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A study on the effect of natural products against the transmission of B.1.1.529 Omicron

Alkafaas et al., Virology Journal, doi:10.1186/s12985-023-02160-6
Aug 2023  
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Review of natural products for SARS-CoV-2 omicron including an In Silico study showing quercetin, curcumin, ascorbic acid, nigellidine, and chloroquine among many compounds docked to the ACE2 metallopeptidase domain. Quercetin, curcumin, and ascorbic acid bound ACE2 with energy scores of -16.51, -13.5, and -12.55 kcal/mol. Nigellidine and chloroquine bound with lower affinity (-11.73 and -10.33 kcal/mol). The results suggest these compounds may have potential to inhibit SARS-CoV-2 infection by binding the ACE2 receptor.
Study covers quercetin, curcumin, nigella sativa, vitamin C, and HCQ.
Alkafaas et al., 25 Aug 2023, peer-reviewed, 12 authors. Contact:,,,,
In Silico studies are an important part of preclinical research, however results may be very different in vivo.
This PaperNigella SativaAll
A study on the effect of natural products against the transmission of B.1.1.529 Omicron
Samar Sami Alkafaas, Abanoub Mosaad Abdallah, Aya Misbah Hussien, Heba Bedair, Mahmoud Abdo, Soumya Ghosh, Sara Samy Elkafas, Wilgince Apollon, Morteza Saki, Samah A Loutfy, Helen Onyeaka, Mohamed Hessien
Virology Journal, doi:10.1186/s12985-023-02160-6
Background The recent outbreak of the Coronavirus pandemic resulted in a successful vaccination program launched by the World Health Organization. However, a large population is still unvaccinated, leading to the emergence of mutated strains like alpha, beta, delta, and B.1.1.529 (Omicron). Recent reports from the World Health Organization raised concerns about the Omicron variant, which emerged in South Africa during a surge in COVID-19 cases in November 2021. Vaccines are not proven completely effective or safe against Omicron, leading to clinical trials for combating infection by the mutated virus. The absence of suitable pharmaceuticals has led scientists and clinicians to search for alternative and supplementary therapies, including dietary patterns, to reduce the effect of mutated strains. Main body This review analyzed Coronavirus aetiology, epidemiology, and natural products for combating Omicron. Although the literature search did not include keywords related to in silico or computational research, in silico investigations were emphasized in this study. Molecular docking was implemented to compare the interaction between natural products and Chloroquine with the ACE2 receptor protein amino acid residues of Omicron. The global Omicron infection proceeding SARS-CoV-2 vaccination was also elucidated. The docking results suggest that DGCG may bind to the ACE2 receptor three times more effectively than standard chloroquine. Conclusion The emergence of the Omicron variant has highlighted the need for alternative therapies to reduce the impact of mutated strains. The current review suggests that natural products such as DGCG may be effective in binding to the ACE2 receptor and combating the Omicron variant, however, further research is required to validate the results of this study and explore the potential of natural products to mitigate COVID-19. Highlights • There are 32 mutations in the spike of the Omicron variant. • Non-SARS-COV-2 vaccinated individuals accelerate transmission of Omicron variant.
Declarations Ethics approval and consent to participate Not applicable. Consent for publication All the authors read and agreed to publish this article. Competing interests The authors declare that they have no competing interests. Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Aanouz, Belhassan, El-Khatabi, Lakhlifi, El-Ldrissi et al., Moroccan medicinal plants as inhibitors against SARS-CoV-2 main protease: computational investigations, J Biomol Struct Dyn
Abdallah, Gomha, Zaki, Abolibda, Kheder, A green synthesis, DFT calculations, and molecular docking study of some new indeno[2,1-b]quinoxalines containing thiazole moiety, J Mol Struct
Abubakar, Usman, Batiha, Martins, Malami et al., Natural Products Modulating Angiotensin Converting Enzyme 2 (ACE2) as Potential COVID-19 Therapies, Front Pharmacol
Adem, Eyupoglu, Sarfraz, Rasul, Ali et al., Identification of potent COVID-19 main protease (Mpro) inhibitors from natural polyphenols: an in silico strategy unveils a hope against CORONA, Drug Dev Res
Ahmadi, Ayazi-Nasrabadi, Astaxanthin protective barrier and its ability to improve the health in patients with COVID-19, Iran J Microbiol
Al-Harrasi, Behl, Upadhyay, Chigurupati, Bhatt et al., Targeting natural products against SARS-CoV-2, Environ Sci Pollut Res
Al-Qaisi, Garawi, Karawi, Hammood, Abdallah et al., Antiureolytic activity of new water-soluble thiadiazole derivatives: Spectroscopic, DFT, and molecular docking studies, Spectrochim Acta A Mol Biomol Spectrosc
