The impact of asprin use on the outcome of patients admitted to the intensive care unit with COVID-19 infection

{ 'institution': [{'name': 'Research Square'}], 'indexed': {'date-parts': [[2022, 12, 1]], 'date-time': '2022-12-01T06:01:35Z', 'timestamp': 1669874495833}, 'posted': {'date-parts': [[2022, 11, 30]]}, 'group-title': 'In Review', 'reference-count': 15, 'publisher': 'Research Square Platform LLC', 'license': [ { 'start': { 'date-parts': [[2022, 11, 30]], 'date-time': '2022-11-30T00:00:00Z', 'timestamp': 1669766400000}, 'content-version': 'unspecified', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0/'}], 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'accepted': {'date-parts': [[2022, 11, 25]]}, 'abstract': '<jats:title>Abstract</jats:title>\n' ' <jats:p>Background\n' ' Our objective in this study is to know the impact of the use of asprin in anti-aggregation ' 'dose on the evolution during hospitalization of patients admitted in intensive care unit for ' 'a severe infection by SARS-COV-2.\n' 'Methods\n' ' We conducted a prospective study of patients admitted to our department with severe COVID-19 ' 'infection during the period between March 2020 and March 2022, analyzing the difference ' 'between the placebo group and the aspirin group on the primary endpoint of all-cause hospital ' 'mortality and the composite secondary endpoint of use of mechanical ventilation and ' 'thromboembolic events.\n' 'Results\n' ' Out of 1124 patients included, 32.6% died, with a protective effect of aspirin against ' 'placebo (Hazard-ratio\u2009=\u20090.691, p\u2009=\u20090.003), for thrombo-embolic ' 'complications, 104 events were observed, with a protective effect of aspirin ' '(Hazard-Ratio\u2009=\u20090.448 and p\u2009=\u20090.001), finally regarding mechanical ' 'ventilation, there was no remarkable benefit on our sample.\n' 'Conclusion\n' ' Given the divergence of results of studies published in the literature, the availability of ' 'results of large randomized controlled trials is a necessity.</jats:p>', 'DOI': '10.21203/rs.3.rs-2313880/v1', 'type': 'posted-content', 'created': { 'date-parts': [[2022, 11, 30]], 'date-time': '2022-11-30T19:44:40Z', 'timestamp': 1669837480000}, 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'The impact of asprin use on the outcome of patients admitted to the intensive care unit with ' 'COVID-19 infection', 'prefix': '10.21203', 'author': [ { 'given': 'Ghizlane El', 'family': 'Aidouni', 'sequence': 'first', 'affiliation': [{'name': 'Mohammed I st University'}]}, { 'given': 'Amine', 'family': 'Bouchlarhem', 'sequence': 'additional', 'affiliation': [{'name': 'Mohammed I st University'}]}, { 'given': 'Houssam', 'family': 'Bkiyar', 'sequence': 'additional', 'affiliation': [{'name': 'Mohammed I st University'}]}, { 'given': 'Nabila', 'family': 'Ismaili', 'sequence': 'additional', 'affiliation': [{'name': 'Mohammed I st University'}]}, { 'given': 'Noha El', 'family': 'Ouafi', 'sequence': 'additional', 'affiliation': [{'name': 'Mohammed I st University'}]}, { 'given': 'Brahim', 'family': 'housni', 'sequence': 'additional', 'affiliation': [{'name': 'Mohammed I st University'}]}], 'member': '8761', 'reference': [ { 'issue': '3', 'key': 'ref1', 'doi-asserted-by': 'publisher', 'first-page': '100742', 'DOI': '10.1016/j.cpcardiol.2020.100742', 'article-title': 'Thrombosis and Coagulopathy in COVID-19', 'volume': '46', 'author': 'Gómez-Mesa JE', 'year': '2021', 'unstructured': 'Gómez-Mesa JE, Galindo-Coral S, Montes MC, Muñoz Martin AJ. 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