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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Mortality -7% Improvement Relative Risk Death or respiratory sup.. 30% Aspirin for COVID-19  Sisinni et al.  Prophylaxis Is prophylaxis with aspirin beneficial for COVID-19? Retrospective 984 patients in Italy Lower death/intubation with aspirin (p=0.012) c19early.org Sisinni et al., Int. J. Cardiology, Oct 2021 Favors aspirin Favors control

Pre-admission acetylsalicylic acid therapy and impact on in-hospital outcome in COVID-19 patients: The ASA-CARE study

Sisinni et al., International Journal of Cardiology, doi:10.1016/j.ijcard.2021.09.058
Oct 2021  
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Aspirin for COVID-19
24th treatment shown to reduce risk in August 2021
 
*, now known with p = 0.000087 from 73 studies, recognized in 2 countries.
Lower risk for mortality and progression.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,100+ studies for 60+ treatments. c19early.org
Retrospective 984 COVID-19 patients, 253 taking aspirin prior to admission, showing lower risk of respiratory support upgrade with treatment.
risk of death, 7.1% higher, RR 1.07, p = 0.65, treatment 93 of 253 (36.8%), control 251 of 731 (34.3%).
risk of death or respiratory support upgrade, 30.3% lower, RR 0.70, p = 0.01, treatment 253, control 731, multivariate.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Sisinni et al., 4 Oct 2021, retrospective, Italy, peer-reviewed, 18 authors.
This PaperAspirinAll
Pre-admission acetylsalicylic acid therapy and impact on in-hospital outcome in COVID-19 patients: The ASA-CARE study
Antonio Sisinni, Luca Rossi, Antonio Battista, Enrico Poletti, Federica Battista, Rosa Alessia Battista, Alessandro Malagoli, Andrea Biagi, Alessia Zanni, Concetta Sticozzi, Greta Comastri, Massimiliano M Marrocco-Trischitta, Alberto Monello, Alberto Margonato, Francesco Bandera, Pasquale Vergara, Marco Guazzi, MD Cosmo Godino
International Journal of Cardiology, doi:10.1016/j.ijcard.2021.09.058
This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
b Values are avaible for 97% of the entire study cohort. c Fever was classified as highest patient temperature 37.3 °C or higher. To minimize interference of treatment, the highest patient temperature was defined using the self-reported highest temperature before taking antipyretic drug. d ACE-I/ARB use was defined as use of these drugs at the time of admission that continued through hospitalization. e Values are avaible for 25% of the entire study cohort. f Including azithromycin 500 mg daily dose p.o. and/or ceftriaxone 2000 mg daily dose i.v. J o u r n a l P r e -p r o o f Journal Pre-proof J o u r n a l P r e -p r o o f
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Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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