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Supplementary Data — Aspirin for COVID-19: real-time meta analysis of 61 studies
Covid Analysis, December 2022
https://c19early.org/emeta.html
 
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Connors (DB RCT) 67% 0.33 [0.01-7.96] hosp. 0/144 1/136 Improvement, RR [CI] Treatment Control Connors (DB RCT) 19% 0.81 [0.28-2.35] progression 6/144 7/136 Connors (DB RCT) 6% 0.94 [0.06-15.0] progression 1/144 1/136 Alamdari -28% 1.28 [0.67-2.43] death 9/53 54/406 Husain 80% 0.20 [0.01-3.55] death 0/11 3/31 Husain 65% 0.35 [0.05-2.51] no recov. 1/11 8/31 Husain 96% 0.04 [0.00-0.64] progression 0/11 17/31 Goshua (PSM) 35% 0.65 [0.42-0.98] death 319 (n) 319 (n) Goshua (PSM) -49% 1.49 [1.03-2.18] ventilation 319 (n) 319 (n) Goshua (PSM) -45% 1.45 [1.06-1.98] ICU 319 (n) 319 (n) Meizlish (PSM) 48% 0.52 [0.34-0.81] death 319 (n) 319 (n) Liu (PSM) 75% 0.25 [0.07-0.87] death 2/28 11/204 Liu (PSM) 81% 0.19 [0.05-0.78] death 1/28 9/204 Liu (PSM) -2% 1.02 [0.64-1.61] viral time 24 (n) 24 (n) Mura (PSM) 15% 0.85 [0.69-1.01] death 527 (n) 527 (n) Mura (PSM) 37% 0.63 [0.47-0.83] death 305 (n) 305 (n) Chow 47% 0.53 [0.31-0.90] death 26/98 73/314 Chow 44% 0.56 [0.37-0.85] ventilation 35/98 152/314 Chow 43% 0.57 [0.38-0.85] ICU 38/98 160/314 Haji Aghajani 25% 0.75 [0.57-0.99] death 336 (n) 655 (n) Elhadi (ICU) 10% 0.90 [0.67-1.21] death 22/40 259/425 ICU patients Sahai (PSM) 13% 0.87 [0.56-1.34] death 33/248 38/248 Pourhoseingholi -32% 1.32 [1.02-1.71] death 71/290 268/2,178 Vahedian-Azimi 22% 0.78 [0.33-1.74] death 13/337 28/250 Vahedian-Azimi -10% 1.10 [0.68-1.68] ICU 36/337 44/250 Abdelwahab -8% 1.08 [0.15-3.82] ventilation 11/31 6/36 Karruli (ICU) 46% 0.54 [0.09-3.13] death 1/5 22/27 ICU patients Al Harthi (PSM) 27% 0.73 [0.56-0.97] death 98/176 107/173 Al Harthi (PSM) 14% 0.86 [0.65-1.14] death 95/176 97/175 Kim (PSM) 34% 0.66 [0.36-1.23] death 14/124 23/135 Kim (PSM) -102% 2.02 [0.83-4.90] ventilation 13/124 7/135 Kim (PSM) -91% 1.91 [0.57-6.35] ICU 7/124 4/135 Zhao 43% 0.57 [0.41-0.78] death 121/473 140/473 Zhao 28% 0.72 [0.54-0.96] death 473 (n) 1,597 (n) RECOVERY (RCT) 4% 0.96 [0.89-1.04] death 7,351 (n) 7,541 (n) RECOVERY (RCT) 17% 0.83 [0.66-1.04] death 7,351 (n) 7,541 (n) RECOVERY (RCT) 5% 0.95 [0.87-1.05] ventilation 7,351 (n) 7,541 (n) RECOVERY (RCT) 6% 0.94 [0.91-0.98] no disch. 7,351 (n) 7,541 (n) RECOVERY (RCT) 16% 0.84 [0.71-0.99] no disch. 7,351 (n) 7,541 (n) Mustafa 44% 0.56 [0.21-1.51] death 4/66 41/378 Bradbury (RCT) 16% 0.84 [0.70-1.00] death 165/563 170/521 Bradbury (RCT) 17% 0.83 [0.67-1.02] no disch. 