Mortality Risk Factors among Hospitalized COVID-19 Patients in a Major Referral Center in Iran

{ 'indexed': {'date-parts': [[2024, 4, 8]], 'date-time': '2024-04-08T20:32:41Z', 'timestamp': 1712608361775}, 'reference-count': 49, 'publisher': 'Tohoku University Medical Press', 'issue': '1', 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'published-print': {'date-parts': [[2020]]}, 'DOI': '10.1620/tjem.252.73', 'type': 'journal-article', 'created': {'date-parts': [[2020, 9, 8]], 'date-time': '2020-09-08T22:06:25Z', 'timestamp': 1599602785000}, 'page': '73-84', 'source': 'Crossref', 'is-referenced-by-count': 96, 'title': 'Mortality Risk Factors among Hospitalized COVID-19 Patients in a Major Referral Center in Iran', 'prefix': '10.1620', 'volume': '252', 'author': [ { 'given': 'Nasser Malekpour', 'family': 'Alamdari', 'sequence': 'first', 'affiliation': [ { 'name': 'Department of General Surgery, Critical Care Quality Improvement ' 'Research Center, Shahid Modarres Hospital, Shahid Beheshti ' 'University of Medical Sciences'}]}, { 'given': 'Siamak', 'family': 'Afaghi', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Internal Medicine, Shahid Modarres Hospital, ' 'Shahid Beheshti University of Medical Sciences'}]}, { 'given': 'Fatemeh Sadat', 'family': 'Rahimi', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Internal Medicine, Shahid Modarres Hospital, ' 'Shahid Beheshti University of Medical Sciences'}]}, { 'given': 'Farzad Esmaeili', 'family': 'Tarki', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Internal Medicine, Shahid Modarres Hospital, ' 'Shahid Beheshti University of Medical Sciences'}]}, { 'given': 'Sasan', 'family': 'Tavana', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Pulmonary Medicine, Clinical Research and ' 'Development Center, Shahid Modarres Hospital, Shahid Beheshti ' 'University of Medical Sciences'}]}, { 'given': 'Alireza', 'family': 'Zali', 'sequence': 'additional', 'affiliation': [ { 'name': 'Functional Neurosurgery Research Center, Shahid Modarres ' 'Hospital, Shahid Beheshti University of Medical Sciences'}]}, { 'given': 'Mohammad', 'family': 'Fathi', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Anesthesiology, Critical Care Quality Improvement ' 'Research Center, Shahid Modarres Hospital, Shahid Beheshti ' 'University of Medical Sciences'}]}, { 'given': 'Sara', 'family': 'Besharat', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Radiology, Clinical Research and Development ' 'Center, Shahid Modarres Hospital, Shahid Beheshti University of ' 'Medical Sciences'}]}, { 'given': 'Leyla', 'family': 'Bagheri', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Internal Medicine, Shahid Modarres Hospital, ' 'Shahid Beheshti University of Medical Sciences'}]}, { 'given': 'Fatemeh', 'family': 'Pourmotahari', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Radiology, Clinical Research and Development ' 'Center, Shahid Modarres Hospital, Shahid Beheshti University of ' 'Medical Sciences'}]}, { 'given': 'Seyed Sina Naghibi', 'family': 'Irvani', 'sequence': 'additional', 'affiliation': [ { 'name': 'Research Institute for Endocrine Science, Shahid Beheshti ' 'University of Medical Sciences'}]}, { 'given': 'Ali', 'family': 'Dabbagh', 'sequence': 'additional', 'affiliation': [ { 'name': 'Anesthesiology Research Center, Shahid Beheshti University of ' 'Medical Science'}]}, { 'given': 'Seyed Ali', 'family': 'Mousavi', 'sequence': 'additional', 'affiliation': [ { 'name': 'Hematology, Oncology, and Hematopoietic Stem Cell ' 'Transplantation Research Center, Shariati Hospital, Tehran ' 'University of Medical Science'}]}], 'member': '622', 'reference': [ { 'key': '1', 'unstructured': 'Abdi, M. 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(2020) Effect of high vs low doses of ' 'chloroquine diphosphate as adjunctive therapy for patients hospitalized ' 'with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ' 'infection: a randomized clinical trial. <i>JAMA Netw. Open</i>, 3, ' 'e208857.', 'DOI': '10.1001/jamanetworkopen.2020.8857'}, { 'key': '4', 'unstructured': 'Boulware, D.R., Pullen, M.F., Bangdiwala, A.S., Pastick, K.A., Lofgren, ' 'S.M., Okafor, E.C., Skipper, C.P., Nascene, A.A., Nicol, M.R., Abassi, ' 'M., Engen, N.W., Cheng, M.P., LaBar, D., Lother, S.A., MacKenzie, L.J., ' 'et al. (2020) A randomized trial of hydroxychloroquine as postexposure ' 'prophylaxis for Covid-19. <i>N. Engl. J. Med.</i>, 383, 517-525.'}, { 'key': '5', 'doi-asserted-by': 'crossref', 'unstructured': 'Casey, K., Iteen, A., Nicolini, R. &amp; Auten, J. (2020) COVID-19 ' 'pneumonia with hemoptysis: acute segmental pulmonary emboli associated ' 'with novel coronavirus infection. <i>Am. J. Emerg. Med.</i>, 38, 1544. ' 'e1-3.', 'DOI': '10.1016/j.ajem.2020.04.011'}, { 'key': '6', 'unstructured': 'Conti, P. &amp; Younes, A. (2020) Coronavirus COV-19/SARS-CoV-2 affects ' 'women less than men: clinical response to viral infection. <i>J. Biol. ' 'Regul. Homeost. Agents</i>, 34, 339-343.'}, { 'key': '7', 'unstructured': 'Cucinotta, D. &amp; Vanelli, M. (2020) WHO declares COVID-19 a pandemic. ' '<i>Acta Biomed.</i>, 91, 157-160.'}, { 'key': '8', 'unstructured': 'D’Antiga, L. (2020) Coronaviruses and immunosuppressed patients: the ' 'facts during the third epidemic. <i>Liver Transpl.</i>, 26, 832-834.'}, { 'key': '9', 'doi-asserted-by': 'crossref', 'unstructured': 'Dai, X. (2020) ABO blood group predisposes to COVID-19 severity and ' 'cardiovascular diseases. <i>Eur. J. Prev. Cardiol.</i>, ' '2047487320922370.', 'DOI': '10.1177/2047487320922370'}, { 'key': '10', 'unstructured': 'de Wit, E., van Doremalen, N., Falzarano, D. &amp; Munster, V.J. (2016) ' 'SARS and MERS: recent insights into emerging coronaviruses. <i>Nat. Rev. ' 'Microbiol.</i>, 14, 523-534.'}, { 'key': '11', 'unstructured': 'Duwe, S. (2017) Influenza viruses-antiviral therapy and resistance. ' '<i>GMS Infect. Dis.</i>, 5, Doc04.'