Conv. Plasma
Nigella Sativa
Nitric Oxide
Peg.. Lambda

Home   COVID-19 treatment studies for Aspirin  COVID-19 treatment studies for Aspirin  C19 studies: Aspirin  Aspirin   Select treatmentSelect treatmentTreatmentsTreatments
Alkalinization Meta Lactoferrin Meta
Melatonin Meta
Bromhexine Meta Metformin Meta
Budesonide Meta Molnupiravir Meta
Cannabidiol Meta
Colchicine Meta Nigella Sativa Meta
Conv. Plasma Meta Nitazoxanide Meta
Curcumin Meta Nitric Oxide Meta
Ensovibep Meta Paxlovid Meta
Famotidine Meta Peg.. Lambda Meta
Favipiravir Meta Povidone-Iod.. Meta
Fluvoxamine Meta Quercetin Meta
Hydroxychlor.. Meta Remdesivir Meta
Iota-carragee.. Meta
Ivermectin Meta Zinc Meta

Other Treatments Global Adoption
All Studies   Meta Analysis   Recent:  
0 0.5 1 1.5 2+ Mortality 19% Improvement Relative Risk Ventilation 3% Chow et al. Aspirin for COVID-19 Prophylaxis Is prophylaxis with aspirin beneficial for COVID-19? PSM retrospective 17,347 patients in the USA Lower mortality with aspirin (p=0.005) Chow et al., J. Thrombosis and Haemostasis, doi:10.1111/jth.15517 Favors aspirin Favors control

Association of Pre-Hospital Antiplatelet Therapy with Survival in Patients Hospitalized with COVID-19: A Propensity Score-Matched Analysis

