Abstract: Medicina Clínica 157 (2021) 318–324 www.elsevier.es/medicinaclinica Original article Prognostic factors at admission on patients with cancer and COVID-19: Analysis of HOPE registry data Pedro Pérez-Segura a,∗ , M. Paz-Cabezas a , I.J. Núñez-Gil b , R. Arroyo-Espliguero c , C. Maroun Eid d , R. Romero e , I. Fernández Rozas f , A. Uribarri g , V.M. Becerra-Muñoz h , M. García Aguado i , J. Huang j , E. Rondano k , E. Cerrato l , E. Alfonso Rodríguez m , M.E. Ortega-Armas n , S. Raposeiras Roubin o , M. Pepe p , G. Feltes q , A. Gonzalez r , B. Cortese s , L. Buzón t , I. El-Battrawy u , V. Estrada b a Medical Oncology Dpt. Hospital Clinico San Carlos, Madrid, Spain Hospital Clinico San Carlos, Madrid, Spain c Hospital Universitario Guadalajara, Guadalajara, Spain d Hospital Universitario La Paz. Instituto de Investigación Hospital Universitario La Paz (IdiPAZ), Madrid, Spain e Hospital Universitario Getafe, Madrid, Spain f Hospital Universitario Severo Ochoa, Leganés, Spain g Hospital Clinico Universitario de Valladolid, Valladolid, Spain h Hospital Clinico Universitario Virgen de la Victoria, Málaga, Spain i Hospital Puerta de Hierro de Majadahonda. Majadahonda, Madrid, Spain j The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, China k Sant’Andrea Hospital, Vercelli, Italy l San Luigi Gonzaga University Hospital, Orbassano and Rivoli Infermi Hospital, Rivoli, Turin, Italy m Institute of Cardiology and Cardiovascular Surgery, Havana, Cuba n Hospital General del Norte de Guayaquil IESS Los Ceibos, Guayaquil, Ecuador o University Hospital Alvaro Cunqueiro, Vigo, Spain p Azienda ospedaliero-universitaria consorziale policlinico di Bari, Bari, Italy q Nuestra Señora de América, Madrid, Spain r Hospital Universitario Infanta Sofia. San Sebastian de los Reyes, Madrid, Spain s San Carlo Clinic, Milano, Italy t Hospital Universitario de Burgos, Burgos, Spain u First Department of Medicine, Medical Faculty Mannheim, University Heidelberg, Mannheim, 68167, Germany, DZHK (German Center for Cardiovascular Research), Partner Site, Heidelberg-Mannheim, Mannheim, Germany b a r t i c l e i n f o Article history: Received 23 October 2020 Accepted 24 February 2021 Available online 6 May 2021 Keywords: Cancer COVID19 Prognosis Admission Factors a b s t r a c t Background: Previous works seem to agree in the higher mortality of cancer patients with COVID-19. Identifying potential prognostic factors upon admission could help identify patients with a poor prognosis. Methods: We aimed to explore the characteristics and evolution of COVID-19 cancer patients admitted to hospital in a multicenter international registry (HOPE COVID-19). Our primary objective is to define those characteristics that allow us to identify cancer patients with a worse prognosis (mortality within 30 days after the diagnosis of COVID-19). Results: 5838 patients have been collected in this registry, of whom 770 had cancer among their antecedents. In hospital mortality reached 258 patients (33.51%). The median was 75 years (65–82). Regarding the distribution by sex, 34.55% of the patients (266/770) were women. The distribution by type of cancer: genitourinary 238/745 (31.95%), digestive 124/745 (16.54%), hematologic 95/745 (12.75%). In multivariate regression analysis, factors that are independently associated with mortality at admission are: renal impairment (OR 3.45, CI 97.5% 1.85–6.58), heart disease (2.32, 1.47–3.66), liver disease (4.69,..