Antiviral, anti-inflammatory and antioxidant effects of curcumin and curcuminoids in SH-SY5Y cells infected by SARS-CoV-2

{ 'indexed': {'date-parts': [[2024, 5, 11]], 'date-time': '2024-05-11T00:23:32Z', 'timestamp': 1715387012805}, 'reference-count': 67, 'publisher': 'Springer Science and Business Media LLC', 'issue': '1', 'license': [ { 'start': { 'date-parts': [[2024, 5, 10]], 'date-time': '2024-05-10T00:00:00Z', 'timestamp': 1715299200000}, 'content-version': 'tdm', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0'}, { 'start': { 'date-parts': [[2024, 5, 10]], 'date-time': '2024-05-10T00:00:00Z', 'timestamp': 1715299200000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0'}], 'funder': [ { 'name': 'Fundação de Apoio à Pesquisa, Faculdade de Ciências Médicas da Santa Casa de São ' 'Paulo', 'award': ['2021/2023', '2021/2023']}, { 'DOI': '10.13039/501100001807', 'name': 'Fundação de Amparo à Pesquisa do Estado de São Paulo', 'doi-asserted-by': 'publisher', 'award': ['2020/13480-4', '2016/20796-2', '2019/10922-9']}], 'content-domain': {'domain': ['link.springer.com'], 'crossmark-restriction': False}, 'abstract': '<jats:title>Abstract</jats:title><jats:p>COVID-19, caused by SARS-CoV-2, affects neuronal ' 'cells, causing several symptoms such as memory loss, anosmia and brain inflammation. ' 'Curcuminoids (Me08 e Me23) and curcumin (CUR) are derived from <jats:italic>Curcuma Longa ' 'extract</jats:italic> (EXT). Many therapeutic actions have been linked to these compounds, ' 'including antiviral action. Given the severe implications of COVID-19, especially within the ' 'central nervous system, our study aims to shed light on the therapeutic potential of ' 'curcuminoids against SARS-CoV-2 infection, particularly in neuronal cells. Here, we ' 'investigated the effects of CUR, EXT, Me08 and Me23 in human neuroblastoma SH-SY5Y. We ' 'observed that Me23 significantly decreased the expression of plasma membrane-associated ' 'transmembrane protease serine 2 (TMPRSS2) and TMPRSS11D, consequently mitigating the elevated ' 'ROS levels induced by SARS-CoV-2. Furthermore, Me23 exhibited antioxidative properties by ' 'increasing <jats:italic>NRF2</jats:italic> gene expression and restoring NQO1 activity ' 'following SARS-CoV-2 infection. Both Me08 and Me23 effectively reduced SARS-CoV-2 replication ' 'in SH-SY5Y cells overexpressing ACE2 (SH-ACE2). Additionally, all of these compounds ' 'demonstrated the ability to decrease proinflammatory cytokines such as IL-6, TNF-α, and ' 'IL-17, while Me08 specifically reduced INF-γ levels. Our findings suggest that curcuminoid ' 'Me23 could serve as a potential agent for mitigating the impact of COVID-19, particularly ' 'within the context of central nervous system involvement.</jats:p>', 'DOI': '10.1038/s41598-024-61662-7', 'type': 'journal-article', 'created': {'date-parts': [[2024, 5, 10]], 'date-time': '2024-05-10T04:01:48Z', 'timestamp': 1715313708000}, 'update-policy': 'http://dx.doi.org/10.1007/springer_crossmark_policy', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Antiviral, anti-inflammatory and antioxidant effects of curcumin and curcuminoids in SH-SY5Y ' 'cells infected by SARS-CoV-2', 'prefix': '10.1038', 'volume': '14', 'author': [ {'given': 'Tiago', 'family': 'Nicoliche', 'sequence': 'first', 'affiliation': []}, {'given': 'Cynthia Silva', 'family': 'Bartolomeo', 'sequence': 'additional', 'affiliation': []}, { 'given': 'Robertha Mariana Rodrigues', 'family': 'Lemes', 'sequence': 'additional', 'affiliation': []}, {'given': 'Gabriela Cruz', 'family': 'Pereira', 'sequence': 'additional', 'affiliation': []}, {'given': 'Tamires Alves', 'family': 'Nunes', 'sequence': 'additional', 'affiliation': []}, {'given': 'Rafaela Brito', 'family': 'Oliveira', 'sequence': 'additional', 'affiliation': []}, { 'given': 'Arthur Luiz Miranda', 'family': 'Nicastro', 'sequence': 'additional', 'affiliation': []}, {'given': 'Érica Novaes', 'family': 'Soares', 'sequence': 'additional', 'affiliation': []}, { 'given': 'Brenno Fernandes', 'family': 'da Cunha Lima', 'sequence': 'additional', 'affiliation': []}, { 'given': 'Beatriz Moreira', 'family': 'Rodrigues', 'sequence': 'additional', 'affiliation': []}, {'given': 'Juliana Terzi', 'family': 'Maricato', 'sequence': 'additional', 'affiliation': []}, {'given': 'Liria Hiromi', 'family': 'Okuda', 'sequence': 'additional', 'affiliation': []}, {'given': 'Mirela Inês', 'family': 'de Sairre', 'sequence': 'additional', 'affiliation': []}, {'given': 'Carla Máximo', 'family': 'Prado', 'sequence': 'additional', 'affiliation': []}, {'given': 'Rodrigo Portes', 'family': 'Ureshino', 'sequence': 'additional', 'affiliation': []}, {'given': 'Roberta Sessa', 'family': 'Stilhano', 'sequence': 'additional', 'affiliation': []}], 'member': '297', 'published-online': {'date-parts': [[2024, 5, 10]]}, 'reference': [ { 'key': '61662_CR1', 'doi-asserted-by': 'publisher', 'first-page': '1', 'DOI': '10.1038/s41420-023-01512-z', 'volume': '9', 'author': 'Q Ding', 'year': '2023', 'unstructured': 'Ding, Q. & Zhao, H. 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