Retrospective 131 COVID-19 patients with aspirin use and 131 matched controls in Iran, showing no significant difference in outcomes, however age matching used only two categories, 40-60 and 60+, therefore matching may be very poor given the relationship between age and COVID-19 risk. The percentages given for the control group death/recovery outcomes do not match the reported counts.
This study is excluded in the after exclusion results of meta
analysis:
age matching based on only two categories, matching may be very poor given the relationship between age and COVID-19 risk; inconsistent data.
risk of death, no change, RR 1.00, p = 1.00, treatment 17 of 131 (13.0%), control 17 of 131 (13.0%).
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Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
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Azizi et al., 17 Feb 2023, retrospective, Iran, peer-reviewed, 6 authors.
A study on the effect of aspirin on clinical symptoms, laboratory indices, and outcomes in patients with COVID-19
Roham Azizi, Maryam Dehghani Mobarak, Reza Goujani, Soheil Mohsen Nabi-Afjadi, Mousavi Rizi, Ahmadreza Maghsoudi, A R T I C L E I N F O
doi:10.34172/npj.2023.10506
In a cross-sectional and observational study, the case and control groups were selected based on aspirin use, with non-users divided into two groups (131 medical records of patients with COVID-19 who administered aspirin and 131 of the group of patients with COVID-19 without aspirin administration). Aspirin was found to be ineffective in treating clinical symptoms, laboratory indices, and outcomes in COVID-19 patients.
Authors' contribution The principal investigators of the present study were RA and MDM. AM contributed to the conception and design of the study and revised and revaluated the manuscript. RG conducted data analysis. MNA and SMR collected data. In addition, all authors contributed to the final manuscript, read it, approved it, and attested to its accuracy and validity.
Conflicts of interest The authors declare that they have no competing interests.
Ethical issues The research adhered to the principles of the Helsinki Declaration. Patients' consent was obtained with their knowledge. The permission number of 154/99/30362 was granted by the Ethics Committee in Deputy of Treatment of Social Security Organization. Moreover, the authors have identified ethical concerns (including plagiarism, data fabrication, and double publication).
Funding/Support None.
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