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0 0.5 1 1.5 2+ Mortality -10% Improvement Relative Risk ICU admission -110% Hospitalization time -10% Aspirin for COVID-19  Sullerot et al.  Prophylaxis Is prophylaxis with aspirin beneficial for COVID-19? Retrospective 1,047 patients in multiple countries (Mar - Dec 2020) Higher ICU admission (p=0.007) and longer hospitalization (p=0.024) c19early.org Sullerot et al., GeroScience, January 2022 Favors aspirin Favors control

Premorbid aspirin use is not associated with lower mortality in older inpatients with SARS-CoV-2 pneumonia

Sullerot et al., GeroScience, doi:10.1007/s11357-021-00499-8
Jan 2022  
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Aspirin for COVID-19
19th treatment shown to reduce risk in March 2021
 
*, now known with p = 0.00014 from 72 studies, recognized in 2 countries.
Lower risk for mortality and progression.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,000+ studies for 60+ treatments. c19early.org
Retrospective 1,047 pneumonia patients in 5 COVID-19 geriatric units in France and Switzerland, significantly higher ICU admission and longer hospital stays with existing aspirin treatment. Numbers in this study appear to be inconsistent, for example the abstract says 147 of 301 aspirin patients died, shown as 34.3%, while Table 1 shows 104 of 301 (34.6%).
risk of death, 10.0% higher, RR 1.10, p = 0.52, treatment 101 of 301 (33.6%), control 224 of 746 (30.0%).
risk of ICU admission, 109.7% higher, RR 2.10, p = 0.007, treatment 22 of 301 (7.3%), control 26 of 746 (3.5%).
hospitalization time, 10.0% higher, relative time 1.10, p = 0.02, treatment 301, control 746.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Sullerot et al., 7 Jan 2022, retrospective, propensity score weighting, multiple countries, peer-reviewed, 15 authors, study period 1 March, 2020 - 31 December, 2020.
This PaperAspirinAll
Premorbid aspirin use is not associated with lower mortality in older inpatients with SARS-CoV-2 pneumonia
Coralie Sullerot, Kevin Bouiller, Caroline Laborde, Marine Gilis, Amélie Fèvre, Arthur Hacquin, Patrick Manckoundia, Florence Hoefler, Messaline Bermejo, Aline Mendes, Christine Serratrice, Virginie Prendki, Stéphane Sanchez, Alain Putot
GeroScience, doi:10.1007/s11357-021-00499-8
SIPTW) was applied. To assess the association between aspirin use and in-hospital 30-day mortality, SIPTW-adjusted Kaplan-Meier and Cox proportional hazards regression analyses were performed. Of the 1047 patients with SARS-CoV-2 pneumonia and median age 86 years, 301 (28.7%) were taking aspirin treatment before admission. One hundred forty-seven (34.3%) patients who had taken aspirin died in hospital within 1 month vs 118 patients (30.7%) without aspirin. After SIPTW, aspirin treatment was not significantly associated with lower mortality (adjusted hazard ratio: 1.10 [0.81-1.49], P = .52). Moreover, patients on aspirin had a longer hospital stay and were Abstract Platelet aggregation has been associated with COVID-19 pathogenesis. In older patients hospitalized for SARS-CoV-2 pneumonia, we aimed to investigate the association between aspirin use before admission and the risk of in-hospital all-cause mortality. We performed a retrospective international cohort study in five COVID-19 geriatric units in France and Switzerland. Among 1,357 consecutive hospitalized patients aged 75 or older and testing positive for SARS-CoV-2, we included 1,072 with radiologically confirmed pneumonia. To adjust for confounders, a propensity score for treatment was created, and stabilized inverse probability of treatment weighting
Conflict of interest The authors declare no competing interests. Publisher's note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
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