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Home   COVID-19 treatment studies for Vitamin D  COVID-19 treatment studies for Vitamin D  C19 studies: Vitamin D  Vitamin D   Select treatmentSelect treatmentTreatmentsTreatments
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0 0.5 1 1.5 2+ Mortality 76% Improvement Relative Risk c19early.org/d Abrishami et al. Vitamin D for COVID-19 Sufficiency Are vitamin D levels associated with COVID-19 outcomes? Retrospective 73 patients in Iran Lower mortality with higher vitamin D levels (p=0.04) Abrishami et al., European J. Nutrition, doi:10.1007/s00394-020-02411-0 Favors vitamin D Favors control
Possible association of vitamin D status with lung involvement and outcome in patients with COVID-19: a retrospective study
Abrishami et al., European Journal of Nutrition, doi:10.1007/s00394-020-02411-0
Abrishami et al., Possible association of vitamin D status with lung involvement and outcome in patients with COVID-19: a.., European Journal of Nutrition, doi:10.1007/s00394-020-02411-0
Oct 2020   Source   PDF  
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Retrospective 73 hospitalized patients showing the probability of death in patients with vitamin D deficiency (< 25ng/mL) was 34.6% compared with 6.4% in patients with sufficient vitamin D levels.
This is the 24th of 175 COVID-19 sufficiency studies for vitamin D, which collectively show higher levels reduce risk with p<0.0000000001 (1 in 18 vigintillion).
risk of death, 75.9% lower, RR 0.24, p = 0.04, high D levels (≥25ng/mL) 3 of 47 (6.4%), low D levels (<25ng/mL) 9 of 26 (34.6%), NNT 3.5, adjusted per study, inverted to make RR<1 favor high D levels (≥25ng/mL), Cox model 2.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Abrishami et al., 30 Oct 2020, retrospective, Iran, peer-reviewed, mean age 55.2, 7 authors.
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Possible association of vitamin D status with lung involvement and outcome in patients with COVID-19: a retrospective study
Alireza Abrishami, Nooshin Dalili, Peyman Mohammadi Torbati, Reyhaneh Asgari, Mehran Arab-Ahmadi, Behdad Behnam, Morteza Sanei-Taheri
European Journal of Nutrition, doi:10.1007/s00394-020-02411-0
Purpose Vitamin D deficiency has been reported as a key factor in the development of infectious diseases such as respiratory tract infections and inflammatory processes like acute respiratory distress syndrome. However, the impact of vitamin D on the severity and outcome of COVID-19 is still not fully known. Herein, we aimed to evaluate the prognostic role of serum vitamin D concentration on the extent of lung involvement and final outcome in patients with COVID-19. Methods Seventy-three subjects with confirmed diagnosis of COVID-19 were investigated in this study. The patients had been admitted to our academic hospital from February 28, 2020 to April 19, 2020. Demographic and clinical data, serum 25(OH)D levels, and findings of initial chest computed tomography were recorded. Linear and binary logistic regression, cox regression and ROC curve tests were used for statistical analysis. Results The mean age of patients was 55.18 ± 14.98 years old; 46.4% were male. Mean serum 25(OH)D concentration was significantly lower in the deceased (13.83 ± 12.53 ng/ mL compared with discharged patients (38.41 ± 18.51 ng/mL) (P < 0.001). Higher levels of 25(OH)D were associated with significantly less extent of total lung involvement (β = − 0.10, P = 0.004). In addition, vitamin D deficiency [25(OH) D < 25 ng/mL] was associated with a significant increase in the risk of mortality (hazard ratio = 4.15, P = 0.04). Conclusion This study suggests that serum vitamin D status might provide useful information regarding the clinical course, extent of lung involvement and outcome of patients with COVID-19. However, further studies with larger sample size are needed to confirm these findings.
Conflict of interest All authors declare that they have no conflict of interest.
References
Abrishami, Samavat, Behnam, Arab-Ahmadi, Nafar et al., Clinical course, imaging features, and outcomes of COVID-19 in kidney transplant recipients, Eur Urol, doi:10.1016/j.eururo.2020.04.064
Ali, Role of vitamin D in preventing of COVID-19 infection, progression and severity, J Infect Public Health
Dancer, Parekh, Lax, Souza, Zheng et al., Vitamin D deficiency contributes directly to the acute respiratory distress syndrome (ARDS), Thorax
Ebadi, Montano-Loza, Perspective: improving vitamin D status in the management of COVID-19, Eur J Clin Nutr
Fang, Zhang, Xie, Lin, Ying et al., Sensitivity of chest CT for COVID-19: comparison to RT-PCR, Radiology
Grant, Lahore, Mcdonnell, Baggerly, French et al., Evidence that vitamin D supplementation could reduce risk of influenza and COVID-19 infections and deaths, Nutrients
Guan, Ni, -Y, Hu, Liang et al., Clinical characteristics of coronavirus disease 2019 in China, N Engl J Med
Henry, De Oliveira, Benoit, Plebani, Lippi, Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): a meta-analysis, Clin Chem Lab Med (CCLM)
Ilie, Stefanescu, Smith, The role of Vitamin D in the prevention of Coronavirus Disease 2019 infection and mortality, Aging Clin Exp Res
Jakovac, COVID-19 and vitamin D-is there a link and an opportunity for intervention?, Am J Physiol-Endocrinol Metab
Kearns, Alvarez, Seidel, Tangpricha, Impact of vitamin D on infectious disease, Am J Med Sci
Li, Fang, Li, Pan, Qin et al., CT image visual quantitative evaluation and clinical classification of coronavirus disease (COVID-19), Eur Radiol
Li, Xu, Yu, Wang, Tao et al., Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan, J Allergy Clin Immunol
Martineau, Jolliffe, Hooper, Greenberg, Aloia et al., Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data, BMJ
Onder, Rezza, Brusaferro, Case-fatality rate and characteristics of patients dying in relation to COVID-19 in Italy, JAMA
Parekh, Thickett, Turner, Vitamin D deficiency and acute lung injury, Inflamm Allergy-Drug Targets (Formerly Current Drug Targets-Inflammation & Allergy)
Quesada-Gomez, Bouillon, Is calcifediol better than cholecalciferol for vitamin D supplementation?, Osteoporos Int
Rezaei, Aslani, Marashi, Rezaei, Sharif-Paghaleh, Immunomodulatory effects of vitamin D in influenza infection, Curr Immunol Rev
Scharla, Prevalence of subclinical vitamin D deficiency in different European countries, Osteoporos Int
Sosa Henríquez, De Tejada, Romero, Cholecalciferol or calcifediol in the management of vitamin D deficiency, Nutrients, doi:10.3390/nu12061617
Teymoori-Rad, Shokri, Salimi, Marashi, The interplay between vitamin D and viral infections, Rev Med Virol
Zhao, Zhong, Xie, Yu, Liu, Relation between chest CT findings and clinical conditions of coronavirus disease (COVID-19) pneumonia: a multicenter study, Am J Roentgenol
Zhou, Yu, Du, Fan, Liu et al., Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study, Lancet
Zhu, Zhang, Li, Yang, Song et al., A novel coronavirus from patients with pneumonia in China, 2019, N Engl J Med
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