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0 0.5 1 1.5 2+ Severe case 89% Improvement Relative Risk Hospitalization time 87% Case 24% Demir et al. Vitamin D for COVID-19 Sufficiency Are vitamin D levels associated with COVID-19 outcomes? Retrospective 210 patients in Turkey Lower severe cases (p=0.001) and shorter hospitalization (p=0.001) Demir et al., J. Medical Virology, doi:10.1002/jmv.26832 Favors vitamin D Favors control

Vitamin D deficiency is associated with COVID-19 positivity and the severity of the disease

Demir et al., Journal of Medical Virology, doi:10.1002/jmv.26832
Demir et al., Vitamin D deficiency is associated with COVID-19 positivity and the severity of the disease, Journal of Medical Virology, doi:10.1002/jmv.26832
Jan 2021   Source   PDF  
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Retrospective cohort study of 487 patients finding that lower vitamin D levels is associated with more severe cases as measured by affected lung segments and increased hospitalization time for COVID-19 positive patients, and that lower vitamin D levels increases COVID-19 PCR+ cases.
This is the 45th of 177 COVID-19 sufficiency studies for vitamin D, which collectively show higher levels reduce risk with p<0.0000000001 (1 in 26 vigintillion).
risk of severe case, 89.3% lower, RR 0.11, p < 0.001, high D levels 13, low D levels 99, ratio of the mean number of affected lung segments, >30ng/ml vs. <=10ng/mL.
hospitalization time, 87.1% lower, relative time 0.13, p < 0.001, high D levels 13, low D levels 99, >30ng/ml vs. <=10ng/mL.
risk of case, 24.2% lower, RR 0.76, p = 0.18, high D levels 13 of 31 (41.9%), low D levels 99 of 179 (55.3%), NNT 7.5, >30ng/ml vs. <=10ng/mL.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Demir et al., 29 Jan 2021, retrospective, Turkey, peer-reviewed, 3 authors.
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This PaperVitamin DAll
Vitamin D deficiency is associated with COVID‐19 positivity and severity of the disease
Mustafa Demir, Fadime Demir, Hatice Aygun
Journal of Medical Virology, doi:10.1002/jmv.26832
The present study examined the relationship between polymerase chain reaction (PCR) test positivity and clinical outcomes of vitamin D levels measured within the 6 months before the PCR test in coronavirus disease 2019 (COVID-19)-positive patients. In this retrospective cohort study, COVID-19 (227) and non-COVID-19 patients (260) were divided into four groups according to their vitamin D levels: Group I (0-10 ng/ml), Group II (10-20 ng/ml), Group III (20-30 ng/ml), and Group IV (vitamin D > 30 ng/ml). Laboratory test results and the radiological findings were evaluated. In addition, for comparative purposes, medical records of 1200 patients who had a hospital visit in the November 1, 2019-November 1, 2020 period for complaints due to reasons not related to COVID-19 were investigated for the availability of vitamin D measurements. This search yielded 260 patients with tested vitamin D levels. Vitamin D levels were below 30 ng/ml in 94.27% of 227 COVID-19-positive patients (average age, 46.32 ± 1.24 years [range, 20-80 years] and 56.54% women) while 93.07% of 260 non-COVID-19 patients (average age, 44.63 ± 1.30 years [range, 18-75 years] and 59.50% women) had vitamin D levels below 30 ng/ml. Nevertheless, very severe vitamin D deficiency (<10 ng/ml) was considerably more common in COVID-19 patients (44%) (average age, 44.15 ± 1.89 years [range, 23-80 years] and 57.57% women) than in non-COVID-19 ones (31%) (average age, 46.50 ± 2.21 years [range, 20-75 years] and 62.5% women). Among COVID-19-positive patients, the group with vitamin D levels of >30 ng/ml had significantly lower D-dimer and C-reactive protein (CRP) levels, number levels, number of affected lung segments and shorter hospital stays. No difference was found among the groups in terms of age and gender distribution. Elevated vitamin D levels could decrease COVID-19 PCR positivity, D-dime and CRP levels and the number of affected lung segments in COVID-19-positive patients, thereby shortening the duration of hospital stays and alleviating the intensity of COVID-19.
CONFLICT OF INTERESTS The authors declare that there are no conflict of interests. AUTHOR CONTRIBUTIONS Hatice Aygun conceived and designed the research. Hatice Aygun, Fadime Demir, Mustafa Demir collected, analyzed and interpreted the data. Hatice Aygun wrote the article. All authors read and approved the manuscript.
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