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0 0.5 1 1.5 2+ Symptomatic case 95% Improvement Relative Risk Case 42% Karonova et al. Vitamin D for COVID-19 RCT Prophylaxis Is prophylaxis with vitamin D beneficial for COVID-19? RCT 78 patients in Russia Fewer symptomatic cases with vitamin D (p=0.0024) Karonova et al., Nutrients, doi:10.3390/nu14030505 Favors high dose Favors low dose
Vitamin D Intake May Reduce SARS-CoV-2 Infection Morbidity in Health Care Workers
Karonova et al., Nutrients, doi:10.3390/nu14030505
Karonova et al., Vitamin D Intake May Reduce SARS-CoV-2 Infection Morbidity in Health Care Workers, Nutrients, doi:10.3390/nu14030505
Jan 2022   Source   PDF  
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Small RCT in Russia with 45 high dose vitamin D patients (50,000IU/wk for 2 wks followed by 5,000IU/day) and 46 low dose patients (2,000IU/day), showing lower cases and lower symptomatic cases with high dose treatment.
risk of symptomatic case, 94.6% lower, RR 0.05, p = 0.002, treatment 0 of 38 (0.0%), control 9 of 40 (22.5%), NNT 4.4, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of case, 41.5% lower, RR 0.58, p = 0.10, treatment 10 of 38 (26.3%), control 18 of 40 (45.0%), NNT 5.4.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Karonova et al., 24 Jan 2022, Randomized Controlled Trial, Russia, peer-reviewed, 8 authors.
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Vitamin D Intake May Reduce SARS-CoV-2 Infection Morbidity in Health Care Workers
Tatiana L Karonova, Alena T Chernikova, Ksenia A Golovatyuk, Ekaterina S Bykova, William B Grant, Olga V Kalinina, Elena N Grineva, Evgeny V Shlyakhto
Nutrients, doi:10.3390/nu14030505
In the last 2 years, observational studies have shown that a low 25-hydroxyvitamin D (25(OH)D) level affected the severity of infection with the novel coronavirus . This study aimed to analyze the potential effect of vitamin D supplementation in reducing SARS-CoV-2 infection morbidity and severity in health care workers. Of 128 health care workers, 91 (consisting of 38 medical doctors (42%), 38 nurses (42%), and 15 medical attendants (16%)) were randomized into two groups receiving vitamin D supplementation. Participants of group I (n = 45) received water-soluble cholecalciferol at a dose of 50,000 IU/week for 2 consecutive weeks, followed by 5000 IU/day for the rest of the study. Participants of group II (n = 46) received water-soluble cholecalciferol at a dose of 2000 IU/day. For both groups, treatment lasted 3 months. Baseline serum 25(OH)D level in health care workers varied from 3.0 to 65.1 ng/mL (median, 17.7 (interquartile range, 12.2; 24.7) ng/mL). Vitamin D deficiency, insufficiency, and normal vitamin D status were diagnosed in 60%, 30%, and 10%, respectively. Only 78 subjects completed the study. Vitamin D supplementation was associated with an increase in serum 25(OH)D level, but only intake of 5000 IU/day was accompanied by normalization of serum 25(OH)D level, which occurred in 53% of cases. Neither vitamin D intake nor vitamin D deficiency/insufficiency were associated with a decrease in SARS-CoV-2 morbidity (odds ratio = 2.27; 95% confidence interval, 0.72 to 7.12). However, subjects receiving high-dose vitamin D had only asymptomatic SARS-CoV-2 in 10 (26%) cases; at the same time, participants who received 2000 IU/day showed twice as many SARS-CoV-2 cases, with mild clinical features in half of them.
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