Alghamdi, Algandaby, Al-Abbasi, Eid, Abdallah et al., Protective effect of rutin isolated from Spermococe hispida against cobalt chloride-induced hypoxic injury in H9c2 cells by inhibiting oxidative stress and inducing apoptosis, Oxid Med Cell Longev
Alhouri, Salloum, Harfouch, Soumya, Possible side effects of using detergents during the Covid19 pandemic in Syria, Ann Clin Cases
Alkafaas, Abdallah, Ghosh, Loutfy, Elkafas et al., Insight into the role of clathrin-mediated endocytosis inhibitors in SARS-CoV-2 infection, Rev Med Virol
Alkafaas, Loutfy, Diab, Hessien, Vasopressin induces apoptosis but does not enhance the antiproliferative effect of dynamin 2 or PI3K/Akt inhibition in luminal A breast cancer cells, Med Oncol
Ambati, Phang, Ravi, Aswathanarayana, Astaxanthin: sources, extraction, stability, biological activities and its commercial applications-a review, Mar Drugs
Araf, Akter, Yd, Fatemi, Parvez et al., Omicron variant of SARS-CoV-2: genomics, transmissibility, and responses to current COVID-19 vaccines, J Med Virol
Assessment Rr, Assessment of the further emergence and potential impact of the SARS-CoV-2 Omicron variant of concern in the context of ongoing transmission of the Delta variant of concern in the EU/EEA
Assoumani, Delerce, Houhamdi, Bedotto, Lagier et al., Introduction of the SARS-CoV-2 Beta variant from Comoros into the Marseille geographical area, Travel Med Infect Dis
Atabaki, Roohbakhsh, Moghimi, Mehri, Protective effects of maternal administration of curcumin and hesperidin in the rat offspring following repeated febrile seizure: role of inflammation and TLR4, Int Immunopharmacol
Awadasseid, Wu, Tanaka, Zhang, Current advances in the development of SARS-CoV-2 vaccines, Int J Biol Sci
Balkrishna, Haldar, Singh, Roy, Varshney, Coronil, a tri-herbal formulation, attenuates spike-protein-mediated SARS-CoV-2 viral entry into human alveolar epithelial cells and pro-inflammatory cytokines production by inhibiting spike protein-ACE-2 interaction, J Inflamm Res
Balkrishna, Raj, Singh, Varshney, Influence of patient-reported treatment satisfaction on psychological health and quality of life Among patients receiving Divya-Swasari-Coronil-Kit against COVID-19: findings from a cross-sectional "SATISFACTION COVID" survey, Patient Prefer Adherence
Balkrishna, Solleti, Verma, Varshney, Application of humanized zebrafish model in the suppression of SARS-CoV-2 spike protein induced pathology by tri-herbal medicine coronil via cytokine modulation, Molecules
Bao, Pan, Lu, Ni, Zhang et al., The apoptotic effect of sarsasapogenin from Anemarrhena asphodeloides on HepG2 human hepatoma cells, Cell Biol Int
Barickman, Kopsell, Sams, Selenium influences glucosinolate and isothiocyanates and increases sulfur uptake in Arabidopsis thaliana and rapid-cycling Brassica oleracea, J Agric Food Chem
Bellavite, Donzelli, Hesperidin and SARS-CoV-2: new light on the healthy function of citrus fruits, Antioxidants
Blaskó, Hussain, Shamma, Corlumine, a new phthalideisoquinoline alkaloid from Fumaria parviflora, J Nat Prod
Calland, Sahuc, Belouzard, Pène, Bonnafous et al., Polyphenols inhibit hepatitis C virus entry by a new mechanism of action, J Virol
Callaway, Heavily mutated coronavirus variant puts scientists on alert, Nature
Carter, Yu, Sacks, Barnadas, Pereyaslov et al., Global genomic surveillance strategy for pathogens with pandemic and epidemic potential 2022-2032, Bull World Health Organ
Cascella, Rajnik, Aleem, Dulebohn, Napoli, Features, evaluation, and treatment of coronavirus (COVID-19)
Cavezzi, Troiani, Corrao, COVID-19: hemoglobin, iron, and hypoxia beyond inflammation. A narrative review, Clin Pract
Chanet, Milenkovic, Maier, Khan, Rakotomanomana et al., Flavanone metabolites decrease monocyte adhesion to TNF-αactivated endothelial cells by modulating expression of atherosclerosisrelated genes, Br J Nutr
Chanet, Milenkovic, Manach, Mazur, Morand, Citrus flavanones: What is their role in cardiovascular protection?, J Agric Food Chem
Chapman, Andurkar, A review of natural products, their effects on SARS-CoV-2 and their utility as lead compounds in the discovery of drugs for the treatment of COVID-19, Med Chem Res
Chen, Gao, Wang, Wei, Revealing the threat of emerging SARS-CoV-2 mutations to antibody therapies, J Mol Biol
Chen, Wang, Gilby, Wei, B. 1.1. 529): Infectivity, vaccine breakthrough, and antibody resistance
Chen, Wang, Gilby, Wei, Omicron variant (B. 1.1. 529): Infectivity, vaccine breakthrough, and antibody resistance, J Chem Inf Model
Chen, Yiu, Wong, Prediction of the SARS-CoV-2 (2019-nCoV) 3C-like protease (3CL pro) structure: virtual screening reveals velpatasvir, ledipasvir, and other drug repurposing candidates, Research
Cheng, Ng, Chiang, Lin, Antiviral effects of saikosaponins on human coronavirus 229E in vitro, Clin Exp Pharmacol Physiol
