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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Mortality 85% Improvement Relative Risk ICU admission 95% Vitamin D for COVID-19  Jain et al.  Sufficiency Are vitamin D levels associated with COVID-19 outcomes? Prospective study of 154 patients in India Lower mortality (p=0.0014) and ICU admission (p<0.0001) Jain et al., Nature, November 2020 Favors vitamin D Favors control

Analysis of vitamin D level among asymptomatic and critically ill COVID-19 patients and its correlation with inflammatory markers

Jain et al., Nature, doi:10.1038/s41598-020-77093-z
Nov 2020  
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Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
*, now known with p < 0.00000000001 from 119 studies, recognized in 7 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments.
Prospective study of 91 asymptomatic and 63 ICU patients showing significantly higher vitamin D deficiency in the ICU patients (97% vs. 33%).
This is the 28th of 192 COVID-19 sufficiency studies for vitamin D, which collectively show higher levels reduce risk with p<0.0000000001 (1 in 611 vigintillion).
risk of death, 85.2% lower, RR 0.15, p = 0.001, high D levels 2 of 64 (3.1%), low D levels 19 of 90 (21.1%), NNT 5.6, >20ng/mL.
risk of ICU admission, 95.4% lower, RR 0.05, p < 0.001, high D levels 2 of 64 (3.1%), low D levels 61 of 90 (67.8%), NNT 1.5, >20ng/mL.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Jain et al., 19 Nov 2020, prospective, India, peer-reviewed, 6 authors.
This PaperVitamin DAll
Analysis of vitamin D level among asymptomatic and critically ill COVID-19 patients and its correlation with inflammatory markers
Anshul Jain, Rachna Chaurasia, Narendra Singh Sengar, Mayank Singh, Sachin Mahor, Sumit Narain
Scientific Reports, doi:10.1038/s41598-020-77093-z
COVID-19 is characterized by marked variability in clinical severity. Vitamin D had recently been reviewed as one of the factors that may affect the severity in COVID-19. The objective of current study is to analyze the vitamin D level in COVID-19 patients and its impact on the disease severity. After approval from Ethics Committee, M.L.B Medical College the current study was undertaken as continuous prospective observational study of 6 weeks. Participants were COVID-19 patients of age group 30-60 years admitted during the study period of 6 weeks. Study included either asymptomatic COVID-19 patients (Group A) or severely ill patients requiring ICU admission (Group B). Serum concentration of 25 (OH)D, were measured along with serum IL-6; TNFα and serum ferritin. Standard statistical analysis was performed to analyze the differences. Current Study enrolled 154 patients, 91 in Group A and 63 patients in Group B. The mean level of vitamin D (in ng/mL) was 27.89 ± 6.21 in Group A and 14.35 ± 5.79 in Group B, the difference was highly significant. The prevalence of vitamin D deficiency was 32.96% and 96.82% respectively in Group A and Group B. Out of total 154 patients, 90 patients were found to be deficient in vitamin D (Group A: 29; Group B: 61). Serum level of inflammatory markers was found to be higher in vitamin D deficient COVID-19 patients viz. IL-6 level (in pg/mL) 19.34 ± 6.17 vs 12.18 ± 4.29; Serum ferritin 319.17 ± 38.21 ng/mL vs 186.83 ± 20.18 ng/ mL; TNFα level (in pg/mL) 13.26 ± 5.64 vs 11.87 ± 3.15. The fatality rate was high in vitamin D deficient (21% vs 3.1%). Vitamin D level is markedly low in severe COVID-19 patients. Inflammatory response is high in vitamin D deficient COVID-19 patients. This all translates into increased mortality in vitamin D deficient COVID-19 patients. As per the flexible approach in the current COVID-19 pandemic authors recommend mass administration of vitamin D supplements to population at risk for COVID-19. In December 2019, several cases of pneumonia with unknown etiology reported in Wuhan, Hubei Province, China 1,2 . The disease spread quickly to other provinces of China and overseas. On 7 January 2020, a novel coronavirus was identified in the throat swab sample of one such patient and later declared to be the etiologic virus and was subsequently named as 2019nCoV by World Health Organization (WHO) 3 . On worsening of the situation WHO declared the outbreak as the public health emergency of international concern (PHEIC). In February 2020, WHO provided a nomenclature to the epidemic disease caused by SARS-CoV-2 as coronavirus disease 2019 (COVID-19) 4 . As on 12th August 2020 there are more than 20 million cases worldwide 5 , so for now it's almost impossible to contain the disease spread and focus is diverting towards better treatment and prevention of factors that enhance the severity of COVID-19. COVID-19 is characterized by its high infectivity and marked variability in clinical severity, of which..
Author contributions Competing interests The authors declare no competing interests.
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