Network pharmacology and molecular docking reveal the mechanisms of action of Panax notoginseng against post-COVID-19 thromboembolism

{ 'indexed': {'date-parts': [[2024, 5, 7]], 'date-time': '2024-05-07T00:32:44Z', 'timestamp': 1715041964404}, 'reference-count': 10, 'publisher': 'PHARMAKON-Press', 'issue': 'Sup2', 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'published-print': {'date-parts': [[2024, 5, 5]]}, 'abstract': '<jats:p>Panax notoginseng (PNGS) is a potent folk therapy for blood-related diseases. ' 'However, further research is required to fully elucidate the mechanisms of its ' 'pharmacological activities and to explore its therapeutic potential for treating ' 'thromboembolism (TE) caused by the severe acute respiratory syndrome coronavirus 2 ' '(SARS-CoV-2). This study aimed at analysing the molecular mechanisms of PNGS and at ' 'clarifying their potential role in treating TE induced by COVID-19, by employing network ' 'pharmacology and molecular docking. To this end, a network pharmacological ap¬proach was ' 'combined with expression profiling by high-throughput sequencing of GSE156701 so as to ' 'elucidate the compound constituents of PNGS for treating TE caused by SARS-CoV-2 at a ' 'systemic level. Protein-protein interac¬tion network, Gene Ontology, and Kyoto Encyclopedia ' 'of Genes and Genomes analyses were employed in order to decipher the associated drug-target ' 'interactions. The integration of these results suggested that five targets, including the ' 'angiotensin-converting enzyme (ACE), the coagulation factor III (F3), interleukin-1 beta ' '(IL-1β), the mitogen-activated protein kinase 1 (MAPK1), and the plasminogen activator ' 'inhibitor-1 (SERPINE1), represent major genes involved in thromboembolism. The data suggest ' 'that PNGS exerts collective therapeutic effects against TE caused by SARS-CoV-2, and provides ' 'a theoretical basis for further laboratory study of the active drug-like ingredients and the ' 'potential mechanisms of PNGS in TE treatment.</jats:p>', 'DOI': '10.61873/dtfa3974', 'type': 'journal-article', 'created': {'date-parts': [[2024, 5, 6]], 'date-time': '2024-05-06T18:28:05Z', 'timestamp': 1715020085000}, 'page': '181-184', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Network pharmacology and molecular docking reveal the mechanisms of action of Panax notoginseng ' 'against post-COVID-19 thromboembolism', 'prefix': '10.61873', 'volume': '38', 'author': [ { 'ORCID': 'http://orcid.org/0000-0002-4733-9891', 'authenticated-orcid': False, 'given': 'Shouli', 'family': 'Yuan', 'sequence': 'first', 'affiliation': []}, { 'name': 'Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China', 'sequence': 'first', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0003-1204-955X', 'authenticated-orcid': False, 'given': 'Ismael', 'family': 'Obaidi', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0003-1079-5364', 'authenticated-orcid': False, 'given': 'Tao', 'family': 'Zhang', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0009-0005-9502-9045', 'authenticated-orcid': False, 'given': 'Maria', 'family': 'Pigott', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0003-1493-6523', 'authenticated-orcid': False, 'given': 'Shibo', 'family': 'Jiang', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0002-9454-752X', 'authenticated-orcid': False, 'given': 'Helen', 'family': 'Sheridan', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0002-6924-9432', 'authenticated-orcid': False, 'given': 'Junying', 'family': 'Liu', 'sequence': 'additional', 'affiliation': []}, { 'name': 'NatPro Centre for Natural Products Research, School of Pharmacy and Pharmaceutical ' 'Sciences, Trinity College Dublin, Dublin, Ireland', 'sequence': 'additional', 'affiliation': []}, { 'name': 'College of Pharmacy, University of Babylon, Hillah, Iraq', 'sequence': 'additional', 'affiliation': []}, { 'name': 'School of Food Science & Environmental Health, Technological University Dublin, ' 'Grangegorman, Dublin, Ireland', 'sequence': 'additional', 'affiliation': []}, { 'name': 'NatPro Centre for Natural Products Research, School of Pharmacy and Pharmaceutical ' 'Sciences, Trinity College Dublin, Dublin, Ireland', 'sequence': 'additional', 'affiliation': []}, { 'name': 'Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic ' 'Medical Sciences, Shanghai Institute of Infectious Disease and Biosecurity, Fudan ' 'University, Shanghai, China', 'sequence': 'additional', 'affiliation': []}, { 'name': 'NatPro Centre for Natural Products Research, School of Pharmacy and Pharmaceutical ' 'Sciences, Trinity College Dublin, Dublin, Ireland', 'sequence': 'additional', 'affiliation': []}, { 'name': 'NatPro Centre for Natural Products Research, School of Pharmacy and Pharmaceutical ' 'Sciences, Trinity College Dublin, Dublin, Ireland', 'sequence': 'additional', 'affiliation': []}], 'member': '48040', 'published-online': {'date-parts': [[2024, 5, 5]]}, 'reference': [ { 'key': 'ref0', 'doi-asserted-by': 'publisher', 'unstructured': '1. 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