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All Studies   Meta Analysis    Recent:   

In vitro inhibitory effect of Nigella sativa L. extracts on SARS-COV-2 spike protein-ACE2 interaction

Ali et al., Current Therapeutic Research, doi:10.1016/j.curtheres.2024.100759
Aug 2024  
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12th treatment shown to reduce risk in January 2021
 
*, now with p = 0.00016 from 14 studies.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,800+ studies for 95 treatments. c19early.org
In Vitro study showing nigella sativa extracts inhibit the interaction between the S1 subunit of the SARS-CoV-2 spike protein and ACE2 in a dose-dependent manner, with chloroform extract having the highest inhibition of 98.9% at 10 mg/ml. The higher effectiveness of the chloroform extract may be due to the presence of non-polar phytochemicals such as thymoquinone, thymohydroquinone, and nigellidine.
21 preclinical studies support the efficacy of nigella sativa for COVID-19:
Ali et al., 31 Aug 2024, peer-reviewed, 12 authors. Contact: rajan.radhakrishnan@mbru.ac.ae (corresponding author).
In Vitro studies are an important part of preclinical research, however results may be very different in vivo.
This PaperNigella SativaAll
In vitro inhibitory effect of Nigella sativa L. extracts on SARS-COV-2 spike protein-ACE2 interaction.
Najma Ali, Asha Caroline Cyril, Cijo George Vazhappilly, Reem Kais Jan, Haneen Aburamadan, Fatemeh Akbarpoor, S M Shariar Islam, Fazilatun Nessa, Yosra Lozon, Noushad Karuvantevida, Rajan Radhakrishnan
Current Therapeutic Research, doi:10.1016/j.curtheres.2024.100759
for the authentication of NS seeds
Author contribution Conceptualization Conflicts of Interest The authors declare that there is no conflict of interest.
References
Ahmad, Abbasi, Shahid, Gul, Abbasi, Molecular docking, simulation and MM-PBSA studies of nigella sativa compounds: a computational quest to identify potential natural antiviral for COVID-19 treatment, Journal of Biomolecular Structure and Dynamics, doi:10.1080/07391102.2020.1775129
Ali, Vijayan, Dynamics of the ACE2-SARS-CoV-2/SARS-CoV spike protein interface reveal unique mechanisms, Scientific Reports, doi:10.1038/s41598-020-71188-3
Arokiaraj, Menesson, Rose and In-vitro Inhibition of SARS-CoV-2 spike: ACE-2 Interaction, SSRN Electronic Journal, doi:10.2139/ssrn.3612898
Ashraf, Ashraf, Akmal, Ashraf, Kalsoom et al., Prophylactic potential of honey and Nigella sativa L. against hospital and community-based SARS-CoV-2 spread: a structured summary of a study protocol for a randomised controlled trial, Trials, doi:10.1186/s13063-021-05510-3
Duru, Duru, Adegboyega, In silico identification of compounds from Nigella sativa seed oil as potential inhibitors of SARS-CoV-2 targets, Bulletin of the National Research Centre, doi:10.1186/s42269-021-00517-x
Gonfa, Temesgen, Erba, Mengesha, Sivasubramanian, Phytochemicals Analysis, In Vitro Antibacterial Activities of Extracts, and Molecular Docking Studies of the Isolated Compounds from Melhania zavattarii Cufod Leaves, Journal of Tropical Medicine, doi:10.1155/2023/8820543
Imran, Khan, Abida, Alshammari, Alkhaldi et al., Nigella sativa L. and COVID-19: A Glance at The Anti-COVID-19 Chemical Constituents, Clinical Trials, Inventions, and Patent Literature, doi:10.3390/molecules27092750
Jackson, Farzan, Chen, Choe, Mechanisms of SARS-CoV-2 entry into cells, Molecular Cell Biology, doi:10.1038/s41580-021-00418-x
Khazdair, Ghafari, Sadeghi, Possible therapeutic effects of Nigella sativa and its thymoquinone on COVID-19, Pharmaceutical Biology, doi:10.1080/13880209.2021.1931353
Koshak, Koshak, Mobeireek, Badawi, Wali et al., Nigella sativa for the treatment of COVID-19: An open-label randomized controlled clinical trial, Complementary Therapies in Medicine, doi:10.1016/j.ctim.2021.102769
Letko, Marzi, Munster, Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses, Nature Microbiology, doi:10.1038/s41564-020-0688-y
Li, Dietary phytochemicals against COVID-19: A focus on thymoquinone, EFood, doi:10.1002/efd2
Lin, Cherukupalli, Feng, Gao, Kang et al., SARS-CoV-2 Entry Inhibitors Targeting Virus-ACE2 or Virus-TMPRSS2 Interactions, Current Medicinal Chemistry, doi:10.2174/0929867328666210420103021
Maiti, Banerjee, Kanwar, In silico Nigellidine (N. sativa) bind to viral spike/active-sites of ACE1/2, AT1/2 to prevent COVID-19 induced vaso-tumult/vasculardamage/comorbidity, Vascular Pharmacology, doi:10.1016/j.vph.2021.106856
Nugraha, Ridwansyah, Ghozali, Khairani, Atik, Traditional Herbal Medicine Candidates as Complementary Treatments for COVID-19: A Review of Their Mechanisms, Pros and Cons, Evidence-Based Complementary and Alternative Medicine, doi:10.1155/2020/2560645
Tagarro, Cobos-Carrascosa, Villaverde, Sanz-Santaeufemia, Grasa et al., Clinical spectrum of COVID-19 and risk factors associated with severity in Spanish children, European Journal of Pediatrics, doi:10.1007/s00431-021-04306-6
Tito, Colantuono, Pirone, Pedone, Intartaglia et al., Pomegranate Peel Extract as an Inhibitor of SARS-CoV-2 Spike Binding to Human ACE2 Receptor (in vitro): A Promising Source of Novel Antiviral Drugs, Frontiers in Chemistry, doi:10.3389/fchem.2021.638187
Xu, Liu, Xiao, Zhou, Ge et al., Computational and Experimental Studies Reveal That Thymoquinone Blocks the Entry of Coronaviruses Into In Vitro Cells, Infectious Diseases and Therapy, doi:10.1007/s40121-021-00400-2
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