Chiang, Chang, Kuo, Chang, Kuo, Cytotoxic triterpenes from the aerial roots of Ficus microcarpa, Phytochemistry
Chikhale, Sinha, Patil, Prasad, Shakya et al., In-silico investigation of phytochemicals from Asparagus racemosus as plausible antiviral agent in COVID-19, J Biomol Struct Dyn
Choi, Kim, Park, Lee, Kim et al., Anti-thrombotic effect of rutin isolated from Dendropanax morbifera Leveille, J Biosci Bioeng
Choi, Lee, Jung, Jung, Park, Constituents of the essential oil of the Cinnamomum cassia stem bark and the biological properties, Arch Pharmacal Res
Chowdhury, In silico investigation of phytoconstituents from Indian medicinal herb 'Tinospora cordifolia (giloy)'against SARS-CoV-2 (COVID-19) by molecular dynamics approach, J Biomol Struct Dyn
Conti, Ronconi, Caraffa, Gallenga, Ross et al., Induction of pro-inflammatory cytokines (IL-1 and IL-6) and lung inflammation by Coronavirus-19 (COVI-19 or SARS-CoV-2): anti-inflammatory strategies, J Biol Regul Homeost Agents
Covid, Team, SARS-CoV-2 B 11 529 (Omicron) Variant-United States, Morb Mortal Wkly Rep
Da Silva, Da Silva, De Oliveira, Costa, Koolen et al., Flavonoid glycosides and their putative human metabolites as potential inhibitors of the SARS-CoV-2 main protease (Mpro) and RNA-dependent RNA polymerase (RdRp), Memórias do Instituto Oswaldo Cruz
Da, Xu, Wang, Li, Lu et al., Kaempferol promotes apoptosis while inhibiting cell proliferation via androgen-dependent pathway and suppressing vasculogenic mimicry and invasion in prostate cancer, Biomed Pharmacother
Das, Majumder, Mandal, Basak, In-Silico approach for identification of effective and stable inhibitors for COVID-19 main protease (Mpro) from flavonoid based phytochemical constituents of Calendula officinalis, J Biomol Struct Dyn
Del, Singh, Singh, Singh, Kumar et al., Toxicology in vitro anti-free radical activities of kaempferol isolated from Acacia nilotica (L.) willd, Toxicol Vitr
Dongare, Kulkarni, Kondawar, Magdum, Haldavnekar et al., Inhibition of aldose reductase and anti-cataract action of trans-anethole isolated from Foeniculum vulgare Mill. fruits, Food Chem
Dubey, Dubey, Computation screening of narcissoside a glycosyloxyflavone for potential novel coronavirus 2019 (COVID-19) inhibitor, Biomed J
Duraipandiyan, Al-Dhabi, Irudayaraj, Sunil, Hypolipidemic activity of friedelin isolated from Azima tetracantha in hyperlipidemic rats, Rev Bras
Elshamy, Ammar, Hassan, El-Kashak, Ss et al., Farrag A-RH: Topical wound healing activity of myricetin isolated from tecomaria capensis V. aurea, Molecules
Erenler, Sen, Aksit, Demirtas, Yaglioglu et al., Isolation and identification of chemical constituents from Origanum majorana and investigation of antiproliferative and antioxidant activities, J Sci Food Agric
Fakhri, Nouri, Moradi, Farzaei, Astaxanthin, COVID-19 and immune response: focus on oxidative stress, apoptosis and autophagy, Phytother Res
Fang, Gao, Zhu, Kaempferol and quercetin isolated from Euonymus alatus improve glucose uptake of 3T3-L1 cells without adipogenesis activity, Life Sci
Fantini, Scala, Chahinian, Yahi, Structural and molecular modelling studies reveal a new mechanism of action of chloroquine and hydroxychloroquine against SARS-CoV-2 infection, Int J Antimicrob Agents
Fiorino, Gallo, Zippi, Sabbatani, Manfredi et al., Cytokine storm in aged people with CoV-2: possible role of vitamins as therapy or preventive strategy, Aging Clin Exp Res
Garcia-Beltran, Denis, Hoelzemer, Lam, Nitido et al., mRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variant, Cell
Garret, Tapley, Andriesen, Seocharan, Fisher et al., High rate of asymptomatic carriage associated with variant strain Omicron, MedRxiv
Ghosh, Bornman, Zafer, Antimicrobial resistance threats in the emerging COVID-19 pandemic: Where do we stand?, J Infect Public Health
Ghosh, Chakraborty, Biswas, Chowdhuri, Identification of polyphenols from Broussonetia papyrifera as SARS CoV-2 main protease inhibitors using in silico docking and molecular dynamics simulation approaches, J Biomol Struct Dyn
Gupta, Gonzalez-Rojas, Juarez, Casal, Moya et al., Early treatment for Covid-19 with SARS-CoV-2 neutralizing antibody sotrovimab, N Engl J Med
Gupta, Gupta, Bhargava, Andersen, Krpina et al., Novel antiviral activities of obatoclax, emetine, niclosamide, brequinar, and homoharringtonine, Clin Exp Dermatol
Gupta, Mallavarapu, Banerjee, Kumar, Characteristics of an isomenthone-rich somaclonal mutant isolated in a geraniol-rich rosescented geranium accession of Pelargonium graveolens, Flavour Fragr J
Haggag, El-Ashmawy, Okasha, Is hesperidin essential for prophylaxis and treatment of COVID-19 Infection?, Med Hypotheses
Hamza, Ali, Khan, Ahmed, Attique et al., nCOV-19 peptides mass fingerprinting identification, binding, and blocking of inhibitors flavonoids and anthraquinone of Moringa oleifera and hydroxychloroquine, J Biomol Struct Dyn