161/563 167/521 Bradbury (RCT) 21% 0.79 [0.65-0.96] progression 204/563 212/521 Bradbury (RCT) 5% 0.95 [0.77-1.18] progression 563 (n) 521 (n) Chow (PSW) 13% 0.87 [0.81-0.93] death Santoro (PSM) 38% 0.62 [0.42-0.92] death 360 (n) 2,949 (n) Ghati (RCT) 22% 0.78 [0.31-1.98] death 11/442 7/219 Ghati (RCT) 58% 0.42 [0.11-1.62] death 3/221 7/219 Ghati (RCT) 9% 0.91 [0.34-2.42] ventilation 11/442 6/219 Ghati (RCT) 50% 0.50 [0.13-1.96] ventilation 3/221 6/219 Ghati (RCT) 30% 0.70 [0.27-1.81] progression 11/442 7/219 Ghati (RCT) 60% 0.40 [0.10-1.54] progression 3/221 7/219 Karimpour-Razke.. -123% 2.23 [1.26-3.38] death 39/90 64/363 Eikelboom (RCT) -5% 1.05 [0.86-1.28] death 193/1,063 186/1,056 CT​1 Eikelboom (RCT) 8% 0.92 [0.78-1.09] progression 281/1,063 300/1,056 CT​1 Eikelboom (RCT) 11% 0.89 [0.73-1.09] progression 191/1,063 210/1,056 CT​1 Eikelboom (RCT) -9% 1.09 [0.48-2.46] death 12/1,945 11/1,936 Eikelboom (RCT) 20% 0.80 [0.57-1.13] progression 59/1,945 73/1,936 Eikelboom (RCT) 17% 0.83 [0.58-1.19] hosp. 56/1,945 67/1,936 Ali (ICU) 40% 0.60 [0.51-0.72] death 152/660 202/530 ICU patients Ali (ICU) 37% 0.63 [0.47-0.83] ARDS 74/660 95/530 ICU patients Aidouni (ICU) 31% 0.69 [0.54-0.88] death 202/712 165/412 ICU patients Aidouni (ICU) 10% 0.90 [0.74-1.10] ventilation 189/712 121/412 ICU patients Huh 71% 0.29 [0.14-0.58] cases population-based cohort Holt -34% 1.34 [0.98-1.84] death/ICU 35/116 129/573 Wang 58% 0.42 [0.01-1.98] death 1/9 13/49 Formiga (PSM) -3% 1.03 [0.94-1.13] death 1,000/3,291 874/2,885 Formiga (PSM) -3% 1.03 [0.85-1.25] ventilation 213/3,291 181/2,885 Formiga (PSM) -4% 1.04 [0.88-1.23] ICU 283/3,291 238/2,885 Yuan 4% 0.96 [0.47-1.72] death 11/52 29/131 Osborne (PSM) 59% 0.41 [0.35-0.48] death 272/6,300 661/6,300 Osborne (PSM) 60% 0.40 [0.33-0.48] death 170/6,814 427/6,814 Merzon 28% 0.72 [0.53-0.99] cases 73/1,621 589/8,856 Merzon 62% 0.38 [0.02-4.94] death 1/21 6/91 Merzon 10% 0.90 [0.82-1.00] viral time 73 (n) 589 (n) Merzon 15% 0.85 [0.76-0.95] viral time 73 (n) 589 (n) Mulhem -14% 1.14 [0.93-1.40] death 300/1,354 216/1,865 Reese (PSM) -61% 1.61 [1.31-1.99] death 4,921 (n) 4,921 (n) Reese (PSM) -309% 4.09 [3.72-4.50] severe case 4,921 (n) 4,921 (n) Pan -13% 1.13 [0.70-1.82] death 239 (n) 523 (n) Pan -2% 1.02 [0.66-1.57] death/int. 239 (n) 523 (n) Oh 1% 0.99 [0.65-1.50] death n/a n/a Oh 12% 0.88 [0.79-0.99] cases n/a n/a Son (PSM) 24% 0.76 [0.34-1.71] death case control Son (PSM) -7% 1.07 [0.65-1.75] progression case control Son (PSM) -11% 1.11 [0.94-1.30] cases case control Ma (PSM) 9% 0.91 [0.82-1.02] death Ma (PSM) 2% 0.98 [0.92-1.04] hosp. Ma (PSM) -9% 1.09 [0.96-1.25] symp. case Ma (PSM) -7% 1.07 [0.99-1.16] cases Chow (PSM) 