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The relationship between vitamin D and the severity of COVID-19

Basaran et al., Bratislava Medical Journal, doi:10.4149/bll_2021_034

Feb 2021

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Vitamin D for COVID-19

8th treatment shown to reduce risk in October 2020

^*, now known with p < 0.00000000001 from 120 studies, recognized in 8 countries.

Lower risk for mortality, ICU admission, hospitalization, progression, recovery, cases, and viral clearance.

No treatment is 100% effective. Protocols combine complementary and synergistic treatments. ^* >10% efficacy in meta analysis with ≥3 clinical studies.

4,000+ studies for 60+ treatments. c19early.org

Prospective study of 204 patients with COVID-19-like pneumonia in Turkey, 42 outpatients (mild cases), and 162 inpatients (serious cases), showing significantly higher risk of severe cases with vitamin D deficiency.

This is the 47th of 196 COVID-19 sufficiency studies for vitamin D, which collectively show higher levels reduce risk with p<0.0000000001 (1 in 11,637 vigintillion).

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risk of severe case, 68.6% lower, RR 0.31, p = 0.005, high D levels 82 of 119 (68.9%), low D levels 80 of 85 (94.1%), NNT 4.0, inverted to make RR<1 favor high D levels, odds ratio converted to relative risk, >10μg/L, per standard deviation increase in levels.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

Basaran et al., 12 Feb 2021, retrospective, Turkey, peer-reviewed, 6 authors.

This Paper Vitamin D All

The relationship between vitamin D and the severity of COVID-19

N Basaran, M Adas, Y Gokden, N Turgut, T Yildirmak, MD G Guntas

Bratislava Medical Journal, doi:10.4149/bll_2021_034

AIM: Vitamin D, which has immunomodulatory effect, can reduce risk of infections and concentrations of proinfl ammatory cytokines. The aim of this study was to investigate the relationship between the levels of vitamin D and severity of COVID-19. METHODS: A total of 204 patients with COVID-19 disease were enrolled in the study. All patients had viral pneumonia, which was confi rmed with chest computer tomography. All cases were divided in two groupsmild (outpatients); and serious (inpatients)-according to their clinical and laboratory data. Serum vitamin D levels were measured by chemiluminescence method. RESULTS: Vitamin D defi ciency was found in 41.7 % (n = 85) of cases and insuffi ciency was found in 46.0 % (n = 94), while in 12.3 % (n = 25) of cases normal vitamin D levels were found. The odds of having a serious clinical outcome were increased for vitamin D insuffi ciency patients 5.604 times (%95 CI:0.633-49.584) and for vitamin D defi ciency patients 38.095 times (%95 CI:2.965-489.50) for each standard deviation decrease in serum 25(OH)D. CONCLUSION: Adequate levels of vitamin D could suppress infl ammation and reduce the severity of COVID-19. Vitamin D supplementation may have an important role in decreasing the impact of the pandemic (Tab. 5, Fig. 2, Ref. 27

References

Alipio, Vitamin D Supplementation Could Possibly Improve Clinical Outcomes of Patients Infected with Coronavirus, doi:10.2139/ssrn.3571484

Barlow, Svoboda, Mackellar, Antiviralactivity and increased host defense against infl uenza infection elicited by the human cathelicidin LL-37, PLoS ONE, doi:10.1371/journal.pone.0025333

Blondonm, Rodabough, Budrys, The effect of calcium plus vitamin D supplementation on the risk of venous thromboembolism. From the Women's Health Initiative Randomized Controlled Trial, ThrombHaemost, doi:10.1160/TH14-05-0478

Bolland, Avenell, Grey, Should adults take vitamin D supplements to prevent disease?, BMJ, doi:10.1136/bmj.i6201

Chen, Zhou, Dong, Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study, Lancet, doi:10.1016/S0140-6736(20)30211-7

Ebadi, Montano-Loza, Perspective: improving vitamin D status in the management of COVID-19, Eur J ClinNutr, doi:10.1038/s41430-020-0661-0

