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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Mortality 81% Improvement Relative Risk ICU admission 94% Hospitalization time 10% Vitamin D for COVID-19  Yildiz et al.  LATE TREATMENT Is late treatment with vitamin D beneficial for COVID-19? Retrospective 207 patients in Turkey Lower mortality with vitamin D (p=0.038) Yildiz et al., Bratislava Medical J., Sep 2021 Favors vitamin D Favors control

The prognostic significance of vitamin D deficiency in patients with COVID-19 pneumonia

Yildiz et al., Bratislava Medical Journal, doi:10.4149/BLL_2021_119
Sep 2021  
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Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
*, now known with p < 0.00000000001 from 120 studies, recognized in 8 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,100+ studies for 60+ treatments.
Retrospective 207 hospitalized patients in Turkey, 37 with vitamin D levels <30ng/ml treated with a single dose of 300,000IU vitamin D, showing lower mortality with treatment.
Cholecalciferol was used in this study. Meta analysis shows that late stage treatment with calcitriol / calcifediol (or paricalcitol, alfacalcidol, etc.) is more effective than cholecalciferol: 65% [41‑79%] lower risk vs. 39% [26‑49%] lower risk. Cholecalciferol requires two hydroxylation steps to become activated - first in the liver to calcifediol, then in the kidney to calcitriol. Calcitriol, paricalcitol, and alfacalcidol are active vitamin D analogs that do not require conversion. This allows them to have more rapid onset of action compared to cholecalciferol. The time delay for cholecalciferol to increase serum calcifediol levels can be 2-3 days, and the delay for converting calcifediol to active calcitriol can be up to 7 days.
This is the 55th of 120 COVID-19 controlled studies for vitamin D, which collectively show efficacy with p<0.0000000001 (1 in 248 sextillion).
29 studies are RCTs, which show efficacy with p=0.0000024.
risk of death, 80.9% lower, RR 0.19, p = 0.04, treatment 1 of 37 (2.7%), control 24 of 170 (14.1%), NNT 8.8.
risk of ICU admission, 94.5% lower, RR 0.06, p = 0.13, treatment 0 of 37 (0.0%), control 14 of 170 (8.2%), NNT 12, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
hospitalization time, 9.6% lower, relative time 0.90, p = 0.32, treatment 37, control 170.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Yildiz et al., 27 Sep 2021, retrospective, Turkey, peer-reviewed, 5 authors, dosage 300,000IU single dose.
This PaperVitamin DAll
The prognostic significance of vitamin D deficiency in patients with COVID-19 pneumonia
M Yildiz, M U Senel, S Kavurgaci, F E Ozturk, A Ozturk
Bratislava Medical Journal, doi:10.4149/bll_2021_119
BACKGROUND: Vitamin D has anti-infl ammatory and immunomodulatory effects via the downregulation of pro-infl ammatory cytokines. We aimed to demonstrate the effect of vitamin D levels on survival in COVID-19 patients. MATERIALS AND METHODS: 207 COVID-19 patients were included in the study. Serum vitamin D levels were measured, and patients with levels < 20 ng/ml or 21 to 30 ng received a single 300.000 IU dose of vitamin D. RESULTS: Of 207 patients, 37 received vitamin D, while 170 did not. Demographic, radiologic and mean laboratory values were similar between the groups. The mean plasma vitamin D level without vitamin D support (n=170) was 50.82 ± 16.12 ng/ml (30.28 -81.35) vs. 16.98 ± 6.2 ng/ml (4.20 -28.30) in vitamin D group. The most remarkable fi nding were the mortality rates; while only 1 patient (2.7 %) died in the vitamin D group, 24 patients (14.1 %) died in no vitamin D supplementation group (p = 0.038). CONCLUSION: Although a few retrospective studies put forth a relation between vitamin D defi ciency and COVID-19 course severity there is still paucity of data about the effi cacy of vitamin supplementations in COVID-19 patients. A single 300.000 IU dose of vitamin D seems to represent a useful, practical, and safe adjunctive approach for the treatment or prevention of Fig. 1, Ref. 30).
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Late treatment
is less effective
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