Analgesics
Antiandrogens
Antihistamines
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
PPIs
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Abstract
All nigella sativa studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19early.org COVID-19 treatment researchNigella SativaNigella Sativa (more..)
Melatonin Meta
Metformin Meta
Antihistamines Meta
Azvudine Meta Molnupiravir Meta
Bromhexine Meta
Budesonide Meta
Colchicine Meta Nigella Sativa Meta
Conv. Plasma Meta Nitazoxanide Meta
Curcumin Meta PPIs Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   

Nigella sativa, Anthemis hyaline and Citrus sinensis extracts reduce SARS-CoV-2 replication by fluctuating Rho GTPase, PI3K-AKT, and MAPK/ERK pathways in HeLa-CEACAM1a cells

Bostancıklıoğlu et al., Gene, doi:10.1016/j.gene.2024.148366
Mar 2024  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
12th treatment shown to reduce risk in January 2021
 
*, now with p = 0.00016 from 14 studies.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,500+ studies for 81 treatments. c19early.org
In Vitro study showing that nigella sativa, anthemis hyaline, and citrus sinensis extracts reduce SARS-CoV-2 replication in HeLa-CEACAM1a cells. Nigella sativa extract notably increased IL-8 levels, indicating its potential role in modulating inflammatory responses during SARS-CoV-2 infection. Authors found that anthemis hyaline extract showed the most significant reduction in viral load.
20 preclinical studies support the efficacy of nigella sativa for COVID-19:
Bostancıklıoğlu et al., 14 Mar 2024, peer-reviewed, 3 authors.
In Vitro studies are an important part of preclinical research, however results may be very different in vivo.
This PaperNigella SativaAll
{ 'indexed': {'date-parts': [[2024, 3, 16]], 'date-time': '2024-03-16T00:38:26Z', 'timestamp': 1710549506073}, 'reference-count': 44, 'publisher': 'Elsevier BV', 'license': [ { 'start': { 'date-parts': [[2024, 6, 1]], 'date-time': '2024-06-01T00:00:00Z', 'timestamp': 1717200000000}, 'content-version': 'tdm', 'delay-in-days': 0, 'URL': 'https://www.elsevier.com/tdm/userlicense/1.0/'}, { 'start': { 'date-parts': [[2024, 6, 1]], 'date-time': '2024-06-01T00:00:00Z', 'timestamp': 1717200000000}, 'content-version': 'stm-asf', 'delay-in-days': 0, 'URL': 'https://doi.org/10.15223/policy-017'}, { 'start': { 'date-parts': [[2024, 6, 1]], 'date-time': '2024-06-01T00:00:00Z', 'timestamp': 1717200000000}, 'content-version': 'stm-asf', 'delay-in-days': 0, 'URL': 'https://doi.org/10.15223/policy-037'}, { 'start': { 'date-parts': [[2024, 6, 1]], 'date-time': '2024-06-01T00:00:00Z', 'timestamp': 1717200000000}, 'content-version': 'stm-asf', 'delay-in-days': 0, 'URL': 'https://doi.org/10.15223/policy-012'}, { 'start': { 'date-parts': [[2024, 6, 1]], 'date-time': '2024-06-01T00:00:00Z', 'timestamp': 1717200000000}, 'content-version': 'stm-asf', 'delay-in-days': 0, 'URL': 'https://doi.org/10.15223/policy-029'}, { 'start': { 'date-parts': [[2024, 6, 1]], 'date-time': '2024-06-01T00:00:00Z', 'timestamp': 1717200000000}, 'content-version': 'stm-asf', 'delay-in-days': 0, 'URL': 'https://doi.org/10.15223/policy-004'}], 'content-domain': {'domain': ['elsevier.com', 'sciencedirect.com'], 'crossmark-restriction': True}, 'published-print': {'date-parts': [[2024, 6]]}, 'DOI': '10.1016/j.gene.2024.148366', 'type': 'journal-article', 'created': {'date-parts': [[2024, 3, 12]], 'date-time': '2024-03-12T16:28:54Z', 'timestamp': 1710260934000}, 'page': '148366', 'update-policy': 