Vitamin D Levels in COVID-19 Outpatients from Western Mexico: Clinical Correlation and Effect of Its Supplementation
, Vitamin D Levels in COVID-19 Outpatients from Western Mexico: Clinical Correlation and Effect of Its..
, , J. Clinical Medicine, doi:10.3390/jcm10112378
Very small 42 PCR+ outpatient RCT in Mexico, 22 treated with vitamin D. Most patients had insufficient vitamin D levels, there were more symptoms in those with insufficient levels, and there were less cases with fever or with >3 symptoms at day 14 for treatment with vitamin D.
risk of severe case, 89.4% lower, RR 0.11, p = 0.04, treatment 0 of 22 (0.0%), control 4 of 20 (20.0%), NNT 5.0, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), risk of >3 symptoms at day 14.
risk of no recovery, 80.8% lower, RR 0.19, p = 0.22, treatment 0 of 22 (0.0%), control 2 of 20 (10.0%), NNT 10.0, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), risk of fever at day 14, Table S1.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Sánchez-Zuno et al., 28 May 2021, Randomized Controlled Trial, Mexico, peer-reviewed, 12 authors, dosage 10,000IU days 1-14.
Abstract: Journal of
Vitamin D Levels in COVID-19 Outpatients from Western
Mexico: Clinical Correlation and Effect of Its Supplementation
Gabriela Athziri Sánchez-Zuno 1,† , Guillermo González-Estevez 1,2,† , Mónica Guadalupe Matuz-Flores 1 ,
Gabriela Macedo-Ojeda 1,2 , Jorge Hernández-Bello 1,2 , Jesús Carlos Mora-Mora 3 ,
Edsaúl Emilio Pérez-Guerrero 1 , Mariel García-Chagollán 1 , Natali Vega-Magaña 1,3 ,
Francisco Javier Turrubiates-Hernández 1 , Andrea Carolina Machado-Sulbaran 4
and José Francisco Muñoz-Valle 1,2, *
Citation: Sánchez-Zuno, G.A.;
González-Estevez, G.; Matuz-Flores,
M.G.; Macedo-Ojeda, G.;
Hernández-Bello, J.; Mora-Mora, J.C.;
García-Chagollán, M.; Vega-Magaña,
Institute of Research in Biomedical Sciences, Department of Medical Clinics,
University Center of Health Sciences (CUCS), Edificio Q, 950 Sierra Mojada, Guadalajara 44340, Mexico;
email@example.com (G.A.S.-Z.); firstname.lastname@example.org (G.G.-E.);
email@example.com (M.G.M.-F.); firstname.lastname@example.org (G.M.-O.);
email@example.com (J.H.-B.); firstname.lastname@example.org (E.E.P.-G.); email@example.com (M.G.-C.);
firstname.lastname@example.org (N.V.-M.); email@example.com (F.J.T.-H.)
COVID-19 Situation Room (Analysis Group), University of Guadalajara, Guadalajara 44340, Mexico
Laboratory for the Diagnosis of Emerging and Reemerging Diseases (LaDEER),
University Center for Health Sciences (CUCS), Edificio Q, 950 Sierra Mojada, Guadalajara 44340, Mexico;
Institute for Research in Childhood and Adolescent Cancer (INICIA), Department of Human Reproduction,
Child Growth and Development Clinics, University Center for Health Sciences (CUCS), Edificio Q,
950 Sierra Mojada, Guadalajara 44340, Mexico; firstname.lastname@example.org
The authors are considered as the first author.
N.; Turrubiates-Hernández, F.J.; et al.
Vitamin D Levels in COVID-19
Outpatients from Western Mexico:
Clinical Correlation and Effect of Its
Supplementation. J. Clin. Med. 2021,
10, 2378. https://doi.org/10.3390/
Academic Editors: Emmanuel Andrès
and Luca Quartuccio
Received: 16 March 2021
Accepted: 26 May 2021
Published: 28 May 2021
Publisher’s Note: MDPI stays neutral
with regard to jurisdictional claims in
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Abstract: Background: The immunomodulatory effects of vitamin D are known to be beneficial in
viral infections; it is also known that its deficiency is associated with a prognosis more critical of
Coronavirus Disease 2019. This study aimed to determine baseline vitamin D serum concentrations
and the effects of its supplementation in asymptomatic or mildly symptomatic Coronavirus Disease
2019 outpatients. Methods: 42 outpatients were included, 22 of which received a supplement of
10,000 IU of vitamin D3 for 14 days; the remaining 20 outpatients were designated as a control
group. Serum levels of transferrin, ferritin, vitamin D, and D-dimer were measured at baseline in
both groups. After 14 days, serum levels of total vitamin D were determined in the supplemented
group. Results: At baseline, only 19% of infected outpatients had vitamin D levels corresponding to
sufficiency. All outpatients with vitamin D insufficiency had at least one symptom associated with
the disease, while only 75% of patients with symptoms presented sufficiency. On the seventh..
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