Formiga: Does admission acetylsalicylic acid uptake in hospitalized COVID-19 patients have a protective role? Data from the Spanish SEMI-COVID-19 Registry [Aspirin]

Does admission acetylsalicylic acid uptake in hospitalized COVID-19 patients have a protective role? Data from the Spanish SEMI-COVID-19 Registry

Formiga et al., Internal and Emergency Medicine, doi:10.1007/s11739-021-02870-1

Formiga et al., Does admission acetylsalicylic acid uptake in hospitalized COVID-19 patients have a protective role? Data from.., Internal and Emergency Medicine, doi:10.1007/s11739-021-02870-1

Nov 2020 Source PDF

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Retrospective 20,641 hospitalized patients in Spain, showing no significant difference in outcomes with existing aspirin use.

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risk of death, 3.4% higher, RR 1.03, p = 0.48, treatment 1,000 of 3,291 (30.4%), control 874 of 2,885 (30.3%), odds ratio converted to relative risk, propensity score matching.

risk of mechanical ventilation, 3.2% higher, RR 1.03, p = 0.75, treatment 213 of 3,291 (6.5%), control 181 of 2,885 (6.3%), propensity score matching.

risk of ICU admission, 4.2% higher, RR 1.04, p = 0.65, treatment 283 of 3,291 (8.6%), control 238 of 2,885 (8.2%), propensity score matching.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

Formiga et al., 29 Nov 2020, retrospective, USA, peer-reviewed, 24 authors, study period 1 March, 2020 - 1 May, 2021.

Contact: fformiga@bellvitgehospital.cat.

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Abstract: Internal and Emergency Medicine (2022) 17:761–775 https://doi.org/10.1007/s11739-021-02870-1 IM - ORIGINAL Does admission acetylsalicylic acid uptake in hospitalized COVID‑19 patients have a protective role? Data from the Spanish SEMI‑COVID‑19 Registry Francesc Formiga1 · Manuel Rubio‑Rivas1 · José María Mora‑Luján1 · Samara Campos Escudero2 · Rosa Fernandez Madera Martinez3 · Manuel Mendez‑Bailón4 · Pedro Durán‑del Campo5 · Andrea Riaño Pérez6 · Francisco‑Javier García‑Sánchez7 · José Nicolás Alcalá‑Pedrajas8 · Sergio Arnedo Hernández9 · Almudena Hernández Milian10 · Ana Latorre Díez11 · Ricardo Gil Sánchez12 · Ramon Boixeda13 · Julio Vicente14 · Begoña Cortes15 · Carmen Mella Pérez16 · María Esther Guisado Espartero17 · José López Castro18 · Santiago Rodríguez Suárez19 · Jose F. Varona20 · Ricardo Gomez‑Huelgas21 · Jose Manuel Ramos‑Rincón22 · on behalf of the SEMI-COVID-19 SEMI-COVID-19 Network Received: 24 June 2021 / Accepted: 4 October 2021 / Published online: 29 November 2021 © Società Italiana di Medicina Interna (SIMI) 2021 Abstract Acetylsalicylic acid (ASA) is widely used in the treatment and prevention of cardiovascular disorders. Our objective is to evaluate its possible protective role, not only in mortality but also in other aspects such as inflammation, symptomatic thrombosis, and intensive care unit (ICU) admission in hospitalized COVID-19 patients. We realized an observational retrospective cohort study of 20,641 patients with COVID-19 pneumonia collected and followed-up from Mar 1st, 2020 to May 1st, 2021, from the nationwide Spanish SEMI-COVID-19 Registry. Propensity score matching (PSM) was performed to determine whether treatment with ASA affected outcomes in COVID-19 patients. On hospital admission, 3291 (15.9%) patients were receiving ASA. After PSM, 3291 patients exposed to ASA and 2885 not-exposed patients were analyzed. In-hospital mortality was higher in the ASA group (30.4 vs. 16.9%, p < 0.001) in the global sample. After PSM, no differences were found between groups (30.4 vs. 30.3%, p = 0.938). There were no differences in inflammation, symptomatic thrombosis, or ICU admission. In conclusion, ASA intake is not associated with in-hospital mortality or any other health outcome evaluated after applying PSM analysis in a real-world large sample of hospitalized COVID-19 patients. Keywords Acetylsalicylic acid · Coronavirus · COVID-19 · Mortality

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