Abstract: 2022 Evaluating the Effects of Clinical Characteristics and Therapeutic Regimens on Mortality in Hospitalized Patients with Severe COVID-19 Elahe Karimpour-Razkenari1, Javad Boskabadi1, Monireh Ghazaeian2*, Hamidreza Samaee1, Hanieh Azizi1, Fatemeh Esfandiari3, Seyed Abdollah Mousavi4, Sahar Fallah5, Sekineh Talebi6 Department of Clinical Pharmacy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Mazandaran, Iran. 1 Pharmaceutical Sciences Research Center, Department of Clinical Pharmacy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran. 2 School of Medicine, Mazandaran University of Medical Sciences, Sari, Mazandaran, Iran. 3 Department of Pediatric Surgery, Pediatric Infectious Diseases Research Center, Mazandaran University of Medical Sciences, Sari, Iran. 4 Department of Biostatistic, Ibne Sina Medical and Educational Center, Mazandaran University of Medical Sciences, Sari, Mazandaran, Iran. 5 Department of Nursing, Ibne Sina Medical and Educational Center, Mazandaran University of Medical Sciences, Sari, Mazandaran, Iran. 6 Received: 2022-03-29, Revised: 2022-06-10, Accepted: 2022-06-11, Published: 2022-09-30 ARTICLE INFO ABSTRACT Article type: Original article Background: The coronavirus disease 2019 (COVID-19) is highly contagious and has turned into a global health problem. In this study, we investigated the role of clinical and laboratory characteristics along with administered therapeutic agents in patients with COVID-19, and identified some effective factors on the mortality of these individuals. Keywords: COVID-19; Mortality; Epidemiology Methods: In this retrospective study, we evaluated the data from all the hospitalized patients who had been diagnosed with COVID-19 between February 23 and May 23, 2020. The data were obtained from medical records. Additionally, a checklist was used to record demographic, clinical, laboratory, imaging, and treatment data for each patient. Results: Totally, 478 patients were involved in this study, and their median age was 58.5 years. Of these, 53.3% patients were male. The most common pre-existing underlying disease was hypertension (37.9%), and the mortality group had significantly more comorbidities (85.4%). Higher neutrophil lymphocyte ratio (NLR), lymphopenia, and reduced hemoglobin were more frequent in the mortality group (p < 0.001). Similarly, the need to be admitted to the intensive care unit was significantly greater in the mortality group (p<0.001). The most frequently administered therapeutic regimens included hydroxychloroquine and lopinavir/ritonavir, which did not have any correlation with survival outcome. Conclusion: Older age, opioid addiction, cardiovascular disease, kidney disease, baseline NLR and hemoglobin, and ICU admission were independently associated with COVID-19 mortality. On the other hand, hydroxychloroquine and lopinavir/ritonavir indicated no beneficial effects on patients’ outcome. J Pharm Care 2022; 10(3): 103-114. Please cite this paper as: Karimpour-Rrazkenari E, Boskabadi J, Ghazaeian M, Samaee H, Azizi H, Esfandiari F, et al. Evaluating the Effects of Clinical Characteristics and Therapeutic Regimens on Mortality in Hospitalized Patients with Severe COVID-19. J Pharm Care 2022; 10(3): 103-114.