Han, Yuan, Zhao, He, Li et al., Tracking antiangiogenic components from Glycyrrhiza uralensis F isch. based on zebrafish assays using high-speed countercurrent chromatography, J Sep Sci
Hansen, Baum, Pascal, Russo, Giordano et al., Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail, Science
Hart, Miller, Andrews, Waight, Maini et al., Generation time of the alpha and delta SARS-CoV-2 variants: an epidemiological analysis, Lancet Infect Dis
Harvey, Carabelli, Jackson, Gupta, Thomson et al., SARS-CoV-2 variants, spike mutations and immune escape, Nat Rev Microbiol
He, Hong, Pan, Lu, Wei, SARS-CoV-2 Omicron variant: characteristics and prevention, MedComm
Heo, Kim, Choi, Ekanayake, Ahn et al., Hesperidin improves motor disability in rat spinal cord injury through anti-inflammatory and antioxidant mechanism via Nrf-2/HO-1 pathway, Neurosci Lett
Hessien, Donia, Tabll, Adly, Abdelhafez et al., Mechanistic-based classification of endocytosis-related inhibitors: Does it aid in assigning drugs against SARS-CoV-2?, Viruses
Hoffmann, Krüger, Schulz, Cossmann, Rocha et al., The Omicron variant is highly resistant against antibody-mediated neutralizationimplications for control of the COVID-19 pandemic, Cell
Hossain, Yd, Akter, Zheng, Roles of the polybasic furin cleavage site of spike protein in SARS-CoV-2 replication, pathogenesis, and host immune responses and vaccination, J Med Virol
Hu, Guan, Bi, Zhang, Li et al., Efficacy and safety of Lianhuaqingwen capsules, a repurposed Chinese herb, in patients with coronavirus disease 2019: a multicenter, prospective, randomized controlled trial, Phytomedicine
Hu, Ma, Li, Wang, Antioxidant and anti-inflammatory flavonoids from the flowers of Chuju, a medical cultivar of Chrysanthemum morifolim Ramat, J Mex Chem Soc
Hyun, Chung, Cyanidin and malvidin from Oryza sativa cv. heugjinjubyeo mediate cytotoxicity against human monocytic leukemia cells by arrest of G2/M phase and induction of apoptosis, J Agric Food Chem
Imanshahidi, Hosseinzadeh, Pharmacological and therapeutic effects of Berberis vulgaris and its active constituent, berberine, Phytother Res
Iqbal, Khan, Khattak, Biological significance of ascorbic acid (vitamin C) in human health-a review, Pak J Nutr
Iranshahi, Rezaee, Parhiz, Roohbakhsh, Soltani, Protective effects of flavonoids against microbes and toxins: the cases of hesperidin and hesperetin, Life Sci
Jang, Cuendet, Hawthorne, Kardono, Kawanishi et al., Prenylated flavonoids of the leaves of Macaranga conifera with inhibitory activity against cyclooxygenase-2, Phytochemistry
Jansen, Tegomoh, Lange, Showalter, Figliomeni et al., Investigation of a sars-cov-2 b. 1.1. 529 (omicron) variant cluster-Nebraska, November-December 2021, Morbidity and Mortality Weekly Report
Jha, Sharma, Hashiesh, Arunachalam, Meeran et al., β-Caryophyllene, a natural dietary CB2 receptor selective cannabinoid can be a candidate to target the trinity of infection, immunity, and inflammation in Covid-19, Front Pharmacol
Jo, Kim, Cho, Lee, Lee et al., Hesperetin inhibits neuroinflammation on microglia by suppressing inflammatory cytokines and MAPK pathways, Arch Pharmacal Res
Jo, Kim, Kim, Kim, Shin, Flavonoids with inhibitory activity against SARS-CoV-2 3CLpro, J Enzyme Inhib Med Chem
Kadan, Gözler, Shamma, Turkiyenine, a new alkaloid from Chelidonium majus, J Nat Prod
Kang, Choi, Lee, Kwon, Luteolin isolated from the flowers of Lonicera japonica suppresses inflammatory mediator release by blocking NF-κB and MAPKs activation pathways in HMC-1 cells, Molecules
Khalil, Baharum, Fazry, Sidik, Sairi, Non-enzymatic antioxidant from apple snail (Pomacea maculata) extract, Malays Appl Biol
Khan, Ikram, Hahm, Mo, Antioxidant and anti-inflammatory effects of citrus flavonoid hesperetin: special focus on neurological disorders, Antioxidants
Khan, Karim, San, Lustig, Tegally et al., Omicron infection enhances neutralizing immunity against the Delta variant, medRxiv
Kim, Liu, Ziarnik, Cao, Zhang et al., Binding of human ACE2 and RBD of Omicron enhanced by unique interaction patterns among SARS-CoV-2 variants of concern, bioRxiv
Kim, Wie, Ahn, Tanaka, Matsuda et al., Benefits of hesperidin in central nervous system disorders: a review, Anat Cell Biol
Kimura, Matsushita, Yokoi-Hayashi, Okuda, Effects of baicalein isolated from Scutellaria baicalensis Radix on adhesion molecule expression induced by thrombin and thrombin receptor agonist peptide in cultured human umbilical vein endothelial cells, Planta Med
Kishore, Kaur, Singh, Effect of Kaempferol isolated from seeds of Eruca sativa on changes of pain sensitivity in Streptozotocin-induced diabetic neuropathy, Inflammopharmacology
Knox, Hayashi, Suzutani, Ogasawara, Yoshida et al., Activity of anthocyanins from fruit extract of Ribes nigrum L. against influenza A and B viruses, Acta virol
