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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Mortality -49% Improvement Relative Risk Aspirin for COVID-19  Pérez-Segura et al.  Prophylaxis Is prophylaxis with aspirin beneficial for COVID-19? Retrospective 763 patients in multiple countries Higher mortality with aspirin (p=0.00012) c19early.org Pérez-Segura et al., Medicina Clínica, Oct 2021 Favors aspirin Favors control

Prognostic factors at admission on patients with cancer and COVID-19: Analysis of HOPE registry data

Pérez-Segura et al., Medicina Clínica, doi:10.1016/j.medcle.2021.02.010
Oct 2021  
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Aspirin for COVID-19
19th treatment shown to reduce risk in March 2021
 
*, now known with p = 0.00014 from 72 studies, recognized in 2 countries.
Lower risk for mortality and progression.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,000+ studies for 60+ treatments. c19early.org
Retrospective 770 COVID-19 patients with cancer, showing increased mortality with aspirin use in unadjusted results.
risk of death, 49.1% higher, RR 1.49, p < 0.001, treatment 66 of 155 (42.6%), control 183 of 608 (30.1%), odds ratio converted to relative risk.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Pérez-Segura et al., 4 Oct 2021, retrospective, multiple countries, peer-reviewed, 23 authors.
This PaperAspirinAll
Prognostic factors at admission on patients with cancer and COVID-19: Analysis of HOPE registry data
Pedro Pérez-Segura, M Paz-Cabezas, I J Núñez-Gil, R Arroyo-Espliguero, C Maroun Eid, R Romero, I Fernández Rozas, A Uribarri, V M Becerra-Muñoz, M García Aguado, J Huang, E Rondano, E Cerrato, E Alfonso Rodríguez, M E Ortega-Armas, S Raposeiras Roubin, M Pepe, G Feltes, A Gonzalez, B Cortese, L Buzón, I El-Battrawy, V Estrada
Medicina Clínica, doi:10.1016/j.medcli.2021.02.021
Background: Previous works seem to agree in the higher mortality of cancer patients with COVID-19. Identifying potential prognostic factors upon admission could help identify patients with a poor prognosis. Methods: We aimed to explore the characteristics and evolution of COVID-19 cancer patients admitted to hospital in a multicenter international registry (HOPE COVID-19). Our primary objective is to define those characteristics that allow us to identify cancer patients with a worse prognosis (mortality within 30 days after the diagnosis of COVID-19). Results: 5838 patients have been collected in this registry, of whom 770 had cancer among their antecedents. In hospital mortality reached 258 patients (33.51%). The median was 75 years (65-82). Regarding the distribution by sex, 34.55% of the patients (266/770) were women. The distribution by type of cancer: genitourinary 238/745 (31.95%), digestive 124/745 (16.54%), hematologic 95/745 (12.75%). In multivariate regression analysis, factors that are independently associated with mortality at admis-
identification of factors predicting a worse prognosis, such as those presented here, can help us to better manage this process and try to reduce mortality from COVID-19 in the cancer patient. Conflict of interests The authors declare that they have no conflict of interest.
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Who, WHO Director-General's opening remarks at the media briefing con COVID-19
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