Holt: Influence of inhibitors of the renin–angiotensin system on risk of acute respiratory distress syndrome in Danish hospitalized COVID-19 patients [Aspirin]

Influence of inhibitors of the renin–angiotensin system on risk of acute respiratory distress syndrome in Danish hospitalized COVID-19 patients

Holt et al., Journal of Hypertension, doi:10.1097/hjh.0000000000002515

Holt et al., Influence of inhibitors of the renin–angiotensin system on risk of acute respiratory distress syndrome in.., Journal of Hypertension, doi:10.1097/hjh.0000000000002515

May 2020 Source PDF

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Retrospective 689 hospitalized COVID-19 patients in Denmark, showing higher risk of ICU/death with aspirin use in unadjusted results subject to confounding by indication. This study is excluded in the after exclusion results of meta analysis: unadjusted results with no group details.

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This study includes aspirin and spironolactone.

risk of death/ICU, 34.0% higher, RR 1.34, p = 0.09, treatment 35 of 116 (30.2%), control 129 of 573 (22.5%).

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

Holt et al., 7 May 2020, retrospective, Denmark, peer-reviewed, median age 70.0, 4 authors, study period 1 March, 2020 - 1 April, 2020.

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