}, { 'key': '12', 'doi-asserted-by': 'crossref', 'unstructured': 'Gautret, P., Lagier, J.C., Parola, P., Hoang, V.T., Meddeb, L., Mailhe, ' 'M., Doudier, B., Courjon, J., Giordanengo, V., Vieira, V.E., Tissot ' 'Dupont, H., Honoré, S., Colson, P., Chabrière, E., La Scola, B., et al. ' '(2020) Hydroxychloroquine and azithromycin as a treatment of COVID-19: ' 'results of an open-label non-randomized clinical trial. <i>Int. J. ' 'Antimicrob. Agents</i>, 105949.', 'DOI': '10.1016/j.ijantimicag.2020.105949'}, { 'key': '13', 'unstructured': 'Geleris, J., Sun, Y., Platt, J., Zucker, J., Baldwin, M., Hripcsak, G., ' 'Labella, A., Manson, D.K., Kubin, C., Barr, R.G., Sobieszczyk, M.E. ' '&amp; Schluger, N.W. (2020) Observational study of hydroxychloroquine in ' 'hospitalized patients with Covid-19. <i>N. Engl. J. Med.</i>, 382, ' '2411-2418.'}, { 'key': '14', 'unstructured': 'Goldwasser, P. &amp; Feldman, J. (1997) Association of serum albumin and ' 'mortality risk. <i>J. Clin. Epidemiol.</i>, 50, 693-703.'}, { 'key': '15', 'doi-asserted-by': 'crossref', 'unstructured': 'Grasselli, G., Zangrillo, A., Zanella, A., Antonelli, M., Cabrini, L., ' 'Castelli, A., Cereda, D., Coluccello, A., Foti, G., Fumagalli, R., ' 'Iotti, G., Latronico, N., Lorini, L., Merler, S., Natalini, G., et al. ' '(2020) Baseline characteristics and outcomes of 1591 patients infected ' 'with SARS-CoV-2 admitted to ICUs of the Lombardy Region, Italy. ' '<i>JAMA</i>, 323, 1574-1581.', 'DOI': '10.1001/jama.2020.5394'}, { 'key': '16', 'unstructured': 'Guan, W.J., Ni, Z.Y., Hu, Y., Liang, W.H., Ou, C.Q., He, J.X., Liu, L., ' 'Shan, H., Lei, C.L., Hui, D.S.C., Du, B., Li, L.J., Zeng, G., Yuen, ' 'K.Y., Chen, R.C., et al. 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(2018) Predictors of mortality in Middle East ' 'respiratory syndrome (MERS). <i>Thorax</i>, 73, 286-289.', 'DOI': '10.1136/thoraxjnl-2016-209313'}, { 'key': '20', 'doi-asserted-by': 'crossref', 'unstructured': 'Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Fan, ' 'G., Xu, J., Gu, X., Cheng, Z., Yu, T., Xia, J., Wei, Y., Wu, W., et al. ' '(2020) Clinical features of patients infected with 2019 novel ' 'coronavirus in Wuhan, China. <i>Lancet</i>, 395, 497-506.', 'DOI': '10.1016/S0140-6736(20)30183-5'}, { 'key': '21', 'doi-asserted-by': 'crossref', 'unstructured': 'Hui, D.S., Azhar, E.I., Kim, Y.J., Memish, Z.A., Oh, M.D. &amp; Zumla, ' 'A. (2018) Middle East respiratory syndrome coronavirus: risk factors and ' 'determinants of primary, household, and nosocomial transmission. ' '<i>Lancet Infect. Dis.</i>, 18, e217-e227.', 'DOI': '10.1016/S1473-3099(18)30127-0'}, { 'key': '22', 'unstructured': 'Hulme, K.D., Gallo, L.A. &amp; Short, K.R. (2017) Influenza virus and ' 'glycemic variability in diabetes: a killer combination? <i>Front. ' 'Microbiol.</i>, 8, 861.'}, { 'key': '23', 'unstructured': 'Jia, N., Feng, D., Fang, L.Q., Richardus, J.H., Han, X.N., Cao, W.C. ' '&amp; de Vlas, S.J. (2009) Case fatality of SARS in mainland China and ' 'associated risk factors. <i>Trop. Med. Int. Health</i>, 14 Suppl 1, ' '21-27.'}, { 'key': '24', 'unstructured': 'Jin, J.M., Bai, P., He, W., Wu, F., Liu, X.F., Han, D.M., Liu, S. &amp; ' 'Yang, J.K. (2020) Gender differences in patients with COVID-19: focus on ' 'severity and mortality. <i>Front. Public Health</i>, 8, 152.'}, { 'key': '25', 'unstructured': 'Joyce, E., Fabre, A. &amp; Mahon, N. (2013) Hydroxychloroquine ' 'cardiotoxicity presenting as a rapidly evolving biventricular ' 'cardiomyopathy: key diagnostic features and literature review. <i>Eur. ' 'Heart J. Acute Cardiovasc. Care</i>, 2, 77-83.'}, { 'key': '26', 'doi-asserted-by': 'crossref', 'unstructured': 'Kanne, J.P., Little, B.P., Chung, J.H., Elicker, B.M. &amp; Ketai, L.H. ' '(2020) Essentials for radiologists on COVID-19: an update-radiology ' 'scientific expert panel. <i>Radiology</i>, 296, E113-E114.', 'DOI': '10.1148/radiol.2020200527'}, { 'key': '27', 'unstructured': 'Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., Ren, R., Leung, ' 'K.S.M., Lau, E.H.Y., Wong, J.Y., Xing, X., Xiang, N., Wu, Y., Li, C., ' 'Chen, Q., et al. (2020) Early transmission dynamics in Wuhan, China, of ' 'novel coronavirus-infected pneumonia. <i>N. Engl. J. Med.</i>, 382, ' '1199-1207.'}, { 'key': '28', 'unstructured': 'Lippi, G. &amp; Henry, B.M. (2020) Active smoking is not associated with ' 'severity of coronavirus disease 2019 (COVID-19). <i>Eur. J. Intern. ' 'Med.</i>, 75, 107-108.'}, { 'key': '29', 'doi-asserted-by': 'crossref', 'unstructured': 'Mackenzie, J.S. &amp; Smith, D.W. (2020) COVID-19: a novel zoonotic ' 'disease caused by a coronavirus from China: what we know and what we ' 'don’t. <i>Microbiol. Aust.</i>, MA20013.', 'DOI': '10.1071/MA20013'}, { 'key': '30', 'unstructured': 'Milbrandt, E.B., Reade, M.C., Lee, M., Shook, S.L., Angus, D.C., Kong, ' 'L., Carter, M., Yealy, D.M., Kellum, J.A. &amp; Gen, I.M.S.I. (2009) ' 'Prevalence and significance of coagulation abnormalities in ' 'community-acquired pneumonia. <i>Mol. Med.</i>, 15, 438-445.'}, { 'key': '31', 'unstructured': 'Oostra, M., de Haan, C.A., de Groot, R.J. &amp; Rottier, P.J. (2006) ' 'Glycosylation of the severe acute respiratory syndrome coronavirus ' 'triple-spanning membrane proteins 3a and M. <i>J. Virol.</i>, 80, ' '2326-2336.'}, { 'key': '32', 'unstructured': 'Plein, L.M. &amp; Rittner, H.L. (2018) Opioids and the immune system - ' 'friend or foe. <i>Br. J. Pharmacol.</i>, 175, 2717-2725.'}, { 'key': '33', 'unstructured': 'Rao, G.A., Mann, J.R., Shoaibi, A., Bennett, C.L., Nahhas, G., Sutton, ' 'S.S., Jacob, S. &amp; Strayer, S.M. (2014) Azithromycin and levofloxacin ' 'use and increased risk of cardiac arrhythmia and death. <i>Ann. Fam. ' 'Med.</i>, 12, 121-127.'}, { 'key': '34', 'unstructured': 'Rizzo, P., Vieceli Dalla Sega, F., Fortini, F., Marracino, L., Rapezzi, ' 'C. &amp; Ferrari, R. (2020) COVID-19 in the heart and the lungs: could ' 'we “Notch” the inflammatory storm? <i>Basic Res. Cardiol.</i>, 115, 31.'}, { 'key': '35', 'unstructured': 'Rodelo, J.R., De la Rosa, G., Valencia, M.L., Ospina, S., Arango, C.M., ' 'Gómez, C.I., García, A., Nuñez, E. &amp; Jaimes, F.A. (2012) D-dimer is ' 'a significant prognostic factor in patients with suspected infection and ' 'sepsis. <i>Am. J. Emerg. Med.</i>, 30, 1991-1999.'}, { 'key': '36', 'unstructured': 'Rubeiz, G.J., Thill-Baharozian, M., Hardie, D. &amp; Carlson, R.W. ' '(1993) Association of hypomagnesemia and mortality in acutely ill ' 'medical patients. <i>Crit. Care Med.</i>, 21, 203-209.'}, { 'key': '37', 'unstructured': 'Salimi, V., Hennus, M.P., Mokhtari-Azad, T., Shokri, F., Janssen, R., ' 'Hodemaekers, H.M., Rygiel, T.P., Coenjaerts, F.E., Meyaard, L. &amp; ' 'Bont, L. (2013) Opioid receptors control viral replication in the ' 'airways. <i>Crit. Care Med.</i>, 41, 205-214.'}, { 'key': '38', 'doi-asserted-by': 'crossref', 'unstructured': 'Sarnak, M.J. &amp; Jaber, B.L. (2001) Pulmonary infectious mortality ' 'among patients with end-stage renal disease. <i>Chest</i>, 120, ' '1883-1887.', 'DOI': '10.1378/chest.120.6.1883'}, { 'key': '39', 'doi-asserted-by': 'crossref', 'unstructured': 'Shahverdi, E., Moghaddam, M., Talebian, A. &amp; Abolghasemi, H. (2016) ' 'Distribution of blood groups in the Iranian general population. ' '<i>Immunohematology</i>, 32, 135-139.', 'DOI': '10.21307/immunohematology-2019-058'}, { 'key': '40', 'doi-asserted-by': 'crossref', 'unstructured': 'Simonnet, A., Chetboun, M., Poissy, J., Raverdy, V., Noulette, J., ' 'Duhamel, A., Labreuche, J., Mathieu, D., Pattou, F. &amp; Jourdain, M.; ' 'LICORN and the Lille COVID-19 and Obesity study group (2020) High ' 'prevalence of obesity in severe acute respiratory syndrome coronavirus-2 ' '(SARS-CoV-2) requiring invasive mechanical ventilation. <i>Obesity ' '</i>(<i>Silver Spring</i>), 28, 1195-1199.', 'DOI': '10.1002/oby.22831'}, { 'key': '41', 'unstructured': 'Syedmoradi, L., Ghasemi, A., Zahediasl, S. &amp; Azizi, F. (2011) ' 'Prevalence of hypo- and hypermagnesemia in an Iranian urban population. ' '<i>Ann. Hum. Biol.</i>, 38, 150-155.'}, { 'key': '42', 'doi-asserted-by': 'crossref', 'unstructured': 'Wang, H. &amp; Zhang, L. 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' '(2020) Association of chemosensory dysfunction and COVID-19 in patients ' 'presenting with influenza-like symptoms. <i>Int. Forum Allergy ' 'Rhinol.</i>, 10, 806-813.'}, { 'key': '46', 'unstructured': 'Yang, J.K., Feng, Y., Yuan, M.Y., Yuan, S.Y., Fu, H.J., Wu, B.Y., Sun, ' 'G.Z., Yang, G.R., Zhang, X.L., Wang, L., Xu, X., Xu, X.P. &amp; Chan, ' 'J.C. (2006) Plasma glucose levels and diabetes are independent ' 'predictors for mortality and morbidity in patients with SARS. <i>Diabet. ' 'Med.</i>, 23, 623-628.'}, { 'key': '47', 'unstructured': 'Yang, P. &amp; Wang, X. (2020) COVID-19: a new challenge for human ' 'beings. <i>Cell. Mol. Immunol.</i>, 17, 555-557.'}, { 'key': '48', 'doi-asserted-by': 'crossref', 'unstructured': 'Yuan, S. (2015) Statins may decrease the fatality rate of Middle East ' 'respiratory syndrome infection. <i>mBio</i>, 6, e01120.', 'DOI': '10.1128/mBio.01120-15'}, { 'key': '49', 'doi-asserted-by': 'crossref', 'unstructured': 'Zhou, F., Yu, T., Du, R., Fan, G., Liu, Y., Liu, Z., Xiang, J., Wang, ' 'Y., Song, B., Gu, X., Guan, L., Wei, Y., Li, H., Wu, X., Xu, J., et al. ' '(2020) Clinical course and risk factors for mortality of adult ' 'inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. 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