The relationship between vitamin D and the severity of COVID-19

Basaran et al., Bratislava Medical Journal, doi:10.4149/bll_2021_034, Feb 2021

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Vitamin D for COVID-19

8th treatment shown to reduce risk in October 2020, now with p < 0.00000000001 from 126 studies, recognized in 18 countries.

Lower risk for mortality, ICU, hospitalization, progression, recovery, cases, and viral clearance.

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Prospective study of 204 patients with COVID-19-like pneumonia in Turkey, 42 outpatients (mild cases), and 162 inpatients (serious cases), showing significantly higher risk of severe cases with vitamin D deficiency.

This is the 47th of 226 COVID-19 sufficiency studies for vitamin D, which collectively show higher levels reduce risk with p<0.0000000001 (1 in 115,066,047,903,039,356,928 vigintillion).

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risk of severe case, 68.6% lower, RR 0.31, p = 0.005, high D levels 82 of 119 (68.9%), low D levels 80 of 85 (94.1%), NNT 4.0, inverted to make RR<1 favor high D levels, odds ratio converted to relative risk, >10μg/L, per standard deviation increase in levels.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

Basaran et al., 12 Feb 2021, retrospective, Turkey, peer-reviewed, 6 authors.

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The relationship between vitamin D and the severity of COVID-19

N Basaran, M Adas, Y Gokden, N Turgut, T Yildirmak, MD G Guntas

Bratislava Medical Journal, doi:10.4149/bll_2021_034

AIM: Vitamin D, which has immunomodulatory effect, can reduce risk of infections and concentrations of proinfl ammatory cytokines. The aim of this study was to investigate the relationship between the levels of vitamin D and severity of COVID-19. METHODS: A total of 204 patients with COVID-19 disease were enrolled in the study. All patients had viral pneumonia, which was confi rmed with chest computer tomography. All cases were divided in two groupsmild (outpatients); and serious (inpatients)-according to their clinical and laboratory data. Serum vitamin D levels were measured by chemiluminescence method. RESULTS: Vitamin D defi ciency was found in 41.7 % (n = 85) of cases and insuffi ciency was found in 46.0 % (n = 94), while in 12.3 % (n = 25) of cases normal vitamin D levels were found. The odds of having a serious clinical outcome were increased for vitamin D insuffi ciency patients 5.604 times (%95 CI:0.633-49.584) and for vitamin D defi ciency patients 38.095 times (%95 CI:2.965-489.50) for each standard deviation decrease in serum 25(OH)D. CONCLUSION: Adequate levels of vitamin D could suppress infl ammation and reduce the severity of COVID-19. Vitamin D supplementation may have an important role in decreasing the impact of the pandemic (Tab. 5, Fig. 2, Ref. 27

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