El Hassoun, Valaskova, Polak, Hulin, Few Insights on the problem of COVID-19, Bratisl Med J, doi:10.4149/BLL_2020_078

Giannis, Ziogasia, Gianni, Coagulation disorders in coronavirus infected patients: COVID-19, SARS-CoV-1, MERS-CoV and lessons from the past, J Clin Virol, doi:10.1016/j.jcv.2020.104362

Gombart, Pierre, Maggini, A Review of Micronutrients and the Immune System-Working in Harmony to Reduce the Risk of Infection, Nutrients, doi:10.3390/nu12010236

Grant, Lahore, Mcdonnell, Evidence that Vitamin D Supplementation Could Reduce Risk of Infl uenza and COVID-19 Infections and Deaths, Nutrients, doi:10.3390/nu12040988

Hastie, Mackay, Ho, Vitamin D concentrations and CO-VID-19 infection in UK Biobank, Diabetes MetabSyndr, doi:10.1016/j.dsx.2020.04.050

Huang, Wang, Li, Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China, Lancet, doi:10.1016/S0140-6736(20)30183-5

Ilie, Stefanescu, Smith, The role of vitamin D in the prevention of coronavirus disease 2019 infection and mortality

Kong, Zhu, Shi, VDR attenuates acute lung injury by blocking Ang-2-Tie-2 pathway and renin-angiotensin system, Mol Endocrinol, doi:10.1210/me.2013-1146

Laird, Mcnulty, Ward, Vitamin D defi ciency is associated with infl ammation in older Irish adults, J ClinEndocrinolMetab2014, doi:10.1210/jc.2013-3507

Li, Geng, Peng, Meng, Lu, Molecular immune pathogenesis and diagnosis of COVID-19, J Pharm Anal, doi:10.1016/j.jpha.2020.03.001

Mohammad, Mishra, Ashraf, Emerging Role of Vitamin D and its Associated Molecules in Pathways Related to Pathogenesis of Thrombosis, Biomolecules, doi:10.3390/biom9110649

Ni, Tian, Xiang, Yu, Characteristics of infl ammatory factors and lymphocyte subsets in patients with severe COVID-19, J Med Virol, doi:10.1002/jmv.26070

Rhodes, Subramanian, Laird, Kenny, Editorial: low population mortality from COVID-19 in countries south of latitude 35 degrees North supports vitamin D as a factor determining severity, Aliment PharmacolTher, doi:10.1111/apt.15777

Tang, Li, Wang, Sun, Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia, J ThrombHaemost, doi:10.1111/jth.14768

Vanherwegen, Gysemans, Mathieu, Regulation of Immune Function by Vitamin D and Its Use in Diseases of Immunity, Endocrinol Metab Clin North Am, doi:10.1016/j.ecl.2017.07.010

Weir, Thenappan, Bhargava, Chen, Does vitamin D defi ciency increase the severity of COVID-19?

Wu, He, Low Vitamin D Levels Are Associated with the Development of Deep Venous Thromboembolic Events in Patients With-Ischemic Stroke, Clin Appl ThrombHemost, doi:10.1177/1076029618786574

Yormaz, Ergun, Tulek, The evaluation of prognostic value of acute phase reactants in the COVID-19, Bratisl Med J, doi:10.4149/BLL_2020_103

Zhao, Ran, Jiang, D Alleviates Rotavirus Infection through a Microrna-155-5p Mediated Regulation of the TBK1/IRF3 Signaling Pathway In Vivo and In Vitro, Int J Mol Sci, doi:10.3390/ijms20143562

Zhou, She, Wang, Ma, Utility of Ferritin, Procalcitonin, and Creactive Protein in Severe Patients with 2019 Novel Coronavirus Disease, doi:10.21203/rs.3.rs-18079/v1+

Zhou, Yu, Du, Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort, Lancet, doi:10.1016/S0140-6736(20)30566-3

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