A study on the effect of natural products against the transmission of B.1.1.529 Omicron

{ 'indexed': {'date-parts': [[2024, 2, 6]], 'date-time': '2024-02-06T18:28:03Z', 'timestamp': 1707244083411}, 'reference-count': 221, 'publisher': 'Springer Science and Business Media LLC', 'issue': '1', 'license': [ { 'start': { 'date-parts': [[2023, 8, 25]], 'date-time': '2023-08-25T00:00:00Z', 'timestamp': 1692921600000}, 'content-version': 'tdm', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0'}, { 'start': { 'date-parts': [[2023, 8, 25]], 'date-time': '2023-08-25T00:00:00Z', 'timestamp': 1692921600000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0'}], 'funder': [ { 'name': 'The Science, Technology & Innovation Funding Authority (STDF) in cooperation with ' 'the Egyptian Knowledge Bank'}, {'DOI': '10.13039/501100007950', 'name': 'Tanta University', 'doi-asserted-by': 'crossref'}], 'content-domain': {'domain': ['link.springer.com'], 'crossmark-restriction': False}, 'abstract': '<jats:title>Abstract</jats:title><jats:sec>\n' ' <jats:title>Background</jats:title>\n' ' <jats:p>The recent outbreak of the Coronavirus pandemic resulted in a ' 'successful vaccination program launched by the World Health Organization. However, a large ' 'population is still unvaccinated, leading to the emergence of mutated strains like alpha, ' 'beta, delta, and B.1.1.529 (Omicron). Recent reports from the World Health Organization ' 'raised concerns about the Omicron variant, which emerged in South Africa during a surge in ' 'COVID-19 cases in November 2021. Vaccines are not proven completely effective or safe against ' 'Omicron, leading to clinical trials for combating infection by the mutated virus. The absence ' 'of suitable pharmaceuticals has led scientists and clinicians to search for alternative and ' 'supplementary therapies, including dietary patterns, to reduce the effect of mutated ' 'strains.</jats:p>\n' ' </jats:sec><jats:sec>\n' ' <jats:title>Main body</jats:title>\n' ' <jats:p>This review analyzed Coronavirus aetiology, epidemiology, and natural ' 'products for combating Omicron. Although the literature search did not include keywords ' 'related to in silico or computational research, in silico investigations were emphasized in ' 'this study. Molecular docking was implemented to compare the interaction between natural ' 'products and Chloroquine with the ACE2 receptor protein amino acid residues of Omicron. The ' 'global Omicron infection proceeding SARS-CoV-2 vaccination was also elucidated. The docking ' 'results suggest that DGCG may bind to the ACE2 receptor three times more effectively than ' 'standard chloroquine.</jats:p>\n' ' </jats:sec><jats:sec>\n' ' <jats:title>Conclusion</jats:title>\n' ' <jats:p>The emergence of the Omicron variant has highlighted the need for ' 'alternative therapies to reduce the impact of mutated strains. The current review suggests ' 'that natural products such as DGCG may be effective in binding to the ACE2 receptor and ' 'combating the Omicron variant, however, further research is required to validate the results ' 'of this study and explore the potential of natural products to mitigate COVID-19.</jats:p>\n' ' </jats:sec><jats:sec>\n' ' <jats:title>Graphical abstract</jats:title>\n' ' \n' ' </jats:sec>', 'DOI': '10.1186/s12985-023-02160-6', 'type': 'journal-article', 'created': {'date-parts': [[2023, 8, 25]], 'date-time': '2023-08-25T06:02:14Z', 'timestamp': 1692943334000}, 'update-policy': 'http://dx.doi.org/10.1007/springer_crossmark_policy', 'source': 'Crossref', 'is-referenced-by-count': 3, 'title': 'A study on the effect of natural products against the transmission of B.1.1.529 Omicron', 'prefix': '10.1186', 'volume': '20', 'author': [ {'given': 'Samar Sami', 'family': 'Alkafaas', 'sequence': 'first', 'affiliation': []}, {'given': 'Abanoub Mosaad', 'family': 'Abdallah', 'sequence': 'additional', 'affiliation': []}, {'given': 'Aya Misbah', 'family': 'Hussien', 'sequence': 'additional', 'affiliation': []}, {'given': 'Heba', 'family': 'Bedair', 'sequence': 'additional', 'affiliation': []}, {'given': 'Mahmoud', 'family': 'Abdo', 'sequence': 'additional', 'affiliation': []}, {'given': 'Soumya', 'family': 'Ghosh', 'sequence': 'additional', 'affiliation': []}, {'given': 'Sara Samy', 'family': 'Elkafas', 'sequence': 'additional', 'affiliation': []}, {'given': 'Wilgince', 'family': 'Apollon', 'sequence': 'additional', 'affiliation': []}, {'given': 'Morteza', 'family': 'Saki', 'sequence': 'additional', 'affiliation': []}, {'given': 'Samah A.', 'family': 'Loutfy', 'sequence': 'additional', 'affiliation': []}, {'given': 'Helen', 'family': 'Onyeaka', 'sequence': 'additional', 'affiliation': []}, {'given': 'Mohamed', 'family': 'Hessien', 'sequence': 'additional', 'affiliation': []}], 'member': '297', 'published-online': {'date-parts': [[2023, 8, 25]]}, 'reference': [ { 'key': '2160_CR1', 'doi-asserted-by': 'crossref', 'first-page': '1', 'DOI': '10.12998/wjcc.v10.i1.1', 'volume': '10', 'author': 'S-Y Ren', 'year': '2022', 'unstructured': 'Ren S-Y, Wang W-B, Gao R-D, Zhou A-M. 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