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All Studies   Meta Analysis    Recent:   

In vitro antiviral activity against SARS-CoV-2 of common herbal medicinal extracts and their bioactive compounds

Leka et al., Phytotherapy Research, doi:10.1002/ptr.7463
Apr 2022  
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Curcumin for COVID-19
15th treatment shown to reduce risk in February 2021
 
*, now known with p = 0.000000046 from 26 studies.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments. c19early.org
In Vitro study showing antiviral activity of curcumin longa, with protection against SARS-CoV-2-induced cytopathic effects at a concentration of 3.125μg/ml.
In Silico studies predict inhibition of SARS-CoV-2 with curcumin or metabolites via binding to the spike Note A, Nag, Moschovou, Kandeil, Singh (B) (and specifically the receptor binding domain Note B, Kant, Srivastava, Eleraky), Mpro Note C, Moschovou, Kandeil, Srivastava, Naderi Beni, Rajagopal, Rampogu, Sekiou, Singh, Winih Kinasih, Thapa, Bahun, Eleraky, RNA-dependent RNA polymerase Note D, Singh (C), Eleraky, ACE2 Note E, Singh (B), Thapa, Alkafaas, nucleocapsid Note F, Hidayah, Suravajhala, and nsp10 Note G, Suravajhala proteins. In Vitro studies demonstrate inhibition of the spike Note A, Mohd Abd Razak (and specifically the receptor binding domain Note B, Goc (B)), Mpro Note C, Bahun, Guijarro-Real, Mohd Abd Razak, Wu, ACE2 Note E, Goc (B), and TMPRSS2 Note H, Goc (B) proteins. In Vitro studies demonstrate efficacy in Calu-3 Note I, Bormann, A549 Note J, Mohd Abd Razak, 293T Note K, Zhang, HEK293-hACE2 Note L, Nittayananta, Wu, 293T/hACE2/TMPRSS2 Note M, Septisetyani, and Vero E6 Note N, Bormann, Eleraky, Kandeil, Leka, Mohd Abd Razak, Nittayananta, Singh, Teshima, Marín-Palma cells. Curcumin is predicted to inhibit the interaction between the SARS-CoV-2 spike protein receptor binding domain and the human ACE2 receptor for the delta and omicron variants Kant, decreases pro-inflammatory cytokines induced by SARS-CoV-2 in peripheral blood mononuclear cells Marín-Palma, and alleviates SARS-CoV-2 spike protein-induced mitochondrial membrane damage and oxidative stress Zhang.
Leka et al., 9 Apr 2022, peer-reviewed, 6 authors.
In Vitro studies are an important part of preclinical research, however results may be very different in vivo.
This PaperCurcuminAll
In vitro antiviral activity against SARS‐CoV ‐2 of common herbal medicinal extracts and their bioactive compounds
Kristi Leka, Carla Hamann, Pauline Desdemoustier, Michel Frédérich, Mutien‐marie Garigliany, Allison Ledoux
Phytotherapy Research, doi:10.1002/ptr.7463
To the Editor, The coronavirus SARS-CoV-2 spread all around the world, leading to an unprecedented pandemic. Up to date, some effective treatments have been highlighted to treat the symptoms, but not to cure the COVID-19 disease. At least, some well-known medicines have been proposed, but have rapidly become the subject of some controversy, such as hydroxychloroquine combined or not azithromycin
FUNDING INFORMATION Fonds Léon Fredericq, Grant/Award Number: 2020-2021 -113 -Sub. F/E; Fondation Hospitalo Universitaire Léon Fredericq. CONFLICT OF INTEREST The authors declare no conflicts of interest.
References
Derosa, Maffioli, D'angelo, Di Pierro, A role for quercetin in coronavirus disease 2019 (COVID-19), Phytotherapy Research, doi:10.1002/ptr.6887
Franco-Paredes, Transmissibility of SARS-CoV-2 among fully vaccinated individuals, The Lancet Infectious Diseases, doi:10.1016/S1473-3099(21)00768-4
Ledoux, Leka, Bonnet, Blanquer, Alembert et al., In vitro antiviral activity against SARS-CoV-2 of 28 Strychnos extracts, Phytotherapy Research, doi:10.1002/ptr.7394
Maisonnasse, Guedj, Contreras, Behillil, Solas et al., Hydroxychloroquine use against SARS-CoV-2 infection in non-human primates, Nature, doi:10.1038/s41586-020-2558-4
Okour, Al-Kofahi, Austin, Hydroxychloroquine and azithromycin as potential treatments for COVID-19; clinical status impacts the outcome, Journal of Pharmacokinetics and Pharmacodynamics, doi:10.1007/s10928-020-09689-x
Saber-Moghaddam, Salari, Hejazi, Amini, Taherzadeh et al., Oral nano-curcumin formulation efficacy in management of mild to moderate hospitalized coronavirus disease-19 patients: An open label nonrandomized clinical trial, Phytotherapy Research, doi:10.1002/ptr.7004
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Tutunchi, Naeini, Ostadrahimi, Hosseinzadeh-Attar, Naringenin, a flavanone with antiviral and anti-inflammatory effects: A promising treatment strategy against COVID-19, Phytotherapy Research, doi:10.1002/ptr.6781
Zahedipour, Hosseini, Sathyapalan, Majeed, Jamialahmadi et al., Potential effects of curcumin in the treatment of COVID-19 infection, Phytotherapy Research, doi:10.1002/ptr.6738
Zaidi, Dehgani-Mobaraki, The mechanisms of action of ivermectin against SARS-CoV-2-An extensive review, The Journal of Antibiotics, doi:10.1038/s41429-021-00491-6
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