Nigella sativa, Anthemis hyaline and Citrus sinensis extracts reduce SARS-CoV-2 replication by fluctuating Rho GTPase, PI3K-AKT, and MAPK/ERK pathways in HeLa-CEACAM1a cells

Bostancıklıoğlu et al., Gene, doi:10.1016/j.gene.2024.148366, Mar 2024

Nigella Sativa for COVID-19

13th treatment shown to reduce risk in January 2021, now with p = 0.00003 from 15 studies.

No treatment is 100% effective.
Protocols combine treatments.

In vitro study showing that nigella sativa, anthemis hyaline, and citrus sinensis extracts reduce SARS-CoV-2 replication in HeLa-CEACAM1a cells. Nigella sativa extract notably increased IL-8 levels, indicating its potential role in modulating inflammatory responses during SARS-CoV-2 infection. Authors found that anthemis hyaline extract showed the most significant reduction in viral load.
22 preclinical studies support the efficacy of nigella sativa for COVID-19:
Bostancıklıoğlu et al., 14 Mar 2024, peer-reviewed, 3 authors.
In vitro studies are an important part of preclinical research, however results may be very different in vivo.
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