19% 0.81 [0.76-0.87] death 1,280/6,781 2,271/10,566 Chow (PSM) 3% 0.97 [0.93-1.02] ventilation 2,122/6,781 3,403/10,566 Kim (PSM) -700% 8.00 [1.07-59.6] death 6/15 1/20 Kim (PSM) -433% 5.33 [0.66-43.0] ventilation 4/15 1/20 Kim (PSM) -433% 5.33 [0.66-43.0] ICU 4/15 1/20 Kim (PSM) 33% 0.67 [0.30-1.36] cases 15/136 20/136 Kim (PSM) 34% 0.66 [0.36-1.23] death 14/124 23/135 Kim (PSM) -102% 2.02 [0.83-4.90] ventilation 13/124 7/135 Kim (PSM) -91% 1.91 [0.57-6.35] ICU 7/124 4/135 Basheer -13% 1.13 [1.05-1.21] death 45/140 29/250 Sisinni -7% 1.07 [0.89-1.29] death 93/253 251/731 Sisinni 30% 0.70 [0.53-0.92] death/int. 253 (n) 731 (n) Pérez-Segura -49% 1.49 [1.20-1.80] death 66/155 183/608 Sullerot (PSW) -10% 1.10 [0.81-1.49] death 101/301 224/746 Sullerot (PSW) -110% 2.10 [1.21-3.64] ICU 22/301 26/746 Sullerot (PSW) -10% 1.10 [1.01-1.20] hosp. time 301 (n) 746 (n) Monserrat .. (PSM) -31% 1.31 [1.01-1.71] death n/a n/a Levy 26% 0.74 [0.49-1.10] death/hosp. 29/159 178/690 Nimer 4% 0.96 [0.69-1.33] hosp. 83/427 136/1,721 Nimer -18% 1.18 [0.87-1.56] severe case 98/427 162/1,721 Gogtay -6% 1.06 [0.51-1.89] death 12/38 21/87 Gogtay 50% 0.50 [0.18-1.22] ventilation 5/38 21/87 Gogtay 49% 0.51 [0.06-1.46] ICU 9/38 38/87 Drew 22% 0.78 [0.49-1.24] progression n/a n/a Drew -3% 1.03 [0.83-1.28] cases n/a n/a Campbell (PSW) 3% 0.97 [0.95-1.00] death 419 (n) 20,311 (n) Campbell (PSW) 2% 0.98 [0.95-1.00] death 419 (n) 20,311 (n) Lal 11% 0.89 [0.82-0.97] death 4,691 (n) 16,888 (n) Lal 22% 0.78 [0.73-0.84] ICU 4,691 (n) 16,888 (n) Lal 9% 0.91 [0.84-0.99] progression 4,691 (n) 16,888 (n) Botton -4% 1.04 [0.98-1.10] death/int. Botton -3% 1.03 [1.00-1.06] hosp. Malik 14% 0.86 [0.39-1.80] death 15/87 24/223 Malik 28% 0.72 [0.44-1.11] ICU 28/87 77/223 Malik 25% 0.75 [0.38-1.39] ARDS 13/87 40/223 Malik 2% 0.98 [0.53-1.78] hosp. 25 (n) 176 (n) Abul 33% 0.67 [0.47-0.95] death 46/511 201/1,176 Abul 40% 0.60 [0.40-0.90] death 33/511 154/1,176 Abul 20% 0.80 [0.60-1.07] hosp. 103/511 352/1,176 Loucera 18% 0.82 [0.74-0.92] death 2,127 (n) 13,841 (n) Morrison (PSM) 8% 0.92 [0.73-1.18] death 1,667 (n) 1,667 (n) Morrison (PSM) -1% 1.01 [0.71-1.43] ventilation 1,667 (n) 1,667 (n) Morrison (PSM) -12% 1.12 [0.88-1.43] ICU 1,667 (n) 1,667 (n) Morrison (PSM) -18% 1.18 [1.00-1.39] hosp. 1,667 (n) 1,667 (n) Ali 28% 0.72 [0.51-1.03] death 481 (n) 1,164 (n) Aspirin COVID-19 outcomes c19early.org/e Dec 2022 1 CT: study uses combined treatment Favors aspirin Favors control
Figure S1. All outcomes.
Please send us corrections, updates, or comments. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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