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A study on the effect of natural products against the transmission of B.1.1.529 Omicron

Alkafaas et al., Virology Journal, doi:10.1186/s12985-023-02160-6

Aug 2023

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Curcumin for COVID-19

15th treatment shown to reduce risk in February 2021, now with p = 0.0000000096 from 27 studies.

Lower risk for mortality, ventilation, hospitalization, progression, recovery, and viral clearance.

No treatment is 100% effective. Protocols combine treatments.

5,100+ studies for 112 treatments. c19early.org

Review of natural products for SARS-CoV-2 omicron including an In Silico study showing quercetin, curcumin, ascorbic acid, nigellidine, and chloroquine among many compounds docked to the ACE2 metallopeptidase domain. Quercetin, curcumin, and ascorbic acid bound ACE2 with energy scores of -16.51, -13.5, and -12.55 kcal/mol. Nigellidine and chloroquine bound with lower affinity (-11.73 and -10.33 kcal/mol). The results suggest these compounds may have potential to inhibit SARS-CoV-2 infection by binding the ACE2 receptor.

51 preclinical studies support the efficacy of curcumin for COVID-19:

26 In Silico studies1-26

24 In Vitro studies1,3,7,9,13,19,23,27-43

1 In Vivo animal study7

In Silico studies predict inhibition of SARS-CoV-2 with curcumin or metabolites via binding to the spikeA,2,7,12,14,20,23,44 (and specifically the receptor binding domainB,10,13,16), M^proC,2,7,9,11-13,15,16,18,21,23,24,26,40,44, RNA-dependent RNA polymeraseD,2,13,22,44, PLproE,2, ACE2F,14,15,17, nucleocapsidG,8,25, nsp10H,25, and helicaseI,29 proteins. In Vitro studies demonstrate inhibition of the spikeA,34 (and specifically the receptor binding domainB,43), M^proC,19,34,40,42, ACE2F,43, and TMPRSS2J,43 proteins, and inhibition of spike-ACE2 interactionK,27. In Vitro studies demonstrate efficacy in Calu-3L,41, A549M,34, 293TN,3, HEK293-hACE2O,19,32, 293T/hACE2/TMPRSS2P,33, Vero E6Q,9,13,23,32,34,36,37,39,41, and SH-SY5YR,31 cells. Curcumin is predicted to inhibit the interaction between the SARS-CoV-2 spike protein receptor binding domain and the human ACE2 receptor for the delta and omicron variants10, decreases pro-inflammatory cytokines induced by SARS-CoV-2 in peripheral blood mononuclear cells39, alleviates SARS-CoV-2 spike protein-induced mitochondrial membrane damage and oxidative stress3, may limit COVID-19 induced cardiac damage by inhibiting the NF-κB signaling pathway which mediates the profibrotic effects of the SARS-CoV-2 spike protein on cardiac fibroblasts45, and inhibits SARS-CoV-2 ORF3a ion channel activity, which contributes to viral pathogenicity and cytotoxicity35.

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Study covers quercetin, curcumin, nigella sativa, vitamin C, and HCQ.

1. Al balawi et al., Assessing multi-target antiviral and antioxidant activities of natural compounds against SARS-CoV-2: an integrated in vitro and in silico study, Bioresources and Bioprocessing, doi:10.1186/s40643-024-00822-z.springeropen.com, doi.org.

2. Haque et al., Exploring potential therapeutic candidates against COVID-19: a molecular docking study, Discover Molecules, doi:10.1007/s44345-024-00005-5.springer.com, doi.org.

3. Zhang et al., Computational Discovery of Mitochondrial Dysfunction Biomarkers in Severe SARS-CoV-2 Infection: Facilitating Pytomedicine Screening, Phytomedicine, doi:10.1016/j.phymed.2024.155784.sciencedirect.com, doi.org.

4. Öztürkkan et al., In Silico investigation of the effects of curcuminoids on the spike protein of the omicron variant of SARS-CoV-2, Baku State University Journal of Chemistry and Material Sciences, 1:2, bsuj.bsu.edu.az/uploads/pdf/ec4204d62f7802de54e6092bf7860029.pdf.edu.az.

5. Yunze et al., Therapeutic effect and potential mechanism of curcumin, an active ingredient in Tongnao Decoction, on COVID-19 combined with stroke: a network pharmacology study and GEO database mining, Research Square, doi:10.21203/rs.3.rs-4329762/v1.researchsquare.com, doi.org.

6. Agamah et al., Network-based multi-omics-disease-drug associations reveal drug repurposing candidates for COVID-19 disease phases, ScienceOpen, doi:10.58647/DRUGARXIV.PR000010.v1.scienceopen.com, doi.org.

7. Boseila et al., Throat spray formulated with virucidal Pharmaceutical excipients as an effective early prophylactic or treatment strategy against pharyngitis post-exposure to SARS CoV-2, European Journal of Pharmaceutics and Biopharmaceutics, doi:10.1016/j.ejpb.2024.114279.sciencedirect.com, doi.org.

8. Hidayah et al., Bioinformatics study of curcumin, demethoxycurcumin, bisdemethoxycurcumin and cyclocurcumin compounds in Curcuma longa as an antiviral agent via nucleocapsid on SARS-CoV-2 inhibition, International Conference on Organic and Applied Chemistry, doi:10.1063/5.0197724.aip.org, doi.org.

9. Singh et al., Unlocking the potential of phytochemicals in inhibiting SARS-CoV-2 M Pro protein - An in-silico and cell-based approach, Research Square, doi:10.21203/rs.3.rs-3888947/v1.researchsquare.com, doi.org.

10. Kant et al., Structure-based drug discovery to identify SARS-CoV2 spike protein–ACE2 interaction inhibitors, Journal of Biomolecular Structure and Dynamics, doi:10.1080/07391102.2023.2300060.tandfonline.com, doi.org.

11. Naderi Beni et al., In silico studies of anti-oxidative and hot temperament-based phytochemicals as natural inhibitors of SARS-CoV-2 Mpro, PLOS ONE, doi:10.1371/journal.pone.0295014.plos.org, doi.org.

12. Moschovou et al., Exploring the Binding Effects of Natural Products and Antihypertensive Drugs on SARS-CoV-2: An In Silico Investigation of Main Protease and Spike Protein, International Journal of Molecular Sciences, doi:10.3390/ijms242115894.mdpi.com, doi.org.

13. Eleraky et al., Curcumin Transferosome-Loaded Thermosensitive Intranasal in situ Gel as Prospective Antiviral Therapy for SARS-Cov-2, International Journal of Nanomedicine, doi:10.2147/IJN.S423251.dovepress.com, doi.org.

14. Singh (B) et al., Computational studies to analyze effect of curcumin inhibition on coronavirus D614G mutated spike protein, The Seybold Report, doi:10.17605/OSF.IO/TKEXJ.ac.in, doi.org.

15. Thapa et al., In-silico Approach for Predicting the Inhibitory Effect of Home Remedies on Severe Acute Respiratory Syndrome Coronavirus-2, Makara Journal of Science, doi:10.7454/mss.v27i3.1609.ac.id, doi.org.

16. Srivastava et al., Paradigm of Well-Orchestrated Pharmacokinetic Properties of Curcuminoids Relative to Conventional Drugs for the Inactivation of SARS-CoV-2 Receptors: An In Silico Approach, Stresses, doi:10.3390/stresses3030043.mdpi.com, doi.org.

17. Alkafaas et al., A study on the effect of natural products against the transmission of B.1.1.529 Omicron, Virology Journal, doi:10.1186/s12985-023-02160-6.biomedcentral.com, doi.org.

18. Winih Kinasih et al., Analisis in silico interaksi senyawa kurkuminoid terhadap enzim main protease 6LU7 dari SARS-CoV-2, Duta Pharma Journal, doi:10.47701/djp.v3i1.2904.ac.id, doi.org.

19. Wu et al., Potential Mechanism of Curcumin and Resveratrol against SARS-CoV-2, Research Square, doi:10.21203/rs.3.rs-2780614/v1.researchsquare.com, doi.org.

20. Nag et al., Curcumin inhibits spike protein of new SARS-CoV-2 variant of concern (VOC) Omicron, an in silico study, Computers in Biology and Medicine, doi:10.1016/j.compbiomed.2022.105552.sciencedirect.com, doi.org.

21. Rampogu et al., Molecular Docking and Molecular Dynamics Simulations Discover Curcumin Analogue as a Plausible Dual Inhibitor for SARS-CoV-2, International Journal of Molecular Sciences, doi:10.3390/ijms23031771.mdpi.com, doi.org.

22. Singh (C) et al., Potential of turmeric-derived compounds against RNA-dependent RNA polymerase of SARS-CoV-2: An in-silico approach, Computers in Biology and Medicine, doi:10.1016/j.compbiomed.2021.104965.sciencedirect.com, doi.org.

23. Kandeil et al., Bioactive Polyphenolic Compounds Showing Strong Antiviral Activities against Severe Acute Respiratory Syndrome Coronavirus 2, Pathogens, doi:10.3390/pathogens10060758.mdpi.com, doi.org.

24. Rajagopal et al., Activity of phytochemical constituents of Curcuma longa (turmeric) and Andrographis paniculata against coronavirus (COVID-19): an in silico approach, Future Journal of Pharmaceutical Sciences, doi:10.1186/s43094-020-00126-x.springeropen.com, doi.org.

25. Suravajhala et al., Comparative Docking Studies on Curcumin with COVID-19 Proteins, Preprints, doi:10.20944/preprints202005.0439.v3.preprints.org, doi.org.

26. Sekiou et al., In-Silico Identification of Potent Inhibitors of COVID-19 Main Protease (Mpro) and Angiotensin Converting Enzyme 2 (ACE2) from Natural Products: Quercetin, Hispidulin, and Cirsimaritin Exhibited Better Potential Inhibition than Hydroxy-Chloroquine Against COVID-19 Main Protease Active Site and ACE2, ChemRxiv, doi:10.26434/chemrxiv.12181404.v1.chemrxiv.org, doi.org.

27. Emam et al., Establishment of in-house assay for screening of anti-SARS-CoV-2 protein inhibitors, AMB Express, doi:10.1186/s13568-024-01739-8.springeropen.com, doi.org.

28. Van Tin et al., Spike Protein of SARS-CoV-2 Activates Cardiac Fibrogenesis through NLRP3 Inflammasomes and NF-κB Signaling, Cells, doi:10.3390/cells13161331.mdpi.com, doi.org.

29. Li et al., Thermal shift assay (TSA)-based drug screening strategy for rapid discovery of inhibitors against the Nsp13 helicase of SARS-CoV-2, Animals and Zoonoses, doi:10.1016/j.azn.2024.06.001.sciencedirect.com, doi.org.

30. Kamble et al., Nanoparticulate curcumin spray imparts prophylactic and therapeutic properties against SARS-CoV-2, Emergent Materials, doi:10.1007/s42247-024-00754-6.springer.com, doi.org.

31. Nicoliche et al., Antiviral, anti-inflammatory and antioxidant effects of curcumin and curcuminoids in SH-SY5Y cells infected by SARS-CoV-2, Scientific Reports, doi:10.1038/s41598-024-61662-7.nature.com, doi.org.

32. Nittayananta et al., A novel film spray containing curcumin inhibits SARS-CoV-2 and influenza virus infection and enhances mucosal immunity, Virology Journal, doi:10.1186/s12985-023-02282-x.biomedcentral.com, doi.org.

33. Septisetyani et al., Curcumin and turmeric extract inhibited SARS-CoV-2 pseudovirus cell entry and Spike mediated cell fusion, bioRxiv, doi:10.1101/2023.09.28.560070.biorxiv.org, doi.org.

34. Mohd Abd Razak et al., In Vitro Anti-SARS-CoV-2 Activities of Curcumin and Selected Phenolic Compounds, Natural Product Communications, doi:10.1177/1934578X231188861.sagepub.com, doi.org.

35. Fam et al., Channel activity of SARS-CoV-2 viroporin ORF3a inhibited by adamantanes and phenolic plant metabolites, Scientific Reports, doi:10.1038/s41598-023-31764-9.nature.com, doi.org.

36. Teshima et al., Antiviral activity of curcumin and its analogs selected by an artificial intelligence-supported activity prediction system in SARS-CoV-2-infected VeroE6 cells, Natural Product Research, doi:10.1080/14786419.2023.2194647.tandfonline.com, doi.org.

37. Leka et al., In vitro antiviral activity against SARS-CoV-2 of common herbal medicinal extracts and their bioactive compounds, Phytotherapy Research, doi:10.1002/ptr.7463.wiley.com, doi.org.

38. Goc et al., Inhibitory effects of specific combination of natural compounds against SARS-CoV-2 and its Alpha, Beta, Gamma, Delta, Kappa, and Mu variants, European Journal of Microbiology and Immunology, doi:10.1556/1886.2021.00022.akjournals.com, doi.org.

39. Marín-Palma et al., Curcumin Inhibits In Vitro SARS-CoV-2 Infection In Vero E6 Cells through Multiple Antiviral Mechanisms, Molecules, doi:10.3390/molecules26226900.mdpi.com, doi.org.

40. Bahun et al., Inhibition of the SARS-CoV-2 3CLpro main protease by plant polyphenols, Food Chemistry, doi:10.1016/j.foodchem.2021.131594.sciencedirect.com, doi.org.

41. Bormann et al., Turmeric Root and Its Bioactive Ingredient Curcumin Effectively Neutralize SARS-CoV-2 In Vitro, Viruses, doi:10.3390/v13101914.mdpi.com, doi.org.

42. Guijarro-Real et al., Potential In Vitro Inhibition of Selected Plant Extracts against SARS-CoV-2 Chymotripsin-Like Protease (3CLPro) Activity, Foods, doi:10.3390/foods10071503.mdpi.com, doi.org.

43. Goc (B) et al., Phenolic compounds disrupt spike-mediated receptor-binding and entry of SARS-CoV-2 pseudo-virions, PLOS ONE, doi:10.1371/journal.pone.0253489.plos.org, doi.org.

44. Al balawi (B) et al., Assessing multi-target antiviral and antioxidant activities of natural compounds against SARS-CoV-2: an integrated in vitro and in silico study, Bioresources and Bioprocessing, doi:10.1186/s40643-024-00822-z.springeropen.com, doi.org.

45. Van Tin (B) et al., Spike Protein of SARS-CoV-2 Activates Cardiac Fibrogenesis through NLRP3 Inflammasomes and NF-κB Signaling, Cells, doi:10.3390/cells13161331.mdpi.com, doi.org.

a. The trimeric spike (S) protein is a glycoprotein that mediates viral entry by binding to the host ACE2 receptor, is critical for SARS-CoV-2's ability to infect host cells, and is a target of neutralizing antibodies. Inhibition of the spike protein prevents viral attachment, halting infection at the earliest stage.

b. The receptor binding domain is a specific region of the spike protein that binds ACE2 and is a major target of neutralizing antibodies. Focusing on the precise binding site allows highly specific disruption of viral attachment with reduced potential for off-target effects.

c. The main protease or M^pro, also known as 3CL^pro or nsp5, is a cysteine protease that cleaves viral polyproteins into functional units needed for replication. Inhibiting M^pro disrupts the SARS-CoV-2 lifecycle within the host cell, preventing the creation of new copies.

d. RNA-dependent RNA polymerase (RdRp), also called nsp12, is the core enzyme of the viral replicase-transcriptase complex that copies the positive-sense viral RNA genome into negative-sense templates for progeny RNA synthesis. Inhibiting RdRp blocks viral genome replication and transcription.

e. The papain-like protease (PLpro) has multiple functions including cleaving viral polyproteins and suppressing the host immune response by deubiquitination and deISGylation of host proteins. Inhibiting PLpro may block viral replication and help restore normal immune responses.

f. The angiotensin converting enzyme 2 (ACE2) protein is a host cell transmembrane protein that serves as the cellular receptor for the SARS-CoV-2 spike protein. ACE2 is expressed on many cell types, including epithelial cells in the lungs, and allows the virus to enter and infect host cells. Inhibition may affect ACE2's physiological function in blood pressure control.

g. The nucleocapsid (N) protein binds and encapsulates the viral genome by coating the viral RNA. N enables formation and release of infectious virions and plays additional roles in viral replication and pathogenesis. N is also an immunodominant antigen used in diagnostic assays.

h. Non-structural protein 10 (nsp10) serves as an RNA chaperone and stabilizes conformations of nsp12 and nsp14 in the replicase-transcriptase complex, which synthesizes new viral RNAs. Nsp10 disruption may destabilize replicase-transcriptase complex activity.

i. The helicase, or nsp13, protein unwinds the double-stranded viral RNA, a crucial step in replication and transcription. Inhibition may prevent viral genome replication and the creation of new virus components.

j. Transmembrane protease serine 2 (TMPRSS2) is a host cell protease that primes the spike protein, facilitating cellular entry. TMPRSS2 activity helps enable cleavage of the spike protein required for membrane fusion and virus entry. Inhibition may especially protect respiratory epithelial cells, buy may have physiological effects.

k. The interaction between the SARS-CoV-2 spike protein and the human ACE2 receptor is a primary method of viral entry, inhibiting this interaction can prevent the virus from attaching to and entering host cells, halting infection at an early stage.

l. Calu-3 is a human lung adenocarcinoma cell line with moderate ACE2 and TMPRSS2 expression and SARS-CoV-2 susceptibility. It provides a model of the human respiratory epithelium, but many not be ideal for modeling early stages of infection due to the moderate expression levels of ACE2 and TMPRSS2.

m. A549 is a human lung carcinoma cell line with low ACE2 expression and SARS-CoV-2 susceptibility. Viral entry/replication can be studied but the cells may not replicate all aspects of lung infection.

n. 293T is a human embryonic kidney cell line that can be engineered for high ACE2 expression and SARS-CoV-2 susceptibility. 293T cells are easily transfected and support high protein expression.

o. HEK293-hACE2 is a human embryonic kidney cell line with high ACE2 expression and SARS-CoV-2 susceptibility. Cells have been transfected with a plasmid to express the human ACE2 (hACE2) protein.

p. 293T/hACE2/TMPRSS2 is a human embryonic kidney cell line engineered for high ACE2 and TMPRSS2 expression, which mimics key aspects of human infection. 293T/hACE2/TMPRSS2 cells are very susceptible to SARS-CoV-2 infection.

q. Vero E6 is an African green monkey kidney cell line with low/no ACE2 expression and high SARS-CoV-2 susceptibility. The cell line is easy to maintain and supports robust viral replication, however the monkey origin may not accurately represent human responses.

r. SH-SY5Y is a human neuroblastoma cell line that exhibits neuronal phenotypes. It is commonly used as an in vitro model for studying neurotoxicity, neurodegenerative diseases, and neuronal differentiation.

