All Studies Meta Analysis Recent:

Nanoparticulate curcumin spray imparts prophylactic and therapeutic properties against SARS-CoV-2

Kamble et al., Emergent Materials, doi:10.1007/s42247-024-00754-6

Jun 2024

Post
Facebook

Source PDF All Studies Meta AnalysisMeta

Curcumin for COVID-19

15th treatment shown to reduce risk in February 2021

^*, now with p = 0.0000000096 from 27 studies.

Lower risk for mortality, ventilation, hospitalization, progression, recovery, and viral clearance.

No treatment is 100% effective. Protocols combine treatments. ^* >10% efficacy, ≥3 studies.

4,500+ studies for 81 treatments. c19early.org

In Vitro study showing that a water-dispersible nano-spray formulation of curcumin inhibits SARS-CoV-2 infection in Vero E6 cells. Authors found that pre-treatment effectively inhibited SARS-CoV-2 infection, and subsequent exposure to the nanoformulation after infection inhibited viral particle spread. There was no cytotoxicity at the tested concentrations on Vero E6 cells.

45 preclinical studies support the efficacy of curcumin for COVID-19:

24 In Silico studies1-24

20 In Vitro studies1,5,7,11,17,21,25-38

1 In Vivo animal study5

In Silico studies predict inhibition of SARS-CoV-2 with curcumin or metabolites via binding to the spikeA,5,10,12,18,21 (and specifically the receptor binding domainB,8,11,14), M^proC,5,7,9-11,13,14,16,19,21,22,24,35, RNA-dependent RNA polymeraseD,11,20, ACE2E,12,13,15, nucleocapsidF,6,23, nsp10G,23, and helicaseH,25 proteins. In Vitro studies demonstrate inhibition of the spikeA,30 (and specifically the receptor binding domainB,38), M^proC,17,30,35,37, ACE2E,38, and TMPRSS2I,38 proteins. In Vitro studies demonstrate efficacy in Calu-3J,36, A549K,30, 293TL,1, HEK293-hACE2M,17,28, 293T/hACE2/TMPRSS2N,29, Vero E6O,7,11,21,28,30-32,34,36, and SH-SY5YP,27 cells. Curcumin is predicted to inhibit the interaction between the SARS-CoV-2 spike protein receptor binding domain and the human ACE2 receptor for the delta and omicron variants8, decreases pro-inflammatory cytokines induced by SARS-CoV-2 in peripheral blood mononuclear cells34, and alleviates SARS-CoV-2 spike protein-induced mitochondrial membrane damage and oxidative stress1.

4 studies investigate novel formulations of curcumin for improved efficacy11,26,39,40

Important missing comments or errors? Let us know.

1. Zhang et al., Computational Discovery of Mitochondrial Dysfunction Biomarkers in Severe SARS-CoV-2 Infection: Facilitating Pytomedicine Screening, Phytomedicine, doi:10.1016/j.phymed.2024.155784.sciencedirect.com, doi.org.

2. Öztürkkan et al., In Silico investigation of the effects of curcuminoids on the spike protein of the omicron variant of SARS-CoV-2, Baku State University Journal of Chemistry and Material Sciences, 1:2, bsuj.bsu.edu.az/uploads/pdf/ec4204d62f7802de54e6092bf7860029.pdf.edu.az.

3. Yunze et al., Therapeutic effect and potential mechanism of curcumin, an active ingredient in Tongnao Decoction, on COVID-19 combined with stroke: a network pharmacology study and GEO database mining, Research Square, doi:10.21203/rs.3.rs-4329762/v1.researchsquare.com, doi.org.

4. Agamah et al., Network-based multi-omics-disease-drug associations reveal drug repurposing candidates for COVID-19 disease phases, ScienceOpen, doi:10.58647/DRUGARXIV.PR000010.v1.scienceopen.com, doi.org.

5. Boseila et al., Throat spray formulated with virucidal Pharmaceutical excipients as an effective early prophylactic or treatment strategy against pharyngitis post-exposure to SARS CoV-2, European Journal of Pharmaceutics and Biopharmaceutics, doi:10.1016/j.ejpb.2024.114279.sciencedirect.com, doi.org.

6. Hidayah et al., Bioinformatics study of curcumin, demethoxycurcumin, bisdemethoxycurcumin and cyclocurcumin compounds in Curcuma longa as an antiviral agent via nucleocapsid on SARS-CoV-2 inhibition, International Conference on Organic and Applied Chemistry, doi:10.1063/5.0197724.aip.org, doi.org.

7. Singh et al., Unlocking the potential of phytochemicals in inhibiting SARS-CoV-2 M Pro protein - An in-silico and cell-based approach, Research Square, doi:10.21203/rs.3.rs-3888947/v1.researchsquare.com, doi.org.

8. Kant et al., Structure-based drug discovery to identify SARS-CoV2 spike protein–ACE2 interaction inhibitors, Journal of Biomolecular Structure and Dynamics, doi:10.1080/07391102.2023.2300060.tandfonline.com, doi.org.

9. Naderi Beni et al., In silico studies of anti-oxidative and hot temperament-based phytochemicals as natural inhibitors of SARS-CoV-2 Mpro, PLOS ONE, doi:10.1371/journal.pone.0295014.plos.org, doi.org.

