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0 0.5 1 1.5 2+ Mortality -28% Improvement Relative Risk Alamdari et al. Aspirin for COVID-19 LATE TREATMENT Is late treatment with aspirin beneficial for COVID-19? Retrospective 459 patients in Iran Higher mortality with aspirin (not stat. sig., p=0.52) Alamdari et al., Tohoku J. Exp. Med., 2020, 252,.., doi:10.1620/tjem.252.73 Favors aspirin Favors control
Mortality Risk Factors among Hospitalized COVID-19 Patients in a Major Referral Center in Iran
Alamdari et al., Tohoku J. Exp. Med., 2020, 252, 73-84, doi:10.1620/tjem.252.73
Alamdari et al., Mortality Risk Factors among Hospitalized COVID-19 Patients in a Major Referral Center in Iran, Tohoku J. Exp. Med., 2020, 252, 73-84, doi:10.1620/tjem.252.73
Sep 2020   Source   PDF  
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Retrospective 459 patients in Iran, 53 treated with aspirin, showing no significant difference with treatment. This study is excluded in the after exclusion results of meta analysis: substantial unadjusted confounding by indication likely.
This study includes aspirin and HCQ.
risk of death, 27.7% higher, RR 1.28, p = 0.52, treatment 9 of 53 (17.0%), control 54 of 406 (13.3%).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Alamdari et al., 9 Sep 2020, retrospective, Iran, peer-reviewed, 14 authors, average treatment delay 5.72 days.
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Mortality Risk Factors among Hospitalized COVID-19 Patients in a Major Referral Center in Iran
Nasser Malekpour Alamdari, Siamak Afaghi, Fatemeh Sadat Rahimi, Farzad Esmaeili Tarki, Sasan Tavana, Alireza Zali, Mohammad Fathi, Sara Besharat, Leyla Bagheri, Fatemeh Pourmotahari, Seyed Sina Naghibi Irvani, Ali Dabbagh, Seyed Ali Mousavi
The Tohoku Journal of Experimental Medicine, doi:10.1620/tjem.252.73
The Coronavirus Disease 2019 (COVID-19) pandemic has killed many people worldwide since December 2019, and Iran has been among the most affected countries. In this retrospective study, we aimed to determine the prognostic factors associated with mortality in COVID-19 patients by analyzing 396 survived and 63 non-survived patients in Shahid Modarres Hospital, Tehran, Iran, from January 30 th until April 5 th , 2020. As the results, the BMI > 35 (p = 0.0003), lung cancer (p = 0.007), chronic kidney disease (p = 0.002), Immunocompromised condition (p = 0.003), and diabetes (p = 0.018) were more frequently observed in the expired group. The history of statins use was more common in the discharged group (p = 0.002), while there was no significant difference in the drug history of angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, nonsteroidal anti-inflammatory drugs, aspirin, and/or steroids, and in the past-year influenza vaccination. Multivariable regression demonstrated rising odds of in-hospital death related with age (odds ratio (OR) = 1.055, p = 0.002), levels of C-reactive protein (CRP) (OR = 2.915, p < 0.001), creatinine (OR = 1.740, p = 0.023), lymphocyte count (OR = 0.999, p = 0.008), and magnesium level (OR = 0.032, p < 0.001) on admission. In conclusion, the patients with older age and higher BMI with lymphopenia, hypomagnesemia, elevated CRP and/or raised creatinine on admission are at higher risk of mortality due to the COVID-19 infection, which requires the physicians to use timely and strong therapeutic measures for such patients.
Conflict of Interest The authors declare no conflict of interest.
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Late treatment
is less effective
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