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0 0.5 1 1.5 2+ Mortality 76% Improvement Relative Risk Vitamin D for COVID-19  Abrishami et al.  Sufficiency Are vitamin D levels associated with COVID-19 outcomes? Retrospective 73 patients in Iran Lower mortality with higher vitamin D levels (p=0.04) Abrishami et al., European J. Nutrition, Oct 2020 Favors vitamin D Favors control

Possible association of vitamin D status with lung involvement and outcome in patients with COVID-19: a retrospective study

Abrishami et al., European Journal of Nutrition, doi:10.1007/s00394-020-02411-0
Oct 2020  
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Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
*, now known with p < 0.00000000001 from 120 studies, recognized in 8 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,000+ studies for 60+ treatments.
Retrospective 73 hospitalized patients showing the probability of death in patients with vitamin D deficiency (< 25ng/mL) was 34.6% compared with 6.4% in patients with sufficient vitamin D levels.
This is the 24th of 196 COVID-19 sufficiency studies for vitamin D, which collectively show higher levels reduce risk with p<0.0000000001 (1 in 11,637 vigintillion).
risk of death, 75.9% lower, RR 0.24, p = 0.04, high D levels (≥25ng/mL) 3 of 47 (6.4%), low D levels (<25ng/mL) 9 of 26 (34.6%), NNT 3.5, adjusted per study, inverted to make RR<1 favor high D levels (≥25ng/mL), Cox model 2.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Abrishami et al., 30 Oct 2020, retrospective, Iran, peer-reviewed, mean age 55.2, 7 authors.
This PaperVitamin DAll
Possible association of vitamin D status with lung involvement and outcome in patients with COVID-19: a retrospective study
Alireza Abrishami, Nooshin Dalili, Peyman Mohammadi Torbati, Reyhaneh Asgari, Mehran Arab-Ahmadi, Behdad Behnam, Morteza Sanei-Taheri
European Journal of Nutrition, doi:10.1007/s00394-020-02411-0
Purpose Vitamin D deficiency has been reported as a key factor in the development of infectious diseases such as respiratory tract infections and inflammatory processes like acute respiratory distress syndrome. However, the impact of vitamin D on the severity and outcome of COVID-19 is still not fully known. Herein, we aimed to evaluate the prognostic role of serum vitamin D concentration on the extent of lung involvement and final outcome in patients with COVID-19. Methods Seventy-three subjects with confirmed diagnosis of COVID-19 were investigated in this study. The patients had been admitted to our academic hospital from February 28, 2020 to April 19, 2020. Demographic and clinical data, serum 25(OH)D levels, and findings of initial chest computed tomography were recorded. Linear and binary logistic regression, cox regression and ROC curve tests were used for statistical analysis. Results The mean age of patients was 55.18 ± 14.98 years old; 46.4% were male. Mean serum 25(OH)D concentration was significantly lower in the deceased (13.83 ± 12.53 ng/ mL compared with discharged patients (38.41 ± 18.51 ng/mL) (P < 0.001). Higher levels of 25(OH)D were associated with significantly less extent of total lung involvement (β = − 0.10, P = 0.004). In addition, vitamin D deficiency [25(OH) D < 25 ng/mL] was associated with a significant increase in the risk of mortality (hazard ratio = 4.15, P = 0.04). Conclusion This study suggests that serum vitamin D status might provide useful information regarding the clinical course, extent of lung involvement and outcome of patients with COVID-19. However, further studies with larger sample size are needed to confirm these findings.
Conflict of interest All authors declare that they have no conflict of interest.
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