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Nigellidine (Nigella sativa, black-cumin seed) docking to SARS CoV-2 nsp3 and host inflammatory proteins may inhibit viral replication/transcription

Banerjee et al., Natural Product Research, doi:10.1080/14786419.2021.2018430
Dec 2021  
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12th treatment shown to reduce risk in January 2021, now with p = 0.00016 from 14 studies.
No treatment is 100% effective. Protocols combine treatments.
5,300+ studies for 116 treatments. c19early.org
In Silico study showing nigella sativa docking to SARS CoV-2 Nsp3 and host inflammatory proteins, which may inhibit viral replication.
22 preclinical studies support the efficacy of nigella sativa for COVID-19:
Banerjee et al., 22 Dec 2021, peer-reviewed, 6 authors.
In Silico studies are an important part of preclinical research, however results may be very different in vivo.
This PaperNigella SativaAll
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"Publication History", "name": "publication_history" }, "label": "Accepted", "name": "accepted", "order": 2, "value": "2021-12-05" }, { "group": { "label": "Publication History", "name": "publication_history" }, "label": "Published", "name": "published", "order": 3, "value": "2021-12-22" } ], "author": [ { "affiliation": [ { "name": "Department of Biochemistry and Biotechnology, Cell and Molecular Therapeutics Laboratory, Oriental Institute of Science and Technology, Midnapore, India" } ], "family": "Banerjee", "given": "Amrita", "sequence": "first" }, { "affiliation": [ { "name": "Department of Biochemistry and Biotechnology, Cell and Molecular Therapeutics Laboratory, Oriental Institute of Science and Technology, Midnapore, India" } ], "family": "Kanwar", "given": "Mehak", "sequence": "additional" }, { "ORCID": "http://orcid.org/0000-0002-9292-992X", "affiliation": [ { "name": "Department of Microbiology and, Director, Environment Conservation Centre, Raiganj University, Uttar 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