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Nanoparticulate curcumin spray imparts prophylactic and therapeutic properties against SARS-CoV-2

Kamble et al., Emergent Materials, doi:10.1007/s42247-024-00754-6
Jun 2024  
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Curcumin for COVID-19
14th treatment shown to reduce risk in February 2021
*, now known with p = 0.000000015 from 26 studies.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,200+ studies for 70+ treatments.
In Vitro study showing that a water-dispersible nano-spray formulation of curcumin inhibits SARS-CoV-2 infection in Vero E6 cells. Authors found that pre-treatment effectively inhibited SARS-CoV-2 infection, and subsequent exposure to the nanoformulation after infection inhibited viral particle spread. There was no cytotoxicity at the tested concentrations on Vero E6 cells.
43 preclinical studies support the efficacy of curcumin for COVID-19:
In Silico studies predict inhibition of SARS-CoV-2 with curcumin or metabolites via binding to the spikeA,17,9,20,11,4 (and specifically the receptor binding domainB,7,13,10), MproC,9,20,13,8,21,18,23,6,15,12,33,10,4, RNA-dependent RNA polymeraseD,19,10, ACE2E,11,12,14, nucleocapsidF,5,22, and nsp10G,22 proteins. In Vitro studies demonstrate inhibition of the spikeA,28 (and specifically the receptor binding domainB,36), MproC,33,35,28,16, ACE2E,36, and TMPRSS2H,36 proteins. In Vitro studies demonstrate efficacy in Calu-3I,34, A549J,28, 293TK,1, HEK293-hACE2L,26,16, 293T/hACE2/TMPRSS2M,27, Vero E6N,34,10,20,30,28,26,6,29,32, and SH-SY5YO,25 cells. Curcumin is predicted to inhibit the interaction between the SARS-CoV-2 spike protein receptor binding domain and the human ACE2 receptor for the delta and omicron variants7, decreases pro-inflammatory cytokines induced by SARS-CoV-2 in peripheral blood mononuclear cells32, and alleviates SARS-CoV-2 spike protein-induced mitochondrial membrane damage and oxidative stress1.
4 studies investigate novel formulations of curcumin for improved efficacy10,24,37,38
Kamble et al., 3 Jun 2024, peer-reviewed, 6 authors.
In Vitro studies are an important part of preclinical research, however results may be very different in vivo.
This PaperCurcuminAll
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Ltd, ' 'India. P.P. is Director of Nuimance Phytochemical Pvt. Ltd, India. There are no ' 'conflicts to declare for all other authors.', 'order': 2, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Conflict of interest'}}]}
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