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Potential Mechanism of Curcumin and Resveratrol against SARS-CoV-2

Wu et al., Research Square, doi:10.21203/
Apr 2023  
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In Vitro study showing that curcumin and resveratrol can inhibit SARS-CoV-2 3CLpro activity and spike protein-mediated cell entry, cytokine storm, and oxidative stress. Combined treatment was more effective than either treatment alone.
Wu et al., 13 Apr 2023, preprint, 6 authors.
In Vitro studies are an important part of preclinical research, however results may be very different in vivo.
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AI generated summary. Current AI models can provide useful summaries for non-experts, but may be inaccurate and have limited ability to analyze larger context such as the entire evidence base for curcumin.

Curcumin and resveratrol can inhibit SARS-CoV-2 infection by blocking the binding of the virus to the ACE2 receptor, inhibiting the activity of 3CLpro, and inhibiting the activation of NF-kB.

  • Curcumin and resveratrol are two natural compounds with potential antiviral and anti-inflammatory effects.
  • In this study, the authors found that curcumin and resveratrol could inhibit SARS-CoV-2 3CLpro activity, which is essential for the virus to enter cells.
  • Curcumin and resveratrol could also significantly alleviate spike protein-mediated cytokine storm and oxidative stress.
  • The combined treatment of curcumin and resveratrol showed a better effect than either compound alone.

The authors conclude that curcumin and resveratrol could be potential therapeutic agents for COVID-19. However, further research is needed to confirm these findings in clinical trials.

Here are some additional details from the article:

  • Curcumin is a compound found in turmeric, and resveratrol is a compound found in grapes.
  • Both curcumin and resveratrol have been shown to have anti-inflammatory and antioxidant effects in vitro and in vivo.
  • In this study, the authors found that curcumin and resveratrol could inhibit SARS-CoV-2 3CLpro activity in vitro.
  • SARS-CoV-2 3CLpro is an enzyme that is essential for the virus to enter cells.
  • The authors also found that curcumin and resveratrol could significantly alleviate spike protein-mediated cytokine storm and oxidative stress in mice.
  • Cytokine storm is a condition in which the body's immune system overreacts to a viral infection.
  • Oxidative stress is a condition in which the body's cells are damaged by free radicals.
  • The authors conclude that curcumin and resveratrol could be potential therapeutic agents for COVID-19.

However, it is important to note that this study was conducted in vitro. Further research is needed to confirm these findings in clinical trials.

Potential Mechanism of Curcumin and Resveratrol against SARS-CoV-2
Wei Wu, Junxi Wu, Xuxu Ji, Ji Liu, Fuchang Geng
Recently, World Health Organization predicted a near end of COVID-19 pandemic. However, the prediction should be interpreted cautiously. Due to SARS-CoV-2 continuous mutation-evolve, limited durability of infection-acquired protection in individuals with hybrid immunity, and the effects of long COVID-19 or Post-COVID-19 syndrome, COVID-19 may continue to be a worldwide threat. Alternative therapeutics are incorporated into some countries' health guidelines for COVID-19. Qiannan herbal, an ancient medical book of Yi Nationality in China, recorded that grapes and turmeric were often used to treat respiratory diseases. Curcumin and resveratrol are the primary bioactive compounds in turmeric and grapes, respectively. The clinical trials con rmed that curcumin or resveratrol supplementation could cause moderate or marked improvements in COVID-19 patients. Exploring the potential mechanisms is of great signi cance. This study found that curcumin and resveratrol could effectively inhibit SARS-CoV-23CLpro activity and spike protein-mediated cell entry. Curcumin and resveratrol could signi cantly alleviate spike protein-mediated cytokine storm via inhibiting over-activation of NFKB, and effectively ameliorate spike protein-mediated oxidative stress through scavenging ROS and enhancing function of antioxidation system. The combined treatment showed a better effect than alone treatment. Therefore, curcumin and resveratrol could inhibit SARS-CoV-23C-like proteinase activity and Spike protein-mediated cell entry, cytokine storm, and oxidative stress.
In conclusion, curcumin and resveratrol could inhibit SARS-CoV-2 3CLpro activity and spike proteinmediated cell entry, cytokine storm, and oxidative stress. The above conclusions are shown in Supplementary Fig. 5 . Our study provides a reference of nutrient supplementation for preventing and treating COVID-19. Methods Venn analysis and Enrichment analysis Firstly, COVID-19, curcumin, and resveratrol were separately input into Gene or Pubchem database at National Center for Biotechnology Information (NCBI) and ltered with Homo sapiens, and the gene sets were Cell culture and reagents Vero cells and HEK293T-hACE2 cells were obtained from the Laboratory of Biochemistry and Molecular Biology, Sichuan University. Cells were maintained in Dulbecco's Modi ed Eagle's Medium (DMEM) supplemented with 10% FBS and incubated at 37°C with 5% CO2. Fetal bovine serum (FBS), DMEM, and phosphate-buffered saline (PBS) were bought from Gibco (Grand Island, NY, USA). Pyrrolidinedithiocarbamate ammonium (PDTC), curcumin, and resveratrol were obtained from Solarbio. Ebselen was purchased from Beyotime. Cell viability assay Vero E6 cells were..
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