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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Mortality 24% Improvement Relative Risk Progression -7% Case -11% Aspirin for COVID-19  Son et al.  Prophylaxis Is prophylaxis with aspirin beneficial for COVID-19? PSM retrospective 11,475 patients in South Korea Lower mortality with aspirin (not stat. sig., p=0.52) c19early.org Son et al., Medicine, July 2021 Favors aspirin Favors control

Effect of aspirin on coronavirus disease 2019

Son et al., Medicine, doi:10.1097/MD.0000000000026670
Jul 2021  
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Aspirin for COVID-19
24th treatment shown to reduce risk in August 2021
 
*, now known with p = 0.000087 from 73 studies, recognized in 2 countries.
Lower risk for mortality and progression.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,200+ studies for 70+ treatments. c19early.org
PSM retrospective case control study in South Korea, showing a trend towards lower mortality, but no significant differences with aspirin use.
risk of death, 24.0% lower, OR 0.76, p = 0.52, treatment 37 of 128 (28.9%) cases, 31 of 128 (24.2%) controls, adjusted per study, case control OR, group 1, model 2 (most data in group and adjustments), multivariable.
risk of progression, 7.0% higher, OR 1.07, p = 0.80, treatment 77 of 339 (22.7%) cases, 58 of 339 (17.1%) controls, adjusted per study, case control OR, complications, group 1, model 2 (most data in group and adjustments), multivariable.
risk of case, 11.0% higher, OR 1.11, p = 0.21, treatment 313 of 3,825 (8.2%) cases, 617 of 7,650 (8.1%) controls, adjusted per study, case control OR, group 1, PSM 1, model 2 (most data in group and adjustments), multivariable.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Son et al., 30 Jul 2021, retrospective, propensity score matching, South Korea, peer-reviewed, 6 authors.
This PaperAspirinAll
Effect of aspirin on coronavirus disease 2019
MD a , Minkook Son, MD a , Je Myung-Giun Noh, Jeong Hoon Lee, MD c Jeongkuk Seo, MD, PhD Hansoo Park, PhD Sung Yang
Medicine, doi:10.1097/md.0000000000026670
Several studies reported that aspirin can potentially help prevent infection and serious complications of coronavirus disease (COVID-19), but no study has elucidated a definitive association between aspirin and COVID-19. This study aims to investigate the association between aspirin and COVID-19. This case-control study used demographic, clinical, and health screening laboratory test data collected from the National Health Insurance Service database. Patients who tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection until June 4, 2020, were matched with control patients using propensity score matching according to their SARS-CoV-2 status, the composite of complications, and death. The composite of complications included intensive care unit admission, use of vasopressors, high-flow oxygen therapy, renal replacement therapy, extracorporeal membrane oxygenation, and death. Exposure to aspirin was defined as having a prescription for aspirin for more than 14 days, including the index date. After matching, multivariableadjusted conditional logistic regression analysis was performed. To confirm the robustness of this study, we used 2 study groups, 3 propensity score matching methods, and 3 models for conditional logistic regression analyses. The crude odds ratio and 95% confidence interval for SARS-CoV-2 infection between the groups without and with exposure to aspirin were 1.21 (1.04-1.41), but the adjusted odds ratios (95% confidence interval) were not significant. There was no association between aspirin exposure and COVID-19 status. Multiple statistical analyses, including subgroup analysis, revealed consistent results. Furthermore, the results of analysis for complications and death were not significant. Aspirin exposure was not associated with COVID-19-related complications and mortality in COVID-19 patients. In this nationwide population-based case-control study, aspirin use was not associated with SARS-CoV-2 infection or related complications. With several ongoing randomized controlled trials of aspirin in COVID-19 patients, more studies would be able to confirm the effectiveness of aspirin in COVID-19.
Author contributions
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'reference-count': 39, 'references-count': 39, 'relation': {}, 'score': 1, 'short-container-title': [], 'short-title': [], 'source': 'Crossref', 'subject': ['General Medicine'], 'subtitle': ['A nationwide case-control study in South Korea'], 'title': ['Effect of aspirin on coronavirus disease 2019'], 'type': 'journal-article', 'volume': '100'}
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Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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