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0 0.5 1 1.5 2+ ICU admission 59% Improvement Relative Risk Mortality 24% Ventilation 9% c19early.org/d Orchard et al. Vitamin D for COVID-19 Sufficiency Are vitamin D levels associated with COVID-19 outcomes? Retrospective 115 patients in the United Kingdom Lower ICU admission with higher vitamin D levels (p=0.0014) Orchard et al., Clin Chem Lab Med, doi:10.1515/cclm-2020-1567 Favors vitamin D Favors control
Vitamin-D levels and intensive care unit outcomes of a cohort of critically ill COVID-19 patients
Orchard et al., Clin Chem Lab Med, doi:10.1515/cclm-2020-1567
Orchard et al., Vitamin-D levels and intensive care unit outcomes of a cohort of critically ill COVID-19 patients, Clin Chem Lab Med, doi:10.1515/cclm-2020-1567
Jan 2021   Source   PDF  
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Retrospective 165 hospitalized patients with known vitamin D levels, showing an associated between vitamin D deficiency and ICU admission. There was no statistically significant difference in clinical outcomes for ICU patients. It's unclear why authors do not provide clinical outcomes for all patients rather than ICU only.
risk of ICU admission, 58.8% lower, RR 0.41, p = 0.001, high D levels 9 of 40 (22.5%), low D levels 41 of 75 (54.7%), NNT 3.1, all hospitalized patients, >50 nmol/L.
risk of death, 24.1% lower, RR 0.76, p = 1.00, high D levels 1 of 9 (11.1%), low D levels 6 of 41 (14.6%), NNT 28, ICU patients only, >50 nmol/L.
risk of mechanical ventilation, 8.9% lower, RR 0.91, p = 0.70, high D levels 6 of 9 (66.7%), low D levels 30 of 41 (73.2%), NNT 15, ICU patients only, >50 nmol/L.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Orchard et al., 19 Jan 2021, retrospective, United Kingdom, peer-reviewed, 7 authors.
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Abstract: Clin Chem Lab Med 2021; 59(6): 1155–1163 Laurence Orchard*, Matthew Baldry, Myra Nasim-Mohi, Chantelle Monck, Kordo Saeed, Michael P. W. Grocott and Dushianthan Ahilanandan on behalf of the University Hospital Southampton Critical Care Team and the REACT COVID Investigators Vitamin-D levels and intensive care unit outcomes of a cohort of critically ill COVID-19 patients https://doi.org/10.1515/cclm-2020-1567 Received October 21, 2020; accepted December 28, 2020; published online January 19, 2021 Abstract Objectives: The pattern of global COVID-19 has caused many to propose a possible link between susceptibility, severity and vitamin-D levels. Vitamin-D has known UHS Critical Care Clinical Team: Dr. Sanjay Gupta, Dr. Julian Nixon, Professor Michael P W Grocott, Professor Denny ZH Levett, Dr. Michael Stewart, Dr. Ahilanadan Dushianthan, Dr. David Sparkes, Dr. Robert Chambers, Dr. Kathleen Nolan, Dr. Suzie Tanser, Dr. Jonathan Fennell, Dr. Michael Celinski, Dr. Dominic Richardson, Dr. Rebecca Cusack, Dr. Benjamin Skinner, Dr. Timothy Nicholson-Robert, Dr. Mai Wakatsuki, Dr. Ben Thomas, Dr. Francois Wessels. REACT Investigators: Professor Tom Wilkinson, Dr. Anna Freeman, Dr. Hannah Burke, Dr. Ahilanadan Dushianthan, Dr. Michael Celinski, Professor James Batchelor, Professor Saul Faust, Professor Gareth Thomas, Professor Christopher Kip. *Corresponding author: Dr. Laurence Orchard, General Intensive Care Unit, University Hospital Southampton NHS Foundation Trust, Tremona Road, Southampton, UK, Phone: +44 7791190726, E-mail: laurence.orchard@nhs.net Matthew Baldry and Myra Nasim-Mohi, General Intensive Care Unit, University Hospital Southampton NHS Foundation Trust, Southampton, UK Chantelle Monck, Southampton Specialist Virology Centre, University of Southampton School of Medicine, University Hospital Southampton NHS Foundation Trust, Southampton, UK Kordo Saeed, Microbiology Innovation and Research Unit, Department of Microbiology, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Faculty of Medicine, University of Southampton University, Hospital Southampton, Southampton, UK Michael P. W. Grocott and Dushianthan Ahilanandan, General Intensive Care Unit, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Faculty of Medicine, University of Southampton University, Hospital Southampton, Southampton, UK; and NIHR Southampton Clinical Research Facility and NIHR Southampton Biomedical Research Centre, University Hospital Southampton/University of Southampton, Southampton, UK immune modulatory effects and deficiency has been linked to increased severity of viral infections. Methods: We evaluated patients admitted with confirmed SARS-COV-2 to our hospital between March-June 2020. Demographics and outcomes were assessed for those admitted to the intensive care unit (ICU) with normal (>50 nmol/L) and low (<50 nmol/L) vitamin-D. Results: There were 646 SARS-COV-2 PCR positive hospitalisations and 165 (25.5%) had plasma vitamin-D levels. Fifty patients were admitted to ICU. There was no difference in vitamin-D levels of those hospitalised (34, IQR 18.5–66 nmol/L) and those admitted to the ICU (31.5, IQR 21–42 nmol/L). Higher proportion of vitamin-D deficiency (<50 nmol/L) noted in the ICU group (82.0 vs. 65.2%). Among the ICU patients, low vitamin D level (<50 nmol/L) was associated with younger age (57 vs. 67 years, p=0.04) and lower cycle threshold (CT) real time polymerase chain reaction values (RT-PCR)..
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