Koch, Dietary polyphenols-important non-nutrients in the prevention of chronic noncommunicable diseases, Syst Rev Nutr
Kong, Wu, Gu, Lv, Qi et al., Analysis of the molecular mechanism of Pudilan (PDL) treatment for COVID-19 by network pharmacology tools, Biomed Pharmacother
Korman, Tan, Wong, Luo, Tsai, Inhibition kinetics and emodin cocrystal structure of a type II polyketide ketoreductase, Biochemistry
Kotaki, Adachi, Moriyama, Onodera, Fukushi et al., SARS-CoV-2 Omicron-neutralizing memory B-cells are elicited by two doses of BNT162b2 mRNA vaccine, Sci Immunol
Koyama, Inoue, Sekine, Hayakawa, Homma et al., Relative and absolute stereochemistry of quinadoline B, an inhibitor of lipid droplet synthesis in macrophages, Org Lett
Kubo, Fujita, Nihei, Antimicrobial activity of anethole and related compounds from aniseed, J Sci Food Agric
Kulkarni, Nagarajan, Ramesh, Palaniyandi, Selvam et al., Computational evaluation of major components from plant essential oils as potent inhibitors of SARS-CoV-2 spike protein, J Mol Struct
Kumar, Chowdhury, Jatte, Chakrabarti, Majumder et al., Anthocephaline, a new indole alkaloid and cadambine, a potent inhibitor of DNA topoisomerase IB of Leishmania donovani (LdTOP1LS), isolated from Anthocephalus cadamba, Nat Product Commun
Kumar, Jain, Verma, Phytochemical and pharmacological investigation of Cassia siamea Lamk: an insight, Nat Prod J
Kumar, Kashyap, Chowdhury, Kumar, Panwar et al., Identification of phytochemicals as potential therapeutic agents that binds to Nsp15 protein target of coronavirus (SARS-CoV-2) that are capable of inhibiting virus replication, Phytomedicine
Kumar, Thambiraja, Karuppanan, Subramaniam, Omicron and Delta variant of SARS-CoV-2: a comparative computational study of spike protein, J Med Virol
Kumar, Thambiraja, Karuppanan, Subramaniam, Omicron and Delta variant of SARS-CoV-2: a comparative computational study of spike protein, J Med Virol
Kuppusamy, Lee, Song, Ilavenil, Srigopalram et al., Quantification of major phenolic and flavonoid markers in forage crop Lolium multiflorum using HPLC-DAD, Rev Bras
Larit, Elokely, Nael, Benyahia, León et al., Proposed mechanism for the antitrypanosomal activity of quercetin and myricetin Isolated from Hypericum afrum Lam.: phytochemistry, in vitro testing and modeling studies, Molecules
Lee, Kim, Chang, Hong, Na et al., Antiplatelet effects of Rhus verniciflua Stokes heartwood and its active constituents-fisetin, butein, and sulfuretin-in rats, J Med Food
Lee, Lee, Baek, Kim, Antihyperlipidemic effect of crocin isolated from the fructus of Gardenia jasminoides and its metabolite crocetin, Biol Pharm Bull
Liu, Yang, Xu, Ma, Qin et al., Lycorine reduces mortality of human enterovirus 71-infected mice by inhibiting virus replication, Virol J
Luo, Liu, Li, Pharmacological perspective: glycyrrhizin may be an efficacious therapeutic agent for COVID-19, Int J Antimicrob Agents
Madhi, Kwatra, Myers, Jassat, Dhar et al., Population immunity and Covid-19 severity with Omicron variant in South Africa, N Engl J Med
Maiti, Banerjee, Nazmeen, Kanwar, Das, Active-site molecular docking of nigellidine with nucleocapsid-NSP2-MPro of COVID-19 and to human IL1R-IL6R and strong antioxidant role of Nigella-sativa in experimental rats, J Drug Target
Maroli, Bhasuran, Natarajan, Kolandaivel, Shahat, The potential role of procyanidin as a therapeutic agent against SARS-CoV-2: a text mining, molecular docking and molecular dynamics simulation approach, J Biomol Struct Dyn
Marovich, Mascola, Cohen, Monoclonal antibodies for prevention and treatment of COVID-19, JAMA
Martínez-Vázquez, Apan, Lastra, Bye, A comparative study of the analgesic and anti-inflammatory activities of pectolinarin isolated from Cirsium subcoriaceum and linarin isolated from Buddleia cordata, Planta Med
Matsuo, Ito, The chemical structure of kaki-tannin from immature fruit of the persimmon (Diospyros kaki L.), Agric Biol Chem
Mbs, Ho, Jm, Epicatechin is a promising novel inhibitor of SARS-CoV-2 entry by disrupting interactions between angiotensin-converting enzyme type 2 and the viral receptor binding domain: a computational/simulation study, Comput Biol Med
Mekala, Satyal, Setzer, Phytochemicals from the bark of Rhamnus caroliniana, Nat Prod Commun
Meskini, Rami, Maroofi, Ghosh, Siadat et al., An overview on the epidemiology and immunology of COVID-19, J Infect Public Health
Mete, Gözler, +)-Oxoturkiyenine: an isoquinoline-derived alkaloid from Hypecoum pendulum, J Nat Prod
Mf, Molecular modeling of the interaction of ligands with ACE2-SARS-CoV-2 spike protein complex, Silico Pharmacol
Moe V, None
Mohammed, Gbonjubola, Koorbanally, Islam, Inhibition of key enzymes linked to type 2 diabetes by compounds isolated from Aframomum melegueta fruit, Pharm Biol
Mohapatra, Tiwari, Sarangi, Sharma, Khandia et al., Twin combination of Omicron and Delta variant triggering a Tsunami wave of ever high surges in COVID-19 cases: a challenging global threat with a special focus on Indian sub-continent, J Med Virol
Mohn, Plitzko, Hamburger, A comprehensive metabolite profiling of Isatis tinctoria leaf extracts, Phytochemistry
Moore, June, Cytokine release syndrome in severe COVID-19, Science
Morinaka, Sakamoto, Inukai, Agetsuma, Kitano et al., Morphological alteration caused by brassinosteroid insensitivity increases the biomass and grain production of rice, Plant Physiol
Mu, Sheng, Wang, Amin, Li et al., Potential compound from herbal food of Rhizoma Polygonati for treatment of COVID-19 analyzed by network pharmacology: viral and cancer signaling mechanisms, J Funct Foods
Mudd, Minervina, Pogorelyy, Turner, Kim et al., SARS-CoV-2 mRNA vaccination elicits a robust and persistent T follicular helper cell response in humans, Cell
Muhammad, Ikram, Ullah, Rehman, Mo, Hesperetin, a citrus flavonoid, attenuates LPS-induced neuroinflammation, apoptosis and memory impairments by modulating TLR4/NF-κB signaling, Nutrients
Musarra-Pizzo, Pennisi, Ben-Amor, Mandalari, Sciortino, Antiviral activity exerted by natural products against human viruses, Viruses
Ngwa, Kumar, Thompson, Lyerly, Moore et al., Potential of flavonoid-inspired phytomedicines against COVID-19, Molecules
Nie, Sahoo, Herrmann, Ballauff, Netz et al., Charge matters: mutations in omicron variant favor binding to cells, ChemBio-Chem
Olennikov, Partilkhaev, Isolation and densitometric HPTLC analysis of rutin, narcissin, nicotiflorin, and isoquercitrin in Caragana spinosa shoots, JPC-J Planar Chromatogr Modern TLC
Olivar, Sy, Villanueva, Alejandro, Tan, Alkaloids as chemotaxonomic markers from the Philippine endemic Uncaria perrottetii and Uncaria lanosa f. Philippinensis, J King Saud Univ Sci
Omrani, Keshavarz, Ebrahimi, Mehrabi, Mcgaw et al., Potential natural products against respiratory viruses: a perspective to develop anti-COVID-19 medicines, Front Pharmacol
Omrani, Saad, Baig, Bahloul, Abdul-Matin et al., Ribavirin and interferon alfa-2a for severe Middle East respiratory syndrome coronavirus infection: a retrospective cohort study, Lancet Infect Dis
Organization, Classification of Omicron (B. 1.1. 529): SARS-CoV-2 variant of concern
Organization, Enhancing response to Omicron SARS-CoV-2 variant: Technical brief and priority actions for Member States
Organization, Methods for the detection and characterisation of SARS-CoV-2 variants: first update
Oso, Adeoye, Olaoye, Pharmacoinformatics and hypothetical studies on allicin, curcumin, and gingerol as potential candidates against COVID-19-associated proteases, J Biomol Struct Dyn
Parasher, COVID research: a year of scientific milestones, Nature
Park, Kang, Park, Hesperidin ameliorates hepatic ischemiareperfusion injury in Sprague-Dawley rats, Transplantation Proceedings
Pascarella, Ciccozzi, Bianchi, Benvenuto, Cauda et al., The electrostatic potential of the omicron variant spike is higher than in delta and delta-plus variants: a hint to higher transmissibility, J Med Virol
Pascarella, Ciccozzi, Zella, Bianchi, Benedetti et al., SARS-CoV-2 B. 1.617 Indian variants: Are electrostatic potential changes responsible for a higher transmission rate?, J Med Virol
Peacock, Goldhill, Zhou, Baillon, Frise et al., The furin cleavage site in the SARS-CoV-2 spike protein is required for transmission in ferrets, Nat Microbiol
Pinto, Park, Beltramello, Walls, Tortorici et al., Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody, Nature
Pisoschi, Pop, Iordache, Stanca, Geicu et al., Antioxidant, anti-inflammatory and immunomodulatory roles of vitamins in COVID-19 therapy, Eur J Med Chem
Pour, Fakhri, Asgary, Farzaei, Echeverría, The signaling pathways, and therapeutic targets of antiviral agents: focusing on the antiviral approaches and clinical perspectives of anthocyanins in the management of viral diseases, Front Pharmacol
Prakash, Elavarasan, Subashini, Kanaga, Dhandapani et al., Isolation of hesperetin-A flavonoid from Cordia sebestena flower extract through antioxidant assay guided method and its antibacterial, anticancer effect on cervical cancer via in vitro and in silico molecular docking studies, J Mol Struct
Pulliam, Van Schalkwyk, Govender, Gottberg, Cohen et al., Increased risk of SARS-CoV-2 reinfection associated with emergence of the Omicron variant in South Africa, MedRxiv
Quimque, Notarte, Fernandez, Mendoza, Liman et al., Virtual screeningdriven drug discovery of SARS-CoV2 enzyme inhibitors targeting viral attachment, replication, post-translational modification and host immunity evasion infection mechanisms, J Biomol Struct Dyn
Ren, Wang, Gao, Zhou, Omicron variant (B. 1.1. 529) of SARS-CoV-2: mutation, infectivity, transmission, and vaccine resistance, World J Clin Cases
