The prognostic significance of vitamin D deficiency in patients with COVID-19 pneumonia

Yildiz et al., Bratislava Medical Journal, doi:10.4149/BLL_2021_119

Yildiz et al., The prognostic significance of vitamin D deficiency in patients with COVID-19 pneumonia, Bratislava Medical Journal, doi:10.4149/BLL_2021_119

Sep 2021 Source PDF

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Retrospective 207 hospitalized patients in Turkey, 37 with vitamin D levels <30ng/ml treated with a 300,000IU vitamin D, showing lower mortality with treatment.

This is the 55th of 111 COVID-19 controlled studies for vitamin D, which collectively show efficacy with p<0.0000000001 (1 in 49 sextillion). 27 studies are RCTs, which show efficacy with p=0.00002.

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risk of death, 80.9% lower, RR 0.19, p = 0.04, treatment 1 of 37 (2.7%), control 24 of 170 (14.1%), NNT 8.8.

risk of ICU admission, 94.5% lower, RR 0.06, p = 0.13, treatment 0 of 37 (0.0%), control 14 of 170 (8.2%), NNT 12, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).

hospitalization time, 9.6% lower, relative time 0.90, p = 0.32, treatment 37, control 170.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

Yildiz et al., 27 Sep 2021, retrospective, Turkey, peer-reviewed, 5 authors, dosage 300,000IU single dose.

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The prognostic significance of vitamin D deficiency in patients with COVID-19 pneumonia

M Yildiz, M U Senel, S Kavurgaci, F E Ozturk, A Ozturk

Bratislava Medical Journal, doi:10.4149/bll_2021_119

BACKGROUND: Vitamin D has anti-infl ammatory and immunomodulatory effects via the downregulation of pro-infl ammatory cytokines. We aimed to demonstrate the effect of vitamin D levels on survival in COVID-19 patients. MATERIALS AND METHODS: 207 COVID-19 patients were included in the study. Serum vitamin D levels were measured, and patients with levels < 20 ng/ml or 21 to 30 ng received a single 300.000 IU dose of vitamin D. RESULTS: Of 207 patients, 37 received vitamin D, while 170 did not. Demographic, radiologic and mean laboratory values were similar between the groups. The mean plasma vitamin D level without vitamin D support (n=170) was 50.82 ± 16.12 ng/ml (30.28 -81.35) vs. 16.98 ± 6.2 ng/ml (4.20 -28.30) in vitamin D group. The most remarkable fi nding were the mortality rates; while only 1 patient (2.7 %) died in the vitamin D group, 24 patients (14.1 %) died in no vitamin D supplementation group (p = 0.038). CONCLUSION: Although a few retrospective studies put forth a relation between vitamin D defi ciency and COVID-19 course severity there is still paucity of data about the effi cacy of vitamin supplementations in COVID-19 patients. A single 300.000 IU dose of vitamin D seems to represent a useful, practical, and safe adjunctive approach for the treatment or prevention of Fig. 1, Ref. 30).

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Late treatment
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