10. Moschovou et al., Exploring the Binding Effects of Natural Products and Antihypertensive Drugs on SARS-CoV-2: An In Silico Investigation of Main Protease and Spike Protein, International Journal of Molecular Sciences, doi:10.3390/ijms242115894.mdpi.com, doi.org.

11. Eleraky et al., Curcumin Transferosome-Loaded Thermosensitive Intranasal in situ Gel as Prospective Antiviral Therapy for SARS-Cov-2, International Journal of Nanomedicine, doi:10.2147/IJN.S423251.dovepress.com, doi.org.

12. Singh (B) et al., Computational studies to analyze effect of curcumin inhibition on coronavirus D614G mutated spike protein, The Seybold Report, doi:10.17605/OSF.IO/TKEXJ.ac.in, doi.org.

13. Thapa et al., In-silico Approach for Predicting the Inhibitory Effect of Home Remedies on Severe Acute Respiratory Syndrome Coronavirus-2, Makara Journal of Science, doi:10.7454/mss.v27i3.1609.ac.id, doi.org.

14. Srivastava et al., Paradigm of Well-Orchestrated Pharmacokinetic Properties of Curcuminoids Relative to Conventional Drugs for the Inactivation of SARS-CoV-2 Receptors: An In Silico Approach, Stresses, doi:10.3390/stresses3030043.mdpi.com, doi.org.

15. Alkafaas et al., A study on the effect of natural products against the transmission of B.1.1.529 Omicron, Virology Journal, doi:10.1186/s12985-023-02160-6.biomedcentral.com, doi.org.

16. Winih Kinasih et al., Analisis in silico interaksi senyawa kurkuminoid terhadap enzim main protease 6LU7 dari SARS-CoV-2, Duta Pharma Journal, doi:10.47701/djp.v3i1.2904.ac.id, doi.org.

17. Wu et al., Potential Mechanism of Curcumin and Resveratrol against SARS-CoV-2, Research Square, doi:10.21203/rs.3.rs-2780614/v1.researchsquare.com, doi.org.

18. Nag et al., Curcumin inhibits spike protein of new SARS-CoV-2 variant of concern (VOC) Omicron, an in silico study, Computers in Biology and Medicine, doi:10.1016/j.compbiomed.2022.105552.sciencedirect.com, doi.org.

19. Rampogu et al., Molecular Docking and Molecular Dynamics Simulations Discover Curcumin Analogue as a Plausible Dual Inhibitor for SARS-CoV-2, International Journal of Molecular Sciences, doi:10.3390/ijms23031771.mdpi.com, doi.org.

20. Singh (C) et al., Potential of turmeric-derived compounds against RNA-dependent RNA polymerase of SARS-CoV-2: An in-silico approach, Computers in Biology and Medicine, doi:10.1016/j.compbiomed.2021.104965.sciencedirect.com, doi.org.

21. Kandeil et al., Bioactive Polyphenolic Compounds Showing Strong Antiviral Activities against Severe Acute Respiratory Syndrome Coronavirus 2, Pathogens, doi:10.3390/pathogens10060758.mdpi.com, doi.org.

22. Rajagopal et al., Activity of phytochemical constituents of Curcuma longa (turmeric) and Andrographis paniculata against coronavirus (COVID-19): an in silico approach, Future Journal of Pharmaceutical Sciences, doi:10.1186/s43094-020-00126-x.springeropen.com, doi.org.

23. Suravajhala et al., Comparative Docking Studies on Curcumin with COVID-19 Proteins, MDPI AG, doi:10.20944/preprints202005.0439.v3.preprints.org, doi.org.

24. Sekiou et al., In-Silico Identification of Potent Inhibitors of COVID-19 Main Protease (Mpro) and Angiotensin Converting Enzyme 2 (ACE2) from Natural Products: Quercetin, Hispidulin, and Cirsimaritin Exhibited Better Potential Inhibition than Hydroxy-Chloroquine Against COVID-19 Main Protease Active Site and ACE2, ChemRxiv, doi:10.26434/chemrxiv.12181404.v1.chemrxiv.org, doi.org.

25. Li et al., Thermal shift assay (TSA)-based drug screening strategy for rapid discovery of inhibitors against the Nsp13 helicase of SARS-CoV-2, Animals and Zoonoses, doi:10.1016/j.azn.2024.06.001.sciencedirect.com, doi.org.

26. Kamble et al., Nanoparticulate curcumin spray imparts prophylactic and therapeutic properties against SARS-CoV-2, Emergent Materials, doi:10.1007/s42247-024-00754-6.springer.com, doi.org.

27. Nicoliche et al., Antiviral, anti-inflammatory and antioxidant effects of curcumin and curcuminoids in SH-SY5Y cells infected by SARS-CoV-2, Scientific Reports, doi:10.1038/s41598-024-61662-7.nature.com, doi.org.

28. Nittayananta et al., A novel film spray containing curcumin inhibits SARS-CoV-2 and influenza virus infection and enhances mucosal immunity, Virology Journal, doi:10.1186/s12985-023-02282-x.biomedcentral.com, doi.org.

29. Septisetyani et al., Curcumin and turmeric extract inhibited SARS-CoV-2 pseudovirus cell entry and Spike mediated cell fusion, bioRxiv, doi:10.1101/2023.09.28.560070.biorxiv.org, doi.org.

30. Mohd Abd Razak et al., In Vitro Anti-SARS-CoV-2 Activities of Curcumin and Selected Phenolic Compounds, Natural Product Communications, doi:10.1177/1934578X231188861.sagepub.com, doi.org.

31. Teshima et al., Antiviral activity of curcumin and its analogs selected by an artificial intelligence-supported activity prediction system in SARS-CoV-2-infected VeroE6 cells, Natural Product Research, doi:10.1080/14786419.2023.2194647.tandfonline.com, doi.org.

32. Leka et al., In vitro antiviral activity against SARS-CoV-2 of common herbal medicinal extracts and their bioactive compounds, Phytotherapy Research, doi:10.1002/ptr.7463.wiley.com, doi.org.

33. Goc et al., Inhibitory effects of specific combination of natural compounds against SARS-CoV-2 and its Alpha, Beta, Gamma, Delta, Kappa, and Mu variants, European Journal of Microbiology and Immunology, doi:10.1556/1886.2021.00022.akjournals.com, doi.org.

34. Marín-Palma et al., Curcumin Inhibits In Vitro SARS-CoV-2 Infection In Vero E6 Cells through Multiple Antiviral Mechanisms, Molecules, doi:10.3390/molecules26226900.mdpi.com, doi.org.

35. Bahun et al., Inhibition of the SARS-CoV-2 3CLpro main protease by plant polyphenols, Food Chemistry, doi:10.1016/j.foodchem.2021.131594.sciencedirect.com, doi.org.

36. Bormann et al., Turmeric Root and Its Bioactive Ingredient Curcumin Effectively Neutralize SARS-CoV-2 In Vitro, Viruses, doi:10.3390/v13101914.mdpi.com, doi.org.

37. Guijarro-Real et al., Potential In Vitro Inhibition of Selected Plant Extracts against SARS-CoV-2 Chymotripsin-Like Protease (3CLPro) Activity, Foods, doi:10.3390/foods10071503.mdpi.com, doi.org.

38. Goc (B) et al., Phenolic compounds disrupt spike-mediated receptor-binding and entry of SARS-CoV-2 pseudo-virions, PLOS ONE, doi:10.1371/journal.pone.0253489.plos.org, doi.org.

39. Vaiss et al., Curcumin and quercetin co-encapsulated in nanoemulsions for nasal administration: a promising therapeutic and prophylactic treatment for viral respiratory infections, European Journal of Pharmaceutical Sciences, doi:10.1016/j.ejps.2024.106766.sciencedirect.com, doi.org.

40. Panda et al., The enhanced bioavailability of free curcumin and bioactive-metabolite tetrahydrocurcumin from a dispersible, oleoresin-based turmeric formulation, Medicine, doi:10.1097/MD.0000000000026601.lww.com, doi.org.

a. The trimeric spike (S) protein is a glycoprotein that mediates viral entry by binding to the host ACE2 receptor, is critical for SARS-CoV-2's ability to infect host cells, and is a target of neutralizing antibodies. Inhibition of the spike protein prevents viral attachment, halting infection at the earliest stage.

b. The receptor binding domain is a specific region of the spike protein that binds ACE2 and is a major target of neutralizing antibodies. Focusing on the precise binding site allows highly specific disruption of viral attachment with reduced potential for off-target effects.

c. The main protease or M^pro, also known as 3CL^pro or nsp5, is a cysteine protease that cleaves viral polyproteins into functional units needed for replication. Inhibiting M^pro disrupts the SARS-CoV-2 lifecycle within the host cell, preventing the creation of new copies.

d. RNA-dependent RNA polymerase (RdRp), also called nsp12, is the core enzyme of the viral replicase-transcriptase complex that copies the positive-sense viral RNA genome into negative-sense templates for progeny RNA synthesis. Inhibiting RdRp blocks viral genome replication and transcription.

e. The angiotensin converting enzyme 2 (ACE2) protein is a host cell transmembrane protein that serves as the cellular receptor for the SARS-CoV-2 spike protein. ACE2 is expressed on many cell types, including epithelial cells in the lungs, and allows the virus to enter and infect host cells. Inhibition may affect ACE2's physiological function in blood pressure control.

f. The nucleocapsid (N) protein binds and encapsulates the viral genome by coating the viral RNA. N enables formation and release of infectious virions and plays additional roles in viral replication and pathogenesis. N is also an immunodominant antigen used in diagnostic assays.

g. Non-structural protein 10 (nsp10) serves as an RNA chaperone and stabilizes conformations of nsp12 and nsp14 in the replicase-transcriptase complex, which synthesizes new viral RNAs. Nsp10 disruption may destabilize replicase-transcriptase complex activity.

h. The helicase, or nsp13, protein unwinds the double-stranded viral RNA, a crucial step in replication and transcription. Inhibition may prevent viral genome replication and the creation of new virus components.

i. Transmembrane protease serine 2 (TMPRSS2) is a host cell protease that primes the spike protein, facilitating cellular entry. TMPRSS2 activity helps enable cleavage of the spike protein required for membrane fusion and virus entry. Inhibition may especially protect respiratory epithelial cells, buy may have physiological effects.

j. Calu-3 is a human lung adenocarcinoma cell line with moderate ACE2 and TMPRSS2 expression and SARS-CoV-2 susceptibility. It provides a model of the human respiratory epithelium, but many not be ideal for modeling early stages of infection due to the moderate expression levels of ACE2 and TMPRSS2.

k. A549 is a human lung carcinoma cell line with low ACE2 expression and SARS-CoV-2 susceptibility. Viral entry/replication can be studied but the cells may not replicate all aspects of lung infection.

l. 293T is a human embryonic kidney cell line that can be engineered for high ACE2 expression and SARS-CoV-2 susceptibility. 293T cells are easily transfected and support high protein expression.

m. HEK293-hACE2 is a human embryonic kidney cell line with high ACE2 expression and SARS-CoV-2 susceptibility. Cells have been transfected with a plasmid to express the human ACE2 (hACE2) protein.

n. 293T/hACE2/TMPRSS2 is a human embryonic kidney cell line engineered for high ACE2 and TMPRSS2 expression, which mimics key aspects of human infection. 293T/hACE2/TMPRSS2 cells are very susceptible to SARS-CoV-2 infection.

o. Vero E6 is an African green monkey kidney cell line with low/no ACE2 expression and high SARS-CoV-2 susceptibility. The cell line is easy to maintain and supports robust viral replication, however the monkey origin may not accurately represent human responses.

p. SH-SY5Y is a human neuroblastoma cell line that exhibits neuronal phenotypes. It is commonly used as an in vitro model for studying neurotoxicity, neurodegenerative diseases, and neuronal differentiation.

Kamble et al., 3 Jun 2024, peer-reviewed, 6 authors.

In Vitro studies are an important part of preclinical research, however results may be very different in vivo.

This Paper Curcumin All

{ 'indexed': {'date-parts': [[2024, 6, 4]], 'date-time': '2024-06-04T00:20:27Z', 'timestamp': 1717460427319}, 'reference-count': 33, 'publisher': 'Springer Science and Business Media LLC', 'license': [ { 'start': { 'date-parts': [[2024, 6, 3]], 'date-time': '2024-06-03T00:00:00Z', 'timestamp': 1717372800000}, 'content-version': 'tdm', 'delay-in-days': 0, 'URL': 'https://www.springernature.com/gp/researchers/text-and-data-mining'}, { 'start': { 'date-parts': [[2024, 6, 3]], 'date-time': '2024-06-03T00:00:00Z', 'timestamp': 1717372800000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'https://www.springernature.com/gp/researchers/text-and-data-mining'}], 'funder': [ { 'DOI': '10.13039/501100010710', 'name': 'Savitribai Phule Pune University', 'doi-asserted-by': 'publisher', 'award': ['Dept of Technology']}], 'content-domain': {'domain': ['link.springer.com'], 'crossmark-restriction': False}, 'DOI': '10.1007/s42247-024-00754-6', 'type': 'journal-article', 'created': {'date-parts': [[2024, 6, 3]], 'date-time': '2024-06-03T11:06:09Z', 'timestamp': 1717412769000}, 'update-policy': 'http://dx.doi.org/10.1007/springer_crossmark_policy', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Nanoparticulate curcumin spray imparts prophylactic and therapeutic properties against ' 'SARS-CoV-2', 'prefix': '10.1007', 'author': [ { 'ORCID': 'http://orcid.org/0000-0002-7501-2044', 'authenticated-orcid': False, 'given': 'Swapnil C.', 'family': 'Kamble', 'sequence': 'first', 'affiliation': []}, {'given': 'Prem', 'family': 'Pandey', 'sequence': 'additional', 'affiliation': []}, {'given': 'Vijay K.', 'family': 'Kanuru', 'sequence': 'additional', 'affiliation': []}, {'given': 'Nilesh', 'family': 'Rai', 'sequence': 'additional', 'affiliation': []}, {'given': 'Vibhav', 'family': 'Gautam', 'sequence': 'additional', 'affiliation': []}, {'given': 'Dinesh', 'family': 'Amalnerkar', 'sequence': 'additional', 'affiliation': []}], 'member': '297', 'published-online': {'date-parts': [[2024, 6, 3]]}, 'reference': [ { 'key': '754_CR1', 'unstructured': 'WHO COVID-19 Dashboard. Geneva: World Health Organization, 2020.\xa0' 'https://covid19.who.int/ (last cited: [13 June 2022])'}, { 'key': '754_CR2', 'doi-asserted-by': 'publisher', 'unstructured': 'R.E. Chen et al., Resistance of SARS-CoV-2 variants to neutralization by ' 'monoclonal and serum-derived polyclonal antibodies. Nat. Med. 27(4), ' '717–726 (Apr. 2021). https://doi.org/10.1038/s41591-021-01294-w', 'DOI': '10.1038/s41591-021-01294-w'}, { 'key': '754_CR3', 'doi-asserted-by': 'publisher', 'unstructured': 'P. Wang et al.,\xa0 Increased Resistance of SARS-CoV-2 Variants B.1.351 ' 'and B.1.1.7, bioRxiv Prepr. Serv. Biol, p. 2021.01.25.428137, 2021, ' 'https://doi.org/10.1101/2021.01.25.428137', 'DOI': '10.1101/2021.01.25.428137'}, { 'key': '754_CR4', 'doi-asserted-by': 'publisher', 'unstructured': 'T. Tada et al., Convalescent-phase sera and vaccine-elicited antibodies ' 'largely maintain neutralizing titer against global sars-cov-2 variant ' 'spikes. MBio. 12(3) (Jun. 2021). https://doi.org/10.1128/mBio.00696-21', 'DOI': '10.1128/mBio.00696-21'}, { 'key': '754_CR5', 'doi-asserted-by': 'publisher', 'unstructured': 'C.K. Wibmer, SARS-CoV-2 501Y.V2 escapes neutralization by South African ' 'COVID-19 donor plasma. Nat Med 27, 622–625 (2021). ' 'https://doi.org/10.1038/s41591-021-01285-x', 'DOI': '10.1038/s41591-021-01285-x'}, { 'issue': '1', 'key': '754_CR6', 'doi-asserted-by': 'publisher', 'first-page': '1', 'DOI': '10.1038/s41598-021-95565-8', 'volume': '11', 'author': 'S Lopez-Leon', 'year': '2021', 'unstructured': 'S. Lopez-Leon et al., More than 50 long-term effects of COVID-19: a ' 'systematic review and meta-analysis. Sci. Rep. 11(1), 1–12 (2021). ' 'https://doi.org/10.1038/s41598-021-95565-8', 'journal-title': 'Sci. Rep.'}, { 'issue': '5', 'key': '754_CR7', 'doi-asserted-by': 'publisher', 'first-page': '798', 'DOI': '10.3390/vaccines10050798', 'volume': '10', 'author': 'H Cheng', 'year': '2022', 'unstructured': 'H. Cheng et al., Immunogenicity and safety of homologous and ' 'heterologous prime–boost immunization with COVID-19 vaccine: systematic ' 'review and Meta-analysis. Vaccines. 10(5), 798 (2022). ' 'https://doi.org/10.3390/vaccines10050798', 'journal-title': 'Vaccines'}, { 'key': '754_CR8', 'doi-asserted-by': 'publisher', 'first-page': '116', 'DOI': '10.1016/j.addr.2017.04.008', 'volume': '114', 'author': 'JE Vela Ramirez', 'year': '2017', 'unstructured': 'J.E. Vela Ramirez, L.A. Sharpe, N.A. Peppas, Current state and ' 'challenges in developing oral vaccines. Adv. Drug Deliv Rev. 114, ' '116–131 (2017). https://doi.org/10.1016/j.addr.2017.04.008', 'journal-title': 'Adv. Drug Deliv Rev.'}, { 'key': '754_CR9', 'doi-asserted-by': 'publisher', 'first-page': '118813', 'DOI': '10.1016/j.ijpharm.2019.118813', 'volume': '572', 'author': 'Y Lobaina Mato', 'year': '2019', 'unstructured': 'Y. Lobaina Mato, Nasal route for vaccine and drug delivery: Features and ' 'current opportunities. Intl J Pharm 572, 118813 (2019). ' 'https://doi.org/10.1016/j.ijpharm.2019.118813', 'journal-title': 'Intl J Pharm'}, { 'key': '754_CR10', 'doi-asserted-by': 'publisher', 'first-page': '1', 'DOI': '10.3389/fmed.2021.760170', 'volume': '8', 'author': 'M Cunha', 'year': '2021', 'unstructured': 'M. Cunha et al., Atypical Prolonged Viral Shedding With Intra-Host ' 'SARS-CoV-2 Evolution in a Mildly Affected Symptomatic Patient, Front. ' 'Med\xa08\xa0 1–11, 2021, https://doi.org/10.3389/fmed.2021.760170', 'journal-title': 'Front Med'}, { 'issue': '13', 'key': '754_CR11', 'doi-asserted-by': 'publisher', 'first-page': '1435', 'DOI': '10.1177/0022034520960070', 'volume': '99', 'author': 'LL Fernandes', 'year': '2020', 'unstructured': 'L.L. Fernandes et al., Saliva in the diagnosis of COVID-19: a review and ' 'New Research directions. J. Dent. Res. 99(13), 1435–1443 (2020). ' 'https://doi.org/10.1177/0022034520960070', 'journal-title': 'J. Dent. Res.'}, { 'issue': '10', 'key': '754_CR12', 'doi-asserted-by': 'publisher', 'first-page': '2364', 'DOI': '10.1080/21645515.2017.1356952', 'volume': '13', 'author': 'G Kanojia', 'year': '2017', 'unstructured': 'G. Kanojia, R. ten Have, P.C. Soema, H. Frijlink, J.P. Amorij, G. ' 'Kersten, Developments in the formulation and delivery of spray dried ' 'vaccines. Hum. Vaccines Immunother. 13(10), 2364–2378 (2017). ' 'https://doi.org/10.1080/21645515.2017.1356952', 'journal-title': 'Hum. Vaccines Immunother'}, { 'issue': '2', 'key': '754_CR13', 'doi-asserted-by': 'publisher', 'first-page': '132', 'DOI': '10.1007/s12098-017-2377-2', 'volume': '85', 'author': 'N Garg', 'year': '2018', 'unstructured': 'N. Garg, A. Aggarwal, Advances towards painless vaccination and newer ' 'modes of Vaccine Delivery. Indian J. Pediatr. 85(2), 132–138 (2018). ' 'https://doi.org/10.1007/s12098-017-2377-2', 'journal-title': 'Indian J. Pediatr.'}, { 'issue': '2', 'key': '754_CR14', 'doi-asserted-by': 'publisher', 'first-page': '1', 'DOI': '10.17303/jfn.2021.7.202', 'volume': '7', 'author': 'CG Yedjou', 'year': '2021', 'unstructured': 'C.G. Yedjou, Pharmacological Effects of Selected Medicinal Plants and ' 'Vitamins Against COVID-19. Jacobs J Food Nutr 7(2), 1–18 (2021). ' 'https://doi.org/10.17303/jfn.2021.7.202', 'journal-title': 'Jacobs J Food Nutr'}, { 'key': '754_CR15', 'doi-asserted-by': 'publisher', 'first-page': '177', 'DOI': '10.1016/j.intimp.2017.11.009', 'volume': '54', 'author': 'J Dai', 'year': '2018', 'unstructured': 'J. Dai et al., Inhibition of curcumin on influenza A virus infection and ' 'influenzal pneumonia via oxidative stress, TLR2/4, p38/JNK MAPK and ' 'NF-κB pathways. Int Immunopharmacol 54, 177–187 (2018). ' 'https://doi.org/10.1016/j.intimp.2017.11.009', 'journal-title': 'Int Immunopharmacol'}, { 'issue': '1', 'key': '754_CR16', 'doi-asserted-by': 'publisher', 'first-page': '1', 'DOI': '10.1038/s41598-021-98243-x', 'volume': '11', 'author': 'P Thongsri', 'year': '2021', 'unstructured': 'P. Thongsri, Y. Pewkliang, S. Borwornpinyo, A. Wongkajornsilp, S. ' 'Hongeng, K. Sa-ngiamsuntorn, Curcumin inhibited hepatitis B viral entry ' 'through NTCP binding. Sci. Rep. 11(1), 1–12 (2021). ' 'https://doi.org/10.1038/s41598-021-98243-x', 'journal-title': 'Sci. Rep.'}, { 'issue': '1', 'key': '754_CR17', 'doi-asserted-by': 'publisher', 'first-page': '21', 'DOI': '10.1186/s13063-021-05372-9', 'volume': '22', 'author': 'G Askari', 'year': '2021', 'unstructured': 'G. Askari et al., Effect of curcumin-pipeine supplementation on clinical ' 'status, mortality rate, oxidative stress, and inflammatory markers in ' 'critically ill ICU patients with COVID-19: a structured summary of a ' 'study protocol for a randomized controlled trial. Trials. 22(1), 21–23 ' '(2021). https://doi.org/10.1186/s13063-021-05372-9', 'journal-title': 'Trials'}, { 'issue': '1', 'key': '754_CR18', 'doi-asserted-by': 'publisher', 'first-page': '20', 'DOI': '10.1186/s13063-020-04824-y', 'volume': '21', 'author': 'M Hassaniazad', 'year': '2020', 'unstructured': 'M. Hassaniazad et al., The clinical effect of Nano micelles containing ' 'curcumin as a therapeutic supplement in patients with COVID-19 and the ' 'immune responses balance changes following treatment: a structured ' 'summary of a study protocol for a randomised controlled trial. Trials. ' '21(1), 20–22 (2020). https://doi.org/10.1186/s13063-020-04824-y', 'journal-title': 'Trials'}, { 'key': '754_CR19', 'doi-asserted-by': 'publisher', 'first-page': '1', 'DOI': '10.3389/fphar.2021.669362', 'volume': '12', 'author': 'KS Pawar', 'year': '2021', 'unstructured': 'K.S. Pawar et al., Oral Curcumin with Piperine as Adjuvant Therapy for ' 'the treatment of COVID-19: a Randomized Clinical Trial. Front. ' 'Pharmacol. 12, 1–7 (2021). https://doi.org/10.3389/fphar.2021.669362', 'journal-title': 'Front. Pharmacol.'}, { 'issue': '8', 'key': '754_CR20', 'doi-asserted-by': 'publisher', 'first-page': '4068', 'DOI': '10.1002/fsn3.2226', 'volume': '9', 'author': 'R Ahmadi', 'year': '2021', 'unstructured': 'R. Ahmadi et al., Oral nano-curcumin formulation efficacy in the ' 'management of mild to moderate outpatient COVID-19: a randomized ' 'triple-blind placebo-controlled clinical trial. Food Sci. Nutr. 9(8), ' '4068–4075 (2021). https://doi.org/10.1002/fsn3.2226', 'journal-title': 'Food Sci. Nutr.'}, { 'issue': '76', 'key': '754_CR21', 'doi-asserted-by': 'publisher', 'first-page': '886', 'DOI': '10.4103/pm.pm_252_21', 'volume': '17', 'author': 'RB Humbare', 'year': '2021', 'unstructured': 'R.B. Humbare, J. Sarkar, A.A. Kulkarni, S.C. Kamble, Evaluation of free ' 'radical scavenging with in vitro Antiproliferative properties of ' 'different extracts of Pluchea Lanceolata (DC.) Oliv. And Hiern in Cancer ' 'Cell lines. Pharmacogn Mag. 17(76), 886–892 (2021). ' 'https://doi.org/10.4103/pm.pm_252_21', 'journal-title': 'Pharmacogn Mag'}, { 'key': '754_CR22', 'doi-asserted-by': 'publisher', 'first-page': '911', 'DOI': '10.1016/j.foodhyd.2017.11.038', 'volume': '77', 'author': 'B Sun', 'year': '2018', 'unstructured': 'B. Sun, Y. Tian, L. Chen, Z. Jin, Linear dextrin as curcumin delivery ' 'system: Effect of degree of polymerization on the functional stability ' 'of curcumin. Food Hydrocoll. 77, 911–920 (2018). ' 'https://doi.org/10.1016/j.foodhyd.2017.11.038', 'journal-title': 'Food Hydrocoll.'}, { 'key': '754_CR23', 'doi-asserted-by': 'publisher', 'unstructured': 'V.A. Marcolino, G.M. Zanin, L.R. Durrant, M.D.T. Benassi, G. Matioli, ' 'Interaction of curcumin and bixin with β-cyclodextrin: complexation ' 'methods, stability, and applications in food. J. Agric. Food Chem. ' '59(7), 3348–3357 (Apr. 2011). https://doi.org/10.1021/JF104223K/ASSET.', 'DOI': '10.1021/JF104223K/ASSET'}, { 'key': '754_CR24', 'doi-asserted-by': 'publisher', 'unstructured': 'S. Samimi, N. Maghsoudnia, R.B. Eftekhari, F. Dorkoosh, Lipid-Based ' 'Nanoparticles for Drug Delivery Systems, in Characterization and Biology ' 'of Nanomaterials for Drug Delivery: Nanoscience and Nanotechnology in ' 'Drug Delivery, S. T. Shyam S. Mohapatra, Shivendu Ranjan, Nandita ' 'Dasgupta, Raghvendra Kumar Mishra, I. M. and N. Technologies, and ' 'Characterization and Biology of Nanomaterials for Drug Delivery, Eds., ' '1st ed.Amsterdam: Elsevier Inc., 2018, pp. 47–76. ' 'https://doi.org/10.1016/B978-0-12-814031-4.00003-9', 'DOI': '10.1016/B978-0-12-814031-4.00003-9'}, { 'key': '754_CR25', 'doi-asserted-by': 'publisher', 'first-page': '10', 'DOI': '10.1002/open.202200200', 'volume': '12', 'author': 'P Pandey', 'year': '2023', 'unstructured': 'P. Pandey et al., A Xanthan-Gum-Stabilized PEG-Conjugated Nanocurcumin ' 'Complex: Telescoping Synthesis for Enhanced Permeation Potential, ' 'ChemistryOpen, vol. 12, no. 1, pp. 10–14, 2023, ' 'https://doi.org/10.1002/open.202200200', 'journal-title': 'ChemistryOpen'}, { 'issue': '8', 'key': '754_CR26', 'doi-asserted-by': 'publisher', 'first-page': '14293', 'DOI': '10.3390/molecules200814293', 'volume': '20', 'author': 'X Chen', 'year': '2015', 'unstructured': 'X. Chen, L.Q. Zou, J. Niu, W. Liu, S.F. Peng, C.M. Liu, The stability, ' 'sustained release and cellular antioxidant activity of curcumin ' 'nanoliposomes. Molecules. 20(8), 14293–14311 (2015). ' 'https://doi.org/10.3390/molecules200814293', 'journal-title': 'Molecules'}, { 'issue': '5', 'key': '754_CR27', 'doi-asserted-by': 'publisher', 'first-page': '369', 'DOI': '10.1007/s13659-018-0170-1', 'volume': '8', 'author': 'S Manimaran', 'year': '2018', 'unstructured': 'S. Manimaran et al., Medicinal Plant using Ground State stabilization of ' 'natural antioxidant curcumin by Keto-Enol Tautomerisation. Nat. Prod. ' 'Bioprospect. 8(5), 369–390 (2018). ' 'https://doi.org/10.1007/s13659-018-0170-1', 'journal-title': 'Nat. Prod. Bioprospect'}, { 'issue': '2', 'key': '754_CR28', 'doi-asserted-by': 'publisher', 'first-page': '469', 'DOI': '10.1016/j.carbpol.2011.04.063', 'volume': '86', 'author': 'S Faria', 'year': '2011', 'unstructured': 'S. Faria et al., Characterization of xanthan gum produced from sugar ' 'cane broth. Carbohydr. Polym. 86(2), 469–476 (2011). ' 'https://doi.org/10.1016/j.carbpol.2011.04.063', 'journal-title': 'Carbohydr. Polym.'}, { 'issue': '2', 'key': '754_CR29', 'doi-asserted-by': 'publisher', 'first-page': '179', 'DOI': '10.1016/j.ijmst.2013.04.022', 'volume': '23', 'author': 'W Qin', 'year': '2013', 'unstructured': 'W. Qin et al., Utilization of polysaccharides as depressants for the ' 'flotation separation of copper/lead concentrate. Int. J. Min. Sci. ' 'Technol 23(2), 179–186 (2013). ' 'https://doi.org/10.1016/j.ijmst.2013.04.022', 'journal-title': 'Int. J. Min. Sci. Technol'}, { 'issue': '17', 'key': '754_CR30', 'doi-asserted-by': 'publisher', 'first-page': '4087', 'DOI': '10.1021/jm070295s', 'volume': '50', 'author': 'CC Wen', 'year': '2007', 'unstructured': 'C.C. Wen, Specific plant terpenoids and lignoids possess potent ' 'antiviral activities against severe acute respiratory syndrome ' 'coronavirus. J. Med. Chem 50(17), 4087–4095 (2007). ' 'https://doi.org/10.1021/jm070295s', 'journal-title': 'J. Med. Chem'}, { 'issue': '7826', 'key': '754_CR31', 'doi-asserted-by': 'publisher', 'first-page': '588', 'DOI': '10.1038/s41586-020-2575-3', 'volume': '585', 'author': 'M Hoffmann', 'year': '2020', 'unstructured': 'M. Hoffmann et al., Chloroquine does not inhibit infection of human lung ' 'cells with SARS-CoV-2. Nature. 585(7826), 588–590 (2020). ' 'https://doi.org/10.1038/s41586-020-2575-3', 'journal-title': 'Nature'}, { 'issue': '1', 'key': '754_CR32', 'doi-asserted-by': 'publisher', 'first-page': '1', 'DOI': '10.1038/s41598-021-81462-7', 'volume': '11', 'author': 'AB Jena', 'year': '2021', 'unstructured': 'A.B. Jena, N. Kanungo, V. Nayak, G.B.N. Chainy, J. Dandapat, Catechin ' 'and curcumin interact with S protein of SARS-CoV2 and ACE2 of human cell ' 'membrane: insights from computational studies. Sci. Rep. 11(1), 1–14 ' '(2021). https://doi.org/10.1038/s41598-021-81462-7', 'journal-title': 'Sci. Rep.'}, { 'issue': '2', 'key': '754_CR33', 'doi-asserted-by': 'publisher', 'first-page': '483', 'DOI': '10.1021/acsabm.1c00874', 'volume': '5', 'author': 'VK Sharma', 'year': '2022', 'unstructured': 'V.K. Sharma, N. Prateeksha, S.P. Singh, B.N. Singh, C.V. Rao, S.K. ' 'Barik, Nanocurcumin Potently inhibits SARS-CoV-2 Spike Protein-Induced ' 'Cytokine Storm by Deactivation of MAPK/NF-κB signaling in epithelial ' 'cells. ACS Appl. Bio Mater. 5(2), 483–491 (2022). ' 'https://doi.org/10.1021/acsabm.1c00874', 'journal-title': 'ACS Appl. Bio Mater.'}], 'container-title': 'Emergent Materials', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://link.springer.com/content/pdf/10.1007/s42247-024-00754-6.pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://link.springer.com/article/10.1007/s42247-024-00754-6/fulltext.html', 'content-type': 'text/html', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://link.springer.com/content/pdf/10.1007/s42247-024-00754-6.pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2024, 6, 3]], 'date-time': '2024-06-03T11:06:59Z', 'timestamp': 1717412819000}, 'score': 1, 'resource': {'primary': {'URL': 'https://link.springer.com/10.1007/s42247-024-00754-6'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2024, 6, 3]]}, 'references-count': 33, 'alternative-id': ['754'], 'URL': 'http://dx.doi.org/10.1007/s42247-024-00754-6', 'relation': {}, 'ISSN': ['2522-5731', '2522-574X'], 'subject': [], 'container-title-short': 'emergent mater.', 'published': {'date-parts': [[2024, 6, 3]]}, 'assertion': [ { 'value': '15 December 2023', 'order': 1, 'name': 'received', 'label': 'Received', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'value': '26 May 2024', 'order': 2, 'name': 'accepted', 'label': 'Accepted', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'value': '3 June 2024', 'order': 3, 'name': 'first_online', 'label': 'First Online', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, {'order': 1, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Declarations'}}, { 'value': 'V.K. is Chief Technical and Scientific Officer of Oncocur India Pvt. Ltd, ' 'India. P.P. is Director of Nuimance Phytochemical Pvt. Ltd, India. There are no ' 'conflicts to declare for all other authors.', 'order': 2, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Conflict of interest'}}]}

Download Image

Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.

Submit

Post

@CovidAnalysis

FAQ

Public domain CC0 1.0