Romano, Ruggiero, Squeglia, Maga, Berisio, A structural view of SARS-CoV-2 RNA replication machinery: RNA synthesis, proofreading and final capping, Cells
Sadraei, Asghari, Emami, Inhibitory effect of Rosa damascena Mill flower essential oil, geraniol and citronellol on rat ileum contraction, Res Pharm Sci
Saif, Vaccines for COVID-19: perspectives, prospects, and challenges based on candidate SARS, MERS, and animal coronavirus vaccines, Euro Med J
Salehi, Mashayekh, Taheri, Gholami, Motaghinejad et al., Curcumin can be acts as effective agent for prevent or treatment of alcohol-induced toxicity in hepatocytes: an illustrated mechanistic review, Iran J Pharm Res
Selim, Jaouni, Anticancer and apoptotic effects on cell proliferation of diosgenin isolated from Costus speciosus (Koen.) Sm, BMC Complement Altern Med
Sghaier, Mousslim, Pagano, Ammari, Luis et al., β-eudesmol, a sesquiterpene from Teucrium ramosissimum, inhibits superoxide production, proliferation, adhesion and migration of human tumor cell, Environ Toxicol Pharmacol
Shang, Hou, Long, Chemical composition of essential oil of Artemisia nanschanica Krasch. from Tibetan plateau, Ind Crops Prod
Shanmugaraj, Malla, Khorattanakulchai, Phoolcharoen, SARS-CoV-2 omicron variant: Could it be another threat?, J Med Virol
Sharma, Gautam, Sharma, Singh, Sharma et al., Clinico epidemiological profile of Omicron variant of SARS CoV2 in Rajasthan, medRxiv
Shengqiang, Jizhong, Gang, Lou, Purification of rutin and nicotiflorin from the flowers of Edgeworthia chrysantha Lindl. by high-speed counter-current chromatography, J Chromatogr Sci
Shirole, Shirole, Saraf, In vitro relaxant and spasmolytic effects of essential oil of Pistacia integerrima Stewart ex Brandis Galls, J Ethnopharmacol
Sotto, Giacomo, Amatore, Locatelli, Vitalone et al., A polyphenol rich extract from Solanum melongena L. DR2 peel exhibits antioxidant properties and anti-herpes simplex virus type 1 activity in vitro, Molecules
Souza, Vasconcelos, Prado, Pereira, Zinc, vitamin D and vitamin C: perspectives for COVID-19 with a focus on physical tissue barrier integrity, Front Nutr
Srinivasan, Natarajan, Shivakumar, Nagamurugan, Isolation of Fisetin from Elaeagnus indica Serv. Bull.(Elaeagnaceae) with antioxidant and antiproliferative activity, Free Radic Antioxid
Stasi, Fallani, Voller, Silvestri, Treatment for COVID-19: an overview, Eur J Pharmacol
Swaminathan, Dyason, Maggioni, Von Itzstein, Downard, Binding of a natural anthocyanin inhibitor to influenza neuraminidase by mass spectrometry, Anal Bioanal Chem
Syah, Ghisalberti, Phenolic derivatives with an irregular sesquiterpenyl side chain from Macaranga pruinosa, Nat prod Commun
Tachikawa, Takahashi, Kashimoto, Effects of extract and ingredients isolated from Magnolia obovata thunberg on catecholamine secretion from bovine adrenal chromaffin cells, Biochem Pharmacol
Takeda, Murata, Jamsransuren, Suganuma, Kazami et al., Saxifraga spinulosa-derived components rapidly inactivate multiple viruses including SARS-CoV-2, Viruses
Tam, Thien, Sung, Hoang Anh, Thuy et al., Evaluation of ursolic acid as the main component isolated from Catharanthus roseus against hyperglycemia, Int Lett Nat Sci
Tao, Huang, Zheng, Xu, Case of professor Xu ZOU's acupuncture technique for "benefiting kidney and strengthening anti-pathogenic qi" in promoting the absorption of COVID-19, World J Acupunct Moxib
Thurzo, Bražinová, Markovská, Waczulíková, Smatana et al., Dentistry after Omicron variant: introducing a new biosafety protocol in prevention of COVID-19 in Dental Care
Toledano, Moreno-Fernandez, Juarez, Ochoa, Diaz-Castro, Implications of Vitamins in COVID-19 prevention and treatment through immunomodulatory and anti-oxidative mechanisms, Antioxidants
Torjesen, Covid-19: Omicron may be more transmissible than other variants and partly resistant to existing vaccines, scientists fear, Br Med J Publ Group
Vanblargan, Errico, Halfmann, Zost, Crowe et al., An infectious SARS-CoV-2 B. 1.1. 529 Omicron virus escapes neutralization by therapeutic monoclonal antibodies, Nat Med
Veeramani, Alsaif, Ks, Herbacetin, a flaxseed flavonoid, ameliorates high percent dietary fat induced insulin resistance and lipid accumulation through the regulation of hepatic lipid metabolizing and lipid-regulating enzymes, Chem Biol Interact
Velásquez, Vaccines, medicines and COVID-19: How can WHO be given a stronger voice
Vijayakumar, Ramesh, Joji, Kannan, In silico pharmacokinetic and molecular docking studies of natural flavonoids and synthetic indole chalcones against essential proteins of SARS-CoV-2, Eur J Pharmacol
Vivek-Ananth, Rajan, Biswal, Samal, In silico identification of potential natural product inhibitors of human proteases key to SARS-CoV-2 infection, Molecules
Vázquez-Calvo, De Oya, Martín-Acebes, Garcia-Moruno, Saiz, Antiviral properties of the natural polyphenols delphinidin and epigallocatechin gallate against the flaviviruses West Nile virus, Zika virus, and dengue virus, Front Microbiol
