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All Studies   Meta Analysis   Recent:  
0 0.5 1 1.5 2+ Mortality 75% Improvement Relative Risk Mortality (b) 81% Time to viral- -2% Aspirin for COVID-19  Liu et al.  LATE TREATMENT Is late treatment with aspirin beneficial for COVID-19? PSM retrospective 232 patients in China Lower mortality with aspirin (p=0.03) c19early.org Liu et al., Medicine, February 2021 Favors aspirin Favors control

Effect of low-dose aspirin on mortality and viral duration of the hospitalized adults with COVID-19

Liu et al., Medicine, doi:10.1097/MD.0000000000024544
Feb 2021  
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Retrospective PSM analysis of 232 hospitalized patients, 28 treated with aspirin, showing lower mortality with treatment. There was no significant difference in viral clearance.
Viral load measured by PCR may not accurately reflect infectious virus measured by viral culture. Porter show that viral load early in infection was correlated with infectious virus, but viral load late in infection could be high even with low or undetectable infectious virus. Assessing viral load later in infection may underestimate reductions in infectious virus with treatment.
risk of death, 75.0% lower, HR 0.25, p = 0.03, treatment 2 of 28 (7.1%), control 11 of 204 (5.4%), adjusted per study, 60 days, KM, PSM.
risk of death, 81.0% lower, HR 0.19, p = 0.02, treatment 1 of 28 (3.6%), control 9 of 204 (4.4%), adjusted per study, 30 days, KM, PSM.
time to viral-, 1.9% higher, relative time 1.02, p = 0.94, treatment 24, control 24, PSM.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Liu et al., 12 Feb 2021, retrospective, propensity score matching, China, peer-reviewed, 8 authors.
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