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0 0.5 1 1.5 2+ Mortality 79% Improvement Relative Risk Karimpour-Razkenari et al. Vitamin D LATE TREATMENT Is late treatment with vitamin D beneficial for COVID-19? Retrospective 478 patients in Iran (February - May 2020) Lower mortality with vitamin D (p=0.000092) Karimpour-Razkenari et al., J. Pharmaceutical Care, doi:10.18502/jpc.v10i3.10790 Favors vitamin D Favors control
Evaluating the Effects of Clinical Characteristics and Therapeutic Regimens on Mortality in Hospitalized Patients with Severe COVID-19
Karimpour-Razkenari et al., Journal of Pharmaceutical Care, doi:10.18502/jpc.v10i3.10790
Karimpour-Razkenari et al., Evaluating the Effects of Clinical Characteristics and Therapeutic Regimens on Mortality in Hospitalized.., Journal of Pharmaceutical Care, doi:10.18502/jpc.v10i3.10790
Oct 2022   Source   PDF  
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Retrospective 478 moderate to severe hospitalized patients in Iran, showing lower mortality with vitamin D treatment.
This is the 97th of 111 COVID-19 controlled studies for vitamin D, which collectively show efficacy with p<0.0000000001 (1 in 49 sextillion). 27 studies are RCTs, which show efficacy with p=0.00002.
This study includes aspirin and vitamin D.
risk of death, 79.0% lower, RR 0.21, p < 0.001, treatment 10 of 124 (8.1%), control 93 of 329 (28.3%), NNT 4.9, adjusted per study, inverted to make RR<1 favor treatment, odds ratio converted to relative risk, multivariable.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Karimpour-Razkenari et al., 3 Oct 2022, retrospective, Iran, peer-reviewed, median age 58.5, 9 authors, study period 23 February, 2020 - 23 May, 2020, dosage not specified.
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This PaperVitamin DAll
Evaluating the Effects of Clinical Characteristics and Therapeutic Regimens on Mortality in Hospitalized Patients with Severe COVID-19
Dr Monireh Ghazaeian, Elahe Karimpour-Razkenari, Javad Boskabadi, Hamidreza Samaee, Hanieh Azizi, Fatemeh Esfandiari, Seyed Abdollah Mousavi, Sahar Fallah, Sekineh Talebi
The coronavirus disease 2019 (COVID-19) is highly contagious and has turned into a global health problem. In this study, we investigated the role of clinical and laboratory characteristics along with administered therapeutic agents in patients with COVID-19, and identified some effective factors on the mortality of these individuals. Methods: In this retrospective study, we evaluated the data from all the hospitalized patients who had been diagnosed with COVID-19 between February 23 and May 23, 2020. The data were obtained from medical records. Additionally, a checklist was used to record demographic, clinical, laboratory, imaging, and treatment data for each patient. Results: Totally, 478 patients were involved in this study, and their median age was 58.5 years. Of these, 53.3% patients were male. The most common pre-existing underlying disease was hypertension (37.9%), and the mortality group had significantly more comorbidities (85.4%). Higher neutrophil lymphocyte ratio (NLR), lymphopenia, and reduced hemoglobin were more frequent in the mortality group (p < 0.001). Similarly, the need to be admitted to the intensive care unit was significantly greater in the mortality group (p<0.001). The most frequently administered therapeutic regimens included hydroxychloroquine and lopinavir/ritonavir, which did not have any correlation with survival outcome. Conclusion: Older age, opioid addiction, cardiovascular disease, kidney disease, baseline NLR and hemoglobin, and ICU admission were independently associated with COVID-19 mortality. On the other hand, hydroxychloroquine and lopinavir/ritonavir indicated no beneficial effects on patients' outcome.
September 2022;10(3) Evaluating the Effects of Clinical Characteristics and Therapeutic Regimens
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Late treatment
is less effective
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