Alkafaas et al., 25 Aug 2023, peer-reviewed, 12 authors. Contact: samar.alkafas@science.tanta.edu.eg, samarsamy2017@yahoo.com, ghoshs@ufs.ac.za, soumyaghosh@yahoo.com, h.onyeaka@bham.ac.uk.

In Silico studies are an important part of preclinical research, however results may be very different in vivo.

This Paper Curcumin All

A study on the effect of natural products against the transmission of B.1.1.529 Omicron

Samar Sami Alkafaas, Abanoub Mosaad Abdallah, Aya Misbah Hussien, Heba Bedair, Mahmoud Abdo, Soumya Ghosh, Sara Samy Elkafas, Wilgince Apollon, Morteza Saki, Samah A Loutfy, Helen Onyeaka, Mohamed Hessien

Virology Journal, doi:10.1186/s12985-023-02160-6

Background The recent outbreak of the Coronavirus pandemic resulted in a successful vaccination program launched by the World Health Organization. However, a large population is still unvaccinated, leading to the emergence of mutated strains like alpha, beta, delta, and B.1.1.529 (Omicron). Recent reports from the World Health Organization raised concerns about the Omicron variant, which emerged in South Africa during a surge in COVID-19 cases in November 2021. Vaccines are not proven completely effective or safe against Omicron, leading to clinical trials for combating infection by the mutated virus. The absence of suitable pharmaceuticals has led scientists and clinicians to search for alternative and supplementary therapies, including dietary patterns, to reduce the effect of mutated strains. Main body This review analyzed Coronavirus aetiology, epidemiology, and natural products for combating Omicron. Although the literature search did not include keywords related to in silico or computational research, in silico investigations were emphasized in this study. Molecular docking was implemented to compare the interaction between natural products and Chloroquine with the ACE2 receptor protein amino acid residues of Omicron. The global Omicron infection proceeding SARS-CoV-2 vaccination was also elucidated. The docking results suggest that DGCG may bind to the ACE2 receptor three times more effectively than standard chloroquine. Conclusion The emergence of the Omicron variant has highlighted the need for alternative therapies to reduce the impact of mutated strains. The current review suggests that natural products such as DGCG may be effective in binding to the ACE2 receptor and combating the Omicron variant, however, further research is required to validate the results of this study and explore the potential of natural products to mitigate COVID-19. Highlights • There are 32 mutations in the spike of the Omicron variant. • Non-SARS-COV-2 vaccinated individuals accelerate transmission of Omicron variant.

Declarations Ethics approval and consent to participate Not applicable. Consent for publication All the authors read and agreed to publish this article. Competing interests The authors declare that they have no competing interests. Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

References

Aanouz, Belhassan, El-Khatabi, Lakhlifi, El-Ldrissi et al., Moroccan medicinal plants as inhibitors against SARS-CoV-2 main protease: computational investigations, J Biomol Struct Dyn

Abdallah, Gomha, Zaki, Abolibda, Kheder, A green synthesis, DFT calculations, and molecular docking study of some new indeno[2,1-b]quinoxalines containing thiazole moiety, J Mol Struct

Abubakar, Usman, Batiha, Martins, Malami et al., Natural Products Modulating Angiotensin Converting Enzyme 2 (ACE2) as Potential COVID-19 Therapies, Front Pharmacol

Adem, Eyupoglu, Sarfraz, Rasul, Ali et al., Identification of potent COVID-19 main protease (Mpro) inhibitors from natural polyphenols: an in silico strategy unveils a hope against CORONA, Drug Dev Res

Ahmadi, Ayazi-Nasrabadi, Astaxanthin protective barrier and its ability to improve the health in patients with COVID-19, Iran J Microbiol

Al-Harrasi, Behl, Upadhyay, Chigurupati, Bhatt et al., Targeting natural products against SARS-CoV-2, Environ Sci Pollut Res

Al-Qaisi, Garawi, Karawi, Hammood, Abdallah et al., Antiureolytic activity of new water-soluble thiadiazole derivatives: Spectroscopic, DFT, and molecular docking studies, Spectrochim Acta A Mol Biomol Spectrosc

Alghamdi, Algandaby, Al-Abbasi, Eid, Abdallah et al., Protective effect of rutin isolated from Spermococe hispida against cobalt chloride-induced hypoxic injury in H9c2 cells by inhibiting oxidative stress and inducing apoptosis, Oxid Med Cell Longev

Alhouri, Salloum, Harfouch, Soumya, Possible side effects of using detergents during the Covid19 pandemic in Syria, Ann Clin Cases

Alkafaas, Abdallah, Ghosh, Loutfy, Elkafas et al., Insight into the role of clathrin-mediated endocytosis inhibitors in SARS-CoV-2 infection, Rev Med Virol

Alkafaas, Loutfy, Diab, Hessien, Vasopressin induces apoptosis but does not enhance the antiproliferative effect of dynamin 2 or PI3K/Akt inhibition in luminal A breast cancer cells, Med Oncol

Ambati, Phang, Ravi, Aswathanarayana, Astaxanthin: sources, extraction, stability, biological activities and its commercial applications-a review, Mar Drugs

Araf, Akter, Yd, Fatemi, Parvez et al., Omicron variant of SARS-CoV-2: genomics, transmissibility, and responses to current COVID-19 vaccines, J Med Virol

Assessment Rr, Assessment of the further emergence and potential impact of the SARS-CoV-2 Omicron variant of concern in the context of ongoing transmission of the Delta variant of concern in the EU/EEA

Assoumani, Delerce, Houhamdi, Bedotto, Lagier et al., Introduction of the SARS-CoV-2 Beta variant from Comoros into the Marseille geographical area, Travel Med Infect Dis

Atabaki, Roohbakhsh, Moghimi, Mehri, Protective effects of maternal administration of curcumin and hesperidin in the rat offspring following repeated febrile seizure: role of inflammation and TLR4, Int Immunopharmacol

Awadasseid, Wu, Tanaka, Zhang, Current advances in the development of SARS-CoV-2 vaccines, Int J Biol Sci

Balkrishna, Haldar, Singh, Roy, Varshney, Coronil, a tri-herbal formulation, attenuates spike-protein-mediated SARS-CoV-2 viral entry into human alveolar epithelial cells and pro-inflammatory cytokines production by inhibiting spike protein-ACE-2 interaction, J Inflamm Res

Balkrishna, Raj, Singh, Varshney, Influence of patient-reported treatment satisfaction on psychological health and quality of life Among patients receiving Divya-Swasari-Coronil-Kit against COVID-19: findings from a cross-sectional "SATISFACTION COVID" survey, Patient Prefer Adherence

Balkrishna, Solleti, Verma, Varshney, Application of humanized zebrafish model in the suppression of SARS-CoV-2 spike protein induced pathology by tri-herbal medicine coronil via cytokine modulation, Molecules

Bao, Pan, Lu, Ni, Zhang et al., The apoptotic effect of sarsasapogenin from Anemarrhena asphodeloides on HepG2 human hepatoma cells, Cell Biol Int

Barickman, Kopsell, Sams, Selenium influences glucosinolate and isothiocyanates and increases sulfur uptake in Arabidopsis thaliana and rapid-cycling Brassica oleracea, J Agric Food Chem

Bellavite, Donzelli, Hesperidin and SARS-CoV-2: new light on the healthy function of citrus fruits, Antioxidants

Blaskó, Hussain, Shamma, Corlumine, a new phthalideisoquinoline alkaloid from Fumaria parviflora, J Nat Prod

Calland, Sahuc, Belouzard, Pène, Bonnafous et al., Polyphenols inhibit hepatitis C virus entry by a new mechanism of action, J Virol

Callaway, Heavily mutated coronavirus variant puts scientists on alert, Nature

Carter, Yu, Sacks, Barnadas, Pereyaslov et al., Global genomic surveillance strategy for pathogens with pandemic and epidemic potential 2022-2032, Bull World Health Organ

Cascella, Rajnik, Aleem, Dulebohn, Napoli, Features, evaluation, and treatment of coronavirus (COVID-19)

Cavezzi, Troiani, Corrao, COVID-19: hemoglobin, iron, and hypoxia beyond inflammation. A narrative review, Clin Pract

Chanet, Milenkovic, Maier, Khan, Rakotomanomana et al., Flavanone metabolites decrease monocyte adhesion to TNF-αactivated endothelial cells by modulating expression of atherosclerosisrelated genes, Br J Nutr

Chanet, Milenkovic, Manach, Mazur, Morand, Citrus flavanones: What is their role in cardiovascular protection?, J Agric Food Chem

Chapman, Andurkar, A review of natural products, their effects on SARS-CoV-2 and their utility as lead compounds in the discovery of drugs for the treatment of COVID-19, Med Chem Res

Chen, Gao, Wang, Wei, Revealing the threat of emerging SARS-CoV-2 mutations to antibody therapies, J Mol Biol

Chen, Wang, Gilby, Wei, B. 1.1. 529): Infectivity, vaccine breakthrough, and antibody resistance

Chen, Wang, Gilby, Wei, Omicron variant (B. 1.1. 529): Infectivity, vaccine breakthrough, and antibody resistance, J Chem Inf Model

Chen, Yiu, Wong, Prediction of the SARS-CoV-2 (2019-nCoV) 3C-like protease (3CL pro) structure: virtual screening reveals velpatasvir, ledipasvir, and other drug repurposing candidates, Research

Cheng, Ng, Chiang, Lin, Antiviral effects of saikosaponins on human coronavirus 229E in vitro, Clin Exp Pharmacol Physiol

Chiang, Chang, Kuo, Chang, Kuo, Cytotoxic triterpenes from the aerial roots of Ficus microcarpa, Phytochemistry

Chikhale, Sinha, Patil, Prasad, Shakya et al., In-silico investigation of phytochemicals from Asparagus racemosus as plausible antiviral agent in COVID-19, J Biomol Struct Dyn

Choi, Kim, Park, Lee, Kim et al., Anti-thrombotic effect of rutin isolated from Dendropanax morbifera Leveille, J Biosci Bioeng

Choi, Lee, Jung, Jung, Park, Constituents of the essential oil of the Cinnamomum cassia stem bark and the biological properties, Arch Pharmacal Res

Chowdhury, In silico investigation of phytoconstituents from Indian medicinal herb 'Tinospora cordifolia (giloy)'against SARS-CoV-2 (COVID-19) by molecular dynamics approach, J Biomol Struct Dyn

Conti, Ronconi, Caraffa, Gallenga, Ross et al., Induction of pro-inflammatory cytokines (IL-1 and IL-6) and lung inflammation by Coronavirus-19 (COVI-19 or SARS-CoV-2): anti-inflammatory strategies, J Biol Regul Homeost Agents

Covid, Team, SARS-CoV-2 B 11 529 (Omicron) Variant-United States, Morb Mortal Wkly Rep

Da Silva, Da Silva, De Oliveira, Costa, Koolen et al., Flavonoid glycosides and their putative human metabolites as potential inhibitors of the SARS-CoV-2 main protease (Mpro) and RNA-dependent RNA polymerase (RdRp), Memórias do Instituto Oswaldo Cruz

Da, Xu, Wang, Li, Lu et al., Kaempferol promotes apoptosis while inhibiting cell proliferation via androgen-dependent pathway and suppressing vasculogenic mimicry and invasion in prostate cancer, Biomed Pharmacother

Das, Majumder, Mandal, Basak, In-Silico approach for identification of effective and stable inhibitors for COVID-19 main protease (Mpro) from flavonoid based phytochemical constituents of Calendula officinalis, J Biomol Struct Dyn

Del, Singh, Singh, Singh, Kumar et al., Toxicology in vitro anti-free radical activities of kaempferol isolated from Acacia nilotica (L.) willd, Toxicol Vitr

Dongare, Kulkarni, Kondawar, Magdum, Haldavnekar et al., Inhibition of aldose reductase and anti-cataract action of trans-anethole isolated from Foeniculum vulgare Mill. fruits, Food Chem

Dubey, Dubey, Computation screening of narcissoside a glycosyloxyflavone for potential novel coronavirus 2019 (COVID-19) inhibitor, Biomed J

Duraipandiyan, Al-Dhabi, Irudayaraj, Sunil, Hypolipidemic activity of friedelin isolated from Azima tetracantha in hyperlipidemic rats, Rev Bras

Elshamy, Ammar, Hassan, El-Kashak, Ss et al., Farrag A-RH: Topical wound healing activity of myricetin isolated from tecomaria capensis V. aurea, Molecules

Erenler, Sen, Aksit, Demirtas, Yaglioglu et al., Isolation and identification of chemical constituents from Origanum majorana and investigation of antiproliferative and antioxidant activities, J Sci Food Agric

Fakhri, Nouri, Moradi, Farzaei, Astaxanthin, COVID-19 and immune response: focus on oxidative stress, apoptosis and autophagy, Phytother Res

Fang, Gao, Zhu, Kaempferol and quercetin isolated from Euonymus alatus improve glucose uptake of 3T3-L1 cells without adipogenesis activity, Life Sci

Fantini, Scala, Chahinian, Yahi, Structural and molecular modelling studies reveal a new mechanism of action of chloroquine and hydroxychloroquine against SARS-CoV-2 infection, Int J Antimicrob Agents

Fiorino, Gallo, Zippi, Sabbatani, Manfredi et al., Cytokine storm in aged people with CoV-2: possible role of vitamins as therapy or preventive strategy, Aging Clin Exp Res

Garcia-Beltran, Denis, Hoelzemer, Lam, Nitido et al., mRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variant, Cell

Garret, Tapley, Andriesen, Seocharan, Fisher et al., High rate of asymptomatic carriage associated with variant strain Omicron, MedRxiv

Ghosh, Bornman, Zafer, Antimicrobial resistance threats in the emerging COVID-19 pandemic: Where do we stand?, J Infect Public Health

Ghosh, Chakraborty, Biswas, Chowdhuri, Identification of polyphenols from Broussonetia papyrifera as SARS CoV-2 main protease inhibitors using in silico docking and molecular dynamics simulation approaches, J Biomol Struct Dyn

Gupta, Gonzalez-Rojas, Juarez, Casal, Moya et al., Early treatment for Covid-19 with SARS-CoV-2 neutralizing antibody sotrovimab, N Engl J Med

Gupta, Gupta, Bhargava, Andersen, Krpina et al., Novel antiviral activities of obatoclax, emetine, niclosamide, brequinar, and homoharringtonine, Clin Exp Dermatol

Gupta, Mallavarapu, Banerjee, Kumar, Characteristics of an isomenthone-rich somaclonal mutant isolated in a geraniol-rich rosescented geranium accession of Pelargonium graveolens, Flavour Fragr J

Haggag, El-Ashmawy, Okasha, Is hesperidin essential for prophylaxis and treatment of COVID-19 Infection?, Med Hypotheses

Hamza, Ali, Khan, Ahmed, Attique et al., nCOV-19 peptides mass fingerprinting identification, binding, and blocking of inhibitors flavonoids and anthraquinone of Moringa oleifera and hydroxychloroquine, J Biomol Struct Dyn

Han, Yuan, Zhao, He, Li et al., Tracking antiangiogenic components from Glycyrrhiza uralensis F isch. based on zebrafish assays using high-speed countercurrent chromatography, J Sep Sci

Hansen, Baum, Pascal, Russo, Giordano et al., Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail, Science

Hart, Miller, Andrews, Waight, Maini et al., Generation time of the alpha and delta SARS-CoV-2 variants: an epidemiological analysis, Lancet Infect Dis

Harvey, Carabelli, Jackson, Gupta, Thomson et al., SARS-CoV-2 variants, spike mutations and immune escape, Nat Rev Microbiol

He, Hong, Pan, Lu, Wei, SARS-CoV-2 Omicron variant: characteristics and prevention, MedComm

Heo, Kim, Choi, Ekanayake, Ahn et al., Hesperidin improves motor disability in rat spinal cord injury through anti-inflammatory and antioxidant mechanism via Nrf-2/HO-1 pathway, Neurosci Lett

Hessien, Donia, Tabll, Adly, Abdelhafez et al., Mechanistic-based classification of endocytosis-related inhibitors: Does it aid in assigning drugs against SARS-CoV-2?, Viruses

Hoffmann, Krüger, Schulz, Cossmann, Rocha et al., The Omicron variant is highly resistant against antibody-mediated neutralizationimplications for control of the COVID-19 pandemic, Cell

Hossain, Yd, Akter, Zheng, Roles of the polybasic furin cleavage site of spike protein in SARS-CoV-2 replication, pathogenesis, and host immune responses and vaccination, J Med Virol

Hu, Guan, Bi, Zhang, Li et al., Efficacy and safety of Lianhuaqingwen capsules, a repurposed Chinese herb, in patients with coronavirus disease 2019: a multicenter, prospective, randomized controlled trial, Phytomedicine

Hu, Ma, Li, Wang, Antioxidant and anti-inflammatory flavonoids from the flowers of Chuju, a medical cultivar of Chrysanthemum morifolim Ramat, J Mex Chem Soc

Hyun, Chung, Cyanidin and malvidin from Oryza sativa cv. heugjinjubyeo mediate cytotoxicity against human monocytic leukemia cells by arrest of G2/M phase and induction of apoptosis, J Agric Food Chem

Imanshahidi, Hosseinzadeh, Pharmacological and therapeutic effects of Berberis vulgaris and its active constituent, berberine, Phytother Res

Iqbal, Khan, Khattak, Biological significance of ascorbic acid (vitamin C) in human health-a review, Pak J Nutr

Iranshahi, Rezaee, Parhiz, Roohbakhsh, Soltani, Protective effects of flavonoids against microbes and toxins: the cases of hesperidin and hesperetin, Life Sci

Jang, Cuendet, Hawthorne, Kardono, Kawanishi et al., Prenylated flavonoids of the leaves of Macaranga conifera with inhibitory activity against cyclooxygenase-2, Phytochemistry

Jansen, Tegomoh, Lange, Showalter, Figliomeni et al., Investigation of a sars-cov-2 b. 1.1. 529 (omicron) variant cluster-Nebraska, November-December 2021, Morbidity and Mortality Weekly Report

Jha, Sharma, Hashiesh, Arunachalam, Meeran et al., β-Caryophyllene, a natural dietary CB2 receptor selective cannabinoid can be a candidate to target the trinity of infection, immunity, and inflammation in Covid-19, Front Pharmacol

Jo, Kim, Cho, Lee, Lee et al., Hesperetin inhibits neuroinflammation on microglia by suppressing inflammatory cytokines and MAPK pathways, Arch Pharmacal Res

Jo, Kim, Kim, Kim, Shin, Flavonoids with inhibitory activity against SARS-CoV-2 3CLpro, J Enzyme Inhib Med Chem

Kadan, Gözler, Shamma, Turkiyenine, a new alkaloid from Chelidonium majus, J Nat Prod

Kang, Choi, Lee, Kwon, Luteolin isolated from the flowers of Lonicera japonica suppresses inflammatory mediator release by blocking NF-κB and MAPKs activation pathways in HMC-1 cells, Molecules

Khalil, Baharum, Fazry, Sidik, Sairi, Non-enzymatic antioxidant from apple snail (Pomacea maculata) extract, Malays Appl Biol

Khan, Ikram, Hahm, Mo, Antioxidant and anti-inflammatory effects of citrus flavonoid hesperetin: special focus on neurological disorders, Antioxidants

Khan, Karim, San, Lustig, Tegally et al., Omicron infection enhances neutralizing immunity against the Delta variant, medRxiv

Kim, Liu, Ziarnik, Cao, Zhang et al., Binding of human ACE2 and RBD of Omicron enhanced by unique interaction patterns among SARS-CoV-2 variants of concern, bioRxiv

Kim, Wie, Ahn, Tanaka, Matsuda et al., Benefits of hesperidin in central nervous system disorders: a review, Anat Cell Biol

Kimura, Matsushita, Yokoi-Hayashi, Okuda, Effects of baicalein isolated from Scutellaria baicalensis Radix on adhesion molecule expression induced by thrombin and thrombin receptor agonist peptide in cultured human umbilical vein endothelial cells, Planta Med

Kishore, Kaur, Singh, Effect of Kaempferol isolated from seeds of Eruca sativa on changes of pain sensitivity in Streptozotocin-induced diabetic neuropathy, Inflammopharmacology

Knox, Hayashi, Suzutani, Ogasawara, Yoshida et al., Activity of anthocyanins from fruit extract of Ribes nigrum L. against influenza A and B viruses, Acta virol

Koch, Dietary polyphenols-important non-nutrients in the prevention of chronic noncommunicable diseases, Syst Rev Nutr

Kong, Wu, Gu, Lv, Qi et al., Analysis of the molecular mechanism of Pudilan (PDL) treatment for COVID-19 by network pharmacology tools, Biomed Pharmacother

Korman, Tan, Wong, Luo, Tsai, Inhibition kinetics and emodin cocrystal structure of a type II polyketide ketoreductase, Biochemistry

Kotaki, Adachi, Moriyama, Onodera, Fukushi et al., SARS-CoV-2 Omicron-neutralizing memory B-cells are elicited by two doses of BNT162b2 mRNA vaccine, Sci Immunol

Koyama, Inoue, Sekine, Hayakawa, Homma et al., Relative and absolute stereochemistry of quinadoline B, an inhibitor of lipid droplet synthesis in macrophages, Org Lett

Kubo, Fujita, Nihei, Antimicrobial activity of anethole and related compounds from aniseed, J Sci Food Agric

Kulkarni, Nagarajan, Ramesh, Palaniyandi, Selvam et al., Computational evaluation of major components from plant essential oils as potent inhibitors of SARS-CoV-2 spike protein, J Mol Struct

Kumar, Chowdhury, Jatte, Chakrabarti, Majumder et al., Anthocephaline, a new indole alkaloid and cadambine, a potent inhibitor of DNA topoisomerase IB of Leishmania donovani (LdTOP1LS), isolated from Anthocephalus cadamba, Nat Product Commun

Kumar, Jain, Verma, Phytochemical and pharmacological investigation of Cassia siamea Lamk: an insight, Nat Prod J

Kumar, Kashyap, Chowdhury, Kumar, Panwar et al., Identification of phytochemicals as potential therapeutic agents that binds to Nsp15 protein target of coronavirus (SARS-CoV-2) that are capable of inhibiting virus replication, Phytomedicine

Kumar, Thambiraja, Karuppanan, Subramaniam, Omicron and Delta variant of SARS-CoV-2: a comparative computational study of spike protein, J Med Virol

Kuppusamy, Lee, Song, Ilavenil, Srigopalram et al., Quantification of major phenolic and flavonoid markers in forage crop Lolium multiflorum using HPLC-DAD, Rev Bras

Larit, Elokely, Nael, Benyahia, León et al., Proposed mechanism for the antitrypanosomal activity of quercetin and myricetin Isolated from Hypericum afrum Lam.: phytochemistry, in vitro testing and modeling studies, Molecules

Lee, Kim, Chang, Hong, Na et al., Antiplatelet effects of Rhus verniciflua Stokes heartwood and its active constituents-fisetin, butein, and sulfuretin-in rats, J Med Food

Lee, Lee, Baek, Kim, Antihyperlipidemic effect of crocin isolated from the fructus of Gardenia jasminoides and its metabolite crocetin, Biol Pharm Bull

Liu, Yang, Xu, Ma, Qin et al., Lycorine reduces mortality of human enterovirus 71-infected mice by inhibiting virus replication, Virol J

Luo, Liu, Li, Pharmacological perspective: glycyrrhizin may be an efficacious therapeutic agent for COVID-19, Int J Antimicrob Agents

Madhi, Kwatra, Myers, Jassat, Dhar et al., Population immunity and Covid-19 severity with Omicron variant in South Africa, N Engl J Med

Maiti, Banerjee, Nazmeen, Kanwar, Das, Active-site molecular docking of nigellidine with nucleocapsid-NSP2-MPro of COVID-19 and to human IL1R-IL6R and strong antioxidant role of Nigella-sativa in experimental rats, J Drug Target

Maroli, Bhasuran, Natarajan, Kolandaivel, Shahat, The potential role of procyanidin as a therapeutic agent against SARS-CoV-2: a text mining, molecular docking and molecular dynamics simulation approach, J Biomol Struct Dyn

Marovich, Mascola, Cohen, Monoclonal antibodies for prevention and treatment of COVID-19, JAMA

Martínez-Vázquez, Apan, Lastra, Bye, A comparative study of the analgesic and anti-inflammatory activities of pectolinarin isolated from Cirsium subcoriaceum and linarin isolated from Buddleia cordata, Planta Med

Matsuo, Ito, The chemical structure of kaki-tannin from immature fruit of the persimmon (Diospyros kaki L.), Agric Biol Chem

Mbs, Ho, Jm, Epicatechin is a promising novel inhibitor of SARS-CoV-2 entry by disrupting interactions between angiotensin-converting enzyme type 2 and the viral receptor binding domain: a computational/simulation study, Comput Biol Med

Mekala, Satyal, Setzer, Phytochemicals from the bark of Rhamnus caroliniana, Nat Prod Commun

Meskini, Rami, Maroofi, Ghosh, Siadat et al., An overview on the epidemiology and immunology of COVID-19, J Infect Public Health

Mete, Gözler, +)-Oxoturkiyenine: an isoquinoline-derived alkaloid from Hypecoum pendulum, J Nat Prod

Mf, Molecular modeling of the interaction of ligands with ACE2-SARS-CoV-2 spike protein complex, Silico Pharmacol

Moe V, None

Mohammed, Gbonjubola, Koorbanally, Islam, Inhibition of key enzymes linked to type 2 diabetes by compounds isolated from Aframomum melegueta fruit, Pharm Biol

Mohapatra, Tiwari, Sarangi, Sharma, Khandia et al., Twin combination of Omicron and Delta variant triggering a Tsunami wave of ever high surges in COVID-19 cases: a challenging global threat with a special focus on Indian sub-continent, J Med Virol

Mohn, Plitzko, Hamburger, A comprehensive metabolite profiling of Isatis tinctoria leaf extracts, Phytochemistry

Moore, June, Cytokine release syndrome in severe COVID-19, Science

Morinaka, Sakamoto, Inukai, Agetsuma, Kitano et al., Morphological alteration caused by brassinosteroid insensitivity increases the biomass and grain production of rice, Plant Physiol

Mu, Sheng, Wang, Amin, Li et al., Potential compound from herbal food of Rhizoma Polygonati for treatment of COVID-19 analyzed by network pharmacology: viral and cancer signaling mechanisms, J Funct Foods

Mudd, Minervina, Pogorelyy, Turner, Kim et al., SARS-CoV-2 mRNA vaccination elicits a robust and persistent T follicular helper cell response in humans, Cell

Muhammad, Ikram, Ullah, Rehman, Mo, Hesperetin, a citrus flavonoid, attenuates LPS-induced neuroinflammation, apoptosis and memory impairments by modulating TLR4/NF-κB signaling, Nutrients

Musarra-Pizzo, Pennisi, Ben-Amor, Mandalari, Sciortino, Antiviral activity exerted by natural products against human viruses, Viruses

Ngwa, Kumar, Thompson, Lyerly, Moore et al., Potential of flavonoid-inspired phytomedicines against COVID-19, Molecules

Nie, Sahoo, Herrmann, Ballauff, Netz et al., Charge matters: mutations in omicron variant favor binding to cells, ChemBio-Chem

Olennikov, Partilkhaev, Isolation and densitometric HPTLC analysis of rutin, narcissin, nicotiflorin, and isoquercitrin in Caragana spinosa shoots, JPC-J Planar Chromatogr Modern TLC

Olivar, Sy, Villanueva, Alejandro, Tan, Alkaloids as chemotaxonomic markers from the Philippine endemic Uncaria perrottetii and Uncaria lanosa f. Philippinensis, J King Saud Univ Sci

Omrani, Keshavarz, Ebrahimi, Mehrabi, Mcgaw et al., Potential natural products against respiratory viruses: a perspective to develop anti-COVID-19 medicines, Front Pharmacol

Omrani, Saad, Baig, Bahloul, Abdul-Matin et al., Ribavirin and interferon alfa-2a for severe Middle East respiratory syndrome coronavirus infection: a retrospective cohort study, Lancet Infect Dis

Organization, Classification of Omicron (B. 1.1. 529): SARS-CoV-2 variant of concern

Organization, Enhancing response to Omicron SARS-CoV-2 variant: Technical brief and priority actions for Member States

Organization, Methods for the detection and characterisation of SARS-CoV-2 variants: first update

Oso, Adeoye, Olaoye, Pharmacoinformatics and hypothetical studies on allicin, curcumin, and gingerol as potential candidates against COVID-19-associated proteases, J Biomol Struct Dyn

Parasher, COVID research: a year of scientific milestones, Nature

Park, Kang, Park, Hesperidin ameliorates hepatic ischemiareperfusion injury in Sprague-Dawley rats, Transplantation Proceedings

Pascarella, Ciccozzi, Bianchi, Benvenuto, Cauda et al., The electrostatic potential of the omicron variant spike is higher than in delta and delta-plus variants: a hint to higher transmissibility, J Med Virol

Pascarella, Ciccozzi, Zella, Bianchi, Benedetti et al., SARS-CoV-2 B. 1.617 Indian variants: Are electrostatic potential changes responsible for a higher transmission rate?, J Med Virol

Peacock, Goldhill, Zhou, Baillon, Frise et al., The furin cleavage site in the SARS-CoV-2 spike protein is required for transmission in ferrets, Nat Microbiol

Pinto, Park, Beltramello, Walls, Tortorici et al., Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody, Nature

Pisoschi, Pop, Iordache, Stanca, Geicu et al., Antioxidant, anti-inflammatory and immunomodulatory roles of vitamins in COVID-19 therapy, Eur J Med Chem

Pour, Fakhri, Asgary, Farzaei, Echeverría, The signaling pathways, and therapeutic targets of antiviral agents: focusing on the antiviral approaches and clinical perspectives of anthocyanins in the management of viral diseases, Front Pharmacol

Prakash, Elavarasan, Subashini, Kanaga, Dhandapani et al., Isolation of hesperetin-A flavonoid from Cordia sebestena flower extract through antioxidant assay guided method and its antibacterial, anticancer effect on cervical cancer via in vitro and in silico molecular docking studies, J Mol Struct

Pulliam, Van Schalkwyk, Govender, Gottberg, Cohen et al., Increased risk of SARS-CoV-2 reinfection associated with emergence of the Omicron variant in South Africa, MedRxiv

Quimque, Notarte, Fernandez, Mendoza, Liman et al., Virtual screeningdriven drug discovery of SARS-CoV2 enzyme inhibitors targeting viral attachment, replication, post-translational modification and host immunity evasion infection mechanisms, J Biomol Struct Dyn

Ren, Wang, Gao, Zhou, Omicron variant (B. 1.1. 529) of SARS-CoV-2: mutation, infectivity, transmission, and vaccine resistance, World J Clin Cases

Romano, Ruggiero, Squeglia, Maga, Berisio, A structural view of SARS-CoV-2 RNA replication machinery: RNA synthesis, proofreading and final capping, Cells

Sadraei, Asghari, Emami, Inhibitory effect of Rosa damascena Mill flower essential oil, geraniol and citronellol on rat ileum contraction, Res Pharm Sci

Saif, Vaccines for COVID-19: perspectives, prospects, and challenges based on candidate SARS, MERS, and animal coronavirus vaccines, Euro Med J

Salehi, Mashayekh, Taheri, Gholami, Motaghinejad et al., Curcumin can be acts as effective agent for prevent or treatment of alcohol-induced toxicity in hepatocytes: an illustrated mechanistic review, Iran J Pharm Res

Selim, Jaouni, Anticancer and apoptotic effects on cell proliferation of diosgenin isolated from Costus speciosus (Koen.) Sm, BMC Complement Altern Med

Sghaier, Mousslim, Pagano, Ammari, Luis et al., β-eudesmol, a sesquiterpene from Teucrium ramosissimum, inhibits superoxide production, proliferation, adhesion and migration of human tumor cell, Environ Toxicol Pharmacol

Shang, Hou, Long, Chemical composition of essential oil of Artemisia nanschanica Krasch. from Tibetan plateau, Ind Crops Prod

Shanmugaraj, Malla, Khorattanakulchai, Phoolcharoen, SARS-CoV-2 omicron variant: Could it be another threat?, J Med Virol

Sharma, Gautam, Sharma, Singh, Sharma et al., Clinico epidemiological profile of Omicron variant of SARS CoV2 in Rajasthan, medRxiv

Shengqiang, Jizhong, Gang, Lou, Purification of rutin and nicotiflorin from the flowers of Edgeworthia chrysantha Lindl. by high-speed counter-current chromatography, J Chromatogr Sci

Shirole, Shirole, Saraf, In vitro relaxant and spasmolytic effects of essential oil of Pistacia integerrima Stewart ex Brandis Galls, J Ethnopharmacol

Sotto, Giacomo, Amatore, Locatelli, Vitalone et al., A polyphenol rich extract from Solanum melongena L. DR2 peel exhibits antioxidant properties and anti-herpes simplex virus type 1 activity in vitro, Molecules

Souza, Vasconcelos, Prado, Pereira, Zinc, vitamin D and vitamin C: perspectives for COVID-19 with a focus on physical tissue barrier integrity, Front Nutr

Srinivasan, Natarajan, Shivakumar, Nagamurugan, Isolation of Fisetin from Elaeagnus indica Serv. Bull.(Elaeagnaceae) with antioxidant and antiproliferative activity, Free Radic Antioxid

Stasi, Fallani, Voller, Silvestri, Treatment for COVID-19: an overview, Eur J Pharmacol

Swaminathan, Dyason, Maggioni, Von Itzstein, Downard, Binding of a natural anthocyanin inhibitor to influenza neuraminidase by mass spectrometry, Anal Bioanal Chem

Syah, Ghisalberti, Phenolic derivatives with an irregular sesquiterpenyl side chain from Macaranga pruinosa, Nat prod Commun

Tachikawa, Takahashi, Kashimoto, Effects of extract and ingredients isolated from Magnolia obovata thunberg on catecholamine secretion from bovine adrenal chromaffin cells, Biochem Pharmacol

Takeda, Murata, Jamsransuren, Suganuma, Kazami et al., Saxifraga spinulosa-derived components rapidly inactivate multiple viruses including SARS-CoV-2, Viruses

Tam, Thien, Sung, Hoang Anh, Thuy et al., Evaluation of ursolic acid as the main component isolated from Catharanthus roseus against hyperglycemia, Int Lett Nat Sci

Tao, Huang, Zheng, Xu, Case of professor Xu ZOU's acupuncture technique for "benefiting kidney and strengthening anti-pathogenic qi" in promoting the absorption of COVID-19, World J Acupunct Moxib

Thurzo, Bražinová, Markovská, Waczulíková, Smatana et al., Dentistry after Omicron variant: introducing a new biosafety protocol in prevention of COVID-19 in Dental Care

Toledano, Moreno-Fernandez, Juarez, Ochoa, Diaz-Castro, Implications of Vitamins in COVID-19 prevention and treatment through immunomodulatory and anti-oxidative mechanisms, Antioxidants

Torjesen, Covid-19: Omicron may be more transmissible than other variants and partly resistant to existing vaccines, scientists fear, Br Med J Publ Group

Vanblargan, Errico, Halfmann, Zost, Crowe et al., An infectious SARS-CoV-2 B. 1.1. 529 Omicron virus escapes neutralization by therapeutic monoclonal antibodies, Nat Med

Veeramani, Alsaif, Ks, Herbacetin, a flaxseed flavonoid, ameliorates high percent dietary fat induced insulin resistance and lipid accumulation through the regulation of hepatic lipid metabolizing and lipid-regulating enzymes, Chem Biol Interact

Velásquez, Vaccines, medicines and COVID-19: How can WHO be given a stronger voice

Vijayakumar, Ramesh, Joji, Kannan, In silico pharmacokinetic and molecular docking studies of natural flavonoids and synthetic indole chalcones against essential proteins of SARS-CoV-2, Eur J Pharmacol

Vivek-Ananth, Rajan, Biswal, Samal, In silico identification of potential natural product inhibitors of human proteases key to SARS-CoV-2 infection, Molecules

Vázquez-Calvo, De Oya, Martín-Acebes, Garcia-Moruno, Saiz, Antiviral properties of the natural polyphenols delphinidin and epigallocatechin gallate against the flaviviruses West Nile virus, Zika virus, and dengue virus, Front Microbiol

Wagener, Pickkers, Peterson, Immenschuh, Abraham, Targeting the heme-heme oxygenase system to prevent severe complications following COVID-19 infections, Antioxidants

Wallace, Bailey, Blumberg, Burton-Freeman, Co et al., Fruits, vegetables, and health: a comprehensive narrative, umbrella review of the science and recommendations for enhanced public policy to improve intake, Crit Rev Food Sci Nutr

Wan, Shang, Graham, Baric, Li et al., Receptor recognition by the novel coronavirus from Wuhan: an analysis based on decade-long structural studies of SARS coronavirus, J Virol

Wang, Cheng, Sequence analysis of the emerging Sars-CoV-2 Variant Omicron in South Africa, J Med Virol

Wang, Wang, Yuan, Zhao, Simultaneous analysis of diosgenin and sarsasapogenin in Asparagus officinalis byproduct by thin-layer chromatography, Phytochem Anal

Wasilewicz, Kirchweger, Bojkova, Saad, Langeder et al., Identification of Natural Products Inhibiting SARS-CoV-2 by Targeting Viral Proteases: A Combined in Silico and in Vitro Approach, J Nat Prod

Wei, Wang, Wu, -Q, Lu et al., In silico screening of potential spike glycoprotein inhibitors of SARS-CoV-2 with drug repurposing strategy, Chin J Integr Med

Williamson, Walker, Bhaskaran, Bacon, Bates et al., OpenSAFELY: factors associated with COVID-19 death in 17 million patients, Nature

Wrapp, Wang, Corbett, Goldsmith, Hsieh et al., Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation, Science

Wu, Liu, Yang, Zhang, Zhong et al., Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods, Acta Pharm Sin B

Wu, Tackle the free radicals damage in COVID-19, Nitric Oxide

Wu, Zhao, Haytowitz, Chen, Pehrsson, Effects of domestic cooking on flavonoids in broccoli and calculation of retention factors, Heliyon

Wu, Zhou, Mo, Li, Han et al., The effect of the multiple mutations in Omicron RBD on its binding to human ACE2 receptor and immune evasion: an investigation of molecular dynamics simulations

Yan, Tong, Chu, Sheng, Chen, Preparative isolation and purification of syringin and edgeworoside C from Edgeworthia chrysantha Lindl by high-speed counter-current chromatography, J Chromatogr A

Yang, Chen, Kumar, Yu, Chao et al., Antioxidant and anti-inflammatory potential of hesperetin metabolites obtained from hesperetin-administered rat serum: an ex vivo approach, J Agric Food Chem

Yang, Chen, Li, Zhu, -Y et al., D-limonene is a potential monoterpene to inhibit PI3K/ Akt/IKK-α/NF-κB p65 signaling pathway in coronavirus disease 2019 pulmonary fibrosis, Front Med

Yang, Patel, Blunden, Turner, Mj et al., Crabbine, an aporphine alkaloid from Corydalis lutea, Phytochemistry

Yepes-Pérez, Herrera-Calderon, Sánchez-Aparicio, Tiessler-Sala, Maréchal et al., Investigating potential inhibitory effect of uncaria tomentosa (cat's claw) against the main protease 3CLpro of SARS-CoV-2 by molecular modeling, Evid-Based Complement Altern Med

Yoo, Nam, Kim, Choi, Park, Pectolinarin and pectolinarigenin of Cirsium setidens prevent the hepatic injury in rats caused by D-galactosamine via an antioxidant mechanism, Biol Pharm Bull

Yu, Chen, Lan, Shen, Li, Computational screening of antagonists against the SARS-CoV-2 (COVID-19) coronavirus by molecular docking, Int J Antimicrob Agents

Zhang, Zhang, Li, Xiong, Xiao et al., Gemcitabine, lycorine and oxysophoridine inhibit novel coronavirus (SARS-CoV-2) in cell culture, Emerg Microbes Infect

Zhao, Lu, Peng, Chen, Meng et al., SARS-CoV-2 Omicron variant shows less efficient replication and fusion activity when compared with delta variant in TMPRSS2-expressed cells, Emerg Microbes Infect

Zhao, Zhang, You, Liu, Xu et al., Hepatoprotective effects of nicotiflorin from Nymphaea candida against concanavalin a-induced and d-galactosamine-induced liver injury in mice, Int J Mol Sci

Zheng, Baak, Li, Ren, Yang et al., Network pharmacology analysis of the therapeutic mechanisms of the traditional Chinese herbal formula Lian Hua Qing Wen in Corona virus disease 2019 (COVID-19), gives fundamental support to the clinical use of LHQW, Phytomedicine

Zhou, Gupta, Aggarwal, Aneja, Chandra et al., Brominated derivatives of noscapine are potent microtubule-interfering agents that perturb mitosis and inhibit cell proliferation, Mol Pharmacol

Zhou, Liu, Yang, Characterization of terpene synthase from tea green leafhopper being involved in formation of geraniol in tea (Camellia sinensis) leaves and potential effect of geraniol on insect-derived endobacteria, Biomolecules

Zomborszki, Kúsz, Csupor, Peschel, Rhodiosin and herbacetin in Rhodiola rosea preparations: additional markers for quality control?, Pharm Biol

Čerňáková, Košťálová, Antimicrobial activity of berberine-a constituent of Mahonia aquifolium, Folia Microbiol

{ 'indexed': {'date-parts': [[2024, 2, 6]], 'date-time': '2024-02-06T18:28:03Z', 'timestamp': 1707244083411}, 'reference-count': 221, 'publisher': 'Springer Science and Business Media LLC', 'issue': '1', 'license': [ { 'start': { 'date-parts': [[2023, 8, 25]], 'date-time': '2023-08-25T00:00:00Z', 'timestamp': 1692921600000}, 'content-version': 'tdm', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0'}, { 'start': { 'date-parts': [[2023, 8, 25]], 'date-time': '2023-08-25T00:00:00Z', 'timestamp': 1692921600000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0'}], 'funder': [ { 'name': 'The Science, Technology & Innovation Funding Authority (STDF) in cooperation with ' 'the Egyptian Knowledge Bank'}, {'DOI': '10.13039/501100007950', 'name': 'Tanta University', 'doi-asserted-by': 'crossref'}], 'content-domain': {'domain': ['link.springer.com'], 'crossmark-restriction': False}, 'abstract': 'Abstract\n' ' Background\n' ' The recent outbreak of the Coronavirus pandemic resulted in a ' 'successful vaccination program launched by the World Health Organization. However, a large ' 'population is still unvaccinated, leading to the emergence of mutated strains like alpha, ' 'beta, delta, and B.1.1.529 (Omicron). Recent reports from the World Health Organization ' 'raised concerns about the Omicron variant, which emerged in South Africa during a surge in ' 'COVID-19 cases in November 2021. Vaccines are not proven completely effective or safe against ' 'Omicron, leading to clinical trials for combating infection by the mutated virus. The absence ' 'of suitable pharmaceuticals has led scientists and clinicians to search for alternative and ' 'supplementary therapies, including dietary patterns, to reduce the effect of mutated ' 'strains.\n' ' \n' ' Main body\n' ' This review analyzed Coronavirus aetiology, epidemiology, and natural ' 'products for combating Omicron. Although the literature search did not include keywords ' 'related to in silico or computational research, in silico investigations were emphasized in ' 'this study. Molecular docking was implemented to compare the interaction between natural ' 'products and Chloroquine with the ACE2 receptor protein amino acid residues of Omicron. The ' 'global Omicron infection proceeding SARS-CoV-2 vaccination was also elucidated. The docking ' 'results suggest that DGCG may bind to the ACE2 receptor three times more effectively than ' 'standard chloroquine.\n' ' \n' ' Conclusion\n' ' The emergence of the Omicron variant has highlighted the need for ' 'alternative therapies to reduce the impact of mutated strains. The current review suggests ' 'that natural products such as DGCG may be effective in binding to the ACE2 receptor and ' 'combating the Omicron variant, however, further research is required to validate the results ' 'of this study and explore the potential of natural products to mitigate COVID-19.\n' ' \n' ' Graphical abstract\n' ' \n' ' ', 'DOI': '10.1186/s12985-023-02160-6', 'type': 'journal-article', 'created': {'date-parts': [[2023, 8, 25]], 'date-time': '2023-08-25T06:02:14Z', 'timestamp': 1692943334000}, 'update-policy': 'http://dx.doi.org/10.1007/springer_crossmark_policy', 'source': 'Crossref', 'is-referenced-by-count': 3, 'title': 'A study on the effect of natural products against the transmission of B.1.1.529 Omicron', 'prefix': '10.1186', 'volume': '20', 'author': [ {'given': 'Samar Sami', 'family': 'Alkafaas', 'sequence': 'first', 'affiliation': []}, {'given': 'Abanoub Mosaad', 'family': 'Abdallah', 'sequence': 'additional', 'affiliation': []}, {'given': 'Aya Misbah', 'family': 'Hussien', 'sequence': 'additional', 'affiliation': []}, {'given': 'Heba', 'family': 'Bedair', 'sequence': 'additional', 'affiliation': []}, {'given': 'Mahmoud', 'family': 'Abdo', 'sequence': 'additional', 'affiliation': []}, {'given': 'Soumya', 'family': 'Ghosh', 'sequence': 'additional', 'affiliation': []}, {'given': 'Sara Samy', 'family': 'Elkafas', 'sequence': 'additional', 'affiliation': []}, {'given': 'Wilgince', 'family': 'Apollon', 'sequence': 'additional', 'affiliation': []}, {'given': 'Morteza', 'family': 'Saki', 'sequence': 'additional', 'affiliation': []}, {'given': 'Samah A.', 'family': 'Loutfy', 'sequence': 'additional', 'affiliation': []}, {'given': 'Helen', 'family': 'Onyeaka', 'sequence': 'additional', 'affiliation': []}, {'given': 'Mohamed', 'family': 'Hessien', 'sequence': 'additional', 'affiliation': []}], 'member': '297', 'published-online': {'date-parts': [[2023, 8, 25]]}, 'reference': [ { 'key': '2160_CR1', 'doi-asserted-by': 'crossref', 'first-page': '1', 'DOI': '10.12998/wjcc.v10.i1.1', 'volume': '10', 'author': 'S-Y Ren', 'year': '2022', 'unstructured': 'Ren S-Y, Wang W-B, Gao R-D, Zhou A-M. Omicron variant (B. 1.1. 529) of ' 'SARS-CoV-2: mutation, infectivity, transmission, and vaccine resistance. ' 'World J Clin Cases. 2022;10:1.', 'journal-title': 'World J Clin Cases'}, { 'key': '2160_CR2', 'unstructured': 'Organization WH. Enhancing response to Omicron SARS-CoV-2 variant: ' 'Technical brief and priority actions for Member States. World Health ' 'Organization Headquarters, Geneva, Switzerland Update 2022.'}, { 'key': '2160_CR3', 'doi-asserted-by': 'crossref', 'first-page': '277', 'DOI': '10.1080/22221751.2021.2023329', 'volume': '11', 'author': 'H Zhao', 'year': '2022', 'unstructured': 'Zhao H, Lu L, Peng Z, Chen L-L, Meng X, Zhang C, Ip JD, Chan W-M. Chu ' 'AW-H, Chan K-H: SARS-CoV-2 Omicron variant shows less efficient ' 'replication and fusion activity when compared with delta variant in ' 'TMPRSS2-expressed cells. Emerg Microbes Infect. 2022;11:277–83.', 'journal-title': 'Emerg Microbes Infect'}, { 'key': '2160_CR4', 'doi-asserted-by': 'crossref', 'first-page': '1284', 'DOI': '10.1016/j.jiph.2021.07.021', 'volume': '14', 'author': 'M Meskini', 'year': '2021', 'unstructured': 'Meskini M, Rami MR, Maroofi P, Ghosh S, Siadat SD, Sheikhpour M. An ' 'overview on the epidemiology and immunology of COVID-19. J Infect Public ' 'Health. 2021;14:1284–98.', 'journal-title': 'J Infect Public Health'}, { 'key': '2160_CR5', 'doi-asserted-by': 'crossref', 'unstructured': 'Alkafaas SS, Abdallah AM, Ghosh S, Loutfy SA, Elkafas SS, Abdel Fattah ' 'NF, Hessien M. Insight into the role of clathrin‐mediated endocytosis ' 'inhibitors in SARS‐CoV‐2 infection. Rev Med Virol 2022;e2403.', 'DOI': '10.1002/rmv.2403'}, { 'key': '2160_CR6', 'doi-asserted-by': 'crossref', 'first-page': '1040', 'DOI': '10.3390/v15051040', 'volume': '15', 'author': 'M Hessien', 'year': '2023', 'unstructured': 'Hessien M, Donia T, Tabll AA, Adly E, Abdelhafez TH, Attia A, Alkafaas ' 'SS, Kuna L, Glasnovic M, Cosic V. Mechanistic-based classification of ' 'endocytosis-related inhibitors: Does it aid in assigning drugs against ' 'SARS-CoV-2? Viruses. 2023;15:1040.', 'journal-title': 'Viruses'}, { 'key': '2160_CR7', 'doi-asserted-by': 'crossref', 'first-page': '555', 'DOI': '10.1016/j.jiph.2021.02.011', 'volume': '14', 'author': 'S Ghosh', 'year': '2021', 'unstructured': 'Ghosh S, Bornman C, Zafer MM. Antimicrobial resistance threats in the ' 'emerging COVID-19 pandemic: Where do we stand? J Infect Public Health. ' '2021;14:555–60.', 'journal-title': 'J Infect Public Health'}, { 'key': '2160_CR8', 'doi-asserted-by': 'crossref', 'unstructured': 'Sharma RP, Gautam S, Sharma P, Singh R, Sharma H, Parsoya D, Deba F, ' 'Bhomia N, Potdar VA, Yadav PD. Clinico epidemiological profile of ' 'Omicron variant of SARS CoV2 in Rajasthan. medRxiv 2022.', 'DOI': '10.1101/2022.02.11.22270698'}, { 'key': '2160_CR9', 'unstructured': 'Cascella M, Rajnik M, Aleem A, Dulebohn SC, Di Napoli R. Features, ' 'evaluation, and treatment of coronavirus (COVID-19). Statpearls ' '[internet] 2022.'}, { 'key': '2160_CR10', 'doi-asserted-by': 'crossref', 'first-page': '742', 'DOI': '10.3390/antiox9080742', 'volume': '9', 'author': 'P Bellavite', 'year': '2020', 'unstructured': 'Bellavite P, Donzelli A. Hesperidin and SARS-CoV-2: new light on the ' 'healthy function of citrus fruits. Antioxidants. 2020;9:742.', 'journal-title': 'Antioxidants'}, { 'key': '2160_CR11', 'doi-asserted-by': 'crossref', 'first-page': '125', 'DOI': '10.1016/j.lfs.2015.07.014', 'volume': '137', 'author': 'M Iranshahi', 'year': '2015', 'unstructured': 'Iranshahi M, Rezaee R, Parhiz H, Roohbakhsh A, Soltani F. Protective ' 'effects of flavonoids against microbes and toxins: the cases of ' 'hesperidin and hesperetin. Life Sci. 2015;137:125–32.', 'journal-title': 'Life Sci'}, { 'key': '2160_CR12', 'doi-asserted-by': 'crossref', 'first-page': '2174', 'DOI': '10.1080/10408398.2019.1632258', 'volume': '60', 'author': 'TC Wallace', 'year': '2020', 'unstructured': 'Wallace TC, Bailey RL, Blumberg JB, Burton-Freeman B, Chen CO, ' 'Crowe-White KM, Drewnowski A, Hooshmand S, Johnson E, Lewis R. Fruits, ' 'vegetables, and health: a comprehensive narrative, umbrella review of ' 'the science and recommendations for enhanced public policy to improve ' 'intake. Crit Rev Food Sci Nutr. 2020;60:2174–211.', 'journal-title': 'Crit Rev Food Sci Nutr'}, { 'key': '2160_CR13', 'first-page': '1039', 'volume': '11', 'author': 'W Koch', 'year': '2019', 'unstructured': 'Koch W. Dietary polyphenols—important non-nutrients in the prevention of ' 'chronic noncommunicable diseases. Syst Rev Nutr. 2019;11:1039.', 'journal-title': 'Syst Rev Nutr'}, { 'key': '2160_CR14', 'doi-asserted-by': 'crossref', 'first-page': '586993', 'DOI': '10.3389/fphar.2020.586993', 'volume': '11', 'author': 'M Omrani', 'year': '2021', 'unstructured': 'Omrani M, Keshavarz M, Nejad Ebrahimi S, Mehrabi M, McGaw LJ, Ali ' 'Abdalla M, Mehrbod P. Potential natural products against respiratory ' 'viruses: a perspective to develop anti-COVID-19 medicines. Front ' 'Pharmacol. 2021;11:586993.', 'journal-title': 'Front Pharmacol'}, { 'key': '2160_CR15', 'doi-asserted-by': 'crossref', 'first-page': '40', 'DOI': '10.1007/s00044-021-02826-2', 'volume': '31', 'author': 'RL Chapman', 'year': '2022', 'unstructured': 'Chapman RL, Andurkar SV. A review of natural products, their effects on ' 'SARS-CoV-2 and their utility as lead compounds in the discovery of drugs ' 'for the treatment of COVID-19. Med Chem Res. 2022;31:40–51.', 'journal-title': 'Med Chem Res'}, { 'key': '2160_CR16', 'doi-asserted-by': 'crossref', 'first-page': '828', 'DOI': '10.3390/v13050828', 'volume': '13', 'author': 'M Musarra-Pizzo', 'year': '2021', 'unstructured': 'Musarra-Pizzo M, Pennisi R, Ben-Amor I, Mandalari G, Sciortino MT. ' 'Antiviral activity exerted by natural products against human viruses. ' 'Viruses. 2021;13:828.', 'journal-title': 'Viruses'}, { 'key': '2160_CR17', 'doi-asserted-by': 'crossref', 'first-page': '42404', 'DOI': '10.1007/s11356-022-19770-2', 'volume': '29', 'author': 'A Al-Harrasi', 'year': '2022', 'unstructured': 'Al-Harrasi A, Behl T, Upadhyay T, Chigurupati S, Bhatt S, Sehgal A, ' 'Bhatia S, Singh S, Sharma N, Vijayabalan S. Targeting natural products ' 'against SARS-CoV-2. Environ Sci Pollut Res. 2022;29:42404–32.', 'journal-title': 'Environ Sci Pollut Res'}, { 'key': '2160_CR18', 'doi-asserted-by': 'crossref', 'first-page': '766', 'DOI': '10.1016/j.apsb.2020.02.008', 'volume': '10', 'author': 'C Wu', 'year': '2020', 'unstructured': 'Wu C, Liu Y, Yang Y, Zhang P, Zhong W, Wang Y, Wang Q, Xu Y, Li M, Li X. ' 'Analysis of therapeutic targets for SARS-CoV-2 and discovery of ' 'potential drugs by computational methods. Acta Pharm Sin B. ' '2020;10:766–88.', 'journal-title': 'Acta Pharm Sin B'}, { 'key': '2160_CR19', 'doi-asserted-by': 'crossref', 'first-page': '109957', 'DOI': '10.1016/j.mehy.2020.109957', 'volume': '144', 'author': 'YA Haggag', 'year': '2020', 'unstructured': 'Haggag YA, El-Ashmawy NE, Okasha KM. Is hesperidin essential for ' 'prophylaxis and treatment of COVID-19 Infection? Med Hypotheses. ' '2020;144:109957.', 'journal-title': 'Med Hypotheses'}, { 'key': '2160_CR20', 'doi-asserted-by': 'crossref', 'first-page': '8809', 'DOI': '10.1021/jf300669s', 'volume': '60', 'author': 'A Chanet', 'year': '2012', 'unstructured': 'Chanet A, Milenkovic D, Manach C, Mazur A, Morand C. Citrus flavanones: ' 'What is their role in cardiovascular protection? J Agric Food Chem. ' '2012;60:8809–22.', 'journal-title': 'J Agric Food Chem'}, { 'key': '2160_CR21', 'doi-asserted-by': 'crossref', 'first-page': '430', 'DOI': '10.1038/s41586-020-2521-4', 'volume': '584', 'author': 'EJ Williamson', 'year': '2020', 'unstructured': 'Williamson EJ, Walker AJ, Bhaskaran K, Bacon S, Bates C, Morton CE, ' 'Curtis HJ, Mehrkar A, Evans D, Inglesby P. OpenSAFELY: factors ' 'associated with COVID-19 death in 17 million patients. Nature. ' '2020;584:430.', 'journal-title': 'Nature'}, { 'key': '2160_CR22', 'doi-asserted-by': 'crossref', 'volume-title': 'Vaccines, medicines and COVID-19: How can WHO be given a stronger voice?', 'author': 'G Velásquez', 'year': '2022', 'unstructured': 'Velásquez G. Vaccines, medicines and COVID-19: How can WHO be given a ' 'stronger voice? Springer; 2022.', 'DOI': '10.1007/978-3-030-89125-1'}, { 'key': '2160_CR23', 'doi-asserted-by': 'crossref', 'first-page': '409', 'DOI': '10.1038/s41579-021-00573-0', 'volume': '19', 'author': 'WT Harvey', 'year': '2021', 'unstructured': 'Harvey WT, Carabelli AM, Jackson B, Gupta RK, Thomson EC, Harrison EM, ' 'Ludden C, Reeve R, Rambaut A, Peacock SJ. SARS-CoV-2 variants, spike ' 'mutations and immune escape. Nat Rev Microbiol. 2021;19:409–24.', 'journal-title': 'Nat Rev Microbiol'}, { 'key': '2160_CR24', 'doi-asserted-by': 'crossref', 'unstructured': 'He X, Hong W, Pan X, Lu G, Wei X. SARS‐CoV‐2 Omicron variant: ' 'characteristics and prevention. MedComm 2021.', 'DOI': '10.1002/mco2.110'}, { 'key': '2160_CR25', 'doi-asserted-by': 'crossref', 'unstructured': 'Garret N, Tapley A, Andriesen J, Seocharan I, Fisher LH, Bunts L, Espy ' 'N, Wallis C, Randhawa AK, Goga A. High rate of asymptomatic carriage ' 'associated with variant strain Omicron. MedRxiv 2021.', 'DOI': '10.1101/2021.12.20.21268130'}, { 'key': '2160_CR26', 'unstructured': 'Organization WH: Classification of Omicron (B. 1.1. 529): SARS-CoV-2 ' 'variant of concern. World Health Organization ' 'https://www.who.int/news/item/26-11-2021-classification-of-omicron-(b.1.1.529)-sars-cov-2-variant-of-concern. ' 'Accessed 28 Nov 2021.'}, { 'key': '2160_CR27', 'doi-asserted-by': 'crossref', 'unstructured': 'Pulliam JR, van Schalkwyk C, Govender N, von Gottberg A, Cohen C, Groome ' 'MJ, Dushoff J, Mlisana K, Moultrie H. Increased risk of SARS-CoV-2 ' 'reinfection associated with emergence of the Omicron variant in South ' 'Africa. MedRxiv 2021.', 'DOI': '10.1101/2021.11.11.21266068'}, { 'key': '2160_CR28', 'doi-asserted-by': 'crossref', 'unstructured': 'VanBlargan LA, Errico JM, Halfmann PJ, Zost SJ, Crowe JE, Purcell LA, ' 'Kawaoka Y, Corti D, Fremont DH, Diamond MS. An infectious SARS-CoV-2 B. ' '1.1. 529 Omicron virus escapes neutralization by therapeutic monoclonal ' 'antibodies. Nat Med. 2022;1–6.', 'DOI': '10.21203/rs.3.rs-1175516/v1'}, { 'key': '2160_CR29', 'volume-title': 'Methods for the detection and characterisation of SARS-CoV-2 variants: ' 'first update, 20 December 2021', 'author': 'WH Organization', 'year': '2021', 'unstructured': 'Organization WH. Methods for the detection and characterisation of ' 'SARS-CoV-2 variants: first update, 20 December 2021. Regional Office for ' 'Europe: World Health Organization; 2021.'}, { 'key': '2160_CR30', 'unstructured': 'ASSESSMENT RR. Assessment of the further emergence and potential impact ' 'of the SARS-CoV-2 Omicron variant of concern in the context of ongoing ' 'transmission of the Delta variant of concern in the EU/EEA, 18th update. ' '2021.'}, { 'key': '2160_CR31', 'unstructured': 'Parasher A. COVID research: a year of scientific milestones. Nature ' '2021.'}, { 'key': '2160_CR32', 'doi-asserted-by': 'crossref', 'unstructured': 'Thurzo A, Bražinová A, Markovská N, Waczulíková I, Smatana M, Moravanský ' 'N, Urbanová W, Urban R, Strunga M, Kurilová V. Dentistry after Omicron ' 'variant: introducing a new biosafety protocol in prevention of COVID-19 ' 'in Dental Care. 2022.', 'DOI': '10.20944/preprints202201.0315.v1'}, { 'key': '2160_CR33', 'doi-asserted-by': 'crossref', 'unstructured': 'Jansen L, Tegomoh B, Lange K, Showalter K, Figliomeni J, Abdalhamid B, ' 'Iwen PC, Fauver J, Buss B, Donahue M. Investigation of a sars-cov-2 b. ' '1.1. 529 (omicron) variant cluster—Nebraska, November–December 2021. ' 'Morbidity and Mortality Weekly Report 2021, 70:1782.', 'DOI': '10.15585/mmwr.mm705152e3'}, { 'key': '2160_CR34', 'first-page': '1023', 'volume': '1', 'author': 'A Alhouri', 'year': '2020', 'unstructured': 'Alhouri A, Salloum A, Harfouch RM, Soumya G. Possible side effects of ' 'using detergents during the Covid19 pandemic in Syria. Ann Clin Cases. ' '2020;1:1023.', 'journal-title': 'Ann Clin Cases'}, { 'key': '2160_CR35', 'doi-asserted-by': 'crossref', 'unstructured': 'Nie C, Sahoo AK, Herrmann A, Ballauff M, Netz RR, Haag R. Charge ' 'matters: mutations in omicron variant favor binding to cells. ' 'ChemBioChem. 2022.', 'DOI': '10.1002/cbic.202100681'}, { 'key': '2160_CR36', 'doi-asserted-by': 'crossref', 'unstructured': 'Chen J, Wang R, Gilby NB, Wei G-W. Omicron variant (B. 1.1. 529): ' 'Infectivity, vaccine breakthrough, and antibody resistance. J Chem Inf ' 'Model 2022.', 'DOI': '10.1021/acs.jcim.1c01451'}, { 'key': '2160_CR37', 'doi-asserted-by': 'crossref', 'unstructured': 'Kotaki R, Adachi Y, Moriyama S, Onodera T, Fukushi S, Nagakura T, ' 'Tonouchi K, Terahara K, Sun L, Takano T: SARS-CoV-2 Omicron-neutralizing ' 'memory B-cells are elicited by two doses of BNT162b2 mRNA vaccine. Sci ' 'Immunol. 