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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Mortality 28% Improvement Relative Risk Aspirin for COVID-19  Ali et al.  Prophylaxis Is prophylaxis with aspirin beneficial for COVID-19? Retrospective 1,645 patients in the USA Lower mortality with aspirin (not stat. sig., p=0.067) c19early.org Ali et al., Chest, November 2022 Favors aspirin Favors control

Cardiovascular complications are the primary drivers of mortality in hospitalized patients with SARS-CoV-2 community-acquired pneumonia

Nov 2022  
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Aspirin for COVID-19
24th treatment shown to reduce risk in August 2021
 
*, now known with p = 0.000087 from 73 studies, recognized in 2 countries.
Lower risk for mortality and progression.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,100+ studies for 60+ treatments. c19early.org
Retrospective 1,645 hospitalized patients in the USA, showing lower mortality with aspirin use, without statistical significance.
risk of death, 28.0% lower, HR 0.72, p = 0.07, treatment 481, control 1,164, Cox proportional hazards.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Ali et al., 19 Nov 2022, retrospective, USA, peer-reviewed, 8 authors. Contact: d0shei01@louisville.edu.
This PaperAspirinAll
Cardiovascular Complications Are the Primary Drivers of Mortality in Hospitalized Patients With SARS-CoV-2 Community-Acquired Pneumonia
MD Ahmed Shebl Ali, MD. Daniya Sheikh, MPH Thomas R Chandler, MS MPH Stephen Furmanek, MD PhD Jiapeng Huang, MD, FACP Julio A Ramirez, DO, MSc, FIDSA Forest Arnold, MD Rodrigo Cavallazzi
Chest, doi:10.1016/j.chest.2022.11.013
This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Author Contributions A.S. and D.S. contributed to writing and data interpretation. T.R.C. and S.F. contributed to writing and data analysis. J.H. contributed to writing and data interpretation. J.R. and R.C. contributed to study design, writing and data interpretation. F.A. contributed to data interpretation. R.C. takes the responsibility of the content of the manuscript including data and analysis. Financial/nonfinancial disclosures None J o u r n a l P r e -p r o o f
References
Ackermann, Verleden, Kuehnel, Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19, New England Journal of Medicine
Al-Aly, Xie, Bowe, High-dimensional characterization of post-acute sequelae of COVID-19, Nature
Bonow, Gara, Yancy, Cardiology and COVID-19, JAMA
Bugert, Kwiat, Valera, Bugert, Parvatiyar, Cardiovascular Injury Due to SARS-CoV-2, Curr Clin Microbiol Rep
Chen, Li, Chen, Feng, Xiong, The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2, Cardiovasc Res
Clayton, Thompson, Meade, Recent respiratory infection and risk of cardiovascular disease: case-control study through a general practice database, Eur Heart J
De Wreede, Fiocco, Putter, The mstate package for estimation and prediction in non-and semi-parametric multi-state and competing risks models, Comput Methods Programs Biomed
De Wreede, Fiocco, Putter, mstate: An R Package for the Analysis of Competing Risks and Multi-State Models, Journal of Statistical Software
Furmanek, Glick, Chandler, The City of Louisville Encapsulates the United States Demographics, The University of Louisville Journal of Respiratory Infections
Goyal, Choi, Pinheiro, Clinical Characteristics of Covid-19 in New York City, N Engl J Med
Hamming, Timens, Bulthuis, Lely, Navis et al., Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis, The Journal of pathology
J O U R N A L P R E, -p r o o f
Katsoularis, Fonseca-Rodríguez, Farrington, Lindmark, Connolly, Risk of acute myocardial infarction and ischaemic stroke following COVID-19 in Sweden: a self-controlled case series and matched cohort study, Lancet
Lindner, Fitzek, Bräuninger, Association of Cardiac Infection With SARS-CoV-2 in Confirmed COVID-19 Autopsy Cases, JAMA Cardiol
Luo, Fu, Li, The potential association between common comorbidities and severity and mortality of coronavirus disease 2019: A pooled analysis, Clin Cardiol
Nguyen, Yang, Ito, Matte, Shaman et al., Seasonal Influenza Infections and Cardiovascular Disease Mortality, JAMA Cardiol
Pieralli, Vannucchi, Nozzoli, Acute cardiovascular events in patients with community acquired pneumonia: results from the observational prospective FADOI-ICECAP study, BMC Infect Dis
Piroth, Cottenet, Mariet, Comparison of the characteristics, morbidity, and mortality of COVID-19 and seasonal influenza: a nationwide, population-based retrospective cohort study, Lancet Respir Med
Ramirez, Bordon, Cavallazzi, Characteristics and Outcomes of Adults Hospitalized with SARS-CoV-2 Community-Acquired Pneumonia in Louisville, Kentucky, The University of Louisville Journal of Respiratory Infections
Ramirez, Chandler, Furmanek, Epidemiology and Outcomes of Hospitalized Adults with SARS-CoV-2 Community-Acquired Pneumonia in Louisville, Kentucky, The University of Louisville Journal of Respiratory Infections
Saad, Kennedy, Imran, Association Between COVID-19 Diagnosis and In-Hospital Mortality in Patients Hospitalized With ST-Segment Elevation Myocardial Infarction, Jama
Shi, Qin, Shen, Association of Cardiac Injury With Mortality in Hospitalized Patients With COVID-19 in Wuhan, China, JAMA Cardiol
Wang, Hu, Hu, Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China, Jama
Xie, Xu, Bowe, Al-Aly, Long-term cardiovascular outcomes of COVID-19, Nat Med
Xiong, Redwood, Prendergast, Chen, Coronaviruses and the cardiovascular system: acute and long-term implications, Eur Heart J
Xu, Samanapally, Nathala, Outcomes and Risk Factors for Cardiovascular Events in Hospitalized COVID-19 Patients, J Cardiothorac Vasc Anesth
Zheng, Ma, Zhang, Xie, COVID-19 and the cardiovascular system, Nat Rev Cardiol
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