'http://dx.doi.org/10.1016/elsevier_cm_policy', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Nigella sativa, Anthemis hyaline and Citrus sinensis extracts reduce SARS-CoV-2 replication by ' 'fluctuating Rho GTPase, PI3K-AKT, and MAPK/ERK pathways in HeLa-CEACAM1a cells', 'prefix': '10.1016', 'volume': '911', 'author': [ {'given': 'Mehmet', 'family': 'Bostancıklıoğlu', 'sequence': 'first', 'affiliation': []}, {'given': 'Mehri', 'family': 'İğci', 'sequence': 'additional', 'affiliation': []}, {'given': 'Mustafa', 'family': 'Ulaşlı', 'sequence': 'additional', 'affiliation': []}], 'member': '78', 'reference': [ { 'issue': '2', 'key': '10.1016/j.gene.2024.148366_b0005', 'doi-asserted-by': 'crossref', 'first-page': '199', 'DOI': '10.1515/jbcpp-2013-0027', 'article-title': 'Anticholinesterase and antioxidative properties of water-extractable ' 'phytochemicals from some citrus peels', 'volume': '25', 'author': 'Ademosun', 'year': '2014', 'journal-title': 'J. Basic Clin. Physiol. Pharmacol.'}, { 'issue': '2', 'key': '10.1016/j.gene.2024.148366_b0010', 'article-title': 'Herbal medicine and pattern identification for treating COVID-19: a ' 'rapid review of guidelines', 'volume': '9', 'author': 'Ang', 'year': '2020', 'journal-title': 'Integrat. Med. Res.'}, { 'issue': '6', 'key': '10.1016/j.gene.2024.148366_b0015', 'doi-asserted-by': 'crossref', 'first-page': 'e0251649', 'DOI': '10.1371/journal.pone.0251649', 'article-title': 'Identification and evaluation of the inhibitory effect of Prunella ' 'vulgaris extract on SARS-coronavirus 2 virus entry', 'volume': '16', 'author': 'Ao', 'year': '2021', 'journal-title': 'PLoS One'}, { 'issue': '2', 'key': '10.1016/j.gene.2024.148366_b0020', 'doi-asserted-by': 'crossref', 'first-page': '222', 'DOI': '10.1248/cpb.54.222', 'article-title': 'The essential oil constituents and antimicrobial activity of Anthemis ' 'aciphylla BOISS. var. discoidea BOISS', 'volume': '54', 'author': 'Baser', 'year': '2006', 'journal-title': 'Chem. Pharm. Bull.'}, { 'issue': '4', 'key': '10.1016/j.gene.2024.148366_b0025', 'doi-asserted-by': 'crossref', 'first-page': '873', 'DOI': '10.1007/s40618-020-01325-2', 'article-title': 'Systemic steroids in patients with COVID-19: pros and contras, an ' 'endocrinological point of view', 'volume': '44', 'author': 'Berton', 'year': '2021', 'journal-title': 'J. Endocrinol. Investigat.'}, { 'issue': '5', 'key': '10.1016/j.gene.2024.148366_b0030', 'doi-asserted-by': 'crossref', 'first-page': '1036', 'DOI': '10.1016/j.cell.2020.04.026', 'article-title': 'Imbalanced host response to SARS-CoV-2 drives development of COVID-19', 'volume': '181', 'author': 'Blanco-Melo', 'year': '2020', 'journal-title': 'Cell'}, { 'key': '10.1016/j.gene.2024.148366_b0035', 'doi-asserted-by': 'crossref', 'article-title': 'Protective effectiveness of previous SARS-CoV-2 infection and hybrid ' 'immunity against the omicron variant and severe disease: a systematic ' 'review and meta-regression', 'author': 'Bobrovitz', 'year': '2023', 'journal-title': 'Lancet Infect. Dis.', 'DOI': '10.1016/S1473-3099(22)00801-5'}, { 'issue': '5', 'key': '10.1016/j.gene.2024.148366_b0040', 'doi-asserted-by': 'crossref', 'first-page': 'e1003987', 'DOI': '10.1371/journal.pmed.1003987', 'article-title': 'Occurrence and transmission potential of asymptomatic and ' 'presymptomatic SARS-CoV-2 infections: update of a living systematic ' 'review and meta-analysis', 'volume': '19', 'author': 'Buitrago-Garcia', 'year': '2022', 'journal-title': 'PLoS Medicine'}, { 'issue': '3', 'key': '10.1016/j.gene.2024.148366_b0045', 'doi-asserted-by': 'crossref', 'first-page': '229', 'DOI': '10.1056/NEJMoa2029849', 'article-title': 'SARS-CoV-2 neutralizing antibody LY-CoV555 in outpatients with Covid-19', 'volume': '384', 'author': 'Chen', 'year': '2021', 'journal-title': 'New Engl. J. Med.'