Chow et al., Journal of Thrombosis and Haemostasis, doi:10.1111/jth.15517
Chow et al., Association of Pre-Hospital Antiplatelet Therapy with Survival in Patients Hospitalized with COVID-19: A.., Journal of Thrombosis and Haemostasis, doi:10.1111/jth.15517
Aug 2021   Source   PDF  
  All Studies   Meta
PSM retrospective 6,781 hospitalized patients ≥50 years old in the USA who were on pre-hospital antiplatelet therapy (84% aspirin), and 10,566 matched controls, showing lower mortality with treatment.
risk of death, 19.0% lower, HR 0.81, p < 0.005, treatment 1,280 of 6,781 (18.9%), control 2,271 of 10,566 (21.5%), NNT 38, adjusted per study, Kaplan Meier.
risk of mechanical ventilation, 2.8% lower, HR 0.97, p = 0.21, treatment 2,122 of 6,781 (31.3%), control 3,403 of 10,566 (32.2%), NNT 109.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Chow et al., 29 Aug 2021, retrospective, propensity score matching, USA, peer-reviewed, 12 authors.
All Studies   Meta Analysis   Submit Updates or Corrections
This PaperAspirinAll
Association of prehospital antiplatelet therapy with survival in patients hospitalized with COVID‐19: A propensity score‐matched analysis
MD Jonathan H Chow, PhD Ying Ying Yin, MD David P Yamane, MD Danielle Davison, MD Ryan J Keneally, MD Katrina Katrina Hawkins, K Gage Parr, Mustafa Al‐mashat, MD, MBA Jeffery S Berger, PharmD, PA-C Reamer L Bushardt, MD, MPH Michael A Mazzeffi, MD Stuart J Nelson
Journal of Thrombosis and Haemostasis, doi:10.1111/jth.15517
This report describes a cohort observational clinical study. The authors state that the report includes every item in the STROBE checklist for cohort studies.
Ackermann, Verleden, Kuehnel, Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19, N Engl J Med
Beigel, Tomashek, Dodd, Remdesivir for the Treatment of Covid-19 -Final Report, N Engl J Med
Cheruiyot, Kipkorir, Ngure, Misiani, Munguti, Arterial Thrombosis in Coronavirus Disease 2019 Patients: A Rapid Systematic Review, Ann Vasc Surg
Chow, Khanna, Kethireddy, Aspirin Use Is Associated With Decreased Mechanical Ventilation, Intensive Care Unit Admission, and In-Hospital Mortality in Hospitalized Patients With Coronavirus Disease 2019, Anesth Analg
Damman, Woudstra, Kuijt, De Winter, James, P2Y12 platelet inhibition in clinical practice, J Thromb Thrombolysis
Group, Horby, Lim, Dexamethasone in Hospitalized Patients with Covid-19, N Engl J Med
Horby, Pessoa-Amorim, Staplin, COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
Jin, Yang, Chen, Zhang, Duan, Endothelial activation and dysfunction in COVID-19: from basic mechanisms to potential therapeutic approaches, Signal Transduct Target Ther
Kadri, Gundrum, Warner, Uptake and Accuracy of the Diagnosis Code for COVID-19 Among US Hospitalizations, JAMA
Leisman, Ten Pearls and Pitfalls of Propensity Scores in Critical Care Research: A Guide for Clinicians and Researchers, Crit Care Med
Li, Li, Wang, Acute cerebrovascular disease following COVID-19: a single center, retrospective, observational study, Stroke Vasc Neurol
Llitjos, Leclerc, Chochois, High incidence of venous thromboembolic events in anticoagulated severe COVID-19 patients, J Thromb Haemost
Lodigiani, Iapichino, Carenzo, Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in Milan, Italy, Thromb Res
Mcneil, Wolfe, Woods, Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly, N Engl J Med
Meizlish, Goshua, Liu, Intermediate-dose anticoagulation, aspirin, and inhospital mortality in COVID-19: A propensity score-matched analysis, Am J Hematol
Middeldorp, Coppens, Van Haaps, Incidence of venous thromboembolism in hospitalized patients with COVID-19, J Thromb Haemost
Osborne, Veigulis, Arreola, Mahajan, Roosli et al., Association of mortality and aspirin prescription for COVID-19 patients at the Veterans Health Administration, PLoS One
Paranjpe, Fuster, Lala, Association of Treatment Dose Anticoagulation with In-Hospital Survival Among Hospitalized Patients with COVID-19, J Am Coll Cardiol
Pedregosa, Varoquaux, Gramfort, Scikit-learn: Machine Learning in {P}ython, Journal of Machine Learning Research
Ranucci, Ballotta, Dedda, The procoagulant pattern of patients with COVID-19 acute respiratory distress syndrome, J Thromb Haemost
Rapkiewicz, Mai, Carsons, Megakaryocytes and platelet-fibrin thrombi characterize multi-organ thrombosis at autopsy in COVID-19: A case series
Salvarani, Dolci, Massari, Effect of Tocilizumab vs Standard Care on Clinical Worsening in Patients Hospitalized With COVID-19 Pneumonia: A Randomized Clinical Trial, JAMA Intern Med
Spiezia, Boscolo, Poletto, COVID-19-Related Severe Hypercoagulability in Patients Admitted to Intensive Care Unit for Acute Respiratory Failure, Thromb Haemost
Stone, Frigault, Boyd, Efficacy of Tocilizumab in Patients Hospitalized with Covid-19, N Engl J Med
Vanderweele, Ding, Sensitivity Analysis in Observational Research: Introducing the E-Value, Ann Intern Med
Warner, Nylander, Whatling, Anti-platelet therapy: cyclo-oxygenase inhibition and the use of aspirin with particular regard to dual anti-platelet therapy, Br J Clin Pharmacol
Wichmann, Sperhake, Lutgehetmann, Autopsy Findings and Venous Thromboembolism in Patients With COVID-19: A Prospective Cohort Study, Ann Intern Med
Wright, Vogler, Moore, Fibrinolysis Shutdown Correlates to Thromboembolic Events in Severe COVID-19 Infection, J Am Coll Surg
Zhang, Kim, Lonjon, Zhu, Of, Balance diagnostics after propensity score matching, Ann Transl Med
Zheng, Roddick, Association of Aspirin Use for Primary Prevention With Cardiovascular Events and Bleeding Events: A Systematic Review and Meta-analysis, JAMA
Please send us corrections, updates, or comments. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop