Effect of aspirin in COVID-19 outcomes of older adults with a history of coronary artery disease

{ 'indexed': { 'date-parts': [[2022, 12, 21]], 'date-time': '2022-12-21T20:13:26Z', 'timestamp': 1671653606322}, 'reference-count': 0, 'publisher': 'Oxford University Press (OUP)', 'issue': 'Supplement_1', 'license': [ { 'start': { 'date-parts': [[2022, 12, 20]], 'date-time': '2022-12-20T00:00:00Z', 'timestamp': 1671494400000}, 'content-version': 'vor', 'delay-in-days': 49, 'URL': 'https://creativecommons.org/licenses/by/4.0/'}], 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'published-print': {'date-parts': [[2022, 12, 20]]}, 'abstract': '<jats:title>Abstract</jats:title>\n' ' <jats:sec>\n' ' <jats:title>Background</jats:title>\n' ' <jats:p>Advanced age and coronary artery disease (CAD) have been associated ' 'with a dismal prognosis in patients infected with COVID-19, most likely due to the virus’s ' 'thrombogenic effects. Older adults with a history of CAD have routinely used low-dose Aspirin ' '(LDA) as prevention due to their increased risk of cerebro-cardiovascular events. However, it ' 'is unclear if this population would benefit from LDA when infected with COVID-19.</jats:p>\n' ' </jats:sec>\n' ' <jats:sec>\n' ' <jats:title>Methods</jats:title>\n' ' <jats:p>A retrospective study was conducted using the PearlDiver database ' '(PearlDiver Technologies, Fort Wayne, IN). Using ICD codes, patients aged 65–75 and ' 'Elixhauser Comorbidity Score(ECI)&amp;gt;4 with a history of CAD admitted for COVID-19 were ' 'identified. The use of LDA for 1 month before the index event was used to split the cohort ' 'into two matched groups by age, gender, ECI, and other cardiovascular diseases. Records of ' 'groups were reviewed for multiple outcomes 30 days after admission. Pearson’s chi-squared ' 'test was used to compare groups. The strength of association was reported as Risk Ratios ' '(RR).</jats:p>\n' ' </jats:sec>\n' ' <jats:sec>\n' ' <jats:title>Results</jats:title>\n' ' <jats:p>4,017 patients with no difference in the mean age, gender, and ECI ' 'were included in each group. No differences present in 30-days all-cause readmission(RR=1.04, ' 'CI95% =0.92–1.17, p=0.49), mortality(RR=0.63, CI95%=0.30–1.29, p=0.28), ICU ' 'admission(RR=1.01, CI95%=0.89–1.15, p=0.79), gastrointestinal bleeding(RR=1.09, CI95% = ' '0.85–1.40, p=0.51), and intracranial hemorrhage(RR=0.69, CI95%=0.26–1.83, p=0.62) between ' 'groups.</jats:p>\n' ' </jats:sec>\n' ' <jats:sec>\n' ' <jats:title>Conclusion</jats:title>\n' ' <jats:p>LDA didn’t improve the evaluated outcomes in older persons 30 days ' 'after admission. A plausible explanation is that COVID-19’s thrombogenic mechanism is likely ' 'atypical.</jats:p>\n' ' </jats:sec>', 'DOI': '10.1093/geroni/igac059.3047', 'type': 'journal-article', 'created': { 'date-parts': [[2022, 12, 20]], 'date-time': '2022-12-20T18:30:28Z', 'timestamp': 1671561028000}, 'page': '850-851', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'EFFECT OF ASPIRIN IN COVID-19 OUTCOMES OF OLDER ADULTS WITH A HISTORY OF CORONARY ARTERY DISEASE', 'prefix': '10.1093', 'volume': '6', 'author': [ { 'given': 'Ali Vaeli', 'family': 'Zadeh', 'sequence': 'first', 'affiliation': [ { 'name': 'Holy Cross Health-Jim Moran Cardiovascular Research Institute , ' 'Fort Lauderdale, Florida , United States'}]}, { 'given': 'Ricardo Criado', 'family': 'Carrero', 'sequence': 'additional', 'affiliation': [ { 'name': 'University of Miami/Holy Cross Hospital , Fort Lauderdale, ' 'Florida , United States'}]}, { 'given': 'Alan', 'family': 'Wong', 'sequence': 'additional', 'affiliation': [ { 'name': 'Holy Cross Health-University of Miami , Fort Lauderdale, Florida ' ', United States'}]}, { 'given': 'Noah', 'family': 'Mandile', 'sequence': 'additional', 'affiliation': [ { 'name': 'Jim Moran Cardiovascular Institute , Fort Lauderdale, Florida , ' 'United States'}]}, { 'given': 'Marina', 'family': 'Stukova', 'sequence': 'additional', 'affiliation': [ { 'name': 'University of Miami at Holy Cross , Fort Lauderdale, Florida , ' 'United States'}]}, { 'given': 'German', 'family': 'Lopez', 'sequence': 'additional', 'affiliation': [ { 'name': 'University of Miami at Holy Cross , Fort Lauderdale, Florida , ' 'United States'}]}, { 'given': 'Elias', 'family': 'Collado', 'sequence': 'additional', 'affiliation': [ { 'name': 'Holy Cross Health-Jim Moran Cardiovascular Research Institute , ' 'Fort Lauderdale, Florida , United States'}]}, { 'given': 'Joshua', 'family': 'Larned', 'sequence': 'additional', 'affiliation': [ { 'name': 'Holy Cross Health- University of Miami , Miami, Florida , United ' 'States'}]}], 'member': '286', 'published-online': {'date-parts': [[2022, 12, 20]]}, 'container-title': 'Innovation in Aging', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://academic.oup.com/innovateage/article-pdf/6/Supplement_1/850/48309640/igac059.3047.pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'syndication'}, { 'URL': 'https://academic.oup.com/innovateage/article-pdf/6/Supplement_1/850/48309640/igac059.3047.pdf', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2022, 12, 21]], 'date-time': '2022-12-21T19:46:45Z', 'timestamp': 1671652005000}, 'score': 1, 'resource': {'primary': {'URL': 'https://academic.oup.com/innovateage/article/6/Supplement_1/850/6939246'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2022, 11, 1]]}, 'references-count': 0, 'journal-issue': {'issue': 'Supplement_1', 'published-print': {'date-parts': [[2022, 12, 20]]}}, 'URL': 'http://dx.doi.org/10.1093/geroni/igac059.3047', 'relation': {}, 'ISSN': ['2399-5300'], 'subject': [ 'Life-span and Life-course Studies', 'Health Professions (miscellaneous)', 'Health (social science)'], 'published-other': {'date-parts': [[2022, 11, 1]]}, 'published': {'date-parts': [[2022, 11, 1]]}}