2022;eabn8590.', 'DOI': '10.1126/sciimmunol.abn8590'}, { 'key': '2160_CR38', 'doi-asserted-by': 'crossref', 'first-page': '1314', 'DOI': '10.1056/NEJMoa2119658', 'volume': '386', 'author': 'SA Madhi', 'year': '2022', 'unstructured': 'Madhi SA, Kwatra G, Myers JE, Jassat W, Dhar N, Mukendi CK, Nana AJ, ' 'Blumberg L, Welch R, Ngorima-Mabhena N. Population immunity and Covid-19 ' 'severity with Omicron variant in South Africa. N Engl J Med. ' '2022;386:1314–26.', 'journal-title': 'N Engl J Med'}, { 'key': '2160_CR39', 'doi-asserted-by': 'crossref', 'first-page': '102277', 'DOI': '10.1016/j.tmaid.2022.102277', 'volume': '46', 'author': 'L Assoumani', 'year': '2022', 'unstructured': 'Assoumani L, Delerce J, Houhamdi L, Bedotto M, Lagier J-C, Million M, ' 'Levasseur A, Fournier P-E, La Scola B, Raoult D. Introduction of the ' 'SARS-CoV-2 Beta variant from Comoros into the Marseille geographical ' 'area. Travel Med Infect Dis. 2022;46:102277.', 'journal-title': 'Travel Med Infect Dis'}, { 'key': '2160_CR40', 'doi-asserted-by': 'crossref', 'first-page': '1641', 'DOI': '10.1002/jmv.27526', 'volume': '94', 'author': 'S Kumar', 'year': '2022', 'unstructured': 'Kumar S, Thambiraja TS, Karuppanan K, Subramaniam G. Omicron and Delta ' 'variant of SARS-CoV-2: a comparative computational study of spike ' 'protein. J Med Virol. 2022;94:1641–9.', 'journal-title': 'J Med Virol'}, { 'key': '2160_CR41', 'doi-asserted-by': 'crossref', 'first-page': '603', 'DOI': '10.1016/S1473-3099(22)00001-9', 'volume': '22', 'author': 'WS Hart', 'year': '2022', 'unstructured': 'Hart WS, Miller E, Andrews NJ, Waight P, Maini PK, Funk S, Thompson RN. ' 'Generation time of the alpha and delta SARS-CoV-2 variants: an ' 'epidemiological analysis. Lancet Infect Dis. 2022;22:603–10.', 'journal-title': 'Lancet Infect Dis'}, { 'key': '2160_CR42', 'doi-asserted-by': 'crossref', 'first-page': '239', 'DOI': '10.2471/BLT.22.288220', 'volume': '100', 'author': 'LL Carter', 'year': '2022', 'unstructured': 'Carter LL, Yu MA, Sacks JA, Barnadas C, Pereyaslov D, Cognat S, Briand ' 'S, Ryan MJ, Samaan G. Global genomic surveillance strategy for pathogens ' 'with pandemic and epidemic potential 2022–2032. Bull World Health Organ. ' '2022;100:239.', 'journal-title': 'Bull World Health Organ'}, { 'key': '2160_CR43', 'doi-asserted-by': 'crossref', 'unstructured': 'Shanmugaraj B, Malla A, Khorattanakulchai N, Phoolcharoen W. SARS‐CoV‐2 ' 'omicron variant: Could it be another threat? J Med Virol. 2021.', 'DOI': '10.1002/jmv.27532'}, { 'key': '2160_CR44', 'doi-asserted-by': 'crossref', 'unstructured': 'Garcia-Beltran WF, Denis KJS, Hoelzemer A, Lam EC, Nitido AD, Sheehan ' 'ML, Berrios C, Ofoman O, Chang CC, Hauser BM. mRNA-based COVID-19 ' 'vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron ' 'variant. Cell 2022.', 'DOI': '10.1101/2021.12.14.21267755'}, { 'key': '2160_CR45', 'doi-asserted-by': 'crossref', 'unstructured': 'Callaway E. Heavily mutated coronavirus variant puts scientists on ' 'alert. Nature 2021;25.', 'DOI': '10.1038/d41586-021-03552-w'}, { 'key': '2160_CR46', 'doi-asserted-by': 'crossref', 'first-page': '1731', 'DOI': '10.15585/mmwr.mm7050e1', 'volume': '70', 'author': 'Covid C, Team R', 'year': '2021', 'unstructured': 'Covid C, Team R. SARS-CoV-2 B 11 529 (Omicron) Variant—United States, ' 'December 1–8, 2021. Morb Mortal Wkly Rep. 2021;70:1731.', 'journal-title': 'Morb Mortal Wkly Rep'}, { 'key': '2160_CR47', 'doi-asserted-by': 'crossref', 'unstructured': 'Wang L, Cheng G. Sequence analysis of the emerging Sars‐CoV‐2 Variant ' 'Omicron in South Africa. J Med Virol. 2021.', 'DOI': '10.1002/jmv.27516'}, { 'key': '2160_CR48', 'doi-asserted-by': 'crossref', 'unstructured': 'Hossain G, Tang Yd, Akter S, Zheng C. Roles of the polybasic furin ' 'cleavage site of spike protein in SARS‐CoV‐2 replication, pathogenesis, ' 'and host immune responses and vaccination. J Med Virol. 2021.', 'DOI': '10.1002/jmv.27539'}, { 'key': '2160_CR49', 'doi-asserted-by': 'crossref', 'first-page': '899', 'DOI': '10.1038/s41564-021-00908-w', 'volume': '6', 'author': 'TP Peacock', 'year': '2021', 'unstructured': 'Peacock TP, Goldhill DH, Zhou J, Baillon L, Frise R, Swann OC, ' 'Kugathasan R, Penn R, Brown JC, Sanchez-David RY. The furin cleavage ' 'site in the SARS-CoV-2 spike protein is required for transmission in ' 'ferrets. Nat Microbiol. 2021;6:899–909.', 'journal-title': 'Nat Microbiol'}, { 'key': '2160_CR50', 'doi-asserted-by': 'crossref', 'unstructured': 'Kumar S, Thambiraja TS, Karuppanan K, Subramaniam G. Omicron and Delta ' 'variant of SARS‐CoV‐2: a comparative computational study of spike ' 'protein. J Med Virol. 2021.', 'DOI': '10.1101/2021.12.02.470946'}, { 'key': '2160_CR51', 'doi-asserted-by': 'crossref', 'unstructured': 'Wu L, Zhou L, Mo M, Li Y, Han J, Li J, Yang Y, Zhang X, Gong C, Lu K. ' 'The effect of the multiple mutations in Omicron RBD on its binding to ' 'human ACE2 receptor and immune evasion: an investigation of molecular ' 'dynamics simulations. 2021.', 'DOI': '10.26434/chemrxiv-2021-n23f5'}, { 'key': '2160_CR52', 'doi-asserted-by': 'crossref', 'unstructured': 'Torjesen I. Covid-19: Omicron may be more transmissible than other ' 'variants and partly resistant to existing vaccines, scientists fear. Br ' 'Med J Publ Group. 2021.', 'DOI': '10.1136/bmj.n2943'}, { 'key': '2160_CR53', 'doi-asserted-by': 'crossref', 'unstructured': 'Pascarella S, Ciccozzi M, Bianchi M, Benvenuto D, Cauda R, Cassone A: ' 'The electrostatic potential of the omicron variant spike is higher than ' 'in delta and delta‐plus variants: a hint to higher transmissibility? J ' 'Med Virol. 2021.', 'DOI': '10.1002/jmv.27528'}, { 'key': '2160_CR54', 'doi-asserted-by': 'crossref', 'first-page': '6551', 'DOI': '10.1002/jmv.27210', 'volume': '93', 'author': 'S Pascarella', 'year': '2021', 'unstructured': 'Pascarella S, Ciccozzi M, Zella D, Bianchi M, Benedetti F, Benvenuto D, ' 'Broccolo F, Cauda R, Caruso A, Angeletti S. SARS-CoV-2 B. 1.617 Indian ' 'variants: Are electrostatic potential changes responsible for a higher ' 'transmission rate? J Med Virol. 2021;93:6551–6.', 'journal-title': 'J Med Virol'}, { 'key': '2160_CR55', 'doi-asserted-by': 'crossref', 'unstructured': 'Mohapatra RK, Tiwari R, Sarangi AK, Sharma SK, Khandia R, Saikumar G, ' 'Dhama K. Twin combination of Omicron and Delta variant triggering a ' 'Tsunami wave of ever high surges in COVID‐19 cases: a challenging global ' 'threat with a special focus on Indian sub‐continent. J Med Virol. 2022.', 'DOI': '10.1002/jmv.27585'}, { 'key': '2160_CR56', 'doi-asserted-by': 'crossref', 'unstructured': 'Mudd PA, Minervina AA, Pogorelyy MV, Turner JS, Kim W, Kalaidina E, ' 'Petersen J, Schmitz AJ, Lei T, Haile A. SARS-CoV-2 mRNA vaccination ' 'elicits a robust and persistent T follicular helper cell response in ' 'humans. Cell. 2021.', 'DOI': '10.1101/2021.09.08.459485'}, { 'key': '2160_CR57', 'doi-asserted-by': 'crossref', 'unstructured': 'Khan K, Karim F, Cele S, San JE, Lustig G, Tegally H, Bernstein M, Ganga ' 'Y, Jule Z, Reedoy K. Omicron infection enhances neutralizing immunity ' 'against the Delta variant. medRxiv 2021.', 'DOI': '10.1101/2021.12.27.21268439'}, { 'key': '2160_CR58', 'doi-asserted-by': 'crossref', 'first-page': '173644', 'DOI': '10.1016/j.ejphar.2020.173644', 'volume': '889', 'author': 'C Stasi', 'year': '2020', 'unstructured': 'Stasi C, Fallani S, Voller F, Silvestri C. Treatment for COVID-19: an ' 'overview. Eur J Pharmacol. 2020;889:173644.', 'journal-title': 'Eur J Pharmacol'}, { 'key': '2160_CR59', 'doi-asserted-by': 'crossref', 'unstructured': 'Saif LJ. Vaccines for COVID-19: perspectives, prospects, and challenges ' 'based on candidate SARS, MERS, and animal coronavirus vaccines. Euro Med ' 'J. 2020;200324.', 'DOI': '10.33590/emj/200324'}, { 'key': '2160_CR60', 'doi-asserted-by': 'crossref', 'first-page': '8', 'DOI': '10.7150/ijbs.52569', 'volume': '17', 'author': 'A Awadasseid', 'year': '2021', 'unstructured': 'Awadasseid A, Wu Y, Tanaka Y, Zhang W. Current advances in the ' 'development of SARS-CoV-2 vaccines. Int J Biol Sci. 2021;17:8.', 'journal-title': 'Int J Biol Sci'}, { 'key': '2160_CR61', 'doi-asserted-by': 'crossref', 'unstructured': 'Araf Y, Akter F, Tang Yd, Fatemi R, Parvez SA, Zheng C, Hossain G: ' 'Omicron variant of SARS‐CoV‐2: genomics, transmissibility, and responses ' 'to current COVID‐19 vaccines. J Med Virol. 2022.', 'DOI': '10.1002/jmv.27588'}, { 'key': '2160_CR62', 'doi-asserted-by': 'crossref', 'unstructured': 'Hoffmann M, Krüger N, Schulz S, Cossmann A, Rocha C, Kempf A, Nehlmeier ' 'I, Graichen L, Moldenhauer A-S, Winkler MS. The Omicron variant is ' 'highly resistant against antibody-mediated neutralization–implications ' 'for control of the COVID-19 pandemic. Cell 2021.', 'DOI': '10.1101/2021.12.12.472286'}, { 'key': '2160_CR63', 'doi-asserted-by': 'crossref', 'first-page': '131', 'DOI': '10.1001/jama.2020.10245', 'volume': '324', 'author': 'M Marovich', 'year': '2020', 'unstructured': 'Marovich M, Mascola JR, Cohen MS. Monoclonal antibodies for prevention ' 'and treatment of COVID-19. JAMA. 2020;324:131–2.', 'journal-title': 'JAMA'}, { 'key': '2160_CR64', 'doi-asserted-by': 'crossref', 'first-page': '1260', 'DOI': '10.1126/science.abb2507', 'volume': '367', 'author': 'D Wrapp', 'year': '2020', 'unstructured': 'Wrapp D, Wang N, Corbett KS, Goldsmith JA, Hsieh C-L, Abiona O, Graham ' 'BS, McLellan JS. Cryo-EM structure of the 2019-nCoV spike in the ' 'prefusion conformation. Science. 2020;367:1260–3.', 'journal-title': 'Science'}, { 'key': '2160_CR65', 'doi-asserted-by': 'crossref', 'first-page': '290', 'DOI': '10.1038/s41586-020-2349-y', 'volume': '583', 'author': 'D Pinto', 'year': '2020', 'unstructured': 'Pinto D, Park Y-J, Beltramello M, Walls AC, Tortorici MA, Bianchi S, ' 'Jaconi S, Culap K, Zatta F, De Marco A. Cross-neutralization of ' 'SARS-CoV-2 by a human monoclonal SARS-CoV antibody. Nature. ' '2020;583:290–5.', 'journal-title': 'Nature'}, { 'key': '2160_CR66', 'doi-asserted-by': 'crossref', 'first-page': '167155', 'DOI': '10.1016/j.jmb.2021.167155', 'volume': '433', 'author': 'J Chen', 'year': '2021', 'unstructured': 'Chen J, Gao K, Wang R, Wei G-W. Revealing the threat of emerging ' 'SARS-CoV-2 mutations to antibody therapies. J Mol Biol. 2021;433:167155.', 'journal-title': 'J Mol Biol'}, { 'key': '2160_CR67', 'unstructured': 'Chen J, Wang R, Gilby NB, Wei G-W: Omicron (B. 1.1. 529): Infectivity, ' 'vaccine breakthrough, and antibody resistance (preprint).'}, { 'key': '2160_CR68', 'doi-asserted-by': 'crossref', 'first-page': '1010', 'DOI': '10.1126/science.abd0827', 'volume': '369', 'author': 'J Hansen', 'year': '2020', 'unstructured': 'Hansen J, Baum A, Pascal KE, Russo V, Giordano S, Wloga E, Fulton BO, ' 'Yan Y, Koon K, Patel K. Studies in humanized mice and convalescent ' 'humans yield a SARS-CoV-2 antibody cocktail. Science. 2020;369:1010–4.', 'journal-title': 'Science'}, { 'key': '2160_CR69', 'doi-asserted-by': 'crossref', 'first-page': '1941', 'DOI': '10.1056/NEJMoa2107934', 'volume': '385', 'author': 'A Gupta', 'year': '2021', 'unstructured': 'Gupta A, Gonzalez-Rojas Y, Juarez E, Crespo Casal M, Moya J, Falci DR, ' 'Sarkis E, Solis J, Zheng H, Scott N. Early treatment for Covid-19 with ' 'SARS-CoV-2 neutralizing antibody sotrovimab. N Engl J Med. ' '2021;385:1941–50.', 'journal-title': 'N Engl J Med'}, { 'key': '2160_CR70', 'doi-asserted-by': 'crossref', 'unstructured': 'Kim S, Liu Y, Ziarnik M, Cao Y, Zhang XF, Im W. Binding of human ACE2 ' 'and RBD of Omicron enhanced by unique interaction patterns among ' 'SARS-CoV-2 variants of concern. bioRxiv. 2022.', 'DOI': '10.1101/2022.01.24.477633'}, { 'key': '2160_CR71', 'doi-asserted-by': 'crossref', 'unstructured': 'Pisoschi AM, Pop A, Iordache F, Stanca L, Geicu OI, Bilteanu L, Serban ' 'AI: Antioxidant, anti-inflammatory and immunomodulatory roles of ' 'vitamins in COVID-19 therapy. Eur J Med Chem. 2022;114175.', 'DOI': '10.1016/j.ejmech.2022.114175'}, { 'key': '2160_CR72', 'doi-asserted-by': 'crossref', 'first-page': '522', 'DOI': '10.1021/jf2040675', 'volume': '60', 'author': 'H-L Yang', 'year': '2012', 'unstructured': 'Yang H-L, Chen S-C, Senthil Kumar K, Yu K-N, Lee Chao P-D, Tsai S-Y, Hou ' 'Y-C, Hseu Y-C. Antioxidant and anti-inflammatory potential of hesperetin ' 'metabolites obtained from hesperetin-administered rat serum: an ex vivo ' 'approach. J Agric Food Chem. 2012;60:522–32.', 'journal-title': 'J Agric Food Chem'}, { 'key': '2160_CR73', 'doi-asserted-by': 'crossref', 'first-page': '609', 'DOI': '10.3390/antiox9070609', 'volume': '9', 'author': 'A Khan', 'year': '2020', 'unstructured': 'Khan A, Ikram M, Hahm JR, Kim MO. Antioxidant and anti-inflammatory ' 'effects of citrus flavonoid hesperetin: special focus on neurological ' 'disorders. Antioxidants. 2020;9:609.', 'journal-title': 'Antioxidants'}, { 'key': '2160_CR74', 'doi-asserted-by': 'crossref', 'first-page': '695', 'DOI': '10.1007/s12272-019-01174-5', 'volume': '42', 'author': 'SH Jo', 'year': '2019', 'unstructured': 'Jo SH, Kim ME, Cho JH, Lee Y, Lee J, Park Y-D, Lee JS. Hesperetin ' 'inhibits neuroinflammation on microglia by suppressing inflammatory ' 'cytokines and MAPK pathways. Arch Pharmacal Res. 2019;42:695–703.', 'journal-title': 'Arch Pharmacal Res'}, { 'key': '2160_CR75', 'doi-asserted-by': 'crossref', 'first-page': '35', 'DOI': '10.1007/s12032-022-01889-4', 'volume': '40', 'author': 'SS Alkafaas', 'year': '2022', 'unstructured': 'Alkafaas SS, Loutfy SA, Diab T, Hessien M. Vasopressin induces apoptosis ' 'but does not enhance the antiproliferative effect of dynamin 2 or ' 'PI3K/Akt inhibition in luminal A breast cancer cells. Med Oncol. ' '2022;40:35.', 'journal-title': 'Med Oncol'}, { 'key': '2160_CR76', 'first-page': '418', 'volume': '20', 'author': 'E Salehi', 'year': '2021', 'unstructured': 'Salehi E, Mashayekh M, Taheri F, Gholami M, Motaghinejad M, Safari S, ' 'Sepehr A. Curcumin can be acts as effective agent for prevent or ' 'treatment of alcohol-induced toxicity in hepatocytes: an illustrated ' 'mechanistic review. Iran J Pharm Res. 2021;20:418.', 'journal-title': 'Iran J Pharm Res'}, { 'key': '2160_CR77', 'doi-asserted-by': 'crossref', 'first-page': '2707', 'DOI': '10.3390/molecules25112707', 'volume': '25', 'author': 'W Ngwa', 'year': '2020', 'unstructured': 'Ngwa W, Kumar R, Thompson D, Lyerly W, Moore R, Reid T-E, Lowe H, Toyang ' 'N. Potential of flavonoid-inspired phytomedicines against COVID-19. ' 'Molecules. 2020;25:2707.', 'journal-title': 'Molecules'}, { 'key': '2160_CR78', 'doi-asserted-by': 'crossref', 'unstructured': 'Park H-K, Kang SW, Park M-S. Hesperidin ameliorates hepatic ' 'ischemia-reperfusion injury in Sprague-Dawley rats. In: Transplantation ' 'Proceedings. Elsevier; 2019. Pp. 2828–2832.', 'DOI': '10.1016/j.transproceed.2019.02.059'}, { 'key': '2160_CR79', 'doi-asserted-by': 'crossref', 'first-page': '127751', 'DOI': '10.1016/j.molstruc.2020.127751', 'volume': '1207', 'author': 'S Prakash', 'year': '2020', 'unstructured': 'Prakash S, Elavarasan N, Subashini K, Kanaga S, Dhandapani R, Sivanandam ' 'M, Kumaradhas P, Thirunavukkarasu C, Sujatha V. Isolation of ' 'hesperetin-A flavonoid from Cordia sebestena flower extract through ' 'antioxidant assay guided method and its antibacterial, anticancer effect ' 'on cervical cancer via in vitro and in silico molecular docking studies. ' 'J Mol Struct. 2020;1207:127751.', 'journal-title': 'J Mol Struct'}, { 'key': '2160_CR80', 'doi-asserted-by': 'crossref', 'first-page': '822', 'DOI': '10.1002/jsfa.7155', 'volume': '96', 'author': 'R Erenler', 'year': '2016', 'unstructured': 'Erenler R, Sen O, Aksit H, Demirtas I, Yaglioglu AS, Elmastas M, Telci ' 'I. Isolation and identification of chemical constituents from Origanum ' 'majorana and investigation of antiproliferative and antioxidant ' 'activities. J Sci Food Agric. 2016;96:822–36.', 'journal-title': 'J Sci Food Agric'}, { 'key': '2160_CR81', 'doi-asserted-by': 'crossref', 'first-page': '1009', 'DOI': '10.3390/molecules26041009', 'volume': '26', 'author': 'F Larit', 'year': '2021', 'unstructured': 'Larit F, Elokely KM, Nael MA, Benyahia S, León F, Cutler SJ, Ghoneim MM. ' 'Proposed mechanism for the antitrypanosomal activity of quercetin and ' 'myricetin Isolated from Hypericum afrum Lam.: phytochemistry, in vitro ' 'testing and modeling studies. Molecules. 2021;26:1009.', 'journal-title': 'Molecules'}, { 'key': '2160_CR82', 'doi-asserted-by': 'crossref', 'first-page': '4870', 'DOI': '10.3390/molecules25214870', 'volume': '25', 'author': 'AI Elshamy', 'year': '2020', 'unstructured': 'Elshamy AI, Ammar NM, Hassan HA, El-Kashak WA, Al-Rejaie SS, Abd-ElGawad ' 'AM. Farrag A-RH: Topical wound healing activity of myricetin isolated ' 'from tecomaria capensis V. aurea. Molecules. 2020;25:4870.', 'journal-title': 'Molecules'}, { 'key': '2160_CR83', 'doi-asserted-by': 'crossref', 'first-page': '2971', 'DOI': '10.1080/07391102.2020.1758790', 'volume': '39', 'author': 'I Aanouz', 'year': '2021', 'unstructured': 'Aanouz I, Belhassan A, El-Khatabi K, Lakhlifi T, El-Ldrissi M, ' 'Bouachrine M. Moroccan medicinal plants as inhibitors against SARS-CoV-2 ' 'main protease: computational investigations. J Biomol Struct Dyn. ' '2021;39:2971–9.', 'journal-title': 'J Biomol Struct Dyn'}, { 'key': '2160_CR84', 'doi-asserted-by': 'crossref', 'first-page': '134', 'DOI': '10.1055/s-2006-957390', 'volume': '64', 'author': 'M Martínez-Vázquez', 'year': '1998', 'unstructured': 'Martínez-Vázquez M, Apan TOR, Lastra AL, Bye R. A comparative study of ' 'the analgesic and anti-inflammatory activities of pectolinarin isolated ' 'from Cirsium subcoriaceum and linarin isolated from Buddleia cordata. ' 'Planta Med. 1998;64:134–7.', 'journal-title': 'Planta Med'}, { 'key': '2160_CR85', 'doi-asserted-by': 'crossref', 'first-page': '760', 'DOI': '10.1248/bpb.31.760', 'volume': '31', 'author': 'Y-M Yoo', 'year': '2008', 'unstructured': 'Yoo Y-M, Nam J-H, Kim M-Y, Choi J, Park H-J. Pectolinarin and ' 'pectolinarigenin of Cirsium setidens prevent the hepatic injury in rats ' 'caused by D-galactosamine via an antioxidant mechanism. Biol Pharm Bull. ' '2008;31:760–4.', 'journal-title': 'Biol Pharm Bull'}, { 'key': '2160_CR86', 'doi-asserted-by': 'crossref', 'first-page': '167', 'DOI': '10.1016/j.wjam.2020.07.008', 'volume': '30', 'author': 'L-T Tao', 'year': '2020', 'unstructured': 'Tao L-T, Huang T-L, Zheng D-W, Xu Z. Case of professor Xu ZOU’s ' 'acupuncture technique for “benefiting kidney and strengthening ' 'anti-pathogenic qi” in promoting the absorption of COVID-19. World J ' 'Acupunct Moxib. 2020;30:167–70.', 'journal-title': 'World J Acupunct Moxib'}, { 'key': '2160_CR87', 'doi-asserted-by': 'crossref', 'first-page': '5', 'DOI': '10.1186/1475-2891-3-5', 'volume': '3', 'author': 'K Iqbal', 'year': '2004', 'unstructured': 'Iqbal K, Khan A, Khattak M. Biological significance of ascorbic acid ' '(vitamin C) in human health-a review. Pak J Nutr. 2004;3:5–13.', 'journal-title': 'Pak J Nutr'}, { 'key': '2160_CR88', 'doi-asserted-by': 'crossref', 'first-page': 'e01310', 'DOI': '10.1016/j.heliyon.2019.e01310', 'volume': '5', 'author': 'X Wu', 'year': '2019', 'unstructured': 'Wu X, Zhao Y, Haytowitz DB, Chen P, Pehrsson PR. Effects of domestic ' 'cooking on flavonoids in broccoli and calculation of retention factors. ' 'Heliyon. 2019;5:e01310.', 'journal-title': 'Heliyon'}, { 'key': '2160_CR89', 'doi-asserted-by': 'crossref', 'first-page': '104149', 'DOI': '10.1016/j.jff.2020.104149', 'volume': '77', 'author': 'C Mu', 'year': '2021', 'unstructured': 'Mu C, Sheng Y, Wang Q, Amin A, Li X, Xie Y. Potential compound from ' 'herbal food of Rhizoma Polygonati for treatment of COVID-19 analyzed by ' 'network pharmacology: viral and cancer signaling mechanisms. J Funct ' 'Foods. 2021;77:104149.', 'journal-title': 'J Funct Foods'}, { 'key': '2160_CR90', 'doi-asserted-by': 'crossref', 'first-page': '331', 'DOI': '10.1055/s-2001-14328', 'volume': '67', 'author': 'Y Kimura', 'year': '2001', 'unstructured': 'Kimura Y, Matsushita N, Yokoi-Hayashi K, Okuda H. Effects of baicalein ' 'isolated from Scutellaria baicalensis Radix on adhesion molecule ' 'expression induced by thrombin and thrombin receptor agonist peptide in ' 'cultured human umbilical vein endothelial cells. Planta Med. ' '2001;67:331–4.', 'journal-title': 'Planta Med'}, { 'key': '2160_CR91', 'doi-asserted-by': 'crossref', 'first-page': '1539', 'DOI': '10.1080/14756366.2020.1801672', 'volume': '35', 'author': 'S Jo', 'year': '2020', 'unstructured': 'Jo S, Kim S, Kim DY, Kim M-S, Shin DH. Flavonoids with inhibitory ' 'activity against SARS-CoV-2 3CLpro. J Enzyme Inhib Med Chem. ' '2020;35:1539–44.', 'journal-title': 'J Enzyme Inhib Med Chem'}, { 'key': '2160_CR92', 'doi-asserted-by': 'crossref', 'first-page': '1', 'DOI': '10.1186/s12906-015-0836-8', 'volume': '15', 'author': 'S Selim', 'year': '2015', 'unstructured': 'Selim S, Al Jaouni S. Anticancer and apoptotic effects on cell ' 'proliferation of diosgenin isolated from Costus speciosus (Koen.) Sm. ' 'BMC Complement Altern Med. 2015;15:1–7.', 'journal-title': 'BMC Complement Altern Med'}, { 'key': '2160_CR93', 'doi-asserted-by': 'crossref', 'first-page': '385', 'DOI': '10.3390/molecules15010385', 'volume': '15', 'author': 'O-H Kang', 'year': '2010', 'unstructured': 'Kang O-H, Choi J-G, Lee J-H, Kwon D-Y. Luteolin isolated from the ' 'flowers of Lonicera japonica suppresses inflammatory mediator release by ' 'blocking NF-κB and MAPKs activation pathways in HMC-1 cells. Molecules. ' '2010;15:385–98.', 'journal-title': 'Molecules'}, { 'key': '2160_CR94', 'doi-asserted-by': 'crossref', 'first-page': '39', 'DOI': '10.1016/j.niox.2020.06.002', 'volume': '102', 'author': 'J Wu', 'year': '2020', 'unstructured': 'Wu J. Tackle the free radicals damage in COVID-19. Nitric Oxide. ' '2020;102:39–41.', 'journal-title': 'Nitric Oxide'}, { 'key': '2160_CR95', 'doi-asserted-by': 'crossref', 'first-page': '106012', 'DOI': '10.1016/j.ijantimicag.2020.106012', 'volume': '56', 'author': 'R Yu', 'year': '2020', 'unstructured': 'Yu R, Chen L, Lan R, Shen R, Li P. Computational screening of ' 'antagonists against the SARS-CoV-2 (COVID-19) coronavirus by molecular ' 'docking. Int J Antimicrob Agents. 2020;56:106012.', 'journal-title': 'Int J Antimicrob Agents'}, { 'key': '2160_CR96', 'doi-asserted-by': 'crossref', 'first-page': '1', 'DOI': '10.1186/1743-422X-8-1', 'volume': '8', 'author': 'J Liu', 'year': '2011', 'unstructured': 'Liu J, Yang Y, Xu Y, Ma C, Qin C, Zhang L. Lycorine reduces mortality of ' 'human enterovirus 71-infected mice by inhibiting virus replication. ' 'Virol J. 2011;8:1–9.', 'journal-title': 'Virol J'}, { 'key': '2160_CR97', 'doi-asserted-by': 'crossref', 'first-page': '49', 'DOI': '10.1016/j.cbi.2018.04.009', 'volume': '288', 'author': 'C Veeramani', 'year': '2018', 'unstructured': 'Veeramani C, Alsaif MA, Al-Numair KS. Herbacetin, a flaxseed flavonoid, ' 'ameliorates high percent dietary fat induced insulin resistance and ' 'lipid accumulation through the regulation of hepatic lipid metabolizing ' 'and lipid-regulating enzymes. Chem Biol Interact. 2018;288:49–56.', 'journal-title': 'Chem Biol Interact'}, { 'key': '2160_CR98', 'doi-asserted-by': 'crossref', 'first-page': '295', 'DOI': '10.1080/13880209.2019.1577460', 'volume': '57', 'author': 'Z Péter Zomborszki', 'year': '2019', 'unstructured': 'Péter Zomborszki Z, Kúsz N, Csupor D, Peschel W. Rhodiosin and ' 'herbacetin in Rhodiola rosea preparations: additional markers for ' 'quality control? Pharm Biol. 2019;57:295–305.', 'journal-title': 'Pharm Biol'}, { 'key': '2160_CR99', 'doi-asserted-by': 'crossref', 'first-page': '173448', 'DOI': '10.1016/j.ejphar.2020.173448', 'volume': '886', 'author': 'BG Vijayakumar', 'year': '2020', 'unstructured': 'Vijayakumar BG, Ramesh D, Joji A, Kannan T. In silico pharmacokinetic ' 'and molecular docking studies of natural flavonoids and synthetic indole ' 'chalcones against essential proteins of SARS-CoV-2. Eur J Pharmacol. ' '2020;886:173448.', 'journal-title': 'Eur J Pharmacol'}, { 'key': '2160_CR100', 'doi-asserted-by': 'crossref', 'first-page': '2213', 'DOI': '10.1021/jf030370h', 'volume': '52', 'author': 'JW Hyun', 'year': '2004', 'unstructured': 'Hyun JW, Chung HS. Cyanidin and malvidin from Oryza sativa cv. ' 'heugjinjubyeo mediate cytotoxicity against human monocytic leukemia ' 'cells by arrest of G2/M phase and induction of apoptosis. J Agric Food ' 'Chem. 2004;52:2213–7.', 'journal-title': 'J Agric Food Chem'}, { 'key': '2160_CR101', 'doi-asserted-by': 'crossref', 'unstructured': 'Da J, Xu M, Wang Y, Li W, Lu M, Wang Z. Kaempferol promotes apoptosis ' 'while inhibiting cell proliferation via androgen-dependent pathway and ' 'suppressing vasculogenic mimicry and invasion in prostate cancer. Anal ' 'Cell Pathol. 2019;2019.', 'DOI': '10.1155/2019/1907698'}, { 'key': '2160_CR102', 'doi-asserted-by': 'crossref', 'first-page': '110622', 'DOI': '10.1016/j.biopha.2020.110622', 'volume': '131', 'author': 'AA Berretta', 'year': '2020', 'unstructured': 'Berretta AA, Silveira MAD, Capcha JMC, De Jong D. Propolis and its ' 'potential against SARS-CoV-2 infection mechanisms and COVID-19 disease: ' 'Running title: Propolis against SARS-CoV-2 infection and COVID-19. 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Identification of ' 'polyphenols from Broussonetia papyrifera as SARS CoV-2 main protease ' 'inhibitors using in silico docking and molecular dynamics simulation ' 'approaches. J Biomol Struct Dyn. 2021;39:6747–60.', 'journal-title': 'J Biomol Struct Dyn'}, { 'key': '2160_CR123', 'first-page': '1934578X1000500', 'volume': '5', 'author': 'YM Syah', 'year': '2010', 'unstructured': 'Syah YM, Ghisalberti EL. Phenolic derivatives with an irregular ' 'sesquiterpenyl side chain from Macaranga pruinosa. Nat prod Commun. ' '2010;5:1934578X1000500209.', 'journal-title': 'Nat prod Commun'}, { 'key': '2160_CR124', 'doi-asserted-by': 'crossref', 'first-page': '1170', 'DOI': '10.1080/22221751.2020.1772676', 'volume': '9', 'author': 'Y-N Zhang', 'year': '2020', 'unstructured': 'Zhang Y-N, Zhang Q-Y, Li X-D, Xiong J, Xiao S-Q, Wang Z, Zhang Z-R, Deng ' 'C-L, Yang X-L, Wei H-P. Gemcitabine, lycorine and oxysophoridine inhibit ' 'novel coronavirus (SARS-CoV-2) in cell culture. Emerg Microbes Infect. 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' 'F1000Research. 2020;9.', 'DOI': '10.12688/f1000research.22457.1'}, { 'key': '2160_CR147', 'doi-asserted-by': 'crossref', 'first-page': '5273', 'DOI': '10.1021/ol802089p', 'volume': '10', 'author': 'N Koyama', 'year': '2008', 'unstructured': 'Koyama N, Inoue Y, Sekine M, Hayakawa Y, Homma H, O̅mura S, Tomoda H. ' 'Relative and absolute stereochemistry of quinadoline B, an inhibitor of ' 'lipid droplet synthesis in macrophages. Org Lett. 2008;10:5273–6.', 'journal-title': 'Org Lett'}, { 'key': '2160_CR148', 'doi-asserted-by': 'crossref', 'first-page': '6792', 'DOI': '10.1080/07391102.2020.1803968', 'volume': '39', 'author': 'P Chowdhury', 'year': '2021', 'unstructured': 'Chowdhury P. In silico investigation of phytoconstituents from Indian ' 'medicinal herb ‘Tinospora cordifolia (giloy)’against SARS-CoV-2 ' '(COVID-19) by molecular dynamics approach. J Biomol Struct Dyn. 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Active-site molecular ' 'docking of nigellidine with nucleocapsid-NSP2-MPro of COVID-19 and to ' 'human IL1R-IL6R and strong antioxidant role of Nigella-sativa in ' 'experimental rats. J Drug Target. 2020;1–23.'}, { 'key': '2160_CR152', 'doi-asserted-by': 'crossref', 'first-page': '924', 'DOI': '10.1104/pp.106.077081', 'volume': '141', 'author': 'Y Morinaka', 'year': '2006', 'unstructured': 'Morinaka Y, Sakamoto T, Inukai Y, Agetsuma M, Kitano H, Ashikari M, ' 'Matsuoka M. Morphological alteration caused by brassinosteroid ' 'insensitivity increases the biomass and grain production of rice. Plant ' 'Physiol. 2006;141:924–31.', 'journal-title': 'Plant Physiol'}, { 'key': '2160_CR153', 'doi-asserted-by': 'crossref', 'first-page': '799', 'DOI': '10.1124/mol.63.4.799', 'volume': '63', 'author': 'J Zhou', 'year': '2003', 'unstructured': 'Zhou J, Gupta K, Aggarwal S, Aneja R, Chandra R, Panda D, Joshi HC. ' 'Brominated derivatives of noscapine are potent microtubule-interfering ' 'agents that perturb mitosis and inhibit cell proliferation. Mol ' 'Pharmacol. 2003;63:799–807.', 'journal-title': 'Mol Pharmacol'}, { 'key': '2160_CR154', 'doi-asserted-by': 'crossref', 'first-page': '3822', 'DOI': '10.3390/molecules25173822', 'volume': '25', 'author': 'R Vivek-Ananth', 'year': '2020', 'unstructured': 'Vivek-Ananth R, Rana A, Rajan N, Biswal HS, Samal A. In silico ' 'identification of potential natural product inhibitors of human ' 'proteases key to SARS-CoV-2 infection. Molecules. 2020;25:3822.', 'journal-title': 'Molecules'}, { 'key': '2160_CR155', 'doi-asserted-by': 'crossref', 'first-page': '272', 'DOI': '10.1021/np50056a013', 'volume': '51', 'author': 'IE Mete', 'year': '1988', 'unstructured': 'Mete IE, Gözler T. (+)-Oxoturkiyenine: an isoquinoline-derived alkaloid ' 'from Hypecoum pendulum. J Nat Prod. 1988;51:272–4.', 'journal-title': 'J Nat Prod'}, { 'key': '2160_CR156', 'doi-asserted-by': 'crossref', 'first-page': '531', 'DOI': '10.1021/np50068a046', 'volume': '53', 'author': 'G Kadan', 'year': '1990', 'unstructured': 'Kadan G, Gözler T, Shamma M. (-)-Turkiyenine, a new alkaloid from ' 'Chelidonium majus. J Nat Prod. 1990;53:531–2.', 'journal-title': 'J Nat Prod'}, { 'key': '2160_CR157', 'doi-asserted-by': 'crossref', 'first-page': '283', 'DOI': '10.1016/j.jksus.2017.12.008', 'volume': '30', 'author': 'JE Olivar', 'year': '2018', 'unstructured': 'Olivar JE, Sy KA, Villanueva CV, Alejandro GJD, Tan MA. Alkaloids as ' 'chemotaxonomic markers from the Philippine endemic Uncaria perrottetii ' 'and Uncaria lanosa f. Philippinensis. J King Saud Univ Sci. ' '2018;30:283–5.', 'journal-title': 'J King Saud Univ Sci'}, { 'key': '2160_CR158', 'first-page': '1934578X1501000', 'volume': '10', 'author': 'A Kumar', 'year': '2015', 'unstructured': 'Kumar A, Chowdhury SR, Jatte KK, Chakrabarti T, Majumder HK, Jha T, ' 'Mukhopadhyay S. Anthocephaline, a new indole alkaloid and cadambine, a ' 'potent inhibitor of DNA topoisomerase IB of Leishmania donovani ' '(LdTOP1LS), isolated from Anthocephalus cadamba. Nat Product Commun. ' '2015;10:1934578X1501000221.', 'journal-title': 'Nat Product Commun'}, { 'key': '2160_CR159', 'doi-asserted-by': 'crossref', 'unstructured': 'Fakhri S, Nouri Z, Moradi SZ, Farzaei MH. Astaxanthin, COVID‐19 and ' 'immune response: focus on oxidative stress, apoptosis and autophagy. ' 'Phytother Res. 2020.', 'DOI': '10.1002/ptr.6797'}, { 'key': '2160_CR160', 'doi-asserted-by': 'crossref', 'first-page': '115', 'DOI': '10.55230/mabjournal.v49i5.1643', 'volume': '49', 'author': 'K Khalil', 'year': '2020', 'unstructured': 'Khalil K, Baharum SN, Fazry S, Sidik NM, Sairi F. Non-enzymatic ' 'antioxidant from apple snail (Pomacea maculata) extract. Malays Appl ' 'Biol. 2020;49:115–24.', 'journal-title': 'Malays Appl Biol'}, { 'key': '2160_CR161', 'doi-asserted-by': 'crossref', 'first-page': '4089', 'DOI': '10.1080/07391102.2020.1778534', 'volume': '39', 'author': 'M Hamza', 'year': '2021', 'unstructured': 'Hamza M, Ali A, Khan S, Ahmed S, Attique Z, Ur Rehman S, Khan A, Ali H, ' 'Rizwan M, Munir A. nCOV-19 peptides mass fingerprinting identification, ' 'binding, and blocking of inhibitors flavonoids and anthraquinone of ' 'Moringa oleifera and hydroxychloroquine. J Biomol Struct Dyn. ' '2021;39:4089–99.', 'journal-title': 'J Biomol Struct Dyn'}, { 'key': '2160_CR162', 'doi-asserted-by': 'crossref', 'first-page': '385', 'DOI': '10.1016/j.foodchem.2011.11.005', 'volume': '132', 'author': 'V Dongare', 'year': '2012', 'unstructured': 'Dongare V, Kulkarni C, Kondawar M, Magdum C, Haldavnekar V, Arvindekar ' 'A. Inhibition of aldose reductase and anti-cataract action of ' 'trans-anethole isolated from Foeniculum vulgare Mill. fruits. Food Chem. ' '2012;132:385–90.', 'journal-title': 'Food Chem'}, { 'key': '2160_CR163', 'doi-asserted-by': 'crossref', 'first-page': '242', 'DOI': '10.1002/jsfa.3079', 'volume': '88', 'author': 'I Kubo', 'year': '2008', 'unstructured': 'Kubo I, Fujita KI, Nihei KI. Antimicrobial activity of anethole and ' 'related compounds from aniseed. 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Novel antiviral activities of ' 'obatoclax, emetine, niclosamide, brequinar, and homoharringtonine. ' 'Viruses. 2019;11:964.', 'journal-title': 'Viruses'}, { 'key': '2160_CR167', 'doi-asserted-by': 'crossref', 'first-page': '699', 'DOI': '10.3390/v12070699', 'volume': '12', 'author': 'Y Takeda', 'year': '2020', 'unstructured': 'Takeda Y, Murata T, Jamsransuren D, Suganuma K, Kazami Y, Batkhuu J, ' 'Badral D, Ogawa H. Saxifraga spinulosa-derived components rapidly ' 'inactivate multiple viruses including SARS-CoV-2. Viruses. 2020;12:699.', 'journal-title': 'Viruses'}, { 'key': '2160_CR168', 'first-page': '1637', 'volume': '42', 'author': 'T Matsuo', 'year': '1978', 'unstructured': 'Matsuo T, Ito S. The chemical structure of kaki-tannin from immature ' 'fruit of the persimmon (Diospyros kaki L.). Agric Biol Chem. ' '1978;42:1637–43.', 'journal-title': 'Agric Biol Chem'}, { 'key': '2160_CR169', 'first-page': '1934578X1701200', 'volume': '12', 'author': 'AB Mekala', 'year': '2017', 'unstructured': 'Mekala AB, Satyal P, Setzer WN. Phytochemicals from the bark of Rhamnus ' 'caroliniana. Nat Prod Commun. 2017;12:1934578X1701200324.', 'journal-title': 'Nat Prod Commun'}, { 'key': '2160_CR170', 'first-page': '255', 'volume': '7', 'author': 'D Kumar', 'year': '2017', 'unstructured': 'Kumar D, Jain A, Verma A. Phytochemical and pharmacological ' 'investigation of Cassia siamea Lamk: an insight. Nat Prod J. ' '2017;7:255–66.', 'journal-title': 'Nat Prod J'}, { 'key': '2160_CR171', 'doi-asserted-by': 'crossref', 'first-page': '389', 'DOI': '10.1080/07391102.2020.1813630', 'volume': '40', 'author': 'BJ Oso', 'year': '2022', 'unstructured': 'Oso BJ, Adeoye AO, Olaoye IF. Pharmacoinformatics and hypothetical ' 'studies on allicin, curcumin, and gingerol as potential candidates ' 'against COVID-19-associated proteases. J Biomol Struct Dyn. ' '2022;40:389–400.', 'journal-title': 'J Biomol Struct Dyn'}, { 'key': '2160_CR172', 'doi-asserted-by': 'crossref', 'first-page': '1010', 'DOI': '10.1080/13880209.2017.1286358', 'volume': '55', 'author': 'A Mohammed', 'year': '2017', 'unstructured': 'Mohammed A, Gbonjubola VA, Koorbanally NA, Islam MS. Inhibition of key ' 'enzymes linked to type 2 diabetes by compounds isolated from Aframomum ' 'melegueta fruit. Pharm Biol. 2017;55:1010–6.', 'journal-title': 'Pharm Biol'}, { 'key': '2160_CR173', 'doi-asserted-by': 'crossref', 'first-page': '663', 'DOI': '10.1007/s11655-020-3427-6', 'volume': '26', 'author': 'T-z Wei', 'year': '2020', 'unstructured': 'Wei T-z, Wang H, Wu X-q, Lu Y, Guan S-h, Dong F-q, Dong C-l, Zhu G-l, ' 'Bao Y-z, Zhang J. 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' '1993;33:943–5.', 'journal-title': 'Phytochemistry'}, { 'key': '2160_CR176', 'doi-asserted-by': 'crossref', 'first-page': '475', 'DOI': '10.1021/np50016a014', 'volume': '44', 'author': 'G Blaskó', 'year': '1981', 'unstructured': 'Blaskó G, Hussain SF, Shamma M. (-)-Corlumine, a new ' 'phthalideisoquinoline alkaloid from Fumaria parviflora. J Nat Prod. ' '1981;44:475–7.', 'journal-title': 'J Nat Prod'}, { 'key': '2160_CR177', 'doi-asserted-by': 'crossref', 'first-page': '5033', 'DOI': '10.1080/07391102.2020.1784289', 'volume': '39', 'author': 'RV Chikhale', 'year': '2021', 'unstructured': 'Chikhale RV, Sinha SK, Patil RB, Prasad SK, Shakya A, Gurav N, Prasad R, ' 'Dhaswadikar SR, Wanjari M, Gurav SS. In-silico investigation of ' 'phytochemicals from Asparagus racemosus as plausible antiviral agent in ' 'COVID-19. 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J ' 'Ethnopharmacol. 2015;168:61–5.', 'journal-title': 'J Ethnopharmacol'}, { 'key': '2160_CR182', 'doi-asserted-by': 'crossref', 'first-page': '153336', 'DOI': '10.1016/j.phymed.2020.153336', 'volume': '79', 'author': 'S Zheng', 'year': '2020', 'unstructured': 'Zheng S, Baak JP, Li S, Xiao W, Ren H, Yang H, Gan Y, Wen C. Network ' 'pharmacology analysis of the therapeutic mechanisms of the traditional ' 'Chinese herbal formula Lian Hua Qing Wen in Corona virus disease 2019 ' '(COVID-19), gives fundamental support to the clinical use of LHQW. ' 'Phytomedicine. 2020;79:153336.', 'journal-title': 'Phytomedicine'}, { 'key': '2160_CR183', 'doi-asserted-by': 'crossref', 'first-page': '153242', 'DOI': '10.1016/j.phymed.2020.153242', 'volume': '85', 'author': 'K Hu', 'year': '2021', 'unstructured': 'Hu K, Guan W-j, Bi Y, Zhang W, Li L, Zhang B, Liu Q, Song Y, Li X, Duan ' 'Z. 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Coronil, a ' 'tri-herbal formulation, attenuates spike-protein-mediated SARS-CoV-2 ' 'viral entry into human alveolar epithelial cells and pro-inflammatory ' 'cytokines production by inhibiting spike protein-ACE-2 interaction. J ' 'Inflamm Res. 2021;14:869.', 'journal-title': 'J Inflamm Res'}, { 'key': '2160_CR186', 'doi-asserted-by': 'crossref', 'first-page': '899', 'DOI': '10.2147/PPA.S302957', 'volume': '15', 'author': 'A Balkrishna', 'year': '2021', 'unstructured': 'Balkrishna A, Raj P, Singh P, Varshney A. Influence of patient-reported ' 'treatment satisfaction on psychological health and quality of life Among ' 'patients receiving Divya-Swasari-Coronil-Kit against COVID-19: findings ' 'from a cross-sectional “SATISFACTION COVID” survey. Patient Prefer ' 'Adherence. 2021;15:899.', 'journal-title': 'Patient Prefer Adherence'}, { 'key': '2160_CR187', 'doi-asserted-by': 'crossref', 'first-page': '5091', 'DOI': '10.3390/molecules25215091', 'volume': '25', 'author': 'A Balkrishna', 'year': '2020', 'unstructured': 'Balkrishna A, Solleti SK, Verma S, Varshney A. Application of humanized ' 'zebrafish model in the suppression of SARS-CoV-2 spike protein induced ' 'pathology by tri-herbal medicine coronil via cytokine modulation. ' 'Molecules. 2020;25:5091.', 'journal-title': 'Molecules'}, { 'key': '2160_CR188', 'first-page': '434', 'volume': '13', 'author': 'A-R Ahmadi', 'year': '2021', 'unstructured': 'Ahmadi A-R, Ayazi-Nasrabadi R. Astaxanthin protective barrier and its ' 'ability to improve the health in patients with COVID-19. 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' 'Biochemistry. 2008;47:1837–47.', 'journal-title': 'Biochemistry'}, { 'key': '2160_CR191', 'doi-asserted-by': 'crossref', 'first-page': '2115', 'DOI': '10.1007/s40520-020-01669-y', 'volume': '32', 'author': 'S Fiorino', 'year': '2020', 'unstructured': 'Fiorino S, Gallo C, Zippi M, Sabbatani S, Manfredi R, Moretti R, Fogacci ' 'E, Maggioli C, Travasoni Loffredo F, Giampieri E. Cytokine storm in aged ' 'people with CoV-2: possible role of vitamins as therapy or preventive ' 'strategy. Aging Clin Exp Res. 2020;32:2115–31.', 'journal-title': 'Aging Clin Exp Res'}, { 'key': '2160_CR192', 'unstructured': 'Souza ACR, Vasconcelos AR, Prado PS, Pereira CPM. Zinc, vitamin D and ' 'vitamin C: perspectives for COVID-19 with a focus on physical tissue ' 'barrier integrity. 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Identification of potent ' 'COVID-19 main protease (Mpro) inhibitors from natural polyphenols: an in ' 'silico strategy unveils a hope against CORONA. 2020.', 'DOI': '10.20944/preprints202003.0333.v1'}, { 'key': '2160_CR196', 'doi-asserted-by': 'crossref', 'first-page': '217', 'DOI': '10.1002/ddr.21743', 'volume': '82', 'author': 'MA Abosheasha', 'year': '2021', 'unstructured': 'Abosheasha MA, El-Gowily AH. Superiority of cilostazol among ' 'antiplatelet FDA-approved drugs against COVID 19 Mpro and spike protein: ' 'drug repurposing approach. Drug Dev Res. 2021;82:217–29.', 'journal-title': 'Drug Dev Res'}, { 'key': '2160_CR197', 'doi-asserted-by': 'crossref', 'first-page': '369', 'DOI': '10.5115/acb.19.119', 'volume': '52', 'author': 'J Kim', 'year': '2019', 'unstructured': 'Kim J, Wie M-B, Ahn M, Tanaka A, Matsuda H, Shin T. Benefits of ' 'hesperidin in central nervous system disorders: a review. Anat Cell ' 'Biol. 2019;52:369–77.', 'journal-title': 'Anat Cell Biol'}, { 'key': '2160_CR198', 'doi-asserted-by': 'crossref', 'first-page': '134619', 'DOI': '10.1016/j.neulet.2019.134619', 'volume': '715', 'author': 'S-D Heo', 'year': '2020', 'unstructured': 'Heo S-D, Kim J, Choi Y, Ekanayake P, Ahn M, Shin T. Hesperidin improves ' 'motor disability in rat spinal cord injury through anti-inflammatory and ' 'antioxidant mechanism via Nrf-2/HO-1 pathway. Neurosci Lett. ' '2020;715:134619.', 'journal-title': 'Neurosci Lett'}, { 'key': '2160_CR199', 'doi-asserted-by': 'crossref', 'first-page': '106720', 'DOI': '10.1016/j.intimp.2020.106720', 'volume': '86', 'author': 'R Atabaki', 'year': '2020', 'unstructured': 'Atabaki R, Roohbakhsh A, Moghimi A, Mehri S. Protective effects of ' 'maternal administration of curcumin and hesperidin in the rat offspring ' 'following repeated febrile seizure: role of inflammation and TLR4. Int ' 'Immunopharmacol. 2020;86:106720.', 'journal-title': 'Int Immunopharmacol'}, { 'key': '2160_CR200', 'doi-asserted-by': 'crossref', 'first-page': '587', 'DOI': '10.1017/S0007114512005454', 'volume': '110', 'author': 'A Chanet', 'year': '2013', 'unstructured': 'Chanet A, Milenkovic D, Claude S, Maier JA, Khan MK, Rakotomanomana N, ' 'Shinkaruk S, Bérard AM, Bennetau-Pelissero C, Mazur A. Flavanone ' 'metabolites decrease monocyte adhesion to TNF-α-activated endothelial ' 'cells by modulating expression of atherosclerosis-related genes. Br J ' 'Nutr. 2013;110:587–98.', 'journal-title': 'Br J Nutr'}, { 'key': '2160_CR201', 'first-page': '327', 'volume': '34', 'author': 'P Conti', 'year': '2020', 'unstructured': 'Conti P, Ronconi G, Caraffa A, Gallenga C, Ross R, Frydas I, Kritas S. ' 'Induction of pro-inflammatory cytokines (IL-1 and IL-6) and lung ' 'inflammation by Coronavirus-19 (COVI-19 or SARS-CoV-2): ' 'anti-inflammatory strategies. J Biol Regul Homeost Agents. ' '2020;34:327–31.', 'journal-title': 'J Biol Regul Homeost Agents'}, { 'key': '2160_CR202', 'doi-asserted-by': 'crossref', 'first-page': '648', 'DOI': '10.3390/nu11030648', 'volume': '11', 'author': 'T Muhammad', 'year': '2019', 'unstructured': 'Muhammad T, Ikram M, Ullah R, Rehman SU, Kim MO. Hesperetin, a citrus ' 'flavonoid, attenuates LPS-induced neuroinflammation, apoptosis and ' 'memory impairments by modulating TLR4/NF-κB signaling. Nutrients. ' '2019;11:648.', 'journal-title': 'Nutrients'}, { 'key': '2160_CR203', 'doi-asserted-by': 'crossref', 'first-page': '24', 'DOI': '10.4081/cp.2020.1271', 'volume': '10', 'author': 'A Cavezzi', 'year': '2020', 'unstructured': 'Cavezzi A, Troiani E, Corrao S. COVID-19: hemoglobin, iron, and hypoxia ' 'beyond inflammation. A narrative review. Clin Pract. 2020;10:24–30.', 'journal-title': 'Clin Pract'}, { 'key': '2160_CR204', 'doi-asserted-by': 'crossref', 'first-page': '540', 'DOI': '10.3390/antiox9060540', 'volume': '9', 'author': 'FA Wagener', 'year': '2020', 'unstructured': 'Wagener FA, Pickkers P, Peterson SJ, Immenschuh S, Abraham NG. Targeting ' 'the heme-heme oxygenase system to prevent severe complications following ' 'COVID-19 infections. Antioxidants. 2020;9:540.', 'journal-title': 'Antioxidants'}, { 'key': '2160_CR205', 'first-page': 'e00127', 'volume': '94', 'author': 'Y Wan', 'year': '2020', 'unstructured': 'Wan Y, Shang J, Graham R, Baric RS, Li F. Receptor recognition by the ' 'novel coronavirus from Wuhan: an analysis based on decade-long ' 'structural studies of SARS coronavirus. J Virol. 2020;94:e00127-e1120.', 'journal-title': 'J Virol'}, { 'key': '2160_CR206', 'doi-asserted-by': 'crossref', 'first-page': '1444', 'DOI': '10.1126/science.abb2762', 'volume': '367', 'author': 'R Yan', 'year': '2020', 'unstructured': 'Yan R, Zhang Y, Li Y, Xia L, Guo Y, Zhou Q. Structural basis for the ' 'recognition of SARS-CoV-2 by full-length human ACE2. Science. ' '2020;367:1444–8.', 'journal-title': 'Science'}, { 'key': '2160_CR207', 'doi-asserted-by': 'crossref', 'first-page': '473', 'DOI': '10.1126/science.abb8925', 'volume': '368', 'author': 'JB Moore', 'year': '2020', 'unstructured': 'Moore JB, June CH. Cytokine release syndrome in severe COVID-19. ' 'Science. 2020;368:473–4.', 'journal-title': 'Science'}, { 'key': '2160_CR208', 'doi-asserted-by': 'crossref', 'first-page': '105960', 'DOI': '10.1016/j.ijantimicag.2020.105960', 'volume': '55', 'author': 'J Fantini', 'year': '2020', 'unstructured': 'Fantini J, Di Scala C, Chahinian H, Yahi N. Structural and molecular ' 'modelling studies reveal a new mechanism of action of chloroquine and ' 'hydroxychloroquine against SARS-CoV-2 infection. Int J Antimicrob ' 'Agents. 2020;55:105960.', 'journal-title': 'Int J Antimicrob Agents'}, { 'key': '2160_CR209', 'unstructured': 'MOE V: Chemical Computing Group Inc., Montreal, Canada. 2010.'}, { 'key': '2160_CR210', 'doi-asserted-by': 'crossref', 'first-page': '136301', 'DOI': '10.1016/j.molstruc.2023.136301', 'volume': '1292', 'author': 'AM Abdallah', 'year': '2023', 'unstructured': 'Abdallah AM, Gomha SM, Zaki MEA, Abolibda TZ, Kheder NA. A green ' 'synthesis, DFT calculations, and molecular docking study of some new ' 'indeno[2,1-b]quinoxalines containing thiazole moiety. J Mol Struct. ' '2023;1292:136044.', 'journal-title': 'J Mol Struct'}, { 'key': '2160_CR211', 'doi-asserted-by': 'crossref', 'unstructured': 'Al-Qaisi ZH, Al-Garawi ZS, Al-Karawi AJM, Hammood AJ, Abdallah AM, Clegg ' 'W, Mohamed GG. Antiureolytic activity of new water-soluble thiadiazole ' 'derivatives: Spectroscopic, DFT, and molecular docking studies. ' 'Spectrochim Acta A Mol Biomol Spectrosc. 2022;272:120971.', 'DOI': '10.1016/j.saa.2022.120971'}, { 'key': '2160_CR212', 'doi-asserted-by': 'crossref', 'unstructured': 'Abubakar MB, Usman D, El-Saber Batiha G, Cruz-Martins N, Malami I, ' 'Ibrahim KG, Abubakar B, Bello MB, Muhammad A, Gan SH, Dabai AI, Alblihed ' 'M, Ghosh A, Badr RH, Thangadurai D, Imam MU. Natural Products Modulating ' 'Angiotensin Converting Enzyme 2 (ACE2) as Potential COVID-19 Therapies. ' 'Front Pharmacol. 2021;12:629935.', 'DOI': '10.3389/fphar.2021.629935'}, { 'key': '2160_CR213', 'doi-asserted-by': 'crossref', 'first-page': '55', 'DOI': '10.1007/s40203-021-00114-w', 'volume': '9', 'author': 'MF Isaac-Lam', 'year': '2021', 'unstructured': 'Isaac-Lam MF. Molecular modeling of the interaction of ligands with ' 'ACE2–SARS-CoV-2 spike protein complex. In Silico Pharmacol. 2021;9:55.', 'journal-title': 'In Silico Pharmacol'}, { 'key': '2160_CR214', 'doi-asserted-by': 'crossref', 'unstructured': 'Wasilewicz A, Kirchweger B, Bojkova D, Abi Saad MJ, Langeder J, ' 'Bütikofer M, Adelsberger S, Grienke U, Cinatl J Jr, Petermann O, ' 'Scapozza L, Orts J, Kirchmair J, Rabenau HF, Rollinger JM. ' 'Identification of Natural Products Inhibiting SARS-CoV-2 by Targeting ' 'Viral Proteases: A Combined in Silico and in Vitro Approach. J Nat Prod. ' '2023;86(2):264-275.', 'DOI': '10.1021/acs.jnatprod.2c00843'}, { 'key': '2160_CR215', 'doi-asserted-by': 'crossref', 'first-page': '105155', 'DOI': '10.1016/j.compbiomed.2021.105155', 'volume': '141', 'author': 'MBS Al-Shuhaib', 'year': '2022', 'unstructured': 'Al-Shuhaib MBS, Hashim HO, Al-Shuhaib JM. Epicatechin is a promising ' 'novel inhibitor of SARS-CoV-2 entry by disrupting interactions between ' 'angiotensin-converting enzyme type 2 and the viral receptor binding ' 'domain: a computational/simulation study. Comput Biol Med. ' '2022;141:105155.', 'journal-title': 'Comput Biol Med'}, { 'key': '2160_CR216', 'doi-asserted-by': 'crossref', 'unstructured': 'Mohammadi Pour P, Fakhri S, Asgary S, Farzaei MH, Echeverría J. The ' 'signaling pathways, and therapeutic targets of antiviral agents: ' 'focusing on the antiviral approaches and clinical perspectives of ' 'anthocyanins in the management of viral diseases. Front Pharmacol. ' '2019;1207.', 'DOI': '10.3389/fphar.2019.01207'}, { 'key': '2160_CR217', 'first-page': '209', 'volume': '45', 'author': 'Y Knox', 'year': '2001', 'unstructured': 'Knox Y, Hayashi K, Suzutani T, Ogasawara M, Yoshida I, Shiina R, Tsukui ' 'A, Terahara N, Azuma M. Activity of anthocyanins from fruit extract of ' 'Ribes nigrum L. against influenza A and B viruses. Acta virol. ' '2001;45:209–15.', 'journal-title': 'Acta virol'}, { 'key': '2160_CR218', 'doi-asserted-by': 'crossref', 'first-page': '2066', 'DOI': '10.3390/molecules23082066', 'volume': '23', 'author': 'A Di Sotto', 'year': '2018', 'unstructured': 'Di Sotto A, Di Giacomo S, Amatore D, Locatelli M, Vitalone A, Toniolo C, ' 'Rotino GL, Lo Scalzo R, Palamara AT, Marcocci ME. A polyphenol rich ' 'extract from Solanum melongena L. DR2 peel exhibits antioxidant ' 'properties and anti-herpes simplex virus type 1 activity in vitro. ' 'Molecules. 2018;23:2066.', 'journal-title': 'Molecules'}, { 'key': '2160_CR219', 'doi-asserted-by': 'crossref', 'first-page': '1314', 'DOI': '10.3389/fmicb.2017.01314', 'volume': '8', 'author': 'Á Vázquez-Calvo', 'year': '2017', 'unstructured': 'Vázquez-Calvo Á, Jiménez De Oya N, Martín-Acebes MA, Garcia-Moruno E, ' 'Saiz J-C. Antiviral properties of the natural polyphenols delphinidin ' 'and epigallocatechin gallate against the flaviviruses West Nile virus, ' 'Zika virus, and dengue virus. Front Microbiol. 2017;8:1314.', 'journal-title': 'Front Microbiol'}, { 'key': '2160_CR220', 'doi-asserted-by': 'crossref', 'first-page': '10053', 'DOI': '10.1128/JVI.01473-15', 'volume': '89', 'author': 'N Calland', 'year': '2015', 'unstructured': 'Calland N, Sahuc M-E, Belouzard S, Pène V, Bonnafous P, Mesalam AA, ' 'Deloison G, Descamps V, Sahpaz S, Wychowski C. Polyphenols inhibit ' 'hepatitis C virus entry by a new mechanism of action. J Virol. ' '2015;89:10053–63.', 'journal-title': 'J Virol'}, { 'key': '2160_CR221', 'doi-asserted-by': 'crossref', 'first-page': '6563', 'DOI': '10.1007/s00216-013-7068-x', 'volume': '405', 'author': 'K Swaminathan', 'year': '2013', 'unstructured': 'Swaminathan K, Dyason JC, Maggioni A, von Itzstein M, Downard KM. ' 'Binding of a natural anthocyanin inhibitor to influenza neuraminidase by ' 'mass spectrometry. Anal Bioanal Chem. 2013;405:6563–72.', 'journal-title': 'Anal Bioanal Chem'}], 'container-title': 'Virology Journal', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://link.springer.com/content/pdf/10.1186/s12985-023-02160-6.pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://link.springer.com/article/10.1186/s12985-023-02160-6/fulltext.html', 'content-type': 'text/html', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://link.springer.com/content/pdf/10.1186/s12985-023-02160-6.pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2023, 11, 18]], 'date-time': '2023-11-18T22:18:41Z', 'timestamp': 1700345921000}, 'score': 1, 'resource': {'primary': {'URL': 'https://virologyj.biomedcentral.com/articles/10.1186/s12985-023-02160-6'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2023, 8, 25]]}, 'references-count': 221, 'journal-issue': {'issue': '1', 'published-online': {'date-parts': [[2023, 12]]}}, 'alternative-id': ['2160'], 'URL': 'http://dx.doi.org/10.1186/s12985-023-02160-6', 'relation': {}, 'ISSN': ['1743-422X'], 'subject': ['Infectious Diseases', 'Virology'], 'container-title-short': 'Virol J', 'published': {'date-parts': [[2023, 8, 25]]}, 'assertion': [ { 'value': '29 March 2023', 'order': 1, 'name': 'received', 'label': 'Received', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'value': '15 August 2023', 'order': 2, 'name': 'accepted', 'label': 'Accepted', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'value': '25 August 2023', 'order': 3, 'name': 'first_online', 'label': 'First Online', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, {'order': 1, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Declarations'}}, { 'value': 'Not applicable.', 'order': 2, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Ethics approval and consent to participate'}}, { 'value': 'All the authors read and agreed to publish this article.', 'order': 3, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Consent for publication'}}, { 'value': 'The authors declare that they have no competing interests.', 'order': 4, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Competing interests'}}], 'article-number': '191'}

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