}, { 'issue': '7', 'key': '10.1016/j.gene.2024.148366_b0050', 'doi-asserted-by': 'crossref', 'first-page': '1340', 'DOI': '10.3390/antiox12071340', 'article-title': 'The Immunomodulatory Effect of Nigella sativa', 'volume': '12', 'author': 'Ciesielska-Figlon', 'year': '2023', 'journal-title': 'Antioxidants'}, { 'issue': '8', 'key': '10.1016/j.gene.2024.148366_b0055', 'doi-asserted-by': 'crossref', 'first-page': 'e0255644', 'DOI': '10.1371/journal.pone.0255644', 'article-title': 'Impact of early corticosteroids on 60-day mortality in critically ill ' 'patients with COVID-19: A multicenter cohort study of the OUTCOMEREA ' 'network', 'volume': '16', 'author': 'Dupuis', 'year': '2021', 'journal-title': 'PLoS One'}, { 'issue': '7816', 'key': '10.1016/j.gene.2024.148366_b0060', 'doi-asserted-by': 'crossref', 'first-page': '459', 'DOI': '10.1038/s41586-020-2286-9', 'article-title': 'A SARS-CoV-2 protein interaction map reveals targets for drug ' 'repurposing', 'volume': '583', 'author': 'Gordon', 'year': '2020', 'journal-title': 'Nature'}, { 'issue': '1', 'key': '10.1016/j.gene.2024.148366_b0065', 'doi-asserted-by': 'crossref', 'first-page': '56', 'DOI': '10.1078/0944-7113-00376', 'article-title': 'Anticonvulsant effects of thymoquinone, the major constituent of ' 'Nigella sativa seeds, in mice', 'volume': '11', 'author': 'Hosseinzadeh', 'year': '2004', 'journal-title': 'Phytomedicine'}, { 'issue': '23', 'key': '10.1016/j.gene.2024.148366_b0070', 'first-page': '2365', 'article-title': 'Emergency use authorization of remdesivir: the need for a transparent ' 'distribution process', 'volume': '323', 'author': 'Ison', 'year': '2020', 'journal-title': 'JAMA'}, { 'issue': '5', 'key': '10.1016/j.gene.2024.148366_b0075', 'doi-asserted-by': 'crossref', 'first-page': '557', 'DOI': '10.1038/s41562-021-01096-7', 'article-title': 'Socioeconomic impacts of COVID-19 in low-income countries', 'volume': '5', 'author': 'Josephson', 'year': '2021', 'journal-title': 'Nat. Human Behav.'}, { 'issue': '4', 'key': '10.1016/j.gene.2024.148366_b0080', 'doi-asserted-by': 'crossref', 'first-page': '193', 'DOI': '10.1191/0960327103ht349oa', 'article-title': 'Nigella sativa (black cumin) ameliorates potassium bromate-induced ' 'early events of carcinogenesis: diminution of oxidative stress', 'volume': '22', 'author': 'Khan', 'year': '2003', 'journal-title': 'Hum. Exp. Toxicol.'}, { 'key': '10.1016/j.gene.2024.148366_b0085', 'doi-asserted-by': 'crossref', 'first-page': '1929', 'DOI': '10.1007/s00436-011-2719-3', 'article-title': 'Insecticidal evaluation of essential oils of Citrus sinensis L. ' '(Myrtales: Myrtaceae) against housefly, Musca domestica L. (Diptera: ' 'Muscidae)', 'volume': '110', 'author': 'Kumar', 'year': '2012', 'journal-title': 'Parasitol. Res.'}, { 'issue': '2', 'key': '10.1016/j.gene.2024.148366_b0090', 'doi-asserted-by': 'crossref', 'first-page': '62', 'DOI': '10.3831/KPI.2020.23.010', 'article-title': 'Prophetic medicine-Nigella Sativa (Black cumin seeds)–potential herb ' 'for COVID-19?', 'volume': '23', 'author': 'Maideen', 'year': '2020', 'journal-title': 'J. Pharmacopuncture'}, { 'issue': '8', 'key': '10.1016/j.gene.2024.148366_b0095', 'doi-asserted-by': 'crossref', 'first-page': '918', 'DOI': '10.1111/acem.14322', 'article-title': 'Myopericarditis in a previously healthy adolescent male following ' 'COVID-19 vaccination: a case report', 'volume': '28', 'author': 'McLean', 'year': '2021', 'journal-title': 'Acad. Emerg. Med.'