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All Studies   Meta Analysis    Recent:   

Association of Early Aspirin Use With In-Hospital Mortality in Patients With Moderate COVID-19

Chow et al., JAMA Network Open, doi:10.1001/jamanetworkopen.2022.3890
Mar 2022  
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Mortality 13% Improvement Relative Risk Aspirin for COVID-19  Chow et al.  LATE TREATMENT Is late treatment with aspirin beneficial for COVID-19? Retrospective 112,070 patients in the USA Lower mortality with aspirin (p=0.00004) c19early.org Chow et al., JAMA Network Open, March 2022 Favorsaspirin Favorscontrol 0 0.5 1 1.5 2+
Aspirin for COVID-19
24th treatment shown to reduce risk in August 2021
 
*, now with p = 0.000087 from 73 studies, recognized in 3 countries.
Lower risk for mortality and progression.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,300+ studies for 77 treatments. c19early.org
Retrospective 112,269 hospitalized COVID-19 patients in the USA, showing lower mortality with aspirin treatment.
risk of death, 13.5% lower, RR 0.87, p < 0.001, treatment 1,410 of 13,795 (10.2%), control 11,577 of 98,275 (11.8%), NNT 64, adjusted per study, odds ratio converted to relative risk, propensity score weighting.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Chow et al., 24 Mar 2022, retrospective, USA, peer-reviewed, median age 63.0, 89 authors.
This PaperAspirinAll
Association of Early Aspirin Use With In-Hospital Mortality in Patients With Moderate COVID-19
MD Jonathan H Chow, PhD Ali Rahnavard, MD, MSc Mardi Gomberg-Maitland, MS Ranojoy Chatterjee, MS Pranay Patodi, MD David P Yamane, MD Andrea R Levine, MD Danielle Davison, MD Katrina Hawkins, MD Amanda M Jackson, MD Megan T Quintana, MD Allison S Lankford, MD Ryan J Keneally, MD Mustafa Al-Mashat, MD Daniel Fisher, MD Jeffrey Williams, MD, MBA Jeffrey S Berger, MD, MPH Michael A Mazzeffi, PhD Keith A Crandall, Ivy Benjenk, Benjamin Amor, Christopher Austin, Tellen Bennett, Mark Bissell, Samuel Bozzette, Katie Bradwell, Carolyn Bramante, Yooree Chae, Christopher Chute, Marshall Clark, Conor Cook, Mariam Deacy, Alexandra Dest, Racquel Dietz, Thomas Dillon, David Eichmann, Patricia Francis, Rafel Fuentes, Davera Gabriel, Nicole Garbarini, Kenneth Gersing, Andrew Girvin, Alexis Graves, Justin Guinney, Melissa Haendel, Jeremy Harper, Wenndy Hernandez, Stephanie Hong, Warren Kibbe, Farrukh Koraishy, Kristin Kostka, Michael Kurilla, Adam Lee, Harold Lehmann, Hongfang Liu, Amin Manna, Federico Mariona, Julie Mcmurry, Sam Michael, Robert Miller, Richard Moffitt, Michele Morris, Andrew Neumann, Shawn O'neil, Matvey Palchuk, Philip Payne, Emily Pfaff, Nabeel Qureshi, Peter Robinson, Joni Rutter, Joel Saltz, Mary Saltz, Amit Saha, Usman Sheikh, Heidi Spratt, Justin Starren, Christine Suver, Meredity Temple-O'connor, Satyanarayana Vedula, Andrea Volz, Anita Walden, Kellie Walters, Adam Wilcox, Andew Williams, Chunlei Wu, Elizabeth Zampino, Ziaohan Zhang, Richard Zhu
JAMA Network Open, doi:10.1001/jamanetworkopen.2022.3890
IMPORTANCE Prior observational studies suggest that aspirin use may be associated with reduced mortality in high-risk hospitalized patients with COVID-19, but aspirin's efficacy in patients with moderate COVID-19 is not well studied. OBJECTIVE To assess whether early aspirin use is associated with lower odds of in-hospital mortality in patients with moderate COVID-19.
Author Contributions: Drs Chow and Crandall had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Drs Mazzeffi and Crandall, as co-senior authors, contributed equally to the manuscript. Concept and design Conflict of Interest Disclosures: Dr Chow reported serving on the speaker's bureau for La Jolla Pharmaceutical Company outside the submitted work. Dr Gomberg-Maitland reported receiving honoraria from Medscape and serving as a consultant and member of the steering committees for Acceleron/Merck, Bayer, Janssen, and United Therapeutics outside the submitted work. Dr Mazzeffi reported receiving consulting fees from Hemosonics outside the submitted work. Dr Crandall reported receiving grants from the National Institutes of Health (NIH) and the National Science Foundation during the conduct of the study. No other disclosures were reported. Funding/Support: The analyses described in this publication were conducted with data or tools accessed through the National Center for Advancing Translational Sciences (NCATS) N3C Data Enclave and supported by grant U24 TR002306 from the NCATS. This study was also partially supported by grants NSF DEB-2028280 and DEB-2109688 from the National Science Foundation (Drs Rahnavard and Crandall) and 03UL1TR001876-05S1 from the NIH/NCATS (Dr Crandall), as well as an award from the George Washington University Office of the Vice President for Research (Dr..
