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In vitro Potential Antiviral SARS-CoV-19- Activity of Natural Product Thymohydroquinone and Dithymoquinone from Nigela sativia

Esharkawy et al., Bioorganic Chemistry, doi:10.1016/j.bioorg.2021.105587
Jan 2022  
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In Vitro and In Silico study of nigella sativa components, showing anti-SARS-CoV-2 activity at non-cytotoxic nanomolar concentrations for thymohydroquinone with selectivity index 1.4.
Esharkawy et al., 1 Jan 2022, peer-reviewed, 3 authors.
In Vitro studies are an important part of preclinical research, however results may be very different in vivo.
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In vitro potential antiviral SARS-CoV-19- activity of natural product thymohydroquinone and dithymoquinone from Nigella sativa
Eman R Esharkawy, Faisal Almalki, Taibi Ben Hadda
Bioorganic Chemistry, doi:10.1016/j.bioorg.2021.105587
This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Conclusion: The current study highlight in vitro antiviral studies on two compounds from three major compounds in Nigela Sativa depending on bioinformatic analysis, which reveals the importance of three major compounds (TQ, DTQ, and HTQ), as antiviral agents. in vitro antiviral screening on two compounds (DTQ and HTQ) showed the tested drugs exhibited a promising in vitro activity against COVID-19, and have promising antiviral activities, further investigations in clinical trials to determine actual in vivo activity in the treatment of COVID-19 have recommended. Conflict of interest: The authors declare any conflict of interest. Conflict of interest: The author sdeclare any conflict of interest
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