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Mortality and pre-hospitalization use of low-dose aspirin in COVID-19 patients with coronary artery disease

Yuan et al., Journal of Cellular and Molecular Medicine, doi:10.1111/jcmm.16198
Dec 2020  
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Mortality 4% Improvement Relative Risk Aspirin for COVID-19  Yuan et al.  Prophylaxis Is prophylaxis with aspirin beneficial for COVID-19? Retrospective 183 patients in China Study underpowered to detect differences c19early.org Yuan et al., J. Cellular and Molecular.., Dec 2020 Favorsaspirin Favorscontrol 0 0.5 1 1.5 2+
Aspirin for COVID-19
24th treatment shown to reduce risk in August 2021
 
*, now with p = 0.000087 from 73 studies, recognized in 3 countries.
Lower risk for mortality and progression.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,300+ studies for 75 treatments. c19early.org
Retrospective 183 hospitalized patients in China, 52 taking low-dose aspirin prior to hospitalization, showing no significant difference with treatment.
risk of death, 4.4% lower, RR 0.96, p = 0.89, treatment 11 of 52 (21.2%), control 29 of 131 (22.1%), NNT 102, odds ratio converted to relative risk, mutivariate.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Yuan et al., 18 Dec 2020, retrospective, China, peer-reviewed, 6 authors.
This PaperAspirinAll
Mortality and pre‐hospitalization use of low‐dose aspirin in COVID‐19 patients with coronary artery disease
Shuai Yuan, Peng Chen, Huaping Li, Chen Chen, Feng Wang, Dao Wen Wang
Journal of Cellular and Molecular Medicine, doi:10.1111/jcmm.16198
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
S U PP O RTI N G I N FO R M ATI O N Additional supporting information may be found online in the Supporting Information section. How to cite this article:
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We recruited 183 adult patients with CAD ' 'diagnosed with COVID‐19, including 52 taking low‐dose aspirin (mean [SD] age, 69.7 [1.1] ' 'years; 59.6% men) and 131 without using aspirin (mean [SD] age, 71.8 [0.9] years; 51.9% men), ' 'who were admitted in the Tongji hospital in Wuhan, China from January 10, 2020 to March 30, ' '2020. There was no difference on in‐hospital mortality between aspirin group and non‐aspirin ' 'group (21.2% vs. 22.1%, <jats:italic>P</jats:italic>\xa0=\xa0.885). Similarly, for critically ' 'severe COVID‐19 patients, the mortality in aspirin group was close to that in non‐aspirin ' 'group (44% vs. 45.9%, <jats:italic>P</jats:italic>\xa0=\xa0.872). Moreover, the percentage of ' 'patients with CAD taking low‐dose aspirin did not differ between those survivors and ' 'non‐survivors (28.7% vs. 27.5%, <jats:italic>P</jats:italic>\xa0=\xa0.885). Meanwhile, the ' 'usage of aspirin was not correlated with all‐cause mortality in multivariate analysis (OR\xa0' '=\xa00.944, 95% CI: 0.411‐2.172, <jats:italic>P</jats:italic>\xa0=\xa0.893). Collectively, ' 'our study suggested that the pre‐hospitalization use of low‐dose aspirin was not associated ' 'with the clinical outcome of patients with CAD hospitalized with COVID‐19 ' 'infections.</jats:p>', 'DOI': '10.1111/jcmm.16198', 'type': 'journal-article', 'created': { 'date-parts': [[2020, 12, 18]], 'date-time': '2020-12-18T16:48:57Z', 'timestamp': 1608310137000}, 'page': '1263-1273', 'update-policy': 'http://dx.doi.org/10.1002/crossmark_policy', 'source': 'Crossref', 'is-referenced-by-count': 40, 'title': 'Mortality and pre‐hospitalization use of low‐dose aspirin in COVID‐19 patients with coronary ' 'artery disease', 'prefix': '10.1111', 'volume': '25', 'author': [ { 'given': 'Shuai', 'family': 'Yuan', 'sequence': 'first', 'affiliation': [ { 'name': 'Division of Cardiology Department of Internal Medicine Tongji ' 'Hospital Tongji Medical College Huazhong University of Science ' 'and Technology Wuhan China'}, { 'name': 'Hubei Key Laboratory of Genetics and Molecular 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