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'journal-title': 'J Thromb Haemost'}, { 'issue': '10320', 'key': 'zoi220142r8', 'doi-asserted-by': 'publisher', 'first-page': '143', 'DOI': '10.1016/S0140-6736(21)01825-0', 'article-title': 'Aspirin in patients admitted to hospital with COVID-19 (RECOVERY): a ' 'randomised, controlled, open-label, platform trial.', 'volume': '399', 'author': 'RECOVERY Collaborative Group', 'year': '2022', 'journal-title': 'Lancet'}, { 'issue': '3', 'key': 'zoi220142r9', 'doi-asserted-by': 'publisher', 'first-page': '427', 'DOI': '10.1093/jamia/ocaa196', 'article-title': 'The National COVID Cohort Collaborative (N3C): rationale, design, ' 'infrastructure, and deployment.', 'volume': '28', 'author': 'Haendel', 'year': '2021', 'journal-title': 'J Am Med Inform Assoc'}, { 'key': 'zoi220142r10', 'article-title': 'Synergies between centralized and federated approaches to data quality: ' 'a report from the national COVID cohort collaborative.', 'author': 'Pfaff', 'year': '2021', 'journal-title': 'J Am Med Inform Assoc'}, { 'issue': '13', 'key': 'zoi220142r11', 'first-page': '1', 'article-title': 'Ipw: an R package for inverse probability weighting.', 'volume': '43', 'author': 'Van der Wal', 'year': '2011', 'journal-title': 'J Stat Softw'}, { 'issue': '8', 'key': 'zoi220142r13', 'doi-asserted-by': 'publisher', 'first-page': '758', 'DOI': '10.1093/aje/kwv254', 'article-title': 'Using big data to emulate a target trial when a randomized trial is not ' 'available.', 'volume': '183', 'author': 'Hernán', 'year': '2016', 'journal-title': 'Am J Epidemiol'}, { 'key': 'zoi220142r14', 'doi-asserted-by': 'publisher', 'first-page': '70', 'DOI': '10.1016/j.jclinepi.2016.04.014', 'article-title': 'Specifying a target trial prevents immortal time bias and other ' 'self-inflicted injuries in observational analyses.', 'volume': '79', 'author': 'Hernán', 'year': '2016', 'journal-title': 'J Clin Epidemiol'}, { 'issue': '28', 'key': 'zoi220142r15', 'doi-asserted-by': 'publisher', 'first-page': '3661', 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score to predict the ' 'occurrence of critical illness in hospitalized patients with COVID-19.', 'volume': '180', 'author': 'Liang', 'year': '2020', 'journal-title': 'JAMA Intern Med'}, { 'issue': '10229', 'key': 'zoi220142r26', 'doi-asserted-by': 'publisher', 'first-page': '1054', 'DOI': '10.1016/S0140-6736(20)30566-3', 'article-title': 'Clinical course and risk factors for mortality of adult inpatients with ' 'COVID-19 in Wuhan, China: a retrospective cohort study.', 'volume': '395', 'author': 'Zhou', 'year': '2020', 'journal-title': 'Lancet'}, { 'issue': '16', 'key': 'zoi220142r27', 'doi-asserted-by': 'publisher', 'first-page': '1509', 'DOI': '10.1056/NEJMoa1805819', 'article-title': 'Effect of aspirin on cardiovascular events and bleeding in the healthy ' 'elderly.', 'volume': '379', 'author': 'McNeil', 'year': '2018', 'journal-title': 'N Engl J Med'}, { 'issue': '23', 'key': 'zoi220142r28', 'doi-asserted-by': 'publisher', 'first-page': '2510', 'DOI': '10.1001/jama.2014.15690', 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Med'}, { 'key': 'zoi220142r16', 'volume-title': 'Causal Inference: What If', 'author': 'Hernan', 'year': '2020'}, { 'key': 'zoi220142r1', 'unstructured': 'Johns Hopkins University. Coronavirus resource center. Published 2021. ' 'Accessed January 31, 2022. https://coronavirus.jhu.edu/'}, { 'key': 'zoi220142r2', 'unstructured': 'Ritchie? H, Mathieu? E, Rodés-Guirao? L, . Coronavirus pandemic ' '(COVID-19). Published 2021. Accessed January 31, 2022. ' 'https://www.ourworldindata.org/coronavirus'}, { 'key': 'zoi220142r12', 'unstructured': 'Lumley? T. Survey: analysis of complex survey samples. Published 2020. ' 'Accessed August 18, 2021. ' 'https://cran.r-project.org/web/packages/survey/'}], 'container-title': ['JAMA Network Open'], 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://jamanetwork.com/journals/jamanetworkopen/articlepdf/2790439/chow_2022_oi_220142_1647457404.38134.pdf', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2022, 3, 24]], 'date-time': '2022-03-24T21:09:36Z', 'timestamp': 1648156176000}, 'score': 1, 'resource': {'primary': {'URL': 'https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2790439'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2022, 3, 24]]}, 'references-count': 30, 'journal-issue': {'issue': '3', 'published-print': {'date-parts': [[2022, 3, 1]]}}, 'URL': 'http://dx.doi.org/10.1001/jamanetworkopen.2022.3890', 'relation': {}, 'ISSN': ['2574-3805'], 'issn-type': [{'value': '2574-3805', 'type': 'electronic'}], 'subject': ['General Medicine'], 'published': {'date-parts': [[2022, 3, 24]]}}
Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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