Wagener, Pickkers, Peterson, Immenschuh, Abraham, Targeting the heme-heme oxygenase system to prevent severe complications following COVID-19 infections, Antioxidants
Wallace, Bailey, Blumberg, Burton-Freeman, Co et al., Fruits, vegetables, and health: a comprehensive narrative, umbrella review of the science and recommendations for enhanced public policy to improve intake, Crit Rev Food Sci Nutr
Wan, Shang, Graham, Baric, Li et al., Receptor recognition by the novel coronavirus from Wuhan: an analysis based on decade-long structural studies of SARS coronavirus, J Virol
Wang, Cheng, Sequence analysis of the emerging Sars-CoV-2 Variant Omicron in South Africa, J Med Virol
Wang, Wang, Yuan, Zhao, Simultaneous analysis of diosgenin and sarsasapogenin in Asparagus officinalis byproduct by thin-layer chromatography, Phytochem Anal
Wasilewicz, Kirchweger, Bojkova, Saad, Langeder et al., Identification of Natural Products Inhibiting SARS-CoV-2 by Targeting Viral Proteases: A Combined in Silico and in Vitro Approach, J Nat Prod
Wei, Wang, Wu, -Q, Lu et al., In silico screening of potential spike glycoprotein inhibitors of SARS-CoV-2 with drug repurposing strategy, Chin J Integr Med
Williamson, Walker, Bhaskaran, Bacon, Bates et al., OpenSAFELY: factors associated with COVID-19 death in 17 million patients, Nature
Wrapp, Wang, Corbett, Goldsmith, Hsieh et al., Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation, Science
Wu, Liu, Yang, Zhang, Zhong et al., Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods, Acta Pharm Sin B
Wu, Tackle the free radicals damage in COVID-19, Nitric Oxide
Wu, Zhao, Haytowitz, Chen, Pehrsson, Effects of domestic cooking on flavonoids in broccoli and calculation of retention factors, Heliyon
Wu, Zhou, Mo, Li, Han et al., The effect of the multiple mutations in Omicron RBD on its binding to human ACE2 receptor and immune evasion: an investigation of molecular dynamics simulations
Yan, Tong, Chu, Sheng, Chen, Preparative isolation and purification of syringin and edgeworoside C from Edgeworthia chrysantha Lindl by high-speed counter-current chromatography, J Chromatogr A
Yang, Chen, Kumar, Yu, Chao et al., Antioxidant and anti-inflammatory potential of hesperetin metabolites obtained from hesperetin-administered rat serum: an ex vivo approach, J Agric Food Chem
Yang, Chen, Li, Zhu, -Y et al., D-limonene is a potential monoterpene to inhibit PI3K/ Akt/IKK-α/NF-κB p65 signaling pathway in coronavirus disease 2019 pulmonary fibrosis, Front Med
Yang, Patel, Blunden, Turner, Mj et al., Crabbine, an aporphine alkaloid from Corydalis lutea, Phytochemistry
Yepes-Pérez, Herrera-Calderon, Sánchez-Aparicio, Tiessler-Sala, Maréchal et al., Investigating potential inhibitory effect of uncaria tomentosa (cat's claw) against the main protease 3CLpro of SARS-CoV-2 by molecular modeling, Evid-Based Complement Altern Med
Yoo, Nam, Kim, Choi, Park, Pectolinarin and pectolinarigenin of Cirsium setidens prevent the hepatic injury in rats caused by D-galactosamine via an antioxidant mechanism, Biol Pharm Bull
Yu, Chen, Lan, Shen, Li, Computational screening of antagonists against the SARS-CoV-2 (COVID-19) coronavirus by molecular docking, Int J Antimicrob Agents
Zhang, Zhang, Li, Xiong, Xiao et al., Gemcitabine, lycorine and oxysophoridine inhibit novel coronavirus (SARS-CoV-2) in cell culture, Emerg Microbes Infect
Zhao, Lu, Peng, Chen, Meng et al., SARS-CoV-2 Omicron variant shows less efficient replication and fusion activity when compared with delta variant in TMPRSS2-expressed cells, Emerg Microbes Infect
Zhao, Zhang, You, Liu, Xu et al., Hepatoprotective effects of nicotiflorin from Nymphaea candida against concanavalin a-induced and d-galactosamine-induced liver injury in mice, Int J Mol Sci
Zheng, Baak, Li, Ren, Yang et al., Network pharmacology analysis of the therapeutic mechanisms of the traditional Chinese herbal formula Lian Hua Qing Wen in Corona virus disease 2019 (COVID-19), gives fundamental support to the clinical use of LHQW, Phytomedicine
Zhou, Gupta, Aggarwal, Aneja, Chandra et al., Brominated derivatives of noscapine are potent microtubule-interfering agents that perturb mitosis and inhibit cell proliferation, Mol Pharmacol
Zhou, Liu, Yang, Characterization of terpene synthase from tea green leafhopper being involved in formation of geraniol in tea (Camellia sinensis) leaves and potential effect of geraniol on insect-derived endobacteria, Biomolecules
Zomborszki, Kúsz, Csupor, Peschel, Rhodiosin and herbacetin in Rhodiola rosea preparations: additional markers for quality control?, Pharm Biol
Čerňáková, Košťálová, Antimicrobial activity of berberine-a constituent of Mahonia aquifolium, Folia Microbiol
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