}, { 'issue': '5', 'key': '10.1016/j.gene.2024.148366_b0100', 'doi-asserted-by': 'crossref', 'first-page': '549', 'DOI': '10.3390/pr8050549', 'article-title': 'Review of evidence available on hesperidin-rich products as potential ' 'tools against COVID-19 and hydrodynamic cavitation-based extraction as ' 'a method of increasing their production', 'volume': '8', 'author': 'Meneguzzo', 'year': '2020', 'journal-title': 'Processes'}, { 'key': '10.1016/j.gene.2024.148366_b0105', 'series-title': 'Evidence-Based Complementary and Alternative Medicine', 'article-title': 'Historical perspective of traditional indigenous medical practices: the ' 'current renaissance and conservation of herbal resources', 'author': 'Pan', 'year': '2014'}, { 'issue': '4', 'key': '10.1016/j.gene.2024.148366_b0110', 'doi-asserted-by': 'crossref', 'first-page': 'e127', 'DOI': '10.1016/j.jaad.2011.06.030', 'article-title': 'Common complementary and alternative therapies with potential use in ' 'dermatologic surgery: risks and benefits', 'volume': '68', 'author': 'Reddy', 'year': '2013', 'journal-title': 'J. Am. Acad. Dermatol.'}, { 'issue': '2', 'key': '10.1016/j.gene.2024.148366_b0115', 'doi-asserted-by': 'crossref', 'first-page': '167', 'DOI': '10.1038/nrm1587', 'article-title': 'GEF means go: turning on RHO GTPases with guanine nucleotide-exchange ' 'factors', 'volume': '6', 'author': 'Rossman', 'year': '2005', 'journal-title': 'Nat. Rev. Mol. Cell Biol.'}, { 'issue': '4', 'key': '10.1016/j.gene.2024.148366_b0120', 'doi-asserted-by': 'crossref', 'first-page': '472', 'DOI': '10.1080/0972060X.2011.10643603', 'article-title': 'Composition of the essential oils of Anthemis Hyalina DC., Achillea ' 'Nobilis L. and Cichorium intybus L. Three asteraceae herbs growing wild ' 'in Iran', 'volume': '14', 'author': 'Rustaiyan', 'year': '2011', 'journal-title': 'J. Essential Oil Bearing Plants'}, { 'issue': '3', 'key': '10.1016/j.gene.2024.148366_b0125', 'doi-asserted-by': 'crossref', 'first-page': '68', 'DOI': '10.5897/JPP2021.0603', 'article-title': 'Medicinal plant-derived compounds as potential phytotherapy ' 'forCOVID-19: Future perspectives', 'volume': '13', 'author': 'Salama', 'year': '2021', 'journal-title': 'J. Pharmacognosy Phytotherapy'}, { 'issue': '9', 'key': '10.1016/j.gene.2024.148366_b0130', 'doi-asserted-by': 'crossref', 'first-page': '729', 'DOI': '10.1016/S0192-0561(00)00036-9', 'article-title': 'Protective effect of black seed oil from Nigella sativa against murine ' 'cytomegalovirus infection', 'volume': '22', 'author': 'Salem', 'year': '2000', 'journal-title': 'Int. J. Immunopharmacol.'}, { 'issue': '4', 'key': '10.1016/j.gene.2024.148366_b0135', 'doi-asserted-by': 'crossref', 'first-page': '861', 'DOI': '10.1016/j.cell.2021.01.007', 'article-title': 'Adaptive immunity to SARS-CoV-2 and COVID-19', 'volume': '184', 'author': 'Sette', 'year': '2021', 'journal-title': 'Cell'}, { 'issue': '11', 'key': '10.1016/j.gene.2024.148366_b0140', 'doi-asserted-by': 'crossref', 'DOI': '10.1615/IntJMedMushrooms.2021040415', 'article-title': 'Antioxidant, antimicrobial, and antiproliferative activities of wild ' 'mushroom, Laeticutis cristata (Agaricomycetes), from Turkey', 'volume': '23', 'author': 'Sevindik', 