Vitamin D Deficiency Is Inversely Associated with COVID-19 Incidence and Disease Severity in Chinese People
Luo et al.
, Vitamin D Deficiency Is Inversely Associated with COVID-19 Incidence and Disease Severity in Chinese People
, The Journal of Nutrition, doi:10.1093/jn/nxaa332
Retrospective 335 patients in China compared to 560 matched controls showing significanlty lower risk of severe COVID-19 with vitamin D sufficiency (>=30 nmol/L) OR 0.37, p = 0.014.
risk of progression, 63.0% lower, RR 0.37, p = 0.01, high D levels 335, low D levels 560, >30nmol/L.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Luo et al., 13 Nov 2020, retrospective, China, peer-reviewed, median age 56.0, 5 authors.
Abstract: The Journal of Nutrition
Nutrition and Disease
Vitamin D Deficiency Is Inversely Associated
with COVID-19 Incidence and Disease Severity
in Chinese People
Xia Luo, Qing Liao, Ying Shen, Huijun Li, and Liming Cheng
Background: Vitamin D might have beneficial potential in influencing the natural history of the coronavirus disease
2019 (COVID-19) due to its immunomodulatory and anti-inflammatory properties.
Objective: The aim was to investigate whether vitamin D deficiency is associated with COVID-19 incidence and disease
severity in Chinese people.
Methods: In a cross-sectional study we retrospectively analyzed 335 COVID-19 patients (median: 56.0; IQR: 43.0–
64.0 y) who were admitted to the Wuhan Tongji Hospital between 27 February and 21 March 2020. We also included
an age- and sex-matched population of 560 individuals (median: 55; IQR: 49.0–60.0 y) who underwent the physical
examination program. Their serum 25-hydroxyvitamin D [25(OH)D] concentrations were measured during the same
period from 2018–2019. Serum 25(OH)D concentrations were measured for all COVID-19 patients on admission. Severity
of COVID-19 was determined based on the level of respiratory involvement. A general linear model with adjustment
for covariates was used to compare 25(OH)D concentrations between the COVID-19 and 2018–2019 control groups.
Adjusted ORs with 95% CIs for associations between vitamin D status and COVID-19 severity were estimated via
multivariable logistic regression.
Results: In the general linear model adjusted for age, sex, comorbidities, and BMI, serum 25(OH)D concentrations
were significantly lower among COVID-19 patients than the 2018–2019 controls [ln transformed values of
3.32 ± 0.04 vs. 3.46 ± 0.022 ln (nmol/L), P = 0.014]. Multivariable logistic regression showed that male sex (OR: 2.26;
95% CI: 1.06, 4.82), advanced age (≥65 y) (OR: 4.93; 95% CI: 1.44, 16.9), and vitamin D deficiency (<30 nmol/L) (OR:
2.72; 95% CI: 1.23, 6.01) were significantly associated with COVID-19 severity (all P < 0.05).
Conclusions: These findings suggested that vitamin D deficiency impacts COVID-19 hospitalization and severity in
the Chinese population. J Nutr 2020;00:1–6.
Keywords: vitamin D, coronavirus disease, cross-sectional, deficiency, COVID-19 severity
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