Analgesics
Antiandrogens
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Abstract
All vitamin D studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19early.org COVID-19 treatment researchVitamin DVitamin D (more..)
Melatonin Meta
Metformin Meta
Azvudine Meta
Bromhexine Meta Molnupiravir Meta
Budesonide Meta
Colchicine Meta
Conv. Plasma Meta Nigella Sativa Meta
Curcumin Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   

Association of vitamin D with the modulation of the disease severity in COVID-19

Mardani et al., Virus Research, doi:10.1016/j.virusres.2020.198148
Aug 2020  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
 
*, now known with p < 0.00000000001 from 120 studies, recognized in 8 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,100+ studies for 60+ treatments. c19early.org
Prospective study of 123 outpatients in Iran, showing mortality associated with significantly lower vitamin D levels. IR.SBMU.RETECH.REC.1399.131.
Mardani et al., 28 Aug 2020, peer-reviewed, 6 authors.
This PaperVitamin DAll
Association of vitamin D with the modulation of the disease severity in COVID-19
R Mardani, A Alamdary, S D Mousavi Nasab, R Gholami, N Ahmadi, A Gholami
Virus Research, doi:10.1016/j.virusres.2020.198148
Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre -including this research content -immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
Appendix A. Supplementary data Supplementary material related to this article can be found, in the online version, at doi:https://doi.org/10. 1016/j.virusres.2020.198148.
References
Adams, Hewison, Extrarenal expression of the 25-hydroxyvitamin D-1-hydroxylase, Arch. Biochem. Biophys
Ahmed, Human antimicrobial peptides as therapeutics for viral infections, Viruses
Andersen, The proximal origin of SARS-CoV-2, Nat. Med
Chen, Dysregulated renin-angiotensin system contributes to acute lung injury caused by hind-limb ischemia-reperfusion in mice, Shock
D'arienzoa, Coniglio, Assessment of the SARS-CoV-2 basic reproduction number, R0, based on the early phase of COVID-19 outbreak in Italy
Foley, Parfrey, Sarnak, Clinical epidemiology of cardiovascular disease in chronic renal disease, Am. J. Kidney Dis
Garg, Editorial: low population mortality from COVID-19 in countries south of latitude 35 degrees North-supports vitamin D as a factor determining severity. Authors' reply, Aliment. Pharmacol. Ther
Ginde, Mansbach, Camargo, Association between serum 25-hydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey, Arch. Intern. Med
Gombart, The vitamin D-antimicrobial peptide pathway and its role in protection against infection, Future Microbiol
Hastie, Vitamin D concentrations and COVID-19 infection in UK Biobank, Diabetes Metab. Syndr
Hewison, Vitamin D and innate and adaptive immunity, Vitam. Horm
Holick, Vitamin D status: measurement, interpretation, and clinical application, Ann. Epidemiol
Hussain, Bhowmik, Do Vale Moreira, COVID-19 and diabetes: knowledge in progress, Diabetes Res. Clin. Pract
Hussain, Structural variations in human ACE2 may influence its binding with SARS-CoV-2 spike protein, J. Med. Virol
Imai, Angiotensin-converting enzyme 2 protects from severe acute lung failure, Nature
Kamphuis, Type I interferons directly regulate lymphocyte recirculation and cause transient blood lymphopenia, Blood
Kennel, Drake, Hurley, Vitamin D deficiency in adults: when to test and how to treat, Mayo Clin. Proc
Kong, VDR attenuates acute lung injury by blocking Ang-2-Tie-2 pathway and renin-angiotensin system, Mol. Endocrinol
Kuba, A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury, Nat. Med