'year': '2021', 'journal-title': 'Int. J. Med. Mushrooms'}, { 'issue': '10', 'key': '10.1016/j.gene.2024.148366_b0145', 'doi-asserted-by': 'crossref', 'first-page': '1475', 'DOI': '10.1002/ptr.5880', 'article-title': 'Plants of the Melaleuca genus as antimicrobial agents: From farm to ' 'pharmacy', 'volume': '31', 'author': 'Sharifi-Rad', 'year': '2017', 'journal-title': 'Phytotherapy Research'}, { 'key': '10.1016/j.gene.2024.148366_b0150', 'doi-asserted-by': 'crossref', 'DOI': '10.3389/fimmu.2020.585354', 'article-title': 'A review of the progress and challenges of developing a vaccine for ' 'COVID-19', 'volume': '11', 'author': 'Sharma', 'year': '2020', 'journal-title': 'Front. Immunol.'}, { 'issue': '1', 'key': '10.1016/j.gene.2024.148366_b0155', 'first-page': '1', 'article-title': 'A review on novel coronavirus (Covid-19): symptoms, transmission and ' 'diagnosis tests', 'volume': '2', 'author': 'Sheikhi', 'year': '2020', 'journal-title': 'Res. Infect. Diseases Trop. Med.'}, { 'issue': '1', 'key': '10.1016/j.gene.2024.148366_b0160', 'doi-asserted-by': 'crossref', 'DOI': '10.1183/13993003.00956-2021', 'article-title': 'Vaccination against COVID-19: insight from arterial and venous ' 'thrombosis occurrence using data from VigiBase', 'volume': '58', 'author': 'Smadja', 'year': '2021', 'journal-title': 'Eur. Respirat. J.'}, { 'key': '10.1016/j.gene.2024.148366_b0165', 'doi-asserted-by': 'crossref', 'first-page': '97', 'DOI': '10.1007/s12560-013-9106-4', 'article-title': 'Naturally occurring flavonoids against human norovirus surrogates', 'volume': '5', 'author': 'Su', 'year': '2013', 'journal-title': 'Food Environ. Virol.'}, { 'issue': '14', 'key': '10.1016/j.gene.2024.148366_b0170', 'doi-asserted-by': 'crossref', 'first-page': '8312', 'DOI': '10.1021/acsomega.0c00772', 'article-title': 'Investigation into SARS-CoV-2 resistance of compounds in garlic ' 'essential oil', 'volume': '5', 'author': 'Thuy', 'year': '2020', 'journal-title': 'ACS Omega'}, { 'issue': '6', 'key': '10.1016/j.gene.2024.148366_b0175', 'doi-asserted-by': 'crossref', 'first-page': '844', 'DOI': '10.1111/j.1462-5822.2010.01437.x', 'article-title': 'Qualitative and quantitative ultrastructural analysis of the membrane ' 'rearrangements induced by coronavirus', 'volume': '12', 'author': 'Ulasli', 'year': '2010', 'journal-title': 'Cell. Microbiol.'}, { 'issue': '10327', 'key': '10.1016/j.gene.2024.148366_b0180', 'doi-asserted-by': 'crossref', 'first-page': '779', 'DOI': '10.1016/S0140-6736(22)00372-5', 'article-title': 'The global COVID-19 treatment divide', 'volume': '399', 'author': 'Usher', 'year': '2022', 'journal-title': 'Lancet'}, { 'key': '10.1016/j.gene.2024.148366_b0185', 'doi-asserted-by': 'crossref', 'first-page': '1', 'DOI': '10.1186/s13054-020-03400-9', 'article-title': 'Corticosteroid use in COVID-19 patients: a systematic review and ' 'meta-analysis on clinical outcomes', 'volume': '24', 'author': 'Van Paassen', 'year': '2020', 'journal-title': 'Crit. Care'}, { 'issue': '3', 'key': '10.1016/j.gene.2024.148366_b0190', 'doi-asserted-by': 'crossref', 'first-page': '1250', 'DOI': '10.1128/JVI.80.3.1250-1260.2006', 'article-title': 'Redirecting coronavirus to a nonnative receptor through a virus-encoded ' 'targeting adapter', 'volume': '80', 'author': 'Verheije', 'year': '2006', 'journal-title': 'J. Virol.'