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0 0.5 1 1.5 2+ Mortality -13% Improvement Relative Risk Aspirin for COVID-19  Basheer et al.  Prophylaxis Is prophylaxis with aspirin beneficial for COVID-19? Retrospective 390 patients in Israel Higher mortality with aspirin (p=0.0003) Basheer et al., Metabolites, October 2021 Favors aspirin Favors control

Clinical Predictors of Mortality and Critical Illness in Patients with COVID-19 Pneumonia

Basheer et al., Metabolites, doi:10.3390/metabo11100679
Oct 2021  
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Aspirin for COVID-19
24th treatment shown to reduce risk in August 2021
*, now known with p = 0.000087 from 73 studies, recognized in 2 countries.
Lower risk for mortality and progression.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,100+ studies for 60+ treatments.
Retrospective 390 hospitalized patients in Israel, showing higher risk of mortality with prior aspirin use. Details of the analysis are not provided.
risk of death, 13.0% higher, RR 1.13, p < 0.001, treatment 45 of 140 (32.1%), control 29 of 250 (11.6%), adjusted per study, odds ratio converted to relative risk, group sizes approximated (only percentages provided).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Basheer et al., 2 Oct 2021, retrospective, Israel, peer-reviewed, 4 authors.
This PaperAspirinAll
Clinical Predictors of Mortality and Critical Illness in Patients with COVID-19 Pneumonia
Maamoun Basheer, Elias Saad, Rechnitzer Hagai, Nimer Assy
Metabolites, doi:10.3390/metabo11100679
Background/Aim: Early identification of patients with COVID-19 who will develop severe or critical disease symptoms is important for delivering proper and early treatment. We analyzed demographic, clinical, immunological, hematological, biochemical and radiographic findings that may be of utility to clinicians in predicting COVID-19 severity and mortality. Methods: Electronic medical record data from patients diagnosed with COVID-19 from November 2020 to June 2021 in the COVID-19 Department in the Galilee Medical Center, Nahariya, Israel, were collected. Epidemiologic, clinical, laboratory and imaging variables were analyzed. Multivariate stepwise regression analyses and discriminant analyses were used to identify and validate powerful predictors. The main outcome measure was invasive ventilation, or death. Results: The study population included 390 patients, with a mean age of 61 ± 18, and 51% were male. The non-survivors were mostly male, elderly and overweight and significantly suffered from hypertension, diabetes mellitus type 2, lung disease, hemodialysis and past use of aspirin. Four predictive factors were found that associated with increased disease severity and/or mortality: age, NLR, BUN, and use of high flow oxygen therapy (HFNC). The AUC or diagnostic accuracy was 87%, with a sensitivity of 97%, specificity of 60%, PPV of 87% and NPP of 91%. The cytokine levels of CXCL-10, GCSF, IL-2 and IL-6 were significantly reduced upon the discharge of severely ill COVID-19 patients. Conclusions: The predictive factors associated with increased mortality include age, NLR, BUN, and use of HFNC upon admission. Identifying those with higher risks of mortality could help in early interventions to reduce the risk of death.
Conflicts of Interest: The authors declare no conflict of interest. Abbreviations BUN: Blood urea nitrogen; NLR: Neutrophil to lymphocyte ratio; HFNC: High flow nasal cannula
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