Evaluating the Effects of Clinical Characteristics and Therapeutic Regimens on Mortality in Hospitalized Patients with Severe COVID-19
Dr Monireh Ghazaeian, Elahe Karimpour-Razkenari, Javad Boskabadi, Hamidreza Samaee, Hanieh Azizi, Fatemeh Esfandiari, Seyed Abdollah Mousavi, Sahar Fallah, Sekineh Talebi
The coronavirus disease 2019 (COVID-19) is highly contagious and has turned into a global health problem. In this study, we investigated the role of clinical and laboratory characteristics along with administered therapeutic agents in patients with COVID-19, and identified some effective factors on the mortality of these individuals.
Methods: In this retrospective study, we evaluated the data from all the hospitalized patients who had been diagnosed with COVID-19 between February 23 and May 23, 2020. The data were obtained from medical records. Additionally, a checklist was used to record demographic, clinical, laboratory, imaging, and treatment data for each patient. Results: Totally, 478 patients were involved in this study, and their median age was 58.5 years. Of these, 53.3% patients were male. The most common pre-existing underlying disease was hypertension (37.9%), and the mortality group had significantly more comorbidities (85.4%). Higher neutrophil lymphocyte ratio (NLR), lymphopenia, and reduced hemoglobin were more frequent in the mortality group (p < 0.001). Similarly, the need to be admitted to the intensive care unit was significantly greater in the mortality group (p<0.001). The most frequently administered therapeutic regimens included hydroxychloroquine and lopinavir/ritonavir, which did not have any correlation with survival outcome.
Conclusion: Older age, opioid addiction, cardiovascular disease, kidney disease, baseline NLR and hemoglobin, and ICU admission were independently associated with COVID-19 mortality. On the other hand, hydroxychloroquine and lopinavir/ritonavir indicated no beneficial effects on patients' outcome.
September 2022;10(3)
Evaluating the Effects of Clinical Characteristics and Therapeutic Regimens
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'abstract': '<jats:p>Background: The coronavirus disease 2019 (COVID-19) is highly contagious and has '
'turned into a global health problem.\xa0 In this study, we investigated the role of clinical '
'and laboratory characteristics along with administered therapeutic agents in patients with '
'COVID-19, and identified some effective factors on the mortality of these individuals.
\n'
'Methods: In this retrospective study, we evaluated the data from all the hospitalized '
'patients who had been diagnosed with COVID-19 between February 23 and May 23, 2020. The data '
'were obtained from medical records. Additionally, a checklist was used to record demographic, '
'clinical, laboratory, imaging, and treatment data for each patient.
\n'
'Results: Totally, 478 patients were involved in this study, and their median age was 58.5 '
'years. Of these, 53.3% patients were male. The most common pre-existing underlying disease '
'was hypertension (37.9%), and the mortality group had significantly more comorbidities '
'(85.4%).\xa0 Higher neutrophil lymphocyte ratio (NLR), lymphopenia, and reduced hemoglobin '
'were more frequent in the mortality group (p < 0.001).\xa0 Similarly, the need to be '
'admitted to the intensive care unit was significantly greater in the mortality group '
'(p<0.001). The most frequently administered therapeutic regimens included '
'hydroxychloroquine and lopinavir/ritonavir, which did not have any correlation with survival '
'outcome.
\n'
'Conclusion: Older age, opioid addiction, cardiovascular disease, kidney disease, baseline NLR '
'and hemoglobin, and ICU admission were independently associated with COVID-19 mortality. On '
'the other hand, hydroxychloroquine and lopinavir/ritonavir indicated no beneficial effects on '
'patients’ outcome.</jats:p>',
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