}, { 'issue': '6', 'key': '10.1016/j.gene.2024.148366_b0195', 'doi-asserted-by': 'crossref', 'first-page': 'e1000088', 'DOI': '10.1371/journal.ppat.1000088', 'article-title': 'Mouse hepatitis coronavirus RNA replication depends on GBF1-mediated ' 'ARF1 activation', 'volume': '4', 'author': 'Verheije', 'year': '2008', 'journal-title': 'PLoS Pathogens'}, { 'key': '10.1016/j.gene.2024.148366_b0200', 'first-page': '3763', 'article-title': 'Clinical efficacy of Lianhua Qingwen integrated with Western medicine ' 'on COVID-19 by Meta-analysis', 'author': 'Wang', 'year': '2020', 'journal-title': 'Chin. Tradit. Herb. Drug'}, { 'issue': '4', 'key': '10.1016/j.gene.2024.148366_b0205', 'doi-asserted-by': 'crossref', 'first-page': 'e0249481', 'DOI': '10.1371/journal.pone.0249481', 'article-title': 'The proportion and effect of corticosteroid therapy in patients with ' 'COVID-19 infection: a systematic review and meta-analysis', 'volume': '16', 'author': 'Wang', 'year': '2021', 'journal-title': 'PLoS One'}, { 'key': '10.1016/j.gene.2024.148366_b0210', 'unstructured': 'Worldometer Coronavirus. 26 Oct 2023]; Available from: ' 'https://www.worldometers.info/coronavirus/.'}, { 'key': '10.1016/j.gene.2024.148366_b0215', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.clim.2020.108393', 'article-title': 'The use of anti-inflammatory drugs in the treatment of people with ' 'severe coronavirus disease 2019 (COVID-19): The Perspectives of ' 'clinical immunologists from China', 'volume': '214', 'author': 'Zhang', 'year': '2020', 'journal-title': 'Clin. Immunol.'}, { 'issue': '8', 'key': '10.1016/j.gene.2024.148366_b0220', 'doi-asserted-by': 'crossref', 'first-page': '727', 'DOI': '10.1056/NEJMoa2001017', 'article-title': 'A novel coronavirus from patients with pneumonia in China, 2019', 'volume': '382', 'author': 'Zhu', 'year': '2020', 'journal-title': 'New Engl. J. Med.'}], 'container-title': 'Gene', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://api.elsevier.com/content/article/PII:S0378111924002476?httpAccept=text/xml', 'content-type': 'text/xml', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://api.elsevier.com/content/article/PII:S0378111924002476?httpAccept=text/plain', 'content-type': 'text/plain', 'content-version': 'vor', 'intended-application': 'text-mining'}], 'deposited': { 'date-parts': [[2024, 3, 15]], 'date-time': '2024-03-15T23:01:44Z', 'timestamp': 1710543704000}, 'score': 1, 'resource': {'primary': {'URL': 'https://linkinghub.elsevier.com/retrieve/pii/S0378111924002476'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2024, 6]]}, 'references-count': 44, 'alternative-id': ['S0378111924002476'], 'URL': 'http://dx.doi.org/10.1016/j.gene.2024.148366', 'relation': {}, 'ISSN': ['0378-1119'], 'subject': ['Genetics', 'General Medicine'], 'container-title-short': 'Gene', 'published': {'date-parts': [[2024, 6]]}, 'assertion': [ {'value': 'Elsevier', 'name': 'publisher', 'label': 'This article is maintained by'}, { 'value': 'Nigella sativa, Anthemis hyaline and Citrus sinensis extracts reduce SARS-CoV-2 ' 'replication by fluctuating Rho GTPase, PI3K-AKT, and MAPK/ERK pathways in ' 'HeLa-CEACAM1a cells', 'name': 'articletitle', 'label': 'Article Title'}, {'value': 'Gene', 'name': 'journaltitle', 'label': 'Journal Title'}, { 'value': 'https://doi.org/10.1016/j.gene.2024.148366', 'name': 'articlelink', 'label': 'CrossRef DOI link to publisher maintained version'}, {'value': 'article', 'name': 'content_type', 'label': 'Content Type'}, { 'value': '© 2024 Elsevier B.V. All rights reserved.', 'name': 'copyright', 'label': 'Copyright'}], 'article-number': '148366'}
Loading..
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit