, p < 0.001, treatment 2,296, control 3,407, multivariate, patients with CKD stages 4-5.
risk of case, 22.0% lower, HR 0.78, p = 0.01, treatment 163 of 2,296 (7.1%), control 326 of 3,407 (9.6%), NNT 40, multivariate, patients with CKD stages 4-5.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Oristrell et al., 6 Apr 2021, retrospective, Spain, peer-reviewed, 10 authors, dosage calcitriol 0.3μg daily, mean daily dose.
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