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All Studies   Meta Analysis    Recent:   

Antiviral, anti-inflammatory and antioxidant effects of curcumin and curcuminoids in SH-SY5Y cells infected by SARS-CoV-2

Nicoliche et al., Scientific Reports, doi:10.1038/s41598-024-61662-7
May 2024  
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Curcumin for COVID-19
14th treatment shown to reduce risk in February 2021
 
*, now with p = 0.000000015 from 26 studies.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,300+ studies for 77 treatments. c19early.org
In Vitro study showing antiviral, anti-inflammatory, and antioxidant effects of curcumin and curcuminoids in SARS-CoV-2 infected SH-SY5Y human neuroblastoma cells. Authors found that the curcuminoid Me23 significantly decreased expression of the SARS-CoV-2 entry factors TMPRSS2 and TMPRSS11D, mitigated elevated ROS levels induced by infection, increased expression of the antioxidant response regulator NRF2, and restored activity of the NRF2 target NQO1. Both Me08 and Me23 curcuminoids effectively reduced SARS-CoV-2 replication in SH-SY5Y cells overexpressing the ACE2 receptor. All tested compounds (curcumin, turmeric extract, Me08, Me23) decreased levels of the pro-inflammatory cytokines IL-6, TNF-α, and IL-17, while Me08 specifically reduced INF-γ.
44 preclinical studies support the efficacy of curcumin for COVID-19:
In Silico studies predict inhibition of SARS-CoV-2 with curcumin or metabolites via binding to the spikeA,18,10,21,12,5 (and specifically the receptor binding domainB,8,14,11), MproC,10,21,14,9,22,19,24,7,16,13,34,11,5, RNA-dependent RNA polymeraseD,20,11, ACE2E,12,13,15, nucleocapsidF,6,23, and nsp10G,23 proteins. In Vitro studies demonstrate inhibition of the spikeA,29 (and specifically the receptor binding domainB,37), MproC,34,36,29,17, ACE2E,37, and TMPRSS2H,37 proteins. In Vitro studies demonstrate efficacy in Calu-3I,35, A549J,29, 293TK,1, HEK293-hACE2L,27,17, 293T/hACE2/TMPRSS2M,28, Vero E6N,35,11,21,31,29,27,7,30,33, and SH-SY5YO,26 cells. Curcumin is predicted to inhibit the interaction between the SARS-CoV-2 spike protein receptor binding domain and the human ACE2 receptor for the delta and omicron variants8, decreases pro-inflammatory cytokines induced by SARS-CoV-2 in peripheral blood mononuclear cells33, and alleviates SARS-CoV-2 spike protein-induced mitochondrial membrane damage and oxidative stress1.
Nicoliche et al., 10 May 2024, Brazil, peer-reviewed, 16 authors. Contact: roberta.yamaguchi@fcmsantacasasp.edu.br.
In Vitro studies are an important part of preclinical research, however results may be very different in vivo.
This PaperCurcuminAll
Antiviral, anti-inflammatory and antioxidant effects of curcumin and curcuminoids in SH-SY5Y cells infected by SARS-CoV-2
Tiago Nicoliche, Cynthia Silva Bartolomeo, Robertha Mariana Rodrigues Lemes, Gabriela Cruz Pereira, Tamires Alves Nunes, Rafaela Brito Oliveira, Arthur Luiz Miranda Nicastro, Érica Novaes Soares, Brenno Fernandes Da Cunha Lima, Beatriz Moreira Rodrigues, Juliana Terzi Maricato, Liria Hiromi Okuda, Mirela Inês De Sairre, Carla Máximo Prado, Rodrigo Portes Ureshino, Roberta Sessa Stilhano
Scientific Reports, doi:10.1038/s41598-024-61662-7
COVID-19, caused by SARS-CoV-2, affects neuronal cells, causing several symptoms such as memory loss, anosmia and brain inflammation. Curcuminoids (Me08 e Me23) and curcumin (CUR) are derived from Curcuma Longa extract (EXT). Many therapeutic actions have been linked to these compounds, including antiviral action. Given the severe implications of COVID-19, especially within the central nervous system, our study aims to shed light on the therapeutic potential of curcuminoids against SARS-CoV-2 infection, particularly in neuronal cells. Here, we investigated the effects of CUR, EXT, Me08 and Me23 in human neuroblastoma SH-SY5Y. We observed that Me23 significantly decreased the expression of plasma membrane-associated transmembrane protease serine 2 (TMPRSS2) and TMPRSS11D, consequently mitigating the elevated ROS levels induced by SARS-CoV-2. Furthermore, Me23 exhibited antioxidative properties by increasing NRF2 gene expression and restoring NQO1 activity following SARS-CoV-2 infection. Both Me08 and Me23 effectively reduced SARS-CoV-2 replication in SH-SY5Y cells overexpressing ACE2 (SH-ACE2). Additionally, all of these compounds demonstrated the ability to decrease proinflammatory cytokines such as IL-6, TNF-α, and IL-17, while Me08 specifically reduced INF-γ levels. Our findings suggest that curcuminoid Me23 could serve as a potential agent for mitigating the impact of COVID-19, particularly within the context of central nervous system involvement.
Author contributions T Competing interests The authors declare no competing interests. Additional information Supplementary Information The online version contains supplementary material available at https:// doi. org/ 10. 1038/ s41598-024-61662-7. Correspondence and requests for materials should be addressed to R.S.S. Reprints and permissions information is available at www.nature.com/reprints. Publisher's note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
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