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0 0.5 1 1.5 2+ Mortality -32% Improvement Relative Risk Aspirin  Pourhoseingholi et al.  LATE TREATMENT Is late treatment with aspirin beneficial for COVID-19? Prospective study of 2,468 patients in Iran (Feb - Jul 2020) Higher mortality with aspirin (p=0.036) Pourhoseingholi et al., Research Square, May 2021 Favors aspirin Favors control

Case Characteristics, Clinical Data, And Outcomes of Hospitalized COVID-19 Patients In Qom Province, Iran: A Prospective Cohort Study

Pourhoseingholi et al., Research Square, doi:10.21203/
May 2021  
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Prospective study of 2,468 hospitalized COVID-19 patients in Iran, showing higher mortality with aspirin treatment. IR.MUQ.REC.1399.013.
This study includes remdesivir, N-acetylcysteine, aspirin, and vitamin C.
risk of death, 32.0% higher, HR 1.32, p = 0.04, treatment 71 of 290 (24.5%), control 268 of 2,178 (12.3%), adjusted per study, multivariable, Cox proportional hazards.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Pourhoseingholi et al., 26 May 2021, prospective, Iran, preprint, mean age 57.9, 11 authors, study period 2 February, 2020 - 20 July, 2020, average treatment delay 7.4 days.
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Case Characteristics, Clinical Data, And Outcomes of Hospitalized COVID-19 Patients In Qom Province, Iran: A Prospective Cohort Study
Mohamad Amin Pourhoseingholi, Hosein Yousefi, Hassan Fatemi Manesh, Nima Najafian Motahaver, Zahra Heydari, Mehdi Azizmohammad Looha, Nazanin Taraghikhah, Maryam Yazdi, Zahra Salami, Elmira Moallemi, Seyed Hasan Adeli
The outbreak of severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) dates back to December 2019 in China. Iran has been one of the most virus in icted countries. The aim of this study was to report demographics, signs and symptoms, laboratory ndings, therapeutic approaches, and outcomes. This observational cohort study was performed from 20 th February 2020 to 20 th July 2020. Patients' information was recorded in their medical les. Multivariable analysis was performed to assess demographics, signs and symptoms, paraclinical data, treatments, outcomes of disease, and nding the risk factors of death subject to COVID-19. Of all 2468 participants, the mean age was 57.9±17.6 years and 56.8% of patients were male. The most signi cant comorbidities were seen among those who have Hypertension and Diabetes Mellitus. 14.42% were admitted to ICU, and 17.2% died in hospital. The signi cant risk factors of death were ageing, male gender, HTN, CHF, CVA, CKD, increasing ESR, PT, WBC, liver function tests, and decreasing Oxygen saturation. Incontinent results in the case of COVID-19 outcomes and deathrelated risk factors attribute to marked differences in demographics and health care systems. The patients with hazardous risk factors must be detected urgently and monitored closely to save more lives.
Supplementary Files This is a list of supplementary les associated with this preprint. Click to download. app.docx
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Late treatment
is less effective
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