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All Studies   Meta Analysis       

Effect of low-dose aspirin on mortality and viral duration of the hospitalized adults with COVID-19

Liu et al., Medicine, doi:10.1097/MD.0000000000024544
Feb 2021  
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Mortality 75% Improvement Relative Risk Mortality (b) 81% Time to viral- -2% Aspirin for COVID-19  Liu et al.  LATE TREATMENT Is late treatment with aspirin beneficial for COVID-19? PSM retrospective 232 patients in China Lower mortality with aspirin (p=0.03) c19early.org Liu et al., Medicine, February 2021 Favorsaspirin Favorscontrol 0 0.5 1 1.5 2+
Retrospective PSM analysis of 232 hospitalized patients, 28 treated with aspirin, showing lower mortality with treatment. There was no significant difference in viral clearance.
Viral load measured by PCR may not accurately reflect infectious virus measured by viral culture. Porter et al. show that viral load early in infection was correlated with infectious virus, but viral load late in infection could be high even with low or undetectable infectious virus. Assessing viral load later in infection may underestimate reductions in infectious virus with treatment.
Standard of Care (SOC): SOC for COVID-19 in the study country, China, is average with moderate average efficacy for approved treatments2.
risk of death, 75.0% lower, HR 0.25, p = 0.03, treatment 2 of 28 (7.1%), control 11 of 204 (5.4%), adjusted per study, 60 days, KM, PSM.
risk of death, 81.0% lower, HR 0.19, p = 0.02, treatment 1 of 28 (3.6%), control 9 of 204 (4.4%), adjusted per study, 30 days, KM, PSM.
time to viral-, 1.9% higher, relative time 1.02, p = 0.94, treatment 24, control 24, PSM.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Liu et al., 12 Feb 2021, retrospective, propensity score matching, China, peer-reviewed, 8 authors.
This PaperAspirinAll
DOI record: { "DOI": "10.1097/md.0000000000024544", "ISSN": [ "0025-7974", "1536-5964" ], "URL": "http://dx.doi.org/10.1097/MD.0000000000024544", "abstract": "<jats:sec>\n <jats:title>Abstract</jats:title>\n <jats:p>To clarify the effect of aspirin on mortality and viral duration in adults infected with respiratory syndrome coronavirus 2 (SARS-Cov-2).</jats:p>\n <jats:p>After propensity score-matched (PSM) case-control analyses 24 pairs of patients were enrolled and followed up for 2 months. Both 30-day and 60-day mortality in the aspirin group were significantly lower than that in the non-aspirin group (<jats:italic toggle=\"yes\">P</jats:italic> = .021 and <jats:italic toggle=\"yes\">P</jats:italic> = .030, respectively). The viral duration time between the 2 groups was not significantly different (<jats:italic toggle=\"yes\">P</jats:italic> = .942).</jats:p>\n <jats:p>Among adults (with hypertension, cardiovascular diseases) infected with SARS-Cov-2, low-dose aspirin medication (100 mg/day) was associated with lower risk of mortality compared with non-aspirin users.</jats:p>\n </jats:sec>", "author": [ { "affiliation": [ { "name": "Department of Infectious Disease, Yichang Central People's Hospital, The First College of Clinical Medical Science, China Three Gorges University, Yichang" } ], "family": "Liu", "given": "Qiang", "sequence": "first" }, { "affiliation": [ { "name": "Department of Infectious Disease, Yichang Central People's Hospital, The First College of Clinical Medical Science, China Three Gorges University, Yichang" } ], "family": "Huang", "given": "Na", "sequence": "additional" }, { "affiliation": [ { "name": "Department of Infectious Disease, Yichang Central People's Hospital, The First College of Clinical Medical Science, China Three Gorges University, Yichang" } ], "family": "Li", "given": "Anni", "sequence": "additional" }, { "affiliation": [ { "name": "Department of Infectious Disease, Yichang Central People's Hospital, The First College of Clinical Medical Science, China Three Gorges University, Yichang" } ], "family": "Zhou", "given": "Yuanhong", "sequence": "additional" }, { "affiliation": [ { "name": "Department of Infectious Disease, Yichang Central People's Hospital, The First College of Clinical Medical Science, China Three Gorges University, Yichang" } ], "family": "Liang", "given": "Liang", "sequence": "additional" }, { "affiliation": [ { "name": "Department of Infectious Disease, Yichang Central People's Hospital, The First College of Clinical Medical Science, China Three Gorges University, Yichang" } ], "family": "Song", "given": "Xinyu", "sequence": "additional" }, { "affiliation": [ { "name": "State Key Laboratory of Virology, Institute of Medical Virology, School of Medicine, Wuhan University, Wuhan, Hubei, China." } ], "family": "Yang", "given": "Zhanqiu", "sequence": "additional" }, { "ORCID": "http://orcid.org/0000-0002-9437-9896", "affiliation": [ { "name": "Department of Infectious Disease, Yichang Central People's Hospital, The First College of Clinical Medical Science, China Three Gorges University, Yichang" } ], "authenticated-orcid": false, "family": "Zhou", "given": "Xiaolin", "sequence": "additional" } ], "container-title": "Medicine", "content-domain": { "crossmark-restriction": false, "domain": [] }, "created": { "date-parts": [ [ 2021, 2, 22 ] ], "date-time": "2021-02-22T16:34:17Z", "timestamp": 1614011657000 }, "deposited": { "date-parts": [ [ 2023, 9, 16 ] ], "date-time": "2023-09-16T03:08:29Z", "timestamp": 1694833709000 }, "funder": [ { "DOI": "10.13039/501100001809", "award": [ "81402404" ], "doi-asserted-by": "crossref", "name": "National Nature Science Foundation of China" }, { "DOI": 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Late treatment
is less effective
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