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0 0.5 1 1.5 2+ Mortality -6% Improvement Relative Risk Ventilation 40% Discharge -27% Vitamin D for COVID-19  Szeto et al.  Sufficiency Are vitamin D levels associated with COVID-19 outcomes? Retrospective 93 patients in the USA Lower ventilation (p=0.21) and discharge (p=0.5), not sig. Szeto et al., Endocrine Research, December 2020 Favors vitamin D Favors control

Vitamin D Status and COVID-19 Clinical Outcomes in Hospitalized Patients

Szeto et al., Endocrine Research, doi:10.1080/07435800.2020.1867162
Dec 2020  
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Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
*, now known with p < 0.00000000001 from 120 studies, recognized in 8 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,200+ studies for 70+ treatments.
Retrospective 93 hospitalized patients with vitamin D levels 1-365 days before admission, not showing significant differences with vitamin D deficiency or vitamin D levels. Vitamin D levels may vary significantly throughout the year creating a major cofounder that authors do not adjust for.
This is the 34th of 196 COVID-19 sufficiency studies for vitamin D, which collectively show higher levels reduce risk with p<0.0000000001 (1 in 11,637 vigintillion).
risk of death, 5.6% higher, RR 1.06, p = 1.00, high D levels 14 of 58 (24.1%), low D levels 8 of 35 (22.9%).
risk of mechanical ventilation, 39.7% lower, RR 0.60, p = 0.21, high D levels 10 of 58 (17.2%), low D levels 10 of 35 (28.6%), NNT 8.8.
risk of no hospital discharge, 26.7% higher, RR 1.27, p = 0.50, high D levels 21 of 58 (36.2%), low D levels 10 of 35 (28.6%).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Szeto et al., 30 Dec 2020, retrospective, USA, peer-reviewed, 7 authors.
This PaperVitamin DAll
Vitamin D Status and COVID-19 Clinical Outcomes in Hospitalized Patients
Betsy Szeto, Jason E Zucker, Elijah D Lasota, Mishaela R Rubin, Marcella D Walker, Michael T Yin, Adi Cohen
Endocrine Research, doi:10.1080/07435800.2020.1867162
Context: Populations severely affected by COVID-19 are also at risk for vitamin D deficiency. Common risk factors include older age, chronic illness, obesity, and non-Caucasian race. Vitamin D deficiency has been associated with risk for respiratory infections and failure, susceptibility and response to therapy for enveloped virus infection, and immune-mediated inflammatory reaction. Objective: To test the hypothesis that 25-hydroxyvitamin D[25(OH)D] deficiency is a risk factor for severity of COVID-19 respiratory and inflammatory complications. Design: We examined the relationship between prehospitalization 25(OH)D levels (obtained 1-365 days prior to admission) and COVID-19 clinical outcomes in 700 COVID-19 positive hospitalized patients.
Disclosure Statement The authors have nothing to disclose.
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