Vitamin D sufficiency, a serum 25-hydroxyvitamin D at least 30 ng/mL reduced risk for adverse clinical outcomes in patients with COVID-19 infection
Maghbooli et al.,
Vitamin D sufficiency, a serum 25-hydroxyvitamin D at least 30 ng/mL reduced risk for adverse clinical..,
PLOS One, doi:10.1371/journal.pone.0239799
Retrospective 235 hospitalized patients showing a significant association between vitamin D sufficiency and reduction in clinical severity.
For patients over 40, mortality was 9.7% with 25(OH)D levels >30ng/mL, versus 20% for <30ng/mL.
A significant reduction in serum CRP, an inflammatory marker, along with increased lymphocytes percentage suggest that vitamin D sufficiency may help modulate the immune response possibly by reducing the risk for cytokine storm in response to this viral infection.
risk of death, 51.7% lower, RR 0.48, p = 0.08, high D levels 7 of 72 (9.7%), low D levels 27 of 134 (20.1%), NNT 9.6, age >40.
|
risk of mechanical ventilation, 31.6% lower, RR 0.68, p = 0.49, high D levels 6 of 77 (7.8%), low D levels 18 of 158 (11.4%), NNT 28.
|
risk of ICU admission, 32.0% lower, RR 0.68, p = 0.33, high D levels 11 of 77 (14.3%), low D levels 33 of 158 (20.9%), NNT 15, >30nmol/L.
|
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
|
Maghbooli et al., 25 Sep 2020, retrospective, Iran, peer-reviewed, 11 authors.
Abstract: PLOS ONE
RESEARCH ARTICLE
Vitamin D sufficiency, a serum 25hydroxyvitamin D at least 30 ng/mL reduced
risk for adverse clinical outcomes in patients
with COVID-19 infection
a1111111111
a1111111111
a1111111111
a1111111111
a1111111111
OPEN ACCESS
Citation: Maghbooli Z, Sahraian MA, Ebrahimi M,
Pazoki M, Kafan S, Tabriz HM, et al. (2020) Vitamin
D sufficiency, a serum 25-hydroxyvitamin D at
least 30 ng/mL reduced risk for adverse clinical
outcomes in patients with COVID-19 infection.
PLoS ONE 15(9): e0239799. https://doi.org/
10.1371/journal.pone.0239799
Editor: Muhammad Adrish, BronxCare Health
System, Affiliated with Icahn School of Medicine at
Mount Sinai, NY, USA, UNITED STATES
Received: July 19, 2020
Zhila Maghbooli ID1,2, Mohammad Ali Sahraian1*, Mehdi Ebrahimi3, Marzieh Pazoki4,
Samira Kafan5, Hedieh Moradi Tabriz6, Azar Hadadi5, Mahnaz Montazeri5, Mehrad Nasiri2,
Arash Shirvani7, Michael F. Holick7*
1 Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences,
Tehran, Iran, 2 Research Development Center, Sina Hospital, Tehran University of Medical Sciences,
Tehran, Iran, 3 Endocrinology Department, Sina Hospital, Tehran University of Medical Sciences, Tehran,
Iran, 4 Department of Infectious Diseases, Sina Hospital, Tehran University of Medical Sciences, Tehran,
Iran, 5 Department of Internal Medicine, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran,
6 Department of Pathology, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran,
7 Department of Medicine, Section of Endocrinology, Nutrition, Diabetes and Weight Management, Boston
University Medical Center, Boston, Massachusetts, United States of America
* mfholick@bu.edu (MFH); msahrai@tums.ac.ir (MAS)
Abstract
Background
To investigate the association between serum 25-hydroxyvitamin D levels and its effect on
adverse clinical outcomes, and parameters of immune function and mortality due to a
SARS-CoV-2 infection.
Accepted: September 14, 2020
Published: September 25, 2020
Study design
Copyright: © 2020 Maghbooli et al. This is an open
access article distributed under the terms of the
Creative Commons Attribution License, which
permits unrestricted use, distribution, and
reproduction in any medium, provided the original
author and source are credited.
The hospital data of 235 patients infected with COVID-19 were analyzed.
Data Availability Statement: The data is part of the
inpatient database of Sina Hospital COVID-19
Registry (SHCo-19R) and was used under license
for the current study. The datasets used and
analyzed during the current study will be available
from the Research Development Center of Sina
Hospital (Dr. Hale Ashraf; sina.research.
development.center@gmail.com) on reasonable
request. Based on the ethics board of Tehran
University of Medical Sciences, access to data
Results
Based on CDC criteria, among our study patients, 74% had severe COVID-19 infection and
32.8% were vitamin D sufficient. After adjusting for confounding factors, there was a significant association between vitamin D sufficiency and reduction in clinical severity, inpatient
mortality serum levels of C-reactive protein (CRP) and an increase in lymphocyte percentage. Only 9.7% of patients older than 40 years who were vitamin D sufficient succumbed to
the infection compared to 20% who had a circulating level of 25(OH)D< 30 ng/ml. The significant reduction in serum CRP, an inflammatory marker, along with increased..
Please send us corrections, updates, or comments. Vaccines and
treatments are complementary. All practical, effective, and safe means should
be used based on risk/benefit analysis. No treatment, vaccine, or intervention
is 100% available and effective for all current and future variants. We do not
provide medical advice. Before taking any medication, consult a qualified
physician who can provide personalized advice and details of risks and
benefits based on your medical history and situation.
FLCCC and
WCH
provide treatment protocols.
Submit