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0 0.5 1 1.5 2+ Severe case 89% Improvement Relative Risk Recovery 81% c19early.org/d Sánchez-Zuno et al. Vitamin D for COVID-19 RCT EARLY Is early treatment with vitamin D beneficial for COVID-19? RCT 42 patients in Mexico Lower severe cases with vitamin D (p=0.04) Sánchez-Zuno, J. Clinical Medicine, doi:10.3390/jcm10112378 Favors vitamin D Favors control
Vitamin D Levels in COVID-19 Outpatients from Western Mexico: Clinical Correlation and Effect of Its Supplementation
Sánchez-Zuno, J. Clinical Medicine, doi:10.3390/jcm10112378
Sánchez-Zuno, Vitamin D Levels in COVID-19 Outpatients from Western Mexico: Clinical Correlation and Effect of Its.., , J. Clinical Medicine, doi:10.3390/jcm10112378
May 2021   Source   PDF  
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Very small 42 PCR+ outpatient RCT in Mexico, 22 treated with vitamin D. Most patients had insufficient vitamin D levels, there were more symptoms in those with insufficient levels, and there were less cases with fever or with >3 symptoms at day 14 for treatment with vitamin D.
risk of severe case, 89.4% lower, RR 0.11, p = 0.04, treatment 0 of 22 (0.0%), control 4 of 20 (20.0%), NNT 5.0, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), risk of >3 symptoms at day 14.
risk of no recovery, 80.8% lower, RR 0.19, p = 0.22, treatment 0 of 22 (0.0%), control 2 of 20 (10.0%), NNT 10.0, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), risk of fever at day 14, Table S1.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Sánchez-Zuno et al., 28 May 2021, Randomized Controlled Trial, Mexico, peer-reviewed, 12 authors, dosage 10,000IU days 1-14.
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Abstract: Journal of Clinical Medicine Article Vitamin D Levels in COVID-19 Outpatients from Western Mexico: Clinical Correlation and Effect of Its Supplementation Gabriela Athziri Sánchez-Zuno 1,† , Guillermo González-Estevez 1,2,† , Mónica Guadalupe Matuz-Flores 1 , Gabriela Macedo-Ojeda 1,2 , Jorge Hernández-Bello 1,2 , Jesús Carlos Mora-Mora 3 , Edsaúl Emilio Pérez-Guerrero 1 , Mariel García-Chagollán 1 , Natali Vega-Magaña 1,3 , Francisco Javier Turrubiates-Hernández 1 , Andrea Carolina Machado-Sulbaran 4 and José Francisco Muñoz-Valle 1,2, * 1   2 3 Citation: Sánchez-Zuno, G.A.; González-Estevez, G.; Matuz-Flores, 4 M.G.; Macedo-Ojeda, G.; Hernández-Bello, J.; Mora-Mora, J.C.; Pérez-Guerrero, E.E.; García-Chagollán, M.; Vega-Magaña, * † Institute of Research in Biomedical Sciences, Department of Medical Clinics, University Center of Health Sciences (CUCS), Edificio Q, 950 Sierra Mojada, Guadalajara 44340, Mexico; athziri_93_7@hotmail.com (G.A.S.-Z.); guillermo.gonzalezestevez@cucs.udg.mx (G.G.-E.); matuzmonica@gmail.com (M.G.M.-F.); gaby_macedo@yahoo.com.mx (G.M.-O.); jorge89_5@hotmail.com (J.H.-B.); edsaul.perez@gmail.com (E.E.P.-G.); maye_999@hotmail.com (M.G.-C.); alejandra.vega@academicos.udg.mx (N.V.-M.); ln.paco.turrubiates@gmail.com (F.J.T.-H.) COVID-19 Situation Room (Analysis Group), University of Guadalajara, Guadalajara 44340, Mexico Laboratory for the Diagnosis of Emerging and Reemerging Diseases (LaDEER), University Center for Health Sciences (CUCS), Edificio Q, 950 Sierra Mojada, Guadalajara 44340, Mexico; jesus.moram@academicos.udg.mx Institute for Research in Childhood and Adolescent Cancer (INICIA), Department of Human Reproduction, Child Growth and Development Clinics, University Center for Health Sciences (CUCS), Edificio Q, 950 Sierra Mojada, Guadalajara 44340, Mexico; andrecaroms@gmail.com Correspondence: biologiamolecular@hotmail.com The authors are considered as the first author. N.; Turrubiates-Hernández, F.J.; et al. Vitamin D Levels in COVID-19 Outpatients from Western Mexico: Clinical Correlation and Effect of Its Supplementation. J. Clin. Med. 2021, 10, 2378. https://doi.org/10.3390/ jcm10112378 Academic Editors: Emmanuel Andrès and Luca Quartuccio Received: 16 March 2021 Accepted: 26 May 2021 Published: 28 May 2021 Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affil- Abstract: Background: The immunomodulatory effects of vitamin D are known to be beneficial in viral infections; it is also known that its deficiency is associated with a prognosis more critical of Coronavirus Disease 2019. This study aimed to determine baseline vitamin D serum concentrations and the effects of its supplementation in asymptomatic or mildly symptomatic Coronavirus Disease 2019 outpatients. Methods: 42 outpatients were included, 22 of which received a supplement of 10,000 IU of vitamin D3 for 14 days; the remaining 20 outpatients were designated as a control group. Serum levels of transferrin, ferritin, vitamin D, and D-dimer were measured at baseline in both groups. After 14 days, serum levels of total vitamin D were determined in the supplemented group. Results: At baseline, only 19% of infected outpatients had vitamin D levels corresponding to sufficiency. All outpatients with vitamin D insufficiency had at least one symptom associated with the disease, while only 75% of patients with symptoms presented sufficiency. On the seventh..
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