Lagunas-Rangel, Neutrophil-to-lymphocyte ratio and lymphocyte-to-Creactive protein ratio in patients with severe coronavirus disease 2019 (COVID-19): a meta-analysis, J. Med. Virol
Lang, How important is vitamin D in preventing infections?, Osteoporos. Int
Liu, Xue, None, Za Zhi
Mardani, Laboratory parameters in detection of COVID-19 patients with positive RT-PCR; a diagnostic accuracy study, Arch. Acad. Emerg. Med
Maron, Leopold, The role of the renin-angiotensin-aldosterone system in the pathobiology of pulmonary arterial hypertension (2013 Grover Conference series), Pulm. Circ
Martineau, Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data, BMJ
Martins, Neutrophil-lymphocyte ratio in the early diagnosis of sepsis in an intensive care unit: a case-control study, Rev. Bras. Ter. Intensiva
Moromizato, Association of low serum 25-hydroxyvitamin D levels and sepsis in the critically ill, Crit. Care Med
Muniz-Rodriguez, Severe acute respiratory syndrome coronavirus 2 transmission potential, Iran, 2020, Emerg Infect Dis
Nagaoka, Modulation of neutrophil apoptosis by antimicrobial peptides, ISRN Microbiol
Pinto, ACE2 expression is increased in the lungs of patients with comorbidities associated with severe COVID-19, medRxiv
Prietl, Vitamin D and immune function, Nutrients
Sabetta, Serum 25-hydroxyvitamin d and the incidence of acute viral respiratory tract infections in healthy adults, PLoS One
Schalekamp, Danser, How does the angiotensin II type 1 receptor 'trump' the type 2 receptor in blood pressure control?, J. Hypertens
Shenoy, The angiotensin-converting enzyme 2/angiogenesis-(1-7)/Mas axis confers cardiopulmonary protection against lung fibrosis and pulmonary hypertension, Am. J. Respir. Crit. Care Med
Shroff, Wan, Rees, Can vitamin D slow down the progression of chronic kidney disease?, Pediatr. Nephrol
Tan, Lymphopenia predicts disease severity of COVID-19: a descriptive and predictive study, Signal Transduct. Target. Ther
Team, -R, Severe outcomes among patients with coronavirus disease 2019 (COVID-19) -United States, MMWR Morb. Mortal. Wkly. Rep
Tikellis, Thomas, Wan, Receptor recognition by the novel coronavirus from Wuhan: an analysis based on decade-long structural studies of SARS coronavirus, Int. J. Pept
Wang, SARS-CoV-2 infects T lymphocytes through its spike proteinmediated membrane fusion, Cell. Mol. Immunol
Xie, Comparison of different samples for 2019 novel coronavirus detection by nucleic acid amplification tests, Int. J. Infect. Dis
Yu, Captopril pretreatment protects the lung against severe acute pancreatitis induced injury via inhibiting angiotensin II production and suppressing Rho/ROCK pathway, Kaohsiung J. Med. Sci
Zhang, Neutrophil-lymphocyte ratio as an early new marker in AIV-H7N9-infected patients: a retrospective study, Ther. Clin. Risk Manag
Zheng, COVID-19 and the cardiovascular system, Nat. Rev. Cardiol
{ 'DOI': '10.1016/j.virusres.2020.198148', 'ISSN': ['0168-1702'], 'URL': 'http://dx.doi.org/10.1016/j.virusres.2020.198148', 'alternative-id': ['S0168170220310558'], 'article-number': '198148', 'assertion': [ {'label': 'This article is maintained by', 'name': 'publisher', 'value': 'Elsevier'}, { 'label': 'Article Title', 'name': 'articletitle', 'value': 'Association of vitamin D with the modulation of the disease severity in ' 'COVID-19'}, {'label': 'Journal Title', 'name': 'journaltitle', 'value': 'Virus Research'}, { 'label': 'CrossRef DOI link to publisher maintained version', 'name': 'articlelink', 'value': 'https://doi.org/10.1016/j.virusres.2020.198148'}, {'label': 'Content Type', 'name': 'content_type', 'value': 'article'}, {'label': 'Copyright', 'name': 'copyright', 'value': '© 2020 Published by Elsevier B.V.'