In vitro Potential Antiviral SARS-CoV-19- Activity of Natural Product Thymohydroquinone and Dithymoquinone from Nigela sativia
Esharkawy et al.,
In vitro Potential Antiviral SARS-CoV-19- Activity of Natural Product Thymohydroquinone and Dithymoquinone..,
Bioorganic Chemistry, doi:10.1016/j.bioorg.2021.105587 (In Vitro)
In Vitro and
In Silico study of nigella sativa components, showing anti-SARS-CoV-2 activity at non-cytotoxic nanomolar concentrations for thymohydroquinone with selectivity index 1.4.
2 In Vitro studies support the efficacy of nigella sativa
[Esharkawy, Sherwani].
Esharkawy et al., 1 Jan 2022, peer-reviewed, 3 authors.
In Vitro studies are an important part of preclinical research, however results may be very different in vivo.
Abstract: Journal Pre-proofs
In vitro Potential Antiviral SARS-CoV-19- Activity of Natural Product Thymohydroquinone and Dithymoquinone from Nigela sativia
Eman R. Esharkawy, Faisal Almalki, Taibi Ben Hadda
PII:
DOI:
Reference:
S0045-2068(21)00965-2
https://doi.org/10.1016/j.bioorg.2021.105587
YBIOO 105587
To appear in:
Bioorganic Chemistry
Received Date:
Revised Date:
Accepted Date:
29 June 2021
19 December 2021
26 December 2021
Please cite this article as: E.R. Esharkawy, F. Almalki, T. Ben Hadda, In vitro Potential Antiviral SARS-CoV-19Activity of Natural Product Thymohydroquinone and Dithymoquinone from Nigela sativia, Bioorganic
Chemistry (2021), doi: https://doi.org/10.1016/j.bioorg.2021.105587
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In vitro Potential Antiviral SARS-CoV-19- Activity of Natural
Product Thymohydroquinone and Dithymoquinone from Nigela
sativia
Eman R. Esharkawy*1,2, Faisal Almalki3 , Taibi Ben Hadda,3,4
1Department
of Chemistry, Science Faculty, Northern Border University, ARAR, North Region,
Saudi Arabia.
2Department
of Plant Ecology and Range Management, Ecology and Dry Lands Agriculture
Division, Desert Research Center, Mathef El-Mataria, 15753, Egypt.
3Department
of Pharmaceutical Chemistry, Faculty of Pharmacy, Umm AlQura University,
Makkah 21955, Saudi Arabia.
4Laboratory
of Applied Chemistry & Environment, Faculty of Sciences, Mohammed Premier
University, MB 524, 60000 Oujda, Morocco.
Corresponding author: elsharqawyeman2017@gmail.com
Abstract:
Inflammation, oxidation, and compromised immunity all increase the dangers of COVID-19,
whereas many pharmaceutical protocols may lead to increased immunity such as ingesting from
sources containing vitamin E and zinc. A global search for natural remedies to fight COVID-19
has emerged, to assist in the treatment of this infamous coronavirus. Nigella satvia is a worldrenowned plant, an esteemed herbal remedy, which can be used as a liquid medicine to increase
immunity while decreasing the dangers of acute respiratory distress syndrome. Thymoqinone
(TQ), dithymoqinone (DTQ) and thymohydroquinone (THQ), are major compounds of the
essential oil contained in N.sativa. A current study aims to discover the antiviral activity of two
compounds, Thymohydroquinone and Dithymoquinone, which are synthesized through simple
chemical procedures, deriving from thymoquinone, which happens to be a major compound of
Nigella sativa. A half-maximal cytotoxic concentration, “CC50”, was calculated by MTT assay
for each individual drug, The sample showed anti-SARS-CoV-2 activity at non-cytotoxic
1
nanomolar concentrations in vitro with a low selectivity index (CC50/IC50 = 31.74/23.15=1.4),
whereby Dimthymoquinone shows high cytotoxicity.
Keywords: Antiviral, SARSCoV-19, thymoquinon, Dithemoquinone , hydrothymoquinone
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