}], 'author': [ {'affiliation': [], 'family': 'Mardani', 'given': 'R.', 'sequence': 'first'}, { 'ORCID': 'http://orcid.org/0000-0001-7776-8809', 'affiliation': [], 'authenticated-orcid': False, 'family': 'Alamdary', 'given': 'A.', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Mousavi Nasab', 'given': 'S.D.', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Gholami', 'given': 'R.', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Ahmadi', 'given': 'N.', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Gholami', 'given': 'A.', 'sequence': 'additional'}], 'container-title': 'Virus Research', 'container-title-short': 'Virus Research', 'content-domain': {'crossmark-restriction': True, 'domain': ['elsevier.com', 'sciencedirect.com']}, 'created': {'date-parts': [[2020, 8, 28]], 'date-time': '2020-08-28T15:16:50Z', 'timestamp': 1598627810000}, 'deposited': { 'date-parts': [[2020, 10, 14]], 'date-time': '2020-10-14T05:52:00Z', 'timestamp': 1602654720000}, 'indexed': {'date-parts': [[2024, 5, 14]], 'date-time': '2024-05-14T18:33:29Z', 'timestamp': 1715711609265}, 'is-referenced-by-count': 48, 'issued': {'date-parts': [[2020, 11]]}, 'language': 'en', 'license': [ { 'URL': 'https://www.elsevier.com/tdm/userlicense/1.0/', 'content-version': 'tdm', 'delay-in-days': 0, 'start': { 'date-parts': [[2020, 11, 1]], 'date-time': '2020-11-01T00:00:00Z', 'timestamp': 1604188800000}}], 'link': [ { 'URL': 'https://api.elsevier.com/content/article/PII:S0168170220310558?httpAccept=text/xml', 'content-type': 'text/xml', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://api.elsevier.com/content/article/PII:S0168170220310558?httpAccept=text/plain', 'content-type': 'text/plain', 'content-version': 'vor', 'intended-application': 'text-mining'}], 'member': '78', 'original-title': [], 'page': '198148', 'prefix': '10.1016', 'published': {'date-parts': [[2020, 11]]}, 'published-print': {'date-parts': [[2020, 11]]}, 'publisher': 'Elsevier BV', 'reference': [ { 'DOI': '10.1016/j.abb.2012.02.016', 'article-title': 'Extrarenal expression of the 25-hydroxyvitamin D-1-hydroxylase', 'author': 'Adams', 'doi-asserted-by': 'crossref', 'first-page': '95', 'issue': '1', 'journal-title': 'Arch. Biochem. Biophys.', 'key': '10.1016/j.virusres.2020.198148_bib0005', 'volume': '523', 'year': '2012'}, { 'DOI': '10.3390/v11080704', 'article-title': 'Human antimicrobial peptides as therapeutics for viral infections', 'author': 'Ahmed', 'doi-asserted-by': 'crossref', 'issue': '8', 'journal-title': 'Viruses', 'key': '10.1016/j.virusres.2020.198148_bib0010', 'volume': '11', 'year': '2019'}, { 'DOI': '10.1038/s41591-020-0820-9', 'article-title': 'The proximal origin of SARS-CoV-2', 'author': 'Andersen', 'doi-asserted-by': 'crossref', 'first-page': '450', 'issue': '4', 'journal-title': 'Nat. Med.', 'key': '10.1016/j.virusres.2020.198148_bib0015', 'volume': '26', 'year': '2020'}, { 'DOI': '10.1097/SHK.0b013e3182a6953e', 'article-title': 'Dysregulated renin-angiotensin system contributes to acute lung injury ' 'caused by hind-limb ischemia-reperfusion in mice', 'author': 'Chen', 'doi-asserted-by': 'crossref', 'first-page': '420', 'issue': '5', 'journal-title': 'Shock', 'key': '10.1016/j.virusres.2020.198148_bib0020', 'volume': '40', 'year': '2013'}, { 'DOI': '10.1038/s41564-020-0695-z', 'article-title': 'The species Severe acute respiratory syndrome-related coronavirus: ' 'classifying 2019-nCoV and naming it SARS-CoV-2', 'author': 'Coronaviridae Study Group of the International Committee on Taxonomy of, V', 'doi-asserted-by': 'crossref', 'first-page': '536', 'issue': '4', 'journal-title': 'Nat. Microbiol.', 'key': '10.1016/j.virusres.2020.198148_bib0025', 'volume': '5', 'year': '2020'}, { 'DOI': '10.1016/j.bsheal.2020.03.004', 'article-title': 'Assessment of the SARS-CoV-2 basic reproduction number, R0, based on ' 'the early phase of COVID-19 outbreak in Italy', 'author': 'D’Arienzoa', 'doi-asserted-by': 'crossref', 'journal-title': 'J. Biosaf. Health Educ.', 'key': '10.1016/j.virusres.2020.198148_bib0030', 'year': '2020'}, { 'article-title': '[The epidemiological characteristics of an outbreak of 2019 novel ' 'coronavirus diseases (COVID-19) in China]', 'author': 'Epidemiology Working Group for Ncip Epidemic Response, C.C.F.D.C. and ' 'Prevention', 'first-page': '145', 'issue': '2', 'journal-title': 'Zhonghua Liu Xing Bing Xue Za Zhi', 'key': '10.1016/j.virusres.2020.198148_bib0035', 'volume': '41', 'year': '2020'}, { 'DOI': '10.1053/ajkd.1998.v32.pm9820470', 'article-title': 'Clinical epidemiology of cardiovascular disease in chronic renal ' 'disease', 'author': 'Foley', 'doi-asserted-by': 'crossref', 'first-page': 'S112', 'issue': '5 Suppl 3', 'journal-title': 'Am. J. Kidney Dis.', 'key': '10.1016/j.virusres.2020.198148_bib0040', 'volume': '32', 'year': '1998'}, { 'DOI': '10.1111/apt.15796', 'article-title': 'Editorial: low population mortality from COVID-19 in countries south of ' 'latitude 35 degrees North-supports vitamin D as a factor determining ' 'severity. Authors’ reply', 'author': 'Garg', 'doi-asserted-by': 'crossref', 'first-page': '1438', 'issue': '12', 'journal-title': 'Aliment. Pharmacol. Ther.', 'key': '10.1016/j.virusres.2020.198148_bib0045', 'volume': '51', 'year': '2020'}, { 'DOI': '10.1001/archinternmed.2008.560', 'article-title': 'Association between serum 25-hydroxyvitamin D level and upper ' 'respiratory tract infection in the Third National Health and Nutrition ' 'Examination Survey', 'author': 'Ginde', 'doi-asserted-by': 'crossref', 'first-page': '384', 'issue': '4', 'journal-title': 'Arch. Intern. Med.', 'key': '10.1016/j.virusres.2020.198148_bib0050', 'volume': '169', 'year': '2009'}, { 'DOI': '10.2217/fmb.09.87', 'article-title': 'The vitamin D-antimicrobial peptide pathway and its role in protection ' 'against infection', 'author': 'Gombart', 'doi-asserted-by': 'crossref', 'first-page': '1151', 'issue': '9', 'journal-title': 'Future Microbiol.', 'key': '10.1016/j.virusres.2020.198148_bib0055', 'volume': '4', 'year': '2009'}, { 'DOI': '10.1016/j.dsx.2020.04.050', 'article-title': 'Vitamin D concentrations and COVID-19 infection in UK Biobank', 'author': 'Hastie', 'doi-asserted-by': 'crossref', 'first-page': '561', 'issue': '4', 'journal-title': 'Diabetes Metab. Syndr.', 'key': '10.1016/j.virusres.2020.198148_bib0060', 'volume': '14', 'year': '2020'}, { 'DOI': '10.1016/B978-0-12-386960-9.00002-2', 'article-title': 'Vitamin D and innate and adaptive immunity', 'author': 'Hewison', 'doi-asserted-by': 'crossref', 'first-page': '23', 'journal-title': 'Vitam. Horm.', 'key': '10.1016/j.virusres.2020.198148_bib0065', 'volume': '86', 'year': '2011'}, { 'DOI': '10.1016/j.annepidem.2007.12.001', 'article-title': 'Vitamin D status: measurement, interpretation, and clinical application', 'author': 'Holick', 'doi-asserted-by': 'crossref', 'first-page': '73', 'issue': '2', 'journal-title': 'Ann. Epidemiol.', 'key': '10.1016/j.virusres.2020.198148_bib0070', 'volume': '19', 'year': '2009'}, { 'DOI': '10.1002/jmv.25832', 'article-title': 'Structural variations in human ACE2 may influence its binding with ' 'SARS-CoV-2 spike protein', 'author': 'Hussain', 'doi-asserted-by': 'crossref', 'journal-title': 'J. Med. Virol.', 'key': '10.1016/j.virusres.2020.198148_bib0075', 'year': '2020'}, { 'DOI': '10.1016/j.diabres.2020.108142', 'article-title': 'COVID-19 and diabetes: knowledge in progress', 'author': 'Hussain', 'doi-asserted-by': 'crossref', 'first-page': '108142', 'journal-title': 'Diabetes Res. Clin. Pract.', 'key': '10.1016/j.virusres.2020.198148_bib0080', 'volume': '162', 'year': '2020'}, { 'DOI': '10.1038/nature03712', 'article-title': 'Angiotensin-converting enzyme 2 protects from severe acute lung failure', 'author': 'Imai', 'doi-asserted-by': 'crossref', 'first-page': '112', 'issue': '7047', 'journal-title': 'Nature', 'key': '10.1016/j.virusres.2020.198148_bib0085', 'volume': '436', 'year': '2005'}, { 'DOI': '10.1182/blood-2006-06-027599', 'article-title': 'Type I interferons directly regulate lymphocyte recirculation and cause ' 'transient blood lymphopenia', 'author': 'Kamphuis', 'doi-asserted-by': 'crossref', 'first-page': '3253', 'issue': '10', 'journal-title': 'Blood', 'key': '10.1016/j.virusres.2020.198148_bib0090', 'volume': '108', 'year': '2006'}, { 'DOI': '10.4065/mcp.2010.0138', 'article-title': 'Vitamin D deficiency in adults: when to test and how to treat', 'author': 'Kennel', 'doi-asserted-by': 'crossref', 'first-page': '752', 'issue': '8', 'journal-title': 'Mayo Clin. Proc.', 'key': '10.1016/j.virusres.2020.198148_bib0095', 'volume': '85', 'year': '2010'}, { 'DOI': '10.1210/me.2013-1146', 'article-title': 'VDR attenuates acute lung injury by blocking Ang-2-Tie-2 pathway and ' 'renin-angiotensin system', 'author': 'Kong', 'doi-asserted-by': 'crossref', 'first-page': '2116', 'issue': '12', 'journal-title': 'Mol. Endocrinol.', 'key': '10.1016/j.virusres.2020.198148_bib0100', 'volume': '27', 'year': '2013'}, { 'DOI': '10.1038/nm1267', 'article-title': 'A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS ' 'coronavirus-induced lung injury', 'author': 'Kuba', 'doi-asserted-by': 'crossref', 'first-page': '875', 'issue': '8', 'journal-title': 'Nat. Med.', 'key': '10.1016/j.virusres.2020.198148_bib0105', 'volume': '11', 'year': '2005'}, { 'DOI': '10.1002/jmv.25819', 'article-title': 'Neutrophil-to-lymphocyte ratio and lymphocyte-to-C-reactive protein ' 'ratio in patients with severe coronavirus disease 2019 (COVID-19): a ' 'meta-analysis', 'author': 'Lagunas-Rangel', 'doi-asserted-by': 'crossref', 'journal-title': 'J. Med. Virol.', 'key': '10.1016/j.virusres.2020.198148_bib0110', 'year': '2020'}, { 'DOI': '10.1007/s00198-012-2204-6', 'article-title': 'How important is vitamin D in preventing infections?', 'author': 'Lang', 'doi-asserted-by': 'crossref', 'first-page': '1537', 'issue': '5', 'journal-title': 'Osteoporos. Int.', 'key': '10.1016/j.virusres.2020.198148_bib0115', 'volume': '24', 'year': '2013'}, { 'article-title': 'Laboratory parameters in detection of COVID-19 patients with positive ' 'RT-PCR; a diagnostic accuracy study', 'author': 'Mardani', 'first-page': 'e43', 'issue': '1', 'journal-title': 'Arch. Acad. Emerg. Med.', 'key': '10.1016/j.virusres.2020.198148_bib0120', 'volume': '8', 'year': '2020'}, { 'DOI': '10.1086/675984', 'article-title': 'The role of the renin-angiotensin-aldosterone system in the ' 'pathobiology of pulmonary arterial hypertension (2013 Grover Conference ' 'series)', 'author': 'Maron', 'doi-asserted-by': 'crossref', 'first-page': '200', 'issue': '2', 'journal-title': 'Pulm. Circ.', 'key': '10.1016/j.virusres.2020.198148_bib0125', 'volume': '4', 'year': '2014'}, { 'DOI': '10.1136/bmj.i6583', 'article-title': 'Vitamin D supplementation to prevent acute respiratory tract ' 'infections: systematic review and meta-analysis of individual ' 'participant data', 'author': 'Martineau', 'doi-asserted-by': 'crossref', 'first-page': 'i6583', 'journal-title': 'BMJ', 'key': '10.1016/j.virusres.2020.198148_bib0130', 'volume': '356', 'year': '2017'}, { 'DOI': '10.5935/0103-507X.20190010', 'article-title': 'Neutrophil-lymphocyte ratio in the early diagnosis of sepsis in an ' 'intensive care unit: a case-control study', 'author': 'Martins', 'doi-asserted-by': 'crossref', 'first-page': '64', 'issue': '1', 'journal-title': 'Rev. Bras. Ter. Intensiva', 'key': '10.1016/j.virusres.2020.198148_bib0135', 'volume': '31', 'year': '2019'}, { 'DOI': '10.1097/CCM.0b013e31829eb7af', 'article-title': 'Association of low serum 25-hydroxyvitamin D levels and sepsis in the ' 'critically ill', 'author': 'Moromizato', 'doi-asserted-by': 'crossref', 'first-page': '97', 'issue': '1', 'journal-title': 'Crit. Care Med.', 'key': '10.1016/j.virusres.2020.198148_bib0140', 'volume': '42', 'year': '2014'}, { 'DOI': '10.3201/eid2608.200536', 'article-title': 'Severe acute respiratory syndrome coronavirus 2 transmission potential, ' 'Iran, 2020', 'author': 'Muniz-Rodriguez', 'doi-asserted-by': 'crossref', 'issue': '8', 'journal-title': 'Emerg Infect Dis', 'key': '10.1016/j.virusres.2020.198148_bib0145', 'volume': '26', 'year': '2020'}, { 'DOI': '10.5402/2012/345791', 'article-title': 'Modulation of neutrophil apoptosis by antimicrobial peptides', 'author': 'Nagaoka', 'doi-asserted-by': 'crossref', 'first-page': '345791', 'journal-title': 'ISRN Microbiol.', 'key': '10.1016/j.virusres.2020.198148_bib0150', 'volume': '2012', 'year': '2012'}, { 'article-title': 'ACE2 expression is increased in the lungs of patients with ' 'comorbidities associated with severe COVID-19', 'author': 'Pinto', 'journal-title': 'medRxiv', 'key': '10.1016/j.virusres.2020.198148_bib0155', 'year': '2020'}, { 'DOI': '10.3390/nu5072502', 'article-title': 'Vitamin D and immune function', 'author': 'Prietl', 'doi-asserted-by': 'crossref', 'first-page': '2502', 'issue': '7', 'journal-title': 'Nutrients', 'key': '10.1016/j.virusres.2020.198148_bib0160', 'volume': '5', 'year': '2013'}, { 'DOI': '10.1371/journal.pone.0011088', 'article-title': 'Serum 25-hydroxyvitamin d and the incidence of acute viral respiratory ' 'tract infections in healthy adults', 'author': 'Sabetta', 'doi-asserted-by': 'crossref', 'first-page': 'e11088', 'issue': '6', 'journal-title': 'PLoS One', 'key': '10.1016/j.virusres.2020.198148_bib0165', 'volume': '5', 'year': '2010'}, { 'DOI': '10.1097/HJH.0b013e32835d6d11', 'article-title': 'How does the angiotensin II type 1 receptor ‘trump’ the type 2 receptor ' 'in blood pressure control?', 'author': 'Schalekamp', 'doi-asserted-by': 'crossref', 'first-page': '705', 'issue': '4', 'journal-title': 'J. Hypertens.', 'key': '10.1016/j.virusres.2020.198148_bib0170', 'volume': '31', 'year': '2013'}, { 'DOI': '10.1164/rccm.200912-1840OC', 'article-title': 'The angiotensin-converting enzyme 2/angiogenesis-(1-7)/Mas axis confers ' 'cardiopulmonary protection against lung fibrosis and pulmonary ' 'hypertension', 'author': 'Shenoy', 'doi-asserted-by': 'crossref', 'first-page': '1065', 'issue': '8', 'journal-title': 'Am. J. Respir. Crit. Care Med.', 'key': '10.1016/j.virusres.2020.198148_bib0175', 'volume': '182', 'year': '2010'}, { 'DOI': '10.1007/s00467-011-2071-y', 'article-title': 'Can vitamin D slow down the progression of chronic kidney disease?', 'author': 'Shroff', 'doi-asserted-by': 'crossref', 'first-page': '2167', 'issue': '12', 'journal-title': 'Pediatr. Nephrol.', 'key': '10.1016/j.virusres.2020.198148_bib0180', 'volume': '27', 'year': '2012'}, { 'DOI': '10.1038/s41392-020-0148-4', 'article-title': 'Lymphopenia predicts disease severity of COVID-19: a descriptive and ' 'predictive study', 'author': 'Tan', 'doi-asserted-by': 'crossref', 'first-page': '33', 'journal-title': 'Signal Transduct. Target. Ther.', 'key': '10.1016/j.virusres.2020.198148_bib0185', 'volume': '5', 'year': '2020'}, { 'DOI': '10.15585/mmwr.mm6912e2', 'article-title': 'Severe outcomes among patients with coronavirus disease 2019 (COVID-19) ' '- United States, February 12-March 16, 2020', 'author': 'Team', 'doi-asserted-by': 'crossref', 'first-page': '343', 'issue': '12', 'journal-title': 'MMWR Morb. Mortal. Wkly. Rep.', 'key': '10.1016/j.virusres.2020.198148_bib0190', 'volume': '69', 'year': '2020'}, { 'DOI': '10.1155/2012/256294', 'article-title': 'Angiotensin-converting enzyme 2 (ACE2) is a key modulator of the renin ' 'angiotensin system in health and disease', 'author': 'Tikellis', 'doi-asserted-by': 'crossref', 'first-page': '256294', 'journal-title': 'Int. J. Pept.', 'key': '10.1016/j.virusres.2020.198148_bib0195', 'volume': '2012', 'year': '2012'}, { 'DOI': '10.1128/JVI.00127-20', 'article-title': 'Receptor recognition by the novel coronavirus from Wuhan: an analysis ' 'based on decade-long structural studies of SARS coronavirus', 'author': 'Wan', 'doi-asserted-by': 'crossref', 'issue': '7', 'journal-title': 'J. Virol.', 'key': '10.1016/j.virusres.2020.198148_bib0200', 'volume': '94', 'year': '2020'}, { 'DOI': '10.1038/s41423-020-0498-4', 'article-title': 'SARS-CoV-2 infects T lymphocytes through its spike protein-mediated ' 'membrane fusion', 'author': 'Wang', 'doi-asserted-by': 'crossref', 'journal-title': 'Cell. Mol. Immunol.', 'key': '10.1016/j.virusres.2020.198148_bib0205', 'year': '2020'}, { 'DOI': '10.1016/j.ijid.2020.02.050', 'article-title': 'Comparison of different samples for 2019 novel coronavirus detection by ' 'nucleic acid amplification tests', 'author': 'Xie', 'doi-asserted-by': 'crossref', 'first-page': '264', 'journal-title': 'Int. J. Infect. Dis.', 'key': '10.1016/j.virusres.2020.198148_bib0210', 'volume': '93', 'year': '2020'}, { 'DOI': '10.1016/j.kjms.2016.07.008', 'article-title': 'Captopril pretreatment protects the lung against severe acute ' 'pancreatitis induced injury via inhibiting angiotensin II production ' 'and suppressing Rho/ROCK pathway', 'author': 'Yu', 'doi-asserted-by': 'crossref', 'first-page': '439', 'issue': '9', 'journal-title': 'Kaohsiung J. Med. Sci.', 'key': '10.1016/j.virusres.2020.198148_bib0215', 'volume': '32', 'year': '2016'}, { 'DOI': '10.2147/TCRM.S206930', 'article-title': 'Neutrophil-lymphocyte ratio as an early new marker in AIV-H7N9-infected ' 'patients: a retrospective study', 'author': 'Zhang', 'doi-asserted-by': 'crossref', 'first-page': '911', 'journal-title': 'Ther. Clin. Risk Manag.', 'key': '10.1016/j.virusres.2020.198148_bib0220', 'volume': '15', 'year': '2019'}, { 'DOI': '10.1038/s41569-020-0360-5', 'article-title': 'COVID-19 and the cardiovascular system', 'author': 'Zheng', 'doi-asserted-by': 'crossref', 'first-page': '259', 'issue': '5', 'journal-title': 'Nat. Rev. Cardiol.', 'key': '10.1016/j.virusres.2020.198148_bib0225', 'volume': '17', 'year': '2020'}], 'reference-count': 45, 'references-count': 45, 'relation': {}, 'resource': {'primary': {'URL': 'https://linkinghub.elsevier.com/retrieve/pii/S0168170220310558'}}, 'score': 1, 'short-title': [], 'source': 'Crossref', 'subject': [], 'subtitle': [], 'title': 'Association of vitamin D with the modulation of the disease severity in COVID-19', 'type': 'journal-article', 'update-policy': 'http://dx.doi.org/10.1016/elsevier_cm_